Effect of protein deprivation on extrarenal erythropoietin production

Blood ◽  
1978 ◽  
Vol 51 (3) ◽  
pp. 549-553
Author(s):  
A Anagnostou ◽  
S Schade ◽  
J Barone ◽  
W Fried
Keyword(s):  
Protein Deficiency ◽  
Protein Deprivation ◽  
Deficient Diet ◽  
Protein Depletion ◽  
Erythropoietin Production ◽  
Protein Deficient Diet

The production of erythropoietin by rats fed a protein-deficient diet is markedly decreased. This defect can be rapidly reversed by feeding protein. In the reported experiments we investigated the effect of protein deficiency on the extra-renal production of erythropoietin. The results indicate that the production of erythropoietin in nephrectomized animals is insensitive to protein depletion.

scholarly journals Effect of protein deprivation on extrarenal erythropoietin production

Blood ◽  
1978 ◽  
Vol 51 (3) ◽  
pp. 549-553 ◽  
Author(s):  
A Anagnostou ◽  
S Schade ◽  
J Barone ◽  
W Fried
Keyword(s):  
Protein Deficiency ◽  
Protein Deprivation ◽  
Deficient Diet ◽  
Protein Depletion ◽  
Erythropoietin Production ◽  
Protein Deficient Diet

Abstract The production of erythropoietin by rats fed a protein-deficient diet is markedly decreased. This defect can be rapidly reversed by feeding protein. In the reported experiments we investigated the effect of protein deficiency on the extra-renal production of erythropoietin. The results indicate that the production of erythropoietin in nephrectomized animals is insensitive to protein depletion.

scholarly journals The effect of protein-deficient isoenergetic diets on the growth of rat jejunal mucosa

1982 ◽  
Vol 48 (1) ◽  
pp. 25-36 ◽  
Author(s):  
Gabrielle Syme
Keyword(s):  
Surface Area ◽  
G Protein ◽  
Protein Deficiency ◽  
Male Rats ◽  
Jejunal Mucosa ◽  
Metaphase Arrest ◽  
Villus Height ◽  
Deficient Diet ◽  
Protein Deficient Diet ◽  
Delayed Maturation

1. Newly weaned 21-d-old male rats were given isoenergetic diets containing 200, 100 and 50 g protein/kg for 7, 14, 28 or 70 d. The mid-jejunum was removed from the rats and a micrometric analysis of the mucosa was made. The following measurements were made: number of villi/mm2, vilius dimensions, villus surface area, crypt depth, crypt: villus, the number of cells/crypt in metaphase arrest per h.2. Comparisons were made between animals of the same age but on different diets, and animals on the same diet but of different ages. The latter comparison gave information on the effect of protein deficiency on the pattern of maturation of each feature of The villus or crypt studied.3. The effect of protein deficiency was not consistent at each stage of maturation. For instance villus height was decreased when compared with the controls following 28 d on a protein-deficient diet but not after 7 or 70 d.4. The only measurement to be unaffected by protein deficiency was the number of villi per unit area.5. In general the 50 g protein/kg diet had a more pronounced effect than the 100 g protein/kg diet. Protein deficiency delayed maturation by either slowing or inhibiting changes seen in normal maturation.6. In rats given 50 g protein/kg diet, although the villus surface area did not increase as the rats matured there were increases in epithelial cell production rate and number of crypts per villus.

THE EFFECT OF PROTEIN DEFICIENCY ON THE DISTRIBUTION OF NUCLEAR VOLUMES IN PREPARATIONS OF RAT LIVER NUCLEI

1967 ◽  
Vol 45 (7) ◽  
pp. 1185-1189
Author(s):  
Roberto Umaña
Keyword(s):  
Recovery Period ◽  
Experimental Period ◽  
Nuclear Volume ◽  
Protein Deficiency ◽  
Volume Distribution ◽  
Secondary Effect ◽  
Deficient Diet ◽  
Adaptation Mechanism ◽  
Protein Deficient Diet ◽  
Liver Nuclei

