Venous Thromboembolism In Patients With Non-Hodgkin Lymphoma: Analysis Of The Veterans Health Administration (VHA) National Database

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 1701-1701
Author(s):  
Peter A Riedell ◽  
Kristen M. Sanfilippo ◽  
Suhong Luo ◽  
Kenneth R Carson
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Venous Thromboembolism ◽  
Treatment Initiation ◽  
Factors Associated ◽  
Non Hodgkin Lymphoma ◽  
Morbidity Score ◽  
Co Morbidity ◽  
History Of ◽  
The Mean

Abstract Introduction The association between malignancy and venous thromboembolism (VTE) is well known. Non-Hodgkin lymphoma (NHL) increases VTE risk, though most studies do not differentiate between low- and high-grade NHL. In order to better understand the natural history of VTE in NHL, we examined the incidence and factors associated with VTE in patients with diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). Methods Patients diagnosed with DLBCL or FL between 1998 and 2008 and treated within the VHA system with CHOP or CHOP-like regimens (+/- rituximab) were identified in the VA Central Cancer Registry. Those with VTE prior to the lymphoma diagnosis or history of atrial fibrillation were excluded. Data on sex, race, stage, lactate dehydrogenase (LDH), disease histology, B-symptoms, body mass index, co-morbidities, medications, and date of VTE event were obtained. Incident cases of VTE were determined through the use of ICD-9 codes for VTE combined with either pharmacy records of anti-coagulation therapy, placement of a vena-cava filter, or death within 30 days of an ICD-9 code for VTE. Logistic regression analysis was used to identify baseline factors associated with VTE. VTE incidence was then analyzed to evaluate differences before, during, and after treatment. Results 2606 NHL patients (1838 DBLCL, 768 FL) were identified, of whom 179 developed VTE (119 DLBCL, 33 FL) within 2 years of treatment initiation. The mean age at NHL diagnosis was 64 years. A majority of patients were male (97%), Caucasian (87%), and had a diagnosis of DLBCL (70%). The mean Charlson co-morbidity score in the cohort was 2.2. Annualized VTE incidence rates were significantly different between DLBCL and FL patients during the time from diagnosis to treatment initiation (18.7% vs. 6.1%; p<0.001) and in the 6 months after treatment initiation (9.3% and 3.8%; p=0.001). The annualized incidence dropped to 1% or less in both DLBCL and FL patients during the period 6 months to 2 years following treatment initiation. On multivariate logistic regression analysis, factors associated with increased odds of developing VTE within 6 months of treatment initiation included: DLBCL histology (OR 2.04; 95% CI 1.27 – 3.31), BMI ≥ 30 (OR 2.58; 95% CI 1.61 – 4.17), and stage III/IV disease (OR 1.7; 95% CI 1.14 – 2.55). There was a protective association observed for each point increase in the Charlson co-morbidity score (OR= 0.85; 95% CI 0.78 – 0.96). Conclusion VTE risk was greatest in time between diagnosis and 6 months after treatment initiation in all NHL patients. This is potentially due to greater disease burden during the time between diagnosis and treatment initiation and the pro-thrombotic effects of chemotherapy in the six months after treatment initiation. After controlling for potential confounding factors, the odds of VTE were twice as high in DLBCL compared to FL patients. While prophylactic anticoagulation in cancer patients remains controversial, future efforts in NHL should be focused on patients with higher grade histology during the timeframe between diagnosis and shortly after treatment cessation. Disclosures: Carson: Spectrum Pharmaceuticals: Honoraria, Research Funding, Speakers Bureau.

scholarly journals P628 Risk Factors Associated with Extraintestinal Manifestations in Patients with Inflammatory Bowel Diseases

2021 ◽  
Vol 15 (Supplement_1) ◽  
pp. S566-S566
Author(s):  
C Liava ◽  
E Sinakos ◽  
T Dimitroulas ◽  
C Navrozidou ◽  
E Akriviadis
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Aphthous Stomatitis ◽  
Perianal Disease ◽  
Extraintestinal Manifestations ◽  
Factors Associated ◽  
Increased Risk ◽  
History Of ◽  
Inflammatory Bowel

