Helicobacter pylori eradication in patients with type 2 diabetes mellitus: Multicenter prospective observational study

Objective: To compare Helicobacter pylori ( H. pylori) eradication rate of type 2 diabetic patients with non-diabetic subjects. Methods: In this multicenter prospective observational study, H. pylori-infected subjects were enrolled from three university-affiliated hospitals. Eradication regimen was triple therapy with standard dose of proton pump inhibitors (b.i.d), amoxicillin (1.0 g b.i.d), and clarithromycin (500 mg b.i.d) for 7 days. Urea breath test was performed 4 weeks after treatment. Various clinical and laboratory data were collected for identification of factors associated with successful eradication. Results: Totally, 144 subjects were enrolled and 119 (85 non-diabetic and 34 diabetic patients) were finally analyzed. Eradication rate was 75.6% and there was no difference between diabetic patients and non-diabetic subjects (73.5% vs 76.5%, p value: 0.814). Adverse drug reactions were reported in 44.5% of patients. In multivariate analysis for predicting H. pylori eradication in diabetic patients, HbA1c (⩾7.5%) was a significant factor affecting eradication rate (adjusted odds ratio: 0.100, 95% confidence interval: 0.011–0.909, p value: 0.041). Conclusion: Diabetes itself is not a major factor affecting H. pylori eradication. However, poor glucose control may harmfully affect H. pylori eradication.

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Improvement of mild retinopathy in type 2 diabetic patients correlates with narrowing of retinal arterioles. A prospective observational study

Graefe s Archive for Clinical and Experimental Ophthalmology ◽

10.1007/s00417-014-2614-6 ◽

2014 ◽

Vol 252 (10) ◽

pp. 1561-1567 ◽

Cited By ~ 11

Author(s):

Line Pedersen ◽

Peter Jeppesen ◽

Søren Tang Knudsen ◽

Per Løgstrup Poulsen ◽

Toke Bek

Keyword(s):

Observational Study ◽

Prospective Observational Study ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Retinal Arterioles ◽

Type 2 Diabetic

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Helicobacter pylori infection among type 2 diabetics: a case control study

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20200779 ◽

2020 ◽

Vol 8 (3) ◽

pp. 1047

Author(s):

Hafiz Qazi Muhammad Amir ◽

Omaila Ikram ◽

Muhammad Tayyab Zia ◽

Fareha Kashan Theba ◽

Naila Ikram ◽

...

Keyword(s):

Helicobacter Pylori ◽

Case Control Study ◽

Case Control ◽

Helicobacter Pylori Infection ◽

P Value ◽

Type 2 Diabetics ◽

Dyspeptic Symptoms ◽

H Pylori ◽

Control Study

Background: Helicobacter pylori infection has been associated with hyperglycemia among type 2 diabetics. The objective of this study was to compare the H. pylori infection frequency in diabetic and non-diabetic patients.Methods: This case-control study was done at Al-Tibri Medical College and Hospital from May 2019 to August 2019. After written and informed consent, patients between 18-75 years with epigastric burning, dyspepsia, regurgitation were included and with history of eradication therapy, antibiotic or NSAID use in the last 6 months or surgery of upper GI tract months were excluded. Type 2 diabetics were placed in one group and non-diabetic individuals in another. Both groups were compared for presence of H. pylori infection. Data was analysed using SPSS. Demographic variables included age, gender and status of H. pylori infection. Quantitative data was expressed as frequency and percentages. Chi-square test was applied to test for significance keeping p-value of <0.05 statistically significant.Results: From 480 patients, 355 patients showed positive H. pylori, among them 282 were diabetic and 73 non-diabetic (p-value <0.001). Amongst the 355 diabetics, 55% were male Among 73 non-diabetics, 64% were male. All the patients in the study had dyspeptic symptoms and complained of dyspepsia, epigastric burning and regurgitation.Conclusions: A substantial relationship between H. pylori infection among type 2 diabetes mellitus patients was observed compared to non-diabetics. As a result, diabetic patients having active dyspeptic symptoms should undergo further confirmatory tests for diagnosing H. pylori infection.

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Comparison and Effectiveness of Complementary and Alternative Medicine as against Conventional Medicine in the Treatment and Management of Type 2 Diabetes

Journal of Complementary and Alternative Medical Research ◽

10.9734/jocamr/2019/v7i230097 ◽

2019 ◽

pp. 1-8

Author(s):

Cecil Boston ◽

Natasha Wong ◽

Teshawattie Ganga ◽

Khaimwattie Chandradatt ◽

Judith Rosales ◽

...