The effect of a protein-deficient diet and the subsequent recovery period on the distribution of nuclear volumes has been studied. The results support the hypothesis that protein deficiency produces an increase in the proportion of polyploid-type nuclei in the liver as reflected in an increase in the average content of DNA per nucleus. This increase in polyploidy was shown to occur early in the experimental period, suggesting that it represents part of an adaptation mechanism more than a secondary effect produced by the deficiency of amino acids. Throughout the study, it was not possible to demonstrate any relationship between patterns of nuclear volume distribution or the average nuclear volume, and the average DNA content per nucleus. On this basis, it has been suggested that the nuclear volume might not be a unique function of the degree of ploidy, but most probably is an expression of the protein content of the organelle.

scholarly journals Veterinary needs of dogs in two resource-limited communities in the Gauteng and North West provinces of South Africa

2001 ◽  
Vol 72 (4) ◽  
Author(s):  
W.N. Minnaar ◽  
R.C. Krecek
Keyword(s):  
South Africa ◽  
Health Status ◽  
Body Condition ◽  
Veterinary Services ◽  
Structured Interviews ◽  
Deficient Diet ◽  
North West ◽  
The North ◽  
Resource Limited ◽  
Protein Deficient Diet

Information on the socioeconomic aspects and the health status of dogs in 2 resource-limited communities in the North West and Gauteng provinces of South Africa was gathered using semi-structured interviews and a standardised questionnaire. The dogs were examined clinically to determine their health status, and their body condition and age were scored. Most of the dogs (93 % in Jericho and 90 % in Zuurbekom) were infected with hookworm, which poses a threat to animal and human health in the 2 study areas. Many dogs were also being given a protein-deficient diet, which together with hookworm parasites would impact considerably on the dog's health. Dogs were mainly kept for security reasons. The need indicated to be most important by the residents of the 2 commnities was a lack of available and affordable veterinary services.

scholarly journals Iberian pig adaptation to acorn consumption: I. Net portal appearance of metabolites

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e5861 ◽  
Author(s):  
Ignacio Fernández-Fígares ◽  
Jose Miguel Rodríguez-López ◽  
Lucrecia González-Valero ◽  
Manuel Lachica
Keyword(s):  
Sampling Period ◽  
Metabolic Energy ◽  
Blood Collection ◽  
Standard Diet ◽  
Deficient Diet ◽  
Protein Energy ◽  
Sampling Session ◽  
Protein Deficient Diet ◽  
Portal Plasma ◽  
Set Up

Most valuable cured products from Iberian pigs come from pure bred animals raised for a final grazing-fattening period where pigs eat mainly acorns, a low protein energy rich fruit. This is a nutritional challenge for animals fed equilibrated diets from weaning. The aim of the study was to determine net portal appearance (NPA) of metabolites in gilts fed acorns and evaluate adaptational changes after one week of feeding. Two sampling periods were carried out (after one day and after one week of acorn feeding) with six gilts (34 kg average BW) set up with three catheters: in carotid artery and portal vein for blood sampling, and ileal vein for para-aminohippuric acid (PAH) infusion to measure portal plasma flow (PPF). Pigs were fed at 2.5 × ME for maintenance a standard diet in two portions, at 09:00 (0.25) and 15:00 h (the remaining 0.75). On the day prior to the first sampling period, pigs were fed 2.4 kg of oak acorns. After feeding 0.25 of ration a 6 h serial blood collection was initiated. Following an identical protocol, a second sampling session was performed 1 week later. Adaptation to acorn consumption decreased NPA of ammonia (47%,P < 0.001). Although there was a transfer of urea from the gastrointestinal tract to the circulation in both sampling periods, no differences in NPA of urea was found (P > 0.05). NPA of glucose was not influenced by sampling period (P > 0.05), but NPA of lactate was greatly increased (231%,P < 0.001). There was a negative NPA of albumin although adaptation to acorn feeding did not alter it. Although NPA of triglycerides and cholesterol were unchanged, a subtle increase in arterial and portal cholesterol was noticed (9.6%,P < 0.01). Pigs fed a protein deficient diet for one week adapted decreasing NPA of ammonia for saving metabolic energy as less ammonia would become available for conversion to urea.

scholarly journals The effects of a tryptophan- and protein-deficient diet upon growth in rats

