Maternal antibiotic use during pregnancy and asthma in children: population-based cohort study and sibling design

2019 ◽  
Author(s):  
Xiaoqin Liu ◽  
Jianping Chen
Keyword(s):  
Cohort Study ◽  
Antibiotic Use ◽  
Population Based ◽  
Sibling Design ◽  
Asthma In Children

scholarly journals Primary Care Consultations after Hospitalisation for Pneumonia: A Large Population-based Cohort Study

2020 ◽  
pp. BJGP.2020.0890
Author(s):  
Vadsala Baskaran ◽  
Fiona Pearce ◽  
Rowan H Harwood ◽  
Tricia McKeever ◽  
Wei Shen Lim
Keyword(s):  
Primary Care ◽  
Cohort Study ◽  
Large Population ◽  
Significant Proportion ◽  
Antibiotic Use ◽  
Population Based ◽  
Practice Research ◽  
Clinical Practice Research Datalink ◽  
Respiratory Disorder ◽  
The Impact

Background: Up to 70% of patients report ongoing symptoms four weeks after hospitalisation for pneumonia, and the impact on primary care is poorly understood. Aim: To investigate the frequency of primary care consultations after hospitalisation for pneumonia, and the reasons for consultation. Design: Population-based cohort study. Setting: UK primary care database of anonymised medical records (Clinical Practice Research Datalink, CPRD) linked to Hospital Episode Statistics (HES), England. Methods: Adults with the first ICD-10 code for pneumonia (J12-J18) recorded in HES between July 2002-June 2017 were included. Primary care consultation within 30 days of discharge was identified as the recording of any medical Read code (excluding administration-related codes) in CPRD. Competing-risks regression analyses were conducted to determine the predictors of consultation and antibiotic use at consultation; death and readmission were competing events. Reasons for consultation were examined. Results: Of 56,396 adults, 55.9% (n=31,542) consulted primary care within 30 days of discharge. The rate of consultation was highest within 7 days (4.7 per 100 person-days). The strongest predictor for consultation was a higher number of primary care consultations in the year prior to index admission (adjusted sHR 8.98, 95% CI 6.42-12.55). The commonest reason for consultation was for a respiratory disorder (40.7%, n=12,840), 12% for pneumonia specifically. At consultation, 31.1% (n=9,823) received further antibiotics. Penicillins (41.6%, n=5,753) and macrolides (21.9%, n=3,029) were the commonest antibiotics prescribed. Conclusion: Following hospitalisation for pneumonia, a significant proportion of patients consulted primary care within 30 days, highlighting the morbidity experienced by patients during recovery from pneumonia.

scholarly journals Antibiotic use during pregnancy and childhood overweight: A population-based nationwide cohort study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Tine Jess ◽  
Camilla S. Morgen ◽  
Maria C. Harpsøe ◽  
Thorkild I. A. Sørensen ◽  
Teresa A. Ajslev ◽  
...  
Keyword(s):  
Cohort Study ◽  
Antibiotic Use ◽  
Childhood Overweight ◽  
Population Based

scholarly journals Maternal Antibiotic Use and Infections During Pregnancy and Offspring Asthma: The Norwegian Mother, Father and Child Cohort Study and a Nationwide Register Cohort

2021 ◽  
Author(s):  
Aino K. Rantala ◽  
German Tapia ◽  
Maria C Magnus ◽  
Lars Christian Stene ◽  
Jouni JK Jaakkola ◽  
...  
Keyword(s):  
Cohort Study ◽  
Antibiotic Use ◽  
Population Based ◽  
Prescription Database ◽  
Upper Respiratory Tract ◽  
Maternal Characteristics ◽  
Increased Risk ◽  
Norwegian Prescription Database ◽  
Tract Infections