Keyword(s):

Disease Risk ◽

Conventional Medicine ◽

Statistical Significance ◽

Glycosylated Hemoglobin ◽

Fasting Blood Glucose ◽

Laboratory Data ◽

Controlled Study ◽

P Value ◽

Diabetic Patients

Aim: The main objective of the study was to compare, using laboratory data, the efficacy of herbal medicines against conventional drugs in treating and managing diabetes mellitus (DM) among type 2 diabetic (T2DM) patients. Methodology: The study recruited 80 patients from a private Herbal Clinic and the Georgetown Public Hospital Diabetic and Medical Outpatient Clinic after giving their consent and satisfying the inclusion criteria. Laboratory tests and analysis were done using conventional scientific methods and data analyzed using SPSS version 20 with a p-value of 0.05 being used to determine statistical significance. Results: The results showed that age, religion, ethnicity, education, marital status and monthly income have significant associations with the use of herbs. Persons using herbal medicine alone had normal lipid profile, renal function and liver function test, in addition to hemoglobin (Hb), white blood cell count (WBC), glycosylated hemoglobin (HBA1c) and fasting blood glucose (FBS). The most common herbs used were Momordica charantia (local name- karela) and Azadirachta indica (local name- neem), which were used in combination or alone. Results showed a positive effect on coronary heart disease risk. Conclusion: The information generated from the study indicated that a significant number of diabetic patients using herbs alone for their treatment had normal results. However, a more controlled study is required to validate these results.

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A large-scale nationwide multicenter prospective observational study of triple therapy using rabeprazole, amoxicillin, and clarithromycin for Helicobacter pylori eradication in Japan

Journal of Gastroenterology ◽

10.1007/s00535-011-0487-6 ◽

2011 ◽

Vol 47 (3) ◽

pp. 276-283 ◽

Cited By ~ 17

Author(s):

Toshio Fujioka ◽

Nobuo Aoyama ◽

Kyoko Sakai ◽

Yoshiyuki Miwa ◽

Mineo Kudo ◽

...

Keyword(s):

Helicobacter Pylori ◽

Observational Study ◽

Triple Therapy ◽

Large Scale ◽

Prospective Observational Study ◽

Helicobacter Pylori Eradication ◽

Multicenter Prospective Observational Study

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A Multicenter Prospective Observational Study of Triple Therapy with Rabeprazole, Amoxicillin and Metronidazole for Helicobacter pylori in Japan

Internal Medicine ◽

10.2169/internalmedicine.51.8510 ◽

2012 ◽

Vol 51 (22) ◽

pp. 3103-3108 ◽

Cited By ~ 4

Author(s):

Katsuya Sugizaki ◽

Yukinori Sakata ◽

Toshihisa Arai ◽

Yoshinori Furuhata ◽

Norio Iinuma ◽

...

Keyword(s):

Helicobacter Pylori ◽

Observational Study ◽

Triple Therapy ◽

Prospective Observational Study ◽

Multicenter Prospective Observational Study

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Assessment of the Relationship between Carotid Intima-Media Thickening and Early-Stage Diabetic Kidney Disease Coupled with Helicobacter pylori Infection

Disease Markers ◽

10.1155/2018/3793768 ◽

2018 ◽

Vol 2018 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Lei Feng ◽

Changqing Deng ◽

Yanxia Li

Keyword(s):

Helicobacter Pylori ◽

Kidney Disease ◽

Diabetic Kidney Disease ◽

Early Stage ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Diabetic Kidney ◽

H Pylori ◽

Type 2 Diabetic

Objective. This study aimed to explore the associations between carotid intima-media thickness (CIMT) and early-stage diabetic kidney disease (DKD) coupled with Helicobacter pylori (H. pylori) infection in type 2 diabetic patients. Methods. A cross-sectional study including 180 type 2 diabetic participants was conducted to explore the associations between CIMT and early-stage DKD coupled with H. pylori infection, and a stepwise multivariate regression analysis evaluated the correlations of CIMT with clinical and serologic parameters. Results. The type 2 diabetic patients with early-stage DKD coupled with H. pylori infections had the highest CIMT values. Apolipoprotein B (ApoB), urine albumin/creatinine ratio (UACR), and interleukin-6 (IL-6) were independent predictors of CIMT. Conclusions. Early-stage DKD coupled with H. pylori infection may synergistically lead to significant CIMT thickening in type 2 diabetic patients. Additionally, ApoB, UACR, and IL-6 levels were important independent risk factors for increased CIMT.

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