Low-power laser in the prevention of induced oral mucositis in bone marrow transplantation patients: a randomized trial

Blood ◽  
2006 ◽  
Vol 109 (5) ◽  
pp. 2250-2255 ◽  
Author(s):  
Héliton Spíndola Antunes ◽  
Alexandre Mello de Azevedo ◽  
Luiz Fernando da Silva Bouzas ◽  
Carlos Alberto Esteves Adão ◽  
Claudia Tereza Pinheiro ◽  
...  
Keyword(s):  
Low Power ◽  
Oral Mucositis ◽  
World Health ◽  
Control Group ◽  
Clinical Effects ◽  
Power Laser ◽  
Hematopoietic Stem ◽  
Section Area ◽  
The World ◽  
Health Organization

Abstract We investigated the clinical effects of low-power laser therapy (LPLT) on prevention and reduction of severity of conditioning-induced oral mucositis (OM) for hematopoietic stem cell transplantation (HSCT). We randomized 38 patients who underwent autologous (AT) or allogeneic (AL) HSCT. A diode InGaAlP was used, emitting light at 660 nm, 50 mW, and 4 J/cm2, measured at the fiberoptic end with 0.196 cm2 of section area. The evaluation of OM was done using the Oral Mucositis Assessment Scale (OMAS) and the World Health Organization (WHO) scale. In the LPLT group, 94.7% of patients had an OM grade (WHO) lower than or equal to grade 2, including 63.2% with grade 0 and 1, whereas in the controls group, 31.5% of patients had an OM grade lower than or equal to grade 2 (P < .001). Remarkably, the hazard ratio (HR) for grades 2, 3, and 4 OM was 0.41 (range, 0.22-0.75; P = .002) and for grades 3 and 4 it was 0.07 (range, 0.11-0.53; P < .001). Using OMAS by the calculation of ulcerous area, 5.3% of the laser group presented with ulcers of 9.1 cm2 to 18 cm2, whereas 73.6% of the control group presented with ulcers from 9.1 cm2 to 18 cm2 (P = .003). Our results indicate that the use of upfront LPLT in patients who have undergone HSCT is a powerful instrument in reducing the incidence of OM and is now standard in our center.

scholarly journals EFFECT OF GIVING CUCUMBER (Cucumis sativus) TO DECREASE HEMOGLOBIN TROMBOSITE AND IMPROVEMEN IN PRE-ECLAMMED PATIENTS AT DEWI SARTIKA HOSPITAL

2021 ◽  
Vol 3 (1) ◽  
pp. 1-7
Author(s):  
Novia Sarmiati ◽  
Erwin Azizi Jaya Dipraja ◽  
La Banudi
Keyword(s):  
Maternal Mortality ◽  
General Hospital ◽  
World Health ◽  
Group Method ◽  
Control Group ◽  
Live Births ◽  
The World ◽  
Quasi Experimental ◽  
Health Organization ◽  
Number Of Births

Background:According to the World Health Organization (WHO) every day in 2015, around 830 women die from complications of pregnancy and child birth. Globally, maternal mortality in the world is 303,000. The maternal mortality rate (MMR) in Indonesia based on the Indonesian Health Demographic Survey (IDHS) in 2012 was around 359 / 100,000 live births, this figure increased compared to 2007, which was around 228 / 100,000 live births. Data from Dewi Sartika General Hospital with preeclampsia cases for the last three years. In 2017, the number of births in 1855 who experienced preeclampsia were 305 cases. In 2018 the number of births in 1822 who experienced preeclampsia was 334 cases. In 2019 the number of deliveries in 2007 who experienced preeclampsia was 377 cases. For 2020 January to June number of deliveries695 the incidence of preeclampsia was 164 cases. Methods:This study used a quasi-experimental type with a pre-test-post-test control group method design. The population in this study were all 164 preeclampsia patients from August to October 2020. Result:Test data analysis using testwilcoxon test (? = 0.05) in the cucumber group, it was found that p = 0.000 on decreased hemoglobin and increased platelets Conclusion:There is an effect of cucumber on decreasing hemoglobin and increasing platelets in preeclampsia patients at Dewi Sartika General Hospital.

scholarly journals Prion diseases are under compulsory notification in Brazil: Surveillance of cases evaluated by biochemical and/or genetic markers from 2005 to 2007