Abstract Background Risk factors associated with extraintestinal manifestations (EIMs) in patients with inflammatory bowel disease (IBD) have been evaluated mainly in retrospective studies. We aimed to determine risk factors associated with EIMs and to compare the frequency of EIMs between ulcerative colitis (UC) and Crohn’s disease (CD), based on retrospectively-prospectively collected data of a cohort of IBD patients followed in daily clinical practice. Methods Patients with biopsy-confirmed IBD aged 10–80 years old were included in the study. A comprehensive questionnaire was used to collect data on each site visit from July 2018 until March 2020. Logistic regression analysis and multivariable-adjusted models were used to examine risk factors associated with EIMs and chi-squared test was used to compare the frequency of EIMs between patients with UC and CD. Results 300 patients with IBD (180 with CD, 113 with UC, and 7 with indeterminate colitis) were evaluated. EIMs were observed in 49% of patients, with a 2-fold increased risk in CD (OR 2.31; 95% CI:1.37–3.89; P&lt;.005). The musculoskeletal system was affected in 38% (43% in CD vs 29% in UC, OR 1.86; 95% CI:1.08–3.20; P&lt;.05) with peripheral arthropathy being the most common manifestation (33% in CD vs 23% in UC, P=.095), followed by dermatological manifestations (13%), with a 4-fold increased risk of erythema nodosum in CD (11% vs 3% in UC, OR 3.95; 95% CI:1.12–13.93; P&lt;.05). On univariate logistic regression analysis history of hospitalization for IBD, history of surgery for IBD, aphthous stomatitis, perianal disease, thyroiditis Hashimoto, age, use of thiopurines, and/or anti-TNF in the past were associated with increased risk of developing EIMs. A trend for increased risk of EIMs was found for family history of IBD in first-degree relatives (OR 2.47; 95% CI:0.91–6.74; P=.078) and fecal calprotectin above 250 μg/g (OR 2.22; 95% CI:0.90–5.47; P&lt;.084). On multivariate analysis only aphthous stomatitis (OR 4.60; 95% CI:2.32–9.13; P&lt;.001), perianal disease (OR 2.30; 95% CI:1.17–4.50; P&lt;.05), thyroiditis Hashimoto (OR 2.82; 95% CI:1.03–7.74; P&lt;.05) and age (2% increase in risk per year, OR 1.02; 95% CI:1.01–1.03; P&lt;.05) were significant for EIMs. Conclusion In this retrospective/prospective study 49% of IBD patients developed EIMs with a 2-fold increased risk in CD. Musculoskeletal and dermatological manifestations were the most frequent EIMs. Aphthous stomatitis, perianal disease, thyroiditis Hashimoto and age were associated with increased risk of EIMs.

scholarly journals Characteristics and main risk factors correlated to nausea and vomiting after painless digestive endoscopy

2021 ◽  
Author(s):  
Dan Wu ◽  
Cai-Fen Xi ◽  
Ling Zhang ◽  
Peng Xu ◽  
Zhi Chen
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Nausea And Vomiting ◽  
Digestive Endoscopy ◽  
Factors Associated ◽  
Male Ratio ◽  
History Of ◽  
Independent Risk Factors ◽  
Female Weight

Abstract Background Nausea and vomiting is relatively frequent after painless digestive endoscopy. It not only occurs after surgery, but may also occur after painless digestive endoscopy. Here we study the characteristics and main risk factors associated with nausea and vomiting after painless digestive endoscopy. Methods A retrospective analysis of 1336 patients who had undergone painless digestive endoscopy in our hospital from January 2020 to May 2020 was performed. The incidence and timing of nausea and vomiting was examined, and the risk factors of nausea and vomiting of painless digestive endoscopy were analyzed. Results 57 cases had nausea or vomiting (4.3% of 1336 cases, female to male ratio 3.38:1, average age 49.49 ± 13.30 years). 55 cases had nausea (4.1%) and 39 cases had vomiting (2.9%). Nausea and vomiting mostly occur within 6 hours after painless digestive endoscopy. In one-way analysis of variance, female, weight less than 60kg, diazoxide dose exceeding 2.5 mg, history of motion sickness, and history of smoke had significant correlation with nausea and vomiting, while female (OR=3.640, P=0.001), weight less than 60kg (OR 0.942, P=0.001), diazoxide dose exceeding 2.5 mg (OR=2.074, P=0.000) were independent risk factors of nausea and vomiting after painless digestive endoscopy by logistic regression analysis. Conclusions In our patients, female, weight less than 60kg and the dosage of diazoxide more than 2.5mg are the main risk factors of nausea and vomiting after painless digestive endoscopy. This study suggests that the dose of diazoxide no more than 2.5mg may reduce the occurrence of nausea and vomiting after painless digestive endoscopy.

