scholarly journals Swiss institute for translational and entrepreneurial medicine (sitem-insel)

2017 ◽  
Vol 1 (1) ◽  
pp. 2514183X1771410
Author(s):  
Felix J Frey
Keyword(s):  
Private Sector ◽  
Clinical Application ◽  
Translational Medicine ◽  
Continuing Professional Development ◽  
Basic Research ◽  
University Hospital ◽  
Non Profit ◽  
Private Sector Development ◽  
New Findings ◽  
Swiss Institute

sitem-insel – the Swiss Institute for Translational and Entrepreneurial Medicine in Bern – was created to establish, operate and develop a National Center of Excellence for Translational Medicine. sitem-insel is organized as a non-profit oriented public private partnership. Translational medicine is a new, process-oriented discipline that aims to translate new findings and products emerging from private-sector development and basic research into clinical application. The discipline seeks to professionalize the essential interaction between scientists conducting basic research in the private sector and universities, clinicians, regulatory bodies and investors. The mission of sitem-insel is to create and foster an enhanced environment for translational medicine in Switzerland. The sitem-insel strategy rests on three pillars: 1) The sitem-insel School offers university-level continuing professional development courses taught by university and private-sector lecturers. 2) The sitem-insel Enabling Facilities provide infrastructure to foster cooperation between industrial partners, basic scientists and clinicians on the campus of the University Hospital of Bern (Inselspital) with the ultimate goal to bring novel diagnostic and therapeutic products towards clinical application. 3) The sitem-insel Promoting Services aim to optimize the administrative-regulatory effort along the route from laboratory bench to commercial products.

scholarly journals Translational Medicine: What Orthopaedic Perspectives and Challenges Does the Mapping Technology?

2021 ◽  
Author(s):  
Guang Shi ◽  
Wei Liu ◽  
Xiuyun Su ◽  
Xiyu Cai
Keyword(s):  
Clinical Application ◽  
Basic Science ◽  
Translational Medicine ◽  
Clinical Medicine ◽  
Thoracolumbar Spine ◽  
Basic Research ◽  
Science Research ◽  
Lower Limbs ◽  
Upper Limbs ◽  
Mapping Technology

Abstract Background Translational medicine (TM) is a bridge between basic science and clinical medicine by translating new knowledge, mechanisms and technologies generated by basic science research into new ways of preventing, diagnosing and treating disease. The purpose of this study is to systematically review the literature concerning the two-dimensional and three-dimensional mapping technology (MT) for fractures in orthopedics, to clarify what perspectives MT offers and the current challenges in TM. Methods A systematic review was conducted according to PRISMA guidelines. We systematically searched the PubMed, Scopus, IEEE Digital Library, Web of Science database and references of relevant studies, from the establishment of the database through December 2020, for any and all data regarding the application of fracture MT in orthopedics, (including upper limbs, lower limbs, spine, and pelvis). We then made a systematic summary of these research results. Results A total of 2777 articles were retrieved, and 28 articles met the inclusion criteria: 26 were retrospective studies of using fracture MT and 2 were prospective studies using of fracture MT. The application of fracture MT in orthopaedics was as follows: upper limbs (n=10, 35.71%), lower limbs (n=17, 60.71%), thoracolumbar spine (n=1, 3.58%). Article subjects included: how fracture mapping guided preoperative planning (n = 12, 42.86%); illustration of how the characteristics of fracture line distribution helped surgeons identify specific types of fractures (n=9, 32.14%); and how fracture MT illustrated fracture morphology and guided clinical treatment (n=7, 25.00%). Conclusion Today, we need a new generation of researchers: 'translational scientists' who are able to transfer ideas from basic research to clinical science. MT is a better technology to describe the morphological classifications of fractures compared to traditional methods, but its clinical application is still limited. Thus, much further research is needed to determine the potential advantages of this new technique in clinical application or practice. If possible, guidelines are needed to facilitate the development of MT with regard to the additional costs and time constraints required for the developing this technic.

scholarly journals Update on Giardia: Highlights from the seventh International Giardia and Cryptosporidium Conference

Parasite ◽  
2020 ◽  
Vol 27 ◽  
pp. 49 ◽  
Author(s):  
André G. Buret ◽  
Simone M. Cacciò ◽  
Loïc Favennec ◽  
Staffan Svärd
Keyword(s):  
Cell Biology ◽  
Health Management ◽  
Giardia Duodenalis ◽  
Basic Research ◽  
Basic Knowledge ◽  
Future Research ◽  
World Knowledge ◽  
Main Research ◽  
Research Perspectives ◽  
New Findings

Although Giardia duodenalis is recognized as one of the leading causes of parasitic human diarrhea in the world, knowledge of the mechanisms of infection is limited, as the pathophysiological consequences of infection remain incompletely elucidated. Similarly, the reason for and consequences of the very specific genome-organization in this parasite with 2 active nuclei is only partially known. Consistent with its tradition, the 7th International Giardia and Cryptosporidium Conference (IGCC 2019) was held from June 23 to 26, 2019, at the Faculty of Medicine and Pharmacy of the University of Rouen-Normandie, France, to discuss current research perspectives in the field. This renowned event brought together an international delegation of researchers to present and debate recent advances and identify the main research themes and knowledge gaps. The program for this interdisciplinary conference included all aspects of host-parasite relationships, from basic research to applications in human and veterinary medicine, as well as the environmental issues raised by water-borne parasites and their epidemiological consequences. With regard to Giardia and giardiasis, the main areas of research for which new findings and the most impressive communications were presented and discussed included: parasite ecology and epidemiology of giardiasis, Giardia-host interactions, and cell biology of Giardia, genomes and genomic evolution. The high-quality presentations discussed at the Conference noted breakthroughs and identified new opportunities that will inspire researchers and funding agencies to stimulate future research in a “one health” approach to improve basic knowledge and clinical and public health management of zoonotic giardiasis.

MPA Graduates and the Dilemma of Job Satisfaction: Does Crossing the Sector Line Make a Difference

1991 ◽  
Vol 20 (4) ◽  
pp. 449-455 ◽  
Author(s):  
Barrie E. Blunt ◽  
Kris Anne Spring
Keyword(s):  
Job Satisfaction ◽  
Public Sector ◽  
Private Sector ◽  
Work Satisfaction ◽  
Federal State ◽  
Non Profit ◽  
The Public ◽  
Public Sector Employment ◽  
State Regional

This study examines levels of job satisfaction for MPA graduates employed in the public, private, and non-profit sectors. Findings are based on a survey and indicate that MPA graduates derive greater satisfaction with pay and promotion opportunities in the private sector than in the public or non-profit sectors. No significant differences were noted between the sectors with regard to work satisfaction or satisfaction with supervisor or co-workers. Further, no differences in levels of satisfaction were noted between four categories of public sector employment; federal, state, regional, or local.

scholarly journals Post-operative fever in children undergoing mastoidectomy due to complicated acute mastoiditis

2021 ◽  
Author(s):  
Oren Ziv ◽  
Aviad Sapir ◽  
Eugene Leibowitz ◽  
Sofia Kordeluk ◽  
Daniel KAPLAN ◽  
...  
Keyword(s):  
Chart Review ◽  
Tertiary Care ◽  
Retrospective Chart Review ◽  
University Hospital ◽  
Acute Mastoiditis ◽  
Benign Condition ◽  
Subperiosteal Abscess ◽  
Cortical Mastoidectomy ◽  
New Findings ◽  
Mastoid Surgery

Abstract Objectives: To determine the immediate post-operative course and outcome of pediatric patients with complicated acute mastoiditis (CAM) following surgical treatment. Study Design: A retrospective chart review of children diagnosed with CAM who underwent mastoid surgery during 2012-2019. Setting: Tertiary care university hospital. Participants: the study includes 33 patients, divided into two groups: 17 patients with subperiosteal abscess (SPA) alone - single complication group (SCG) and 16 patients with SPA and additional intracranial or intratemporal complications -multiple complications group (MCG). Main Outcome Measures: post-operative fever course and pattern (POF). Results :33 patients belong to the SCG 17(51%) and 16(49%) belonged to the MCG, respectively. 6/17(35.3%) SCG patients experienced POF vs. 12/16(75%) in the MCG (P=0.012). At post-operative day 2 (POD2), 10/13(77%) febrile patients belonged to MCG and 3/13(23%) to SCG (P=0.013). POF was recorded until POD6 in both groups. Seven patients, all from MCG with POF, underwent second imaging with no new findings. Conclusion: Following a cortical mastoidectomy for CAM, POF is not unusual in the first 6 days and seem to be benign condition. POF is more common, higher, and persistent for a longer duration in MCG compared with SCG. At POD 6, fever is expected to normalize in both groups, so if fever persists further evaluation should be considered.

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