scholarly journals Incomplete quality of life data in lung transplant research: comparing cross sectional, repeated measures ANOVA, and multi-level analysis

2005 ◽  
Vol 6 (1) ◽  
Author(s):  
Karin M Vermeulen ◽  
Wendy J Post ◽  
Mark M Span ◽  
Wim van der Bij ◽  
Gerard H Koëter ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Repeated Measures ◽  
Lung Transplant ◽  
Cross Sectional ◽  
Repeated Measures Anova ◽  
Life Data ◽  
Multi Level ◽  
Level Analysis

scholarly journals Long-term employment status and quality of life after cancer: A longitudinal prospective cohort study from diagnosis up to and including 5 years post diagnosis

Work ◽  
2020 ◽  
Vol 66 (4) ◽  
pp. 901-907
Author(s):  
Sietske J. Tamminga ◽  
Lyanne P. Jansen ◽  
Monique H.W. Frings-Dresen ◽  
Angela G.E.M. de Boer
Keyword(s):  
Quality Of Life ◽  
Cancer Survivors ◽  
Cancer Diagnosis ◽  
Employment Status ◽  
Life Outcomes ◽  
Quality Of Life Outcomes ◽  
Multi Level ◽  
After Cancer ◽  
Level Analysis

BACKGROUND: Accumulating evidence suggests that cancer survivors are able to return to work. However, little is known about their work situation 5 years after diagnosis. OBJECTIVE: To explore fluctuations in employment status and its association with quality of life 2, 3, and 5 years after cancer diagnosis of 65 cancer survivors employed at diagnosis. METHODS: In association with a randomised controlled trial (RCT), questionnaires were administrated to eligible cancer survivors at diagnosis, 2, 3, and 5 years thereafter comprising of validated questionnaires related to work (i.e. Work Ability Index (WAI), cancer, and quality of life (QOL) (i.e. SF-36, VAS QOL). The RCT studied a hospital-based work support intervention in female breast and gynaecological cancer survivors who were treated with curative intent and had paid work at diagnosis. Descriptive statistics and longitudinal multi-level analysis were employed. RESULTS: Sixty-five of the 102 eligible cancer survivors participated, who were primarily diagnosed with breast cancer (63%). Two and 5 years after cancer diagnosis respectively 63 (97%) and 48 (81%) participants were employed. Reasons for not being employed after 5 years included receiving unemployment benefits (7%), voluntary unemployment (3%), receiving disability benefits (3%), and early retirement (3%). Longitudinal multi-level analysis showed that employed cancer survivors reported in general statistically significant better quality of life outcomes at 5 years follow-up compared to those not being employed. CONCLUSIONS: We found high employment rates and few fluctuations in employment status. The steepest decline in employment rate occurs after the first two years of diagnosis. Employed participants reported better quality of life outcomes. Survivorship care should therefore focus on the population at risk possibly within the first two years after diagnosis.

A Multi-level Analysis of Thirty-two Societies on Marital and Family Satisfaction

2011 ◽  
Vol 12 (3) ◽  
pp. 325-342 ◽  
Author(s):  
YOSHINORI KAMO ◽  
MAKIKO HORI
Keyword(s):  
Quality Of Life ◽  
Social Relationships ◽  
Family Relationships ◽  
Marital Quality ◽  
Subjective Assessment ◽  
Family Satisfaction ◽  
Multi Level ◽  
The Individual ◽  
Level Analysis

When we examine the quality of life for each individual, several specific dimensions need to be considered. Health conditions and quality of family relationships are critical. When the individual in question is married, his/her marital quality is important. When he/she has a job, subjective assessment of that job is important. Social relationships regarding friends, neighbors, colleagues, relatives, etc. may be critical also. Although the quality of life is more than the sum of qualities of these specific areas of one's life, it is still determined to a great extent by the qualities of these sub-areas, including marital and family relationships (Proulxet al., 2007).

Comparative quality of life in patients randomized contemporaneously to docetaxel or abiraterone in the STAMPEDE trial.

2020 ◽  
Vol 38 (6_suppl) ◽  
pp. 14-14 ◽  
Author(s):  
Hannah L. Rush ◽  
Adrian David Cook ◽  
Christopher D. Brawley ◽  
Laura Murphy ◽  
Archie Macnair ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Repeated Measures ◽  
Treatment Options ◽  
Locally Advanced ◽  
Standard Of Care ◽  
Clinical Parameter ◽  
Cross Sectional ◽  
Multi Stage ◽  
Eortc Qlq