Experiences of cancer patients with outpatient care in the USA: a population-based study

2020 ◽  
Vol 9 (13) ◽  
pp. 959-967
Author(s):  
Omar Abdel-Rahman
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Cancer Patients ◽  
Outpatient Care ◽  
Healthcare Providers ◽  
Multivariable Logistic Regression Analysis ◽  
Factors Associated ◽  
The Usa ◽  
History Of ◽  
History Of Cancer

Aim: To evaluate the patterns of cancer patients-assessed quality of outpatient care in the USA. Materials & methods: Medical Expenditure Panel Survey datasets for the years 2011, 2013, 2015 and 2017 were accessed and adult participants with a history of cancer diagnosis were reviewed. Participants’ assessments of different quality indicators of healthcare providers were reviewed. Multivariable logistic regression analysis for factors associated with a better overall rating of healthcare was then conducted. Results: A total of 8050 participants with a history of cancer were included. Within multivariable logistic regression analysis, factors associated with the better rating of healthcare included; older age (odds ratio [OR]: 1.017; 95% CI: 1.010–1.025), higher income OR (OR: 2.385; 95% CI: 1.735–3.277) and better self-reported health status (OR: 6.691; 95% CI: 3.928–11.396). Conclusion: Cancer patients with older age, higher income and better health status were more likely to be satisfied with the outpatient care they received. The biggest area for potential improvement of patient satisfaction seems to be related to the time spent with healthcare providers.

scholarly journals POS1430 EPIDEMIOLOGY OF LUPUS NEPHRITIS IN BRAZIL: FINDINGS FROM THE MACUNAÍMA STUDY - A NATIONWIDE MULTICENTRIC STUDY

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 999.1-999
Author(s):  
M. Abreu ◽  
O. Monticielo ◽  
V. Fernandes ◽  
A. Cristovão Maiorano ◽  
F. Dos Santos Beserra ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Disease Activity ◽  
Systemic Lupus ◽  
Research Support ◽  
Multicentric Study ◽  
Factors Associated ◽  
Type Iv ◽  
Damage Accrual ◽  
History Of ◽  
The Mean

