scholarly journals Association of lipid profiles and the ratios with arterial stiffness in middle-aged and elderly Chinese

2014 ◽  
Vol 13 (1) ◽  
pp. 37 ◽  
Author(s):  
Weiwei Zhao ◽  
Wei Gong ◽  
Nan Wu ◽  
Yintao Li ◽  
Kuanping Ye ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Lipid Profiles ◽  
Middle Aged ◽  
Elderly Chinese

Discordance Between Apolipoprotein B or Non-HDL-Cholesterol and LDL-Cholesterol in Middle-aged and Elderly Chinese Patients Predicts Arterial Stiffness

2021 ◽  
Author(s):  
Geyue Qu ◽  
Zhongying Zhang ◽  
Hong Zhu
Keyword(s):  
Arterial Stiffness ◽  
Apolipoprotein B ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Lipoprotein Cholesterol ◽  
Chinese Patients ◽  
Middle Aged ◽  
Residual Cardiovascular Risk ◽  
Elderly Chinese ◽  
The Mean

Abstract Background: Discordance of lipid parameters is closely associated with residual cardiovascular risk. This study investigated the discordance between non-high-density lipoprotein cholesterol (non-HDL-C), or apolipoprotein B (apoB), and low-density lipoprotein cholesterol (LDL-C) and assessed arterial stiffness risk.Methods: This study included a total of 402 middle-aged and elderly Northern Chinese individuals, whose brachial-ankle pulse wave conduction velocity(baPWV), as well as clinical and biochemical data, were measured. Arterial stiffness was defined as the upper quartile of the baPWV. All participants were divided into four mutually exclusive concordance/discordance groups based on the lipid goal for very high-risk populations, according to the 2016 European Society of Cardiology / European Atherosclerosis Society guidelines. Discordance was defined as an LDL-C≥ 1.81mmol/L with non-HDL-C< 2.59mmol/L, or apoB <0.80mmol/L, or vice versa.Results: The mean age of the participants was 65.9±13.0 years, and 59.5% were male. The mean LDL-C was 2.41±0.81mmol/L, non-HDL-C 3.06±0.94mmol/L, and apoB 0.84±0.21mmol/L. LDL-C was observed to be discordant with non-HDL-C (20.1%) and apoB (30.8%). When stratified according to LDL-C levels, the baPWV was greater in those patients with higher non-HDL-C or apoB levels. The Spearman analysis showed a significant association between discordant lipid patterns and the presence of arterial stiffness(r= 0.131 and r=0.117, respectively). In the adjusted logistic regression model, low LDL-C and high non-HDL-C or apoB discordance were also associated with the risk of arterial stiffness (OR: 13.412 and OR: 13.054, respectively).Conclusions: There was discordance between the LDL-C and non-HDL-C, or apoB in middle-aged and elderly Chinese individuals, which was associated with a higher risk of arterial stiffness. The non-HDