scholarly journals 2-Hydroxyglutaric aciduria as a cause for seizure-like episodes in a domestic shorthair cat

2019 ◽  
Vol 5 (1) ◽  
pp. 205511691985389
Author(s):  
George J Nye ◽  
Alison C Major ◽  
Francois X Liebel

Case summary A 14-month-old male castrated domestic shorthair cat, which 2 months prior to presentation underwent hindlimb amputation following a road traffic accident, presented for investigation of four suspected generalised tonic–clonic seizures. Neurological examination was unremarkable. Routine blood work (haematology, biochemistry, ammonia, preprandial bile acids) was unremarkable. MRI of the brain identified marked symmetrical T2-weighted hyperintensities of the cerebellum and brainstem, mainly affecting the grey matter. Urine amino acid and mucopolysaccharide levels were unremarkable. Urine organic acids on two separate samples, 35 days apart, identified highly increased excretion of 2-hydroxyglutaric acid, indicative of 2-hydroxyglutaric aciduria. The cat was started on anticonvulsant therapy with phenobarbitone, which, at the point of writing, has improved seizure control, although the cat has not achieved seizure freedom. Relevance and novel information This case report describes the first reported case of a 2-hydroxyglutaric aciduria, an inherited neurometabolic disorder, as a cause for seizure-like episodes in a cat.

Author(s):  
Ehsan Dehdashtian ◽  
Azam Hosseinzadeh ◽  
Karim Hemati ◽  
Mohammad Yahya Karimi ◽  
Iman Fatemi ◽  
...  

Background: Epilepsy, the second most frequent neurological disease, is a chronic disorder with a high lifetime prevalence. Therefore, various studies are needed to find new effective therapeutic agents to treat seizures or prevent its complications. In this study, we investigated the effects of thiamine, melatonin, and their combination on pentylenetetrazol (PTZ)-induced tonic-clonic seizures in mice. Methods: Male mice were randomly divided into six groups, including control, seizure control, diazepam, melatonin, thiamine, and melatonin and thiamine combination groups. Drugs were given orally in drinking water for 14 days. On the 15th day, the seizure was induced (except the control group) by intraperitoneal injection of PTZ. In all groups, the time between the injection the start of the seizure (latency) and the length of the seizure attack (duration) were measured in a 30-minute period. After measuring the latency and duration in all groups, mice were killed by CO2 Box, and their brains were dissected to be analyzed for malondialdehyde (MDA) level as a marker of oxidative stress. Results: The seizure duration was significantly lower in the groups of melatonin, thiamine, and thiamine and melatonin combination compared to the seizure control group. The latency times in these groups were significantly greater than the seizure control group. Moreover, MDA concentrations were lower in these groups compared to the seizure control group. Conclusion: Thiamine, melatonin and their combination can decrease the duration time of seizure and increase the latency period, which may result from inhibition of oxidative stress in the brain.


2020 ◽  
Vol 6 (1) ◽  
pp. 205511692092926
Author(s):  
Natalie Lisiewicz ◽  
Matthew Green ◽  
Mike Targett ◽  
Mark Lowrie

Case summary A 4-year-old cat involved in a road traffic accident presented with paraparesis, which was worse on the right-hand side. Neurolocalisation was to the T3–L3 spinal cord segments. Survey radiographs showed rib fractures but no definitive diagnosis for the paraparesis. CT revealed fracture of the dorsal rim and a T9 rib subluxation through the intervertebral foramen at T8–T9. This caused a contusive spinal injury. Treatment consisted of rest and analgesia. The cat recovered well, with the owner reporting no abnormalities 5 months following the injury. Relevance and novel information Road traffic accidents are a common cause of injury in the cat population, with a significant number having thoracic injuries. These include rib injures such as fractures. This is the first reported case of a traumatic rib subluxation causing a contusive injury in the spinal cord of any species. Previously reported rib subluxations have been seen in humans with spinal deformities. Conservative management in this case was sufficient.


F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 63
Author(s):  
Sunil Munakomi ◽  
Balaji Srinivas ◽  
Iype Cherian

Here we present a very rare case of a woman with a bone fragment in the third ventricle of the brain following compound-depressed skull fractures due to a road traffic accident.There are only few case reports of bullets and textiloma being removed from the third ventricle. Following operative removal of the fragment, the patient was started on cortisol, mineralocorticoid and thyroid hormone replacement. However, the patient eventually died of the severe traumatic hypothalamic insult.


F1000Research ◽  
2015 ◽  
Vol 4 ◽  
pp. 63
Author(s):  
Sunil Munakomi ◽  
Balaji Srinivas ◽  
Iype Cherian

Here we present a very rare case of a woman with a bone fragment in the third ventricle of the brain following compound-depressed skull fractures due to a road traffic accident.There are only few case reports of bullets and textiloma being removed from the third ventricle. Following operative removal of the fragment, the patient was started on cortisol, mineralocorticoid and thyroid hormone replacement. However, the patient eventually died of the severe traumatic hypothalamic insult.