Background:Lupus nephritis (LN) is one of the most serious organic manifestations of systemic lupus erythematosus (SLE). Ethnicity can contribute to disparities in the prevalence and disease activity of LN.Objectives:To assess the prevalence of LN in Brazilian patients with SLE and to determine factors associated with LN activity across the country.Methods:This cross-sectional study (GSK Study 207353) was carried out through face-to-face interviews and review of medical records (12-month study period). Adult patients with SLE (American College of Rheumatology [ACR] criteria, 1997) were included. Five SLE reference teaching centres were selected: North (NO), Northeast (NE), Midwest (CO), Southeast (SE), and South (SU). Patients with another disease whose morbidity surpassed SLE were excluded. LN was defined as reported in the medical record or history of confirmed renal biopsy; disease activity by pre-defined changes in SLE Disease Activity Index (SLEDAI) or the patient’s kidney disease during the study. Activity was assessed during (T0), 6 months before (T6), and 12 months before (T12) the interview. Systemic Lupus International Collaborating Clinics/ACR Damage Index score mapped damage accrual. Two pairings were performed, aiming to discriminate factors associated with LN and its activity, respectively. Matching technique was used to select similar individuals based on propensity scores, obtained from a logistic regression model. A bootstrapping method explored characteristic variables associated with the risk of progressing to LN.Results:Overall, 300 Brazilian patients with SLE were included in the study. Two groups were paired: LN group (N=150) and non-LN group (N = 141). The prevalence of LN in the paired sample (N=291) was 51.5%, with a disparity between centres (p<0.001; Figure 1A). Most patients were female (LN: 92.7%; non-LN: 94.3%) and the mean (standard deviation [SD]) age for the LN and non-LN groups was 39.46 (11.86) and 43.96 (12.18), respectively. History of serositis was associated with the presence of LN (42 [28.0%] vs 21 [14.9%] non-LN; p=0.010). Type IV histological class predominated in both groups, with no disparity between centres. Social disparities were noted between groups. Non-active workers prevailed among the LN group (115 [76.7%] vs 98 [69.5%] for non-LN, p=0.024).When pairing for disease activity at T12, 73 (50.3%) patients with LN (N=145) had active disease. There was regional disparity in terms of disease activity (Figure 1B), with a predominance of active LN in the NO (28 [68.3%]) and SU (16 [55.2%], p=0.026). Type IV histological class was the component most associated with active LN (active: 32 [43.8%]; non-active: 11 [15.3%], p<0.001). Variation in SLEDAI during the study period discriminated between active and non-active LN. The mean (SD) SLEDAI score at T12 was substantially higher in those with active LN compared with non-active LN (7.18 [4.83] vs 2.47 [4.63], p<0.001). As for the pattern of care, corticosteroids users prevailed in those with active LN (62 [84.9%] vs 45 [62.5%] for non-active LN, p=0.004). There was no disparity in the use of immunosuppressants, with the exception of cyclophosphamide use, noted among 16 (21.9%) patients with active LN and 6 (8.3%) patients with non-active LN (p=0.041). Psychotropic or anticonvulsant use was higher in patients with non-active LN (32 [44.4%] vs 17 [23.3%] patients with active LN, p=0.012). Consultation with a neurologist was verified in 15 (20.8%) patients with non-active LN and 6 (8.2%) with active LN (p=0.055). Hospitalisation occurred in 17 patients with non-active (23.6%) and active (23.3%) LN.Conclusion:Disparities in the prevalence of LN and its activity were evident between the regions across Brazil, highlighting differences in clinical factors, regional factors, and patterns of care.Funding:GSKFigure 1.Prevalence of A) LN among regional centres, comparing them to disease activity profile and prescriptive practice, and B) Active and non-active LN according to prescriptive practiceCQ, chloroquine; HCQ, hydroxychloroquine*At T12Acknowledgements:Medical writing assistance was provided by Helen Taylor, Fishawack Indicia Ltd., UK, part of Fishawack Health, and was funded by GSK.Disclosure of Interests:Mirhelen Abreu Grant/research support from: GSK, Amgen, Biogen, Libbs, Odirlei Monticielo Speakers bureau: GSK, AbbVie, UCB, Roche, Novartis, Consultant of: GSK, AbbVie, Janssen, Vander Fernandes Speakers bureau: Janssen, Novartis, Roche, AbbVie, Pfizer, Grant/research support from: Novartis, GSK, Pfizer, Alexandre Cristovão Maiorano: None declared, Fernando dos Santos Beserra: None declared, Flavia Lamarao Employee of: GSK, Nathalie David Shareholder of: GSK, Employee of: GSK, Bruna de Veras Employee of: GSK, Blanca Bica: None declared, Domingos Sávio Nunes de Lima Grant/research support from: GSK, Marta Maria das Chagas Medeiros: None declared

scholarly journals Assessment of pain and postoperative nausea and vomiting and their association in the early postoperative period: an observational study from Palestine

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Reem M. Elsaid ◽  
Ashraqat S. Namrouti ◽  
Ahmad M. Samara ◽  
Wael Sadaqa ◽  
Sa’ed H. Zyoud
Keyword(s):  
Logistic Regression ◽  
Observational Study ◽  
Postoperative Nausea ◽  
Postoperative Nausea And Vomiting ◽  
Binary Logistic Regression ◽  
Nausea And Vomiting ◽  
Prior History ◽  
Factors Associated ◽  
Duration Of Surgery ◽  
History Of

Abstract Background Postoperative nausea and vomiting (PONV) and postoperative pain (POP) are most commonly experienced in the early hours after surgery. Many studies have reported high rates of PONV and POP, and have identified factors that could predict the development of these complications. This study aimed to evaluate the relationship between PONV and POP, and to identify some factors associated with these symptoms. Methods This was a prospective, multicentre, observational study performed at An-Najah National University Hospital and Rafidia Governmental Hospital, the major surgical hospitals in northern Palestine, from October 2019 to February 2020. A data collection form, adapted from multiple previous studies, was used to evaluate factors associated with PONV and POP in patients undergoing elective surgery. Patients were interviewed during the first 24 h following surgery. Multiple binary logistic regression was applied to determine factors that were significantly associated with the occurrence of PONV. Results Of the 211 patients included, nausea occurred in 43.1%, vomiting in 17.5%, and PONV in 45.5%. Multiple binary logistic regression analysis, using PONV as a dependent variable, showed that only patients with a history of PONV [odds ratio (OR) = 2.28; 95% confidence interval (CI) = 1.03–5.01; p = 0.041] and POP (OR = 2.41; 95% CI = 1.17–4.97; p = 0.018) were significantly associated with the occurrence of PONV. Most participants (74.4%) reported experiencing pain at some point during the first 24 h following surgery. Additionally, the type and duration of surgery were significantly associated with POP (p-values were 0.002 and 0.006, respectively). Conclusions PONV and POP are common complications in our surgical patients. Factors associated with PONV include a prior history of PONV and POP. Patients at risk should be identified, the proper formulation of PONV protocols should be considered, and appropriate management plans should be implemented to improve patients’ outcomes.