Abstract Maternal antibiotic use during pregnancy has been linked to asthma risk in children, but the role of underlying infections remains unclear. We investigated the association of maternal antibiotic use and infections during pregnancy with offspring risk of asthma. We used two population-based cohorts: the Norwegian Mother, Father and Child Cohort Study (MoBa) (n=53 417) and a register cohort (n=417 548). Asthma was defined based on dispensed asthma medications at 7 and 13 years from the Norwegian Prescription Database. Self-reported information on antibiotic use and infections during pregnancy was available in MoBa, while registrations of dispensed prescriptions was used to classify use of antibiotics in the register-based cohort. Maternal antibiotic use during pregnancy was associated with asthma at 7 years in both cohorts (aRR 1.23, 95% CI 1.11 - 1.37 in MoBa and aRR 1.21, 95% CI 1.16 - 1.25 in the register-based cohort) and asthma at 13 years in the register cohort (aRR 1.13, 95% CI 1.03-1.23) after adjusting for maternal characteristics. In MoBa, the estimate was attenuated after adjusting for infections during pregnancy. Maternal lower and upper respiratory tract infections (aRR 1.30, 95% CI 1.07 - 1.57 and aRR 1.19, 95% CI 1.09 - 1.30, respectively) and urinary tract infections (aRR 1.26, 95% CI 1.11 - 1.42) showed associations with asthma at 7 after adjusting for confounders, but estimates decreased after adjustment for antibiotics during pregnancy. Our findings suggest that both maternal antibiotic use and infections during pregnancy might be associated with an increased risk of asthma in childhood.

scholarly journals Use of prescription paracetamol during pregnancy and risk of asthma in children: a population-based Danish cohort study

2012 ◽  
pp. 33 ◽  
Author(s):  
Ane Birgitte Andersen ◽  
Lars Pedersen ◽  
Mehnert ◽  
Vera Ehrenstein ◽  
Rune Erichsen
Keyword(s):  
Cohort Study ◽  
Population Based ◽  
Asthma In Children ◽  
Danish Cohort

Maternal antibiotic use during pregnancy and asthma in children: population-based cohort study and sibling design

2021 ◽  
Vol 57 (1) ◽  
pp. 2000937
Author(s):  
Natalie C. Momen ◽  
Xiaoqin Liu
Keyword(s):  
Cohort Study ◽  
Childhood Asthma ◽  
Cox Regression ◽  
Antibiotic Use ◽  
Epidemiological Studies ◽  
Population Based ◽  
Hospital Treatment ◽  
Familial Factors ◽  
Asthma Risk ◽  
Using Data

Antibiotic use during pregnancy may affect asthma risk in offspring. However, epidemiological studies yielded conflicting findings, with an observed association possibly confounded by shared familial factors. We sought to assess the association between maternal antibiotic use during pregnancy and childhood asthma in the offspring, by accounting for time-stable familial factors.We conducted a population-based cohort study and sibling study using data from Danish nationwide registers, which comprised 407 804 liveborn singletons from 2005 to 2011. Antibiotic use during pregnancy was defined as at least one antibiotic prescription filled by the mother from 1 month prior to pregnancy up until delivery, identified in the National Prescription Registry. First-time asthma in the offspring was determined by hospital treatment or asthma medication treatment after age 5 years. We estimated hazard ratios (HRs) of asthma using Cox regression in the population-based cohort and stratified Cox regression in the sibling cohort.Approximately 36.5% of pregnant women redeemed antibiotic prescriptions. Antibiotic use during pregnancy was associated with childhood asthma in cohort analyses (HR 1.21, 95% CI 1.18–1.24), but not in sibling analyses (HR 0.96, 95% CI 0.90–1.03). In the population-based analyses, higher risks of asthma were seen with longer duration of maternal antibiotic use, a higher number of prescriptions and prescriptions of multiple types of antibiotics. All these associations disappeared in the sibling analyses.The associations observed by previous studies for prenatal exposure to antibiotics and offspring asthma risk are likely to be due to confounding factors shared within families.

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