Factors associated with non-adherence to Artemisinin-based combination therapy (ACT) to malaria in a rural population from holoendemic region of western Kenya

Abstract Typical enteropathogenic Escherichia coli (tEPEC) infection is a major cause of diarrhoea and contributor to mortality in children <5 years old in developing countries. Data were analysed from the Global Enteric Multicenter Study examining children <5 years old seeking care for moderate-to-severe diarrhoea (MSD) in Kenya. Stool specimens were tested for enteric pathogens, including by multiplex polymerase chain reaction for gene targets of tEPEC. Demographic, clinical and anthropometric data were collected at enrolment and ~60-days later; multivariable logistic regressions were constructed. Of 1778 MSD cases enrolled from 2008 to 2012, 135 (7.6%) children tested positive for tEPEC. In a case-to-case comparison among MSD cases, tEPEC was independently associated with presentation at enrolment with a loss of skin turgor (adjusted odds ratio (aOR) 2.08, 95% confidence interval (CI) 1.37–3.17), and convulsions (aOR 2.83, 95% CI 1.12–7.14). At follow-up, infants with tEPEC compared to those without were associated with being underweight (OR 2.2, 95% CI 1.3–3.6) and wasted (OR 2.5, 95% CI 1.3–4.6). Among MSD cases, tEPEC was associated with mortality (aOR 2.85, 95% CI 1.47–5.55). This study suggests that tEPEC contributes to morbidity and mortality in children. Interventions aimed at defining and reducing the burden of tEPEC and its sequelae should be urgently investigated, prioritised and implemented.

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Factors Associated with Uptake of Visual Inspection with Acetic Acid (VIA) for Cervical Cancer Screening in Western Kenya

PLoS ONE ◽

10.1371/journal.pone.0157217 ◽

2016 ◽

Vol 11 (6) ◽

pp. e0157217 ◽

Cited By ~ 9

Author(s):

Elkanah Omenge Orang’o ◽

Juddy Wachira ◽

Fredrick Chite Asirwa ◽

Naftali Busakhala ◽

Violet Naanyu ◽

...

Keyword(s):

Cervical Cancer ◽

Acetic Acid ◽

Cancer Screening ◽

Cervical Cancer Screening ◽

Visual Inspection ◽

Western Kenya ◽

Factors Associated

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PREVALENCE OF PREMATURE EJACULATION AND ERECTILE DYSFUNCTION AND THEIR ASSOCIATED FACTORS AMONG URBAN AND RURAL POPULATION OF MALAYSIA

Malaysian Journal of Public Health Medicine ◽

10.37268/mjphm/vol.17/no.3/art.224 ◽

2017 ◽

Vol 17 (3) ◽

pp. 86-96 ◽

Cited By ~ 1

Author(s):

Mohd Rohaizat Hassan ◽

Mohd Fadhli Samsuri ◽

Shamsul Azhar Shah ◽

Nazarudin Safian ◽

Zulkifli Md Zainuddin ◽

...

Keyword(s):

Erectile Dysfunction ◽

Rural Areas ◽

Rural Population ◽

Associated Factors ◽

Premature Ejaculation ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Factors Associated ◽

Urban And Rural Areas

The purpose of this study was to determine the prevalence and factors associated with of Premature Ejaculation &Erectile Dysfunctionamong Malaysian men. A cross-sectional study was conducted in urban and rural areas using standardized and validated self-administered questionnaires. A total of 319 samples were recruited for PE screening. The overall prevalence of PE was 31.7% with 20.7% and 40.8% for urban and rural area respectively. Depression, anxiety and frequent masturbation were significantly associated with PE. While For ED, infrequent sexual intercourse was the sole factor significantly associated with ED.PE and ED were highly prevalent in both urban and rural areas; with several significant preventable associated factors.

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Practices and Predictors of Analgesic Interventions for Adults Undergoing Painful Procedures

American Journal of Critical Care ◽

10.4037/ajcc2002.11.5.415 ◽

2002 ◽

Vol 11 (5) ◽

pp. 415-429 ◽

Cited By ~ 68

Author(s):

Kathleen A. Puntillo ◽

Lorie Rietman Wild ◽

Ann Bonham Morris ◽

Julie Stanik-Hutt ◽

Carol Lynn Thompson ◽

...

Keyword(s):

Combination Therapy ◽

Pain Intensity ◽

Regression Models ◽

Central Venous Catheters ◽

Central Venous ◽

Factors Associated ◽

Anesthetic Agents ◽

Multiple Regression Models ◽

Tracheal Suctioning ◽

To Receive

• Background Research is limited on analgesic practices associated with the commonly performed procedures of turning, inserting central venous catheters, removing wound drains, changing dressings on nonburn wounds, suctioning the trachea, and removing femoral sheaths. • Objective To determine types of analgesics administered for procedures, the prevalence and amounts of drugs given, and factors predictive of analgesic administration. • Methods Pain was assessed before and immediately after procedures. Analgesic, sedative, and anesthetic agents administered within 1 hour before and/or during each procedure were noted. • Results A total of 5957 adult patients at 164 national and 5 international sites participated. Pain intensity increased at the time of procedure for all procedures. More than 63% of patients received no analgesics. Less than 20% received opiates; mean total dose of opiate was 6.44 mg (SD, 8.96 mg). Only 10% of patients received combination therapy. Factors associated with the likelihood of receiving opiates were pain intensity before a procedure, femoral sheath removal, being white, and the duration of a procedure. Patients less likely to receive opiates had a medical diagnosis or were having tracheal suctioning. Only 14.5% of the variance in the amount of opiate administered was explained by factors entered into multiple regression models. Type of procedure was the only significant predictor of amount of opiate administered. • Conclusions Most patients were not intentionally medicated even though pain intensity increased during their procedure. When used, analgesic amounts were low, and combination therapy was infrequent. Clinical trials are needed to evaluate optimal pain management for patients undergoing procedures.

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