scholarly journals Factors associated with the use of fashion braces of the Saudi Arabian Youth: application of the Health Belief Model

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Anwar S. Alhazmi ◽  
Dania E. Al Agili ◽  
Mohammed S. Aldossary ◽  
Shaker M. Hakami ◽  
Bashaer Y. Almalki ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Family Income ◽  
Health Belief ◽  
Intention To Use ◽  
Perceived Susceptibility ◽  
Mean Values ◽  
Factors Associated ◽  
The Mean ◽  
Belief Model ◽  
The Health Belief Model

Abstract Background In spite of the fact that fashion braces (FBs) have been in the spotlight in recent years among both orthodontists and the general public in several countries, there is still limited evidence regarding FBs. The aim was to identify health-related behaviors in using FBs by considering the Health Belief Model (HBM). Methods A cross-sectional study with a random sampling technique was conducted in Jazan, Saudi Arabia. The data was obtained from different middle and high schools students, and first-year students at Jazan University. The questionnaire collected data on demographic characteristics and 27 items to examine the constructs of the HBM. Chi Square test was carried out to establish the factors associated with using, the intention to use, and previous knowledge on the use of fashion braces. Logistic regression analysis was utilized to determine the factors associated with the use of fashion braces. Results 406 study participants completed the questionnaire with a response rate of 88.3%. Majority of respondents were males (52.2%) and > 19 years old (44.3%). Only 9.9% students had used the FBs. However, 25.7% of students had the intention to use them. The perceived susceptibility, perceived benefits and cues to action constructs scores were fair with the mean values of 15.38 (SD = 9.4), 28.17 (SD = 10.8) and 6.65 (SD = 2.50), respectively. However, the perceived barrier score was high with the mean values of 22.14 (SD = 7.50), and lower score of self-efficacy with mean of 8.73 (SD = 3.30). Gender, age, monthly income (family), and education level were significantly (p < 0.05) associated with the use of fashion braces among the study’s participants. Based on the results of logistic regression analysis family income, perceived susceptibility, and risk severity constructs predict the use of fashion braces in the study's sample. Conclusions The current study suggests that the family income, perceived susceptibility, and risk severity of students significantly influence the use of fashion braces. Hence, it is recommended that researchers should investigate effective educational strategies and programs for improving young people’s knowledge about fashion braces and focus more on low family income students so that their using of fashion brace will be decreased.

Comparison Of Drugs in Patients Using New Generation Anticoagulants

2021 ◽  
Vol 6 (14) ◽  
pp. 56-67
Author(s):  
Arslan Say ◽  
Abdülkadir ÇAKMAK ◽  
Gökhan KESKİN ◽  
Erdinç PELİT ◽  
Yılmaz ÖZBAY
Keyword(s):  
Atrial Fibrillation ◽  
Clinical Practice ◽  
Venous Thromboembolism ◽  
Oral Anticoagulants ◽  
Recurrent Venous Thromboembolism ◽  
Anticoagulant Drugs ◽  
History Of ◽  
The Mean ◽  
N 93 ◽  
New Generation