2007 ◽  
Vol 1 (4) ◽  
pp. 347-355 ◽  
Author(s):  
Vilma Regina Martins ◽  
Hélio Rodrigues Gomes ◽  
Leila Chimelli ◽  
Sergio Rosemberg ◽  
Michele Christine Landemberger
Keyword(s):  
Prion Diseases ◽  
World Health ◽  
Control Group ◽  
The United Kingdom ◽  
New Variant ◽  
The World ◽  
Jakob Disease ◽  
Health Organization ◽  
Compulsory Notification ◽  
Codon 129

Abstract The emergence of the new variant of Creutzfeldt-Jakob disease (vCJD) in the United Kingdom has raised concerns over the risks of this prion disease in other parts of the world. Since 2005, human prion diseases have been under compulsory notification in Brazil. It is well known that some polymorphisms within the cellular prion gene (PRNP) have been associated to a higher susceptibility to sporadic CJD (sCJD) and vCJD. Objectives: To describe the first notified cases and to evaluate the presence of mutations and polymorphisms of the PRNP in these cases. Methods: Thirty-five notified cases were evaluated by clinical, auxiliary exams and biochemical and/or genetic tests and classified according to the World Health Organization criteria for CJD. A control group (N=202) was included for the purpose of comparing the genetic analyses. Results: Twenty seven cases (74%) were classified as possible sCJD while 51% fulfilled the criteria for probable sCJD. Brain tissue analysis was available in three cases, where two were classified as definite sCJD and one as unconfirmed sCJD. Mutation of the PRNP was not found, and regarding the codon 129 polymorphism, valine in both alleles (Val129Val) was more frequent in patients than in the control group (OR=4.98; 1.55-15.96; p=0.007) when all possible cases were included, but not when only probable cases were considered. Conclusions: Our data did not show correlation of PRNP polymorphisms with probable sCJD cases. It is necessary to work toward notification of all cases of possible CJD in Brazil and to increase the rate of definitive diagnoses.

scholarly journals Evaluation of seminal fluid leukocyte subpopulations in patients with varicocele

2020 ◽  
Vol 34 ◽  
pp. 205873842092571
Author(s):  
Laura Maria Mongioì ◽  
Angela Alamo ◽  
Aldo E Calogero ◽  
Michele Compagnone ◽  
Filippo Giacone ◽  
...  
Keyword(s):  
Seminal Fluid ◽  
Sperm Concentration ◽  
Sperm Parameters ◽  
World Health ◽  
Lower Percentage ◽  
Control Group ◽  
Healthy Men ◽  
Sperm Analysis ◽  
The World ◽  
Health Organization

Varicocele is a common cause of sperm damage. Some studies showed higher concentration of seminal leukocytes in patients with varicocele. The aim of the study was to evaluate seminal leukocyte subpopulations in patients with varicocele. We enrolled 20 patients with varicocele and 20 age-matched healthy men. Sperm analysis was conducted according to the World Health Organization (WHO) 2010 criteria. We evaluated seminal leukocyte subpopulations and bio-functional sperm parameters by flow cytometry. Patients with varicocele had significantly lower sperm concentration and total number than controls. Regarding seminal leukocyte subpopulations, patients with varicocele had a significantly lower percentage of CD8+ and CD16+ leukocytes and a significantly higher percentage of CD4+ leukocytes than controls. As for bio-functional sperm parameters, we found that patients with varicocele had a significantly lower percentage of alive spermatozoa compared to the control group. These results may explain the increased level of cytokines in the seminal plasma of patients with varicocele.

scholarly journals LA FENILCETONURIA Y LA HIPERACTIVIDAD: RESULTADOS EN NIÑOS EXTREMEÑOS

2016 ◽  
Vol 1 (2) ◽  
pp. 253
Author(s):  
Virgilio García Aparicio ◽  
Florencio Vicente Castro
Keyword(s):  
Total Population ◽  
Development Stage ◽  
World Health ◽  
Control Group ◽  
Severe Mental Retardation ◽  
Exclusion Criteria ◽  
Hyperactivity Disorder ◽  
The World ◽  
Phenylalanine Metabolism ◽  
Health Organization

