Absence of clinical relationship between oxidized low density lipoproteins and diabetic peripheral neuropathy: a case control study

Background: Psoriasis is a chronic inflammatory disorder with defective proliferation and differentiation of keratinocytes. It is associated with metabolic syndrome i.e. dyslipidemia, hypertension, obesity, cardiovascular diseases and insulin resistance. The high incidence of cardiovascular events in psoriasis is highly associated with abnormal lipid metabolism. This case-control study was done in North Indian medical institute to investigate the levels of serum lipids in psoriasis patients taking in account various parameters like weight, height, body mass index, blood pressure and diabetes.Methods: We assessed the fasting lipid profile in 48 psoriasis patients and 48 healthy, age and sex matched controls.Results: The study found significant elevation (p<0.05) of serum total cholesterol, triglycerides, low density lipoproteins (LDL) and very low density lipoproteins (VLDL) in psoriasis patients compared to controls. The levels of high density lipoproteins (HDL) were also significantly lower (p<0.05) in psoriasis patients.Conclusions: This study suggests that psoriasis is a high risk disorder for cardiovascular mortality and morbidity because of its association with dyslipidemia.

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Assessment of tibial and common peroneal nerves in diabetic peripheral neuropathy by diffusion tensor imaging: a case control study

European Radiology ◽

10.1007/s00330-016-4698-3 ◽

2016 ◽

Vol 27 (8) ◽

pp. 3523-3531 ◽

Cited By ~ 18

Author(s):

Chao Wu ◽

Guangbin Wang ◽

Yunxia Zhao ◽

Wen Hao ◽

Lianxin Zhao ◽

...

Keyword(s):

Diffusion Tensor Imaging ◽

Peripheral Neuropathy ◽

Diabetic Peripheral Neuropathy ◽

Case Control Study ◽

Diffusion Tensor ◽

Case Control ◽

Control Study

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The Impact of Diabetic Peripheral Neuropathy on Spatiotemporal Gait Parameters in Stroke Survivors: A Case-Control Study

Sains Malaysiana ◽

10.17576/jsm-2021-5001-19 ◽

2021 ◽

Vol 50 (1) ◽

pp. 191-199

Author(s):

Amirah Mustapa ◽

Maria Justine ◽

Nadia Mohd Mustafah ◽

Haidzir Manaf

Keyword(s):

Peripheral Neuropathy ◽

Diabetic Peripheral Neuropathy ◽

Case Control Study ◽

Case Control ◽

Stroke Survivors ◽

Healthy Controls ◽

Gait Performance ◽

Functional Balance ◽

Gait Parameters ◽

Control Study

The deterioration of gait performance following stroke is related to the impairment of sensorimotor function on the paretic side. Improper gait performance in post-stroke with additional diabetic peripheral neuropathy (DPN) on paretic and non-paretic legs may create destabilizing effects, including serious injuries and falls. Therefore, this study aimed to investigate the effect of DPN on spatiotemporal gait parameters in stroke survivors and determine the correlation of movement functioning and functional balance post-stroke with gait parameters. Ten stroke survivors with DPN, 10 stroke survivors without DPN and 10 healthy controls participated in this case-control study. Movement functioning and functional balance were assessed before the actual testing. Spatiotemporal gait parameters were recorded using the Nexus Vicon motion analysis system. Kruskal-Wallis test was used to analyze the gait parameters and Spearman’s rank-order correlation coefficient was used to identify the correlation between variables. Results showed that stroke survivors with DPN had longer stride time (temporal gait parameter, p = 0.001), lower cadence (p = 0.001) and greater gait variability than those without DPN and the healthy controls. The gait parameters were significantly correlated with movement functioning and functional balance in stroke survivors with DPN (p < 0.05). These findings suggested that DPN possibly affected the gait parameters in stroke survivors. DPN could also play a role in movement functioning and functional balance in stroke survivors.

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Hyperuricemia as an Additional Risk Factor for Coronary Artery Disease: A Hospital Based Case Control Study in Western Region of Nepal

Nepal Journal of Epidemiology ◽

10.3126/nje.v1i3.5571 ◽

1970 ◽

Vol 1 (3) ◽

pp. 81-85

Author(s):

Ankush Mittal ◽

Brijesh Sathian ◽

Arun Kumar ◽

Nishida Chandrasekharan ◽

Shamim Mohammad Farooqui ◽

...

Keyword(s):