1989 ◽  
Vol 27 (4) ◽  
pp. 345-347 ◽  
Author(s):  
Angela H. Becker ◽  
Stephen F. Davis ◽  
Cathy A. Grover ◽  
Cynthia A. Erickson
Keyword(s):  
Deficient Diet ◽  
Protein Deficient Diet

LIPID METABOLISM AND LIPOPROTEIN SUSCEPTIBILITY TO PEROXIDATION ARE AFFECTED BY A PROTEIN-DEFICIENT DIET IN THE RAT

1997 ◽  
Vol 17 (1) ◽  
pp. 125-135 ◽  
Author(s):  
Corinne Moundras ◽  
Christian Demigné ◽  
Christine Morand ◽  
Marie-Anne Levrat ◽  
Christian Rémésy
Keyword(s):  
Lipid Metabolism ◽  
Deficient Diet ◽  
Protein Deficient Diet

scholarly journals INFLUENCE OF DIETARY PROTEIN CONTENT ON Trypanosoma cruzi INFECTION IN GERMFREE AND CONVENTIONAL MICE

1998 ◽  
Vol 40 (6) ◽  
pp. 355-362 ◽  
Author(s):  
Isa P. CINTRA ◽  
Marcelo E. SILVA ◽  
Marcílio E.C. SILVA ◽  
Márcio E. SILVA ◽  
L.C. C. AFONSO ◽  
...  
Keyword(s):  
Weight Gain ◽  
Trypanosoma Cruzi ◽  
Dietary Protein ◽  
Blood Cell Count ◽  
Deficient Diet ◽  
Low Protein ◽  
Protein Deficient Diet ◽  
Red Blood Cell Count ◽  
Cruzi Infection ◽  
Microbiological Status

Germfree (GF) and conventional (CV) mice were fed on diets containing 4.4, 13.2 or 26.4% of protein (weight/weight). CV mice fed on low protein diet did not gain weight during four weeks, whereas the protein deficient diet did not affect the growth of GF mice. After four weeks on these diets, the mice were inoculated with 5x103 trypomastigotes of Trypanosoma cruzi. The protein deficiency affected less the GF than the CV mice, according to the following parameters: weight gain, hemoglobin, plasma protein and albumin levels and water and protein contents of the carcass. Infection with T. cruzi produced a significant decrease in hemoglobin levels, red blood cell count, and water and protein contents in the carcass. This decrease was more pronounced in the GF mice. Histopathologically, there was no difference between the treatments in animals with the same microbiological status (GF or CV). However, the disease was more severe in the GF than in the CV mice.

Increased NaCl preference of rats fed low-protein diet

1996 ◽  
Vol 270 (6) ◽  
pp. R1189-R1196 ◽  
Author(s):  
A. Okiyama ◽  
K. Torii ◽  
M. G. Tordoff
Keyword(s):  
Control Diet ◽  
Physiological Mechanism ◽  
Plasma Renin ◽  
Calcium Deficiency ◽  
Protein Deficiency ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Sodium Balance ◽  
Deficient Diet ◽  
Low Protein

Four studies were conducted to assess the effect of a low-protein diet on NaCl intake. Young rats fed either control (20% casein) or low-protein (5% casein) high-carbohydrate (CHO) diet were allowed to drink either water alone or water and 300 mM NaCl. Relative to rats fed control diet, rats fed the low-protein diet progressively increased NaCl intake so that, despite lower food and water intakes, they drank 180% more NaCl during the last 3 days of the 21-day test. Additional studies found that rats fed low-protein diet always maintained positive sodium balance, were neither sodium depleted nor hypovolemic, and had normal plasma renin activity and aldosterone concentrations. The elevated NaCl intake was not secondary to calcium deficiency and was unaffected by mineral supplementation of the protein-deficient diet. Increases in the diet's CH and/or fat content incidental to decreases in its protein content influenced, but could not completely account for, the effect of protein deficiency on NaCl intake. We conclude that protein deficiency is the primary cause of the elevated NaCl preference produced by being fed a low-protein diet and that a novel physiological mechanism underlies this behavior.

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