14 Background: Docetaxel (DOC) and abiraterone (ABI) both improve overall survival (OS) in men with locally advanced or metastatic hormone-sensitive prostate cancer (HSPC) but no head to head trials compare the 2 agents. STAMPEDE, a multi-arm multi-stage platform trial, recruited patients (pts) to treatments including DOC or ABI between Nov-11 and Mar-13. There was no evidence OS differed between DOC or ABI, thus quality of life (QOL) may increasingly inform treatment options. Methods: QOL scores were analysed in pts contemporaneously randomised to receive DOC or ABI, in addition to standard of care treatment. Self-assessment QOL questionnaires EORTC QLQ C30 and PR25 were completed during treatment and follow-up. These analyses focus on average global QOL over the first 2 years after randomisation, using repeated measures analysis, plus cross-sectional analyses at 3, 6, 12 and 24 months. A score difference of ≥4 points was pre-defined as clinically meaningful. Results: 173 men randomised to DOC and 342 men randomised to ABI participated in the QOL sub-study and contributed to this analysis. Baseline characteristics and proportion of missing data were similar between groups. Baseline global QOL scores were similar (mean (sd): DOC 77.8 (20) and ABI 78.0 (19.3)). Average global QOL over 2 years was higher in pts randomised to ABI than DOC, although the difference was statistically significant it did not meet the pre-defined clinical parameter (+3.9, 95%CI 0.6 to 7.1, p=0.021). Cross-sectional analyses showed clinically meaningful superior QOL in the ABI group at 3 and 6 months (+6.6, 95%CI 2.6 to 10.7, p=0.001; +8.0, 95%CI 3.6 to 12.3, p<0.001), but not at 1 or 2 years (+1.3, 95%CI -3.0 to 5.6, p=0.545; +4.5, 95%CI -0.25 to 9.2, p=0.063). An exploratory analysis indicated average QOL for pts with metastatic disease (n=207) was better in the ABI group (+4.44, 95%CI 0.2 to 8.6, p=0.036). Conclusion: Global QOL was significantly higher in the first 2 years of treatment for the ABI group compared to the DOC group, though did not meet the pre-defined clinically meaningful threshold. The majority of difference was seen in the first year of treatment. This should be considered when discussing treatment options with pts. Clinical trial information: NCT00268476.

scholarly journals Determinants of quality of life after lung transplant: an Italian collaborative study

2016 ◽  
Vol 65 (1) ◽  
Author(s):  
S. Ricotti ◽  
P. Vitulo ◽  
L. Petrucci ◽  
T. Oggionni ◽  
C. Klersy
Keyword(s):  
Quality Of Life ◽  
Lung Transplant ◽  
Collaborative Study ◽  
Survival Rates ◽  
Chronic Respiratory Disease ◽  
Cross Sectional Study ◽  
Exertional Dyspnea ◽  
Cross Sectional ◽  
Sf 36

Background. With the improvement in survival rates after lung transplantation, concern has arisen about evaluating quality of life (QoL). This multicenter cross-sectional study aimed at describing QoL and identifying factors associated with it. Methods. We assessed QoL in 129 lung transplant recipients from 5 centres in Italy, during scheduled followup visits, using the SF-36, GHQ and St George’s respiratory questionnaires (SGRQ). Results. The SF-36 elicited impaired QoL in the physical, but not in the mental domains (PCS=44; MCS=53). The GHQ identified 29 patients (23%) with psychological discomfort and the SGRQ scores were significantly better than those of patients with chronic respiratory disease. On multivariate analysis, exertional dyspnea was an independent predictor of the PCS (adjusted Δ -6.3 (p5. Conclusions. The study identified exertional dyspnea as the main determinant of QoL as measured both by SF36 (PCS) and GHQ. Other objective measures contributed only to the PCS. Thus, the SF-36 (PCS) and GHQ were useful in identifying patients who needed treatment not only for complications but also psychological support and continued physical rehabilitation.

scholarly journals Effect of Different Sports Practice on Sleep Quality and Quality of Life in Children and Adolescents: Randomized Clinical Trial

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Camila Cassemiro Rosa ◽  
William Rodrigues Tebar ◽  
Crystian Bittencourt Soares Oliveira ◽  
Breno Quintella Farah ◽  
Juliano Casonatto ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Trial ◽  
Children And Adolescents ◽  
Randomized Clinical Trial ◽  
Repeated Measures ◽  
Statistical Significance ◽  
Quality Of Sleep ◽  
Cross Sectional ◽  
Cross Sectional Design

Abstract Background Sports practice can promote several health benefits in pediatric populations; nonetheless, most of the studies that investigated these benefits are of cross-sectional design. Thus, our objective was to verify the effectiveness of two types of physical activities through sports, judo and ball games (soccer, volleyball, handball, and basketball) on the quality of sleep and life of Brazilian children and adolescents. Methods The study is a randomized clinical trial, conducted with 65 participants of both sexes (6–15 years old) in a philanthropic institution in Brazil. The variables investigated were the quality of sleep and life, using the mini-sleep questionnaire and KidsCreen-52 questionnaires (this instrument has a scale ranging from 0 to 100, where 100 is the best value for each domain), respectively. The interventions carried out during 12 weeks (twice a week) were judo and ball games. In the statistical analysis, analysis of variance (ANOVA) for repeated measures was used and the level of statistical significance used was 5%. Results Judo (P = 0.032) and ball games (P = 0.005) contributed to improving the quality of sleep in the participants. Considering the score of the domains of quality of life, judo and ball games significantly increased the perception of health and physical activity [mean = 6.9 (8.3%) and 8.91 (12.2%) points, respectively], autonomy [mean = 5.81 (7.3%) and 5.00 (6.9%) points], friends and social support (mean = 2.83 (3.8%) and 12.00 (15.9%) points), provocation and bullying [mean = 10.21 (18.1%) and 2.14 (4.1%) points]. Conclusion It is concluded that both judo and ball games brought benefits to the quality of sleep and life of children and adolescents. Health promotion actions should encourage the increase in sports practice in children and adolescents to improve sleep and quality of life.

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