Coronary Artery Disease ◽

Uric Acid ◽

Coronary Artery ◽

Serum Uric Acid ◽

Case Control Study ◽

Case Control ◽

Low Density Lipoproteins ◽

Low Density ◽

Artery Disease ◽

Control Study

Background In the 21st century, cardiovascular diseases will continue to dominate the disease spectrum and death statistics in both the industrialized and developing worlds. Coronary artery disease (CAD) is the foremost cause of cardiovascular disease related deaths worldwide, with >4.5 million deaths taking place in the developing world. Augmented serum uric acid levels are recurrently come across with hyperlipidemia, atherosclerosis, obesity, glucose intolerance, renal disease, and hypertension which all play a fundamental role in the pathogenesis of coronary artery disease. Materials and methods It was a hospital based case control study carried out in the Department of Biochemistry of Manipal Teaching Hospital, Pokhara, Nepal between 1st January 2010 and 31st December 2010. The variables collected were age, gender, serum uric acid, total cholesterol, low density lipoproteins, triglycerides, high density lipoproteins and very low density lipoproteins. Approval for the study was obtained from the institutional research ethical committee. Results There was insignificant difference for age between groups. In cases of hyperuricemia, there was marked increase in levels of serum uric acid (8.043± 0.43 mg/dl) when compared to controls (4.28 ± 0.66 mg/dl. In patients suffering from coronary artery disease with hyperuricemia, there was marked increased in levels of serum uric acid(8.222 ± 0.39 mg/dl) found to be statistically significant when compared to controls (4.285 ±0.66 mg/dl) and values were quite similar to hyperuricemic patients (8.043 ± 0.43 mg/dl).Further, in patients suffering from coronary artery disease with hyperuricemia, there was marked increased in mean values of serum total cholesterol (257.56 ± 22.65 mg/dl) ) when compared to controls (173.22 ± 32.63mg/dl). Conclusion Hypercholesterolemia due to hyperuricemia is most common modifiable factor for coronary artery disease. Allopurinol and newer urate-lowering agents restores endothelial function in coronary artery disease patients. The ability of physicians to pharmacologically manage serum urate levels, a better understanding of the interaction between hyperuricemia, gout and vascular disease may be critical for the reduction of morbidity and mortality in high-risk coronary artery disease patients.Key words: Hyperuricemia; Coronary artery disease; Nepal DOI: http://dx.doi.org/10.3126/nje.v1i3.5571 Nepal Journal of Epidemiology 2011;1(3) 81-85

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Reconfirmation of newly discovered risk factors of diabetic peripheral neuropathy in patients with type 2 diabetes: A case-control study

PLoS ONE ◽

10.1371/journal.pone.0220175 ◽

2019 ◽

Vol 14 (7) ◽

pp. e0220175

Author(s):

Yen-Wei Pai ◽

Ching-Heng Lin ◽

Shih-Yi Lin ◽

I-Te Lee ◽

Ming-Hong Chang

Keyword(s):

Risk Factors ◽

Type 2 Diabetes ◽

Peripheral Neuropathy ◽

Diabetic Peripheral Neuropathy ◽

Case Control Study ◽

Case Control ◽

Control Study

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Comparison of shoe-length fit between people with and without diabetic peripheral neuropathy: a case–control study

Journal of Foot and Ankle Research ◽

10.1186/1757-1146-5-9 ◽

2012 ◽

Vol 5 (1) ◽

Cited By ~ 15

Author(s):

Alistair D McInnes ◽

Farina Hashmi ◽

Lisa J Farndon ◽

Amanda Church ◽

Maria Haley ◽

...

Keyword(s):

Peripheral Neuropathy ◽

Diabetic Peripheral Neuropathy ◽

Case Control Study ◽

Case Control ◽

Control Study

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First trimester prediction of gestational diabetes mellitus using plasma biomarkers: a case-control study

Journal of Perinatal Medicine ◽

10.1515/jpm-2018-0120 ◽

2019 ◽

Vol 47 (2) ◽

pp. 161-168 ◽

Cited By ~ 6

Author(s):

Paula J. Correa ◽

Pia Venegas ◽

Yasna Palmeiro ◽

Daniela Albers ◽

Gregory Rice ◽

...

Keyword(s):

Diabetes Mellitus ◽

Gestational Diabetes ◽

Gestational Diabetes Mellitus ◽

Case Control Study ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

First Trimester ◽

Case Control ◽

Low Density ◽

Control Study

AbstractObjectivesTo evaluate the first trimester maternal biomarkers for early pregnancy prediction of gestational diabetes mellitus (GDM).MethodsThe study was a case-control study of healthy women with singleton pregnancies at the first trimester carried out at the Obstetrics and Gynecology Unit, Clinica Davila, Santiago, Chile. After obtaining informed consent, peripheral blood samples of pregnant women under 14 weeks of gestation were collected. At 24–28 weeks of pregnancy, women were classified as GDM (n=16) or controls (n=80) based on the results of a 75-g oral glucose tolerance test (OGTT). In all women, we measured concentrations of fasting blood glucose, insulin, glycated hemoglobin, uric acid, cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), triglycerides, aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyl transpeptidase (GGT), alkaline phosphatase (AP), sex hormone-binding globulin (SHBG), adiponectin, tissue plasminogen activator (t-PA), leptin and placental growth factor (PGF).ResultsThe GDM group displayed an increased median concentration of cholesterol (P=0.04), triglycerides (P=0.003), insulin (P=0.003), t-PA (P=0.0088) and homeostatic model assessment (HOMA) (P=0.003) and an increased mean concentration of LDL (P=0.009) when compared to the control group. The receiver operating characteristic (ROC) curve for significant variables achieved an area under the curve (AUC) of 0.870, a sensitivity of 81.4% and a specificity of 80.0%. The OGTT was positive for GDM according to the IADPSG (International Diabetes in Pregnancy Study Group) criteria.ConclusionWomen who subsequently developed GDM showed higher levels of blood-borne biomarkers during the first trimester, compared to women who did not develop GDM. These data warrant validation in a larger cohort.

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