RESUMEN.La Fenilcetonuria (PKU) pertenece a un tipo de hiperfenilalaninemias, éstas son un grupo de errores innatos en el metabolismo del aminoácido fenilalanina, que se caracterizan normalmente por producir un retraso mental severo e incluso la muerte cuando no se tratan adecuadamente. De acuerdo con la Organización Mundial de la Salud (OMS), está catalogada como enfermedad rara. Por otro lado, el Trastorno por Déficit de Atención con Hiperactividad (TDAH) es uno de los trastornos con mayor prevalencia en niños en edad escolar. Consiste en un patrón persistente de déficit que incluye la falta de atención y/o hiperactividad e impulsividad, y se presenta con una frecuencia y una gravedad que es inconsistente y no adaptativa en relación con el nivel de desarrollo del niño (APA, 2000).Objetivo: Comprobar que los niños fenilcetonúricos obtienen resultados significativamente superiores a los niños del grupo control para los indicadores de TDAH.Metodología: la investigación contempla un carácter descriptivo y cuantitativo, se utilizaron las herramientas de entrevista y el cuestionario Conners (padres y profesores) en una muestra de ocho niños extremeños fenilcetonúricos, que representan la población total de fenilcetonúricos en el rango de edad de entre ocho a trece años después de tener en cuenta los criterios de exclusión, y ocho niños extremeños de edad similar como grupo control.ABSTRACT.Phenylketonuria (PKU) is a type of hyperphenylalaninemias, which are an inborn group of errors of the amino acid phenylalanine metabolism that are usually characterized by producing a severe mental retardation and even death if it is not treated properly.According to the World Health Organization (WHO), it is classified as rare disease. On the other hand, Attention Deficit Hyperactivity Disorder (ADHD) is one of the most prevalent disorders in  schoolchildren. It consists of a persistent deficit pattern that includes lack of attention and / or hyperactivity and impulsivity, and it is present with an inconsistent and non adaptative frequency and severity with regard to the child's  development stage (APA, 2000).Objective: To check that PKU children get significantly higher results than the control group of children for ADHD indicators.Methodology: the research includes a descriptive and quantitative approach. Interview tools were used as well as Conners Questionnaire (parents and teachers) in a sample of eight phenylketonuric children from Extremadura, who represents the total population of PKU children aged 8–13, taking into account the exclusion criteria, and eight children from Extremadura aged similarly as control group.

scholarly journals Impact of the World Health Organization Surgical Safety Checklist on Patient Safety

2019 ◽  
Vol 131 (2) ◽  
pp. 420-425 ◽  
Author(s):  
Arvid S. Haugen ◽  
Nick Sevdalis ◽  
Eirik Søfteland
Keyword(s):  
Patient Safety ◽  
World Health Organization ◽  
New Technology ◽  
World Health ◽  
Clinical Effects ◽  
Surgical Safety Checklist ◽  
Surgical Safety ◽  
Advantages And Disadvantages ◽  
The World ◽  
Health Organization

Abstract The incidence of surgical complications has remained largely unchanged over the past two decades. Inherent complexity in surgery, new technology possibilities, increasing age and comorbidity in patients may contribute to this. Surgical safety checklists may be used as some of the tools to prevent such complications. Use of checklists may reduce critical workload by eliminating issues that are already controlled for. The global introduction of the World Health Organization Surgical Safety Checklist aimed to improve safety in both anesthesia and surgery and to reduce complications and mortality by better teamwork, communication, and consistency of care. This review describes a literature synthesis on advantages and disadvantages in use of surgical safety checklists emphasizing checklist development, implementation, and possible clinical effects and using a theoretical framework for quality of provided healthcare (structure—process—outcome) to understand the checklists’ possible impact on patient safety.

Erstes Instrument zur standardisierten Erfassung der Teilhabe Behinderter

2017 ◽  
Vol 79 (07) ◽  
pp. 526-527
Keyword(s):  
World Health Organization ◽  
World Health ◽  
The World ◽  
Health Organization ◽  
Menschen Mit Behinderung

Coenen M et al. [Recommendation for the collection and analysis of data on participation and disability from the perspective of the World Health Organization]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2016; 59: 1060–1067 Um eine gleichberechtigte Teilhabe an der Gesellschaft von Menschen mit Behinderung zu ermöglichen, werden zunächst Daten zu vorhandenen Einschränkungen gebraucht. Erst wenn diese detailliert erhoben wurden, können Konzepte zur Beseitigung von Problemen entwickelt werden. Ein standardisiertes Erhebungsinstrument für alle Aspekte der Funktionsfähigkeit fehlte jedoch bisher.

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