Aim: New generation anticoagulants rapidly find a wider area of use in the clinic due to the use problems of other oral anticoagulants. Anticoagulants such as Dabigatran, Rivaroxaban, and Apixaban with safer treatment intervals have been accepted in clinical practice guidelines and have taken their place as preferred drugs. In this study, we aimed to retrospectively examine the effects of three new-generation anticoagulant drugs on a group of patients. Material and Methods: In this retrospectively planned study, patients diagnosed with atrial fibrillation (n = 522) were divided into three groups according to the drugs used for treatment (Dabigatran, Rivaroxaban, and Apixaban). Routine blood values of the patients in each group were retrospectively scanned according to age, gender, time of drug initiation and presence of chronic disease. Results: According to the results obtained, it was found that the mean HCT, BUN, AST, ALT, MPV, Iron, and Ferritin were higher in patients using Apixaban than those using Dabigatran and Rivaroxaban drugs, but the age, average values of Hgb1 Hgb2, Hgb1, PLT, CrCl, Gfr and INR of the patients using Apixaban lower than those using Dabigatran and Rivaroxaban. The highest rate (22.5%) was found in the group of patients taking apixaban (n=93) when people taking the drugs were examined in terms of mortality. Conclusion: It has been observed that Rivaroxaban can be used more safely in patients with a history of acute cancer and thrombosis, patients with recurrent venous thromboembolism, and patients with high frailty, three drugs should be preferred instead of oral anticoagulants.

scholarly journals Analysis and Factors Associated with Measles in Larut, Matang and Selama Districts, Perak, Malaysia

2020 ◽  
Vol 27 (5) ◽  
pp. 130-140
Author(s):  
Asraf Ahmad Qamruddin ◽  
Reza Qamruddin ◽  
Ayu Malik
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Incidence Rate ◽  
Logistic Regression Analysis ◽  
Protective Factor ◽  
Multiple Logistic Regression Analysis ◽  
Prior History ◽  
Multiple Logistic Regression ◽  
Case Definitions ◽  
Factors Associated

Objectives: To determine the incidence rate of measles and the factors associated with confirmed measles cases in Larut, Matang and Selama districts. Methods: Cross-sectional analysis was carried out looking at all suspected and laboratoryconfirmed measles cases in Larut, Matang and Selama districts between 2015 and 2019. Multiple logistic regression analysis was used to determine the associated factors for laboratory-confirmed measles cases. Results: The incidence rate for suspected measles showed an increasing trend from 2015–2019. For laboratory-confirmed measles cases, the incidence rate showed more variation with an increase to 36.11 per million population in 2017 from 5.67 per million population in 2015. The incidence rate later decreased to 10.99 per million population in 2018 and increased again to 24.47 per million population in 2019. From multiple logistic regression analysis, cases that fulfilled the case definition of measles were more likely to be laboratory-confirmed measles. On the other hand, a prior history of measles immunisation was a protective factor. Conclusion: Measles incidence is increasing in trend. Any suspected measles cases that fulfilled the clinical case definitions need to be further investigated. Immunisation should be promoted as they are effective in preventing and eliminating measles.

scholarly journals Factors associated with depression in the patients with diabetes mellitus type 2

2019 ◽  
Vol 76 (11) ◽  
pp. 1178-1183 ◽  
Author(s):  
Admir Sabanovic ◽  
Natasa Maksimovic ◽  
Mirjana Stojanovic-Tasic ◽  
Marijan Bakic ◽  
Anita Grgurevic
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Logistic Regression Analysis ◽  
Diabetes Mellitus Type 2 ◽  
Multivariate Logistic Regression Analysis ◽  
Multivariate Logistic Regression ◽  
Factors Associated

Background/Aim. The assessment of association of depression and diabetes mellitus type 2 using the Patient Health Questionaire (PHQ-9) has not been done in Montenegro. The aim of this study was to assess the prevalence of depression in the patients with type 2 diabetes mellitus, and to identify the risk factors associated with the presence of depression. Methods. A cross-sectional study was conducted at the General Hospital in Bijelo Polje, from July to September, 2015. It included 70 patients over 35 years of age with the diagnosis of diabetes for at least six months. For the assessment of depression presence and intensity PHQ?9 was used. All variables associated with the presence of depression at a significance level of p < 0.05 were included into the final method of the multivariate logistic regression analysis. Results. Comorbidities were statistically significant more frequent among patients with depression (?2 = 5.40; p = 0.020). Duration of diabetes over five years was significantly associated with depression (?2 = 12.48; p < 0.001). Depression occurred more frequently among physically inactive subjects (?2 = 10.74; p = 0.005). The presence of diabetic polyneuropathy (?2 = 6.04; p = 0.014) and cataract (?2 = 5.351; p = 0.021) were also significantly associated with depression. A multivariate logistic regression analysis showed that the duration of diabetes over five years and presence of cataract were independently associated with depression. Conclusion. The risk factors for depression among the subjects with diabetes were disease duration more than five years and the presence of cataract. Since depression is a serious disease and can be a risk factor for many chronic diseases, the best way of prevention is its early detection and treatment.

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