2008 ◽  
Vol 05 (02) ◽  
pp. 117-118 ◽  
Author(s):  
Deepak Kumar Singh ◽  
Vishnu Gupta ◽  
Sanjeev Chopra ◽  
Pankaj Gupta ◽  
H Bagaria

AbstractPenetrating injuries other than gunshot wounds or low-velocity wounds to the head are extremely rare. We report the case of a 19 year old male who sustained a penetrating craniocerebral trauma following a road traffic accident. Mechanism of injury seems to share characteristics of low velocity projectiles. We discuss the management of this unusual case reviewing the current literature on craniocerebral injuries caused by similar objects.


2020 ◽  
Vol 22 (2) ◽  
pp. 110-117
Author(s):  
Md Mahmudul Islam ◽  
Khondkar AK Azad ◽  
Md Aminul Islam ◽  
Rivu Raj Chakraborty

Background: Chest trauma is responsible for 50% of deaths due to trauma. This kind of death usually occurs immediately after the trauma has occurred. Various therapeutic options have been reported for management of chest injuries like clinical observation, thoracocentesis, tube thoracostomy and open thoracotomy. Objective: To observe the pattern and outcome of management in chest trauma Methods: This is an observational study carried out in Casualty department of Chittagong Medical College Hospital (CMCH), Chittagong, between April 2015 to March 2016. Our study was included all patients, both sexes, following chest injury at Casualty units of Chittagong Medical College Hospital. All the data were recorded through the preformed data collection sheet and analyzed. Result: The mean age was found 37.7±18.1 years with range from 12 to 80 years. Male female ratio was 11.8:1. The mean time elapsed after trauma was found 6.1±3.1 hours with range from 1 to 72 hours. Almost one third (35.7%) patients was affecting road traffic accident followed by 42(27.3%) assault, 35(22.7%) stab injury, 15(9.7%) fall and 7(4.5%) gun shot . More than three fourth (80.5%) patients were managed by tube thoracostomy followed by 28(18.2%) observation and 2(1.3%) ventilatory support. No thoracotomy was done in emergency department. 42(27.2%) patients was found open pneumothorax followed by 41(26.6%) rib fracture, 31(20.1%) haemopneumothorax, 14(9%) simple pneumothorax, 12(7.8%) haemothorax, 6(3.9%) chest wall injury, 5(3.2%) tension pneumothorax, and 3(1.9%) flail chest. About the side of tube 60(39.0%) patients were given tube on left side followed by 57(37.0%) patients on right side, 9(5.8%) patients on both (left & right) side and 28(18.2%) patients needed no tube. Regarding the complications, 13(30%) patients had persistent haemothorax followed by 12(29%)tubes were placed outside triangle of safety, 6(13.9%) tubes were kinked, 6(13.9%) patients developed port side infection, 2(4.5%)tube was placed too shallow, 2(4.5%) patients developed empyema thoracis and 2(4.5%) patients developed bronchopleural fistula. The mean ICT removal information was found 8.8±3.6 days with range from 4 to 18 days. Reinsertion of ICT was done in 6(4.7%) patients. More than two third (68.2%) patients were recovered well, 43(27.9%) patients developed complication and 6(3.9%)patients died. More than two third (66.9%) patients had length of hospital stay 11-20 days. Conclusion: Most of the patients were in 3rd decade and male predominant. Road traffic accident and tube thoracostomy were more common. Open pneumothorax, rib fracture and haemopneumothorax were commonest injuries. Nearly one third of the patients had developed complications. Re-insertion of ICT needed almost five percent and death almost four percent. Journal of Surgical Sciences (2018) Vol. 22 (2) : 110-117


2012 ◽  
Vol 3 (8) ◽  
pp. 282-283
Author(s):  
Dr. Chhaya Lakhani ◽  
◽  
Dr. Rachana Kapadia ◽  
Dr. Dhara Prajapati ◽  
Dr. A.Bhagyalaxmi Dr. A.Bhagyalaxmi

2018 ◽  
Vol 9 (08) ◽  
pp. 20531-20536
Author(s):  
Nusrat Shamima Nur ◽  
M. S. l. Mullick ◽  
Ahmed Hossain

Background: In Bangladesh fatality rate due to road traffic accidents is rising sharply day by day. At least 2297 people were killed and 5480 were injured in road traffic accidents within 1st six months of 2017.Whereas in the previous year at 2016 at least 1941 people were killed and 4794 were injured within the 1st six months. No survey has been reported in Bangladesh yet correlating ADHD as a reason of impulsive driving which ends up in a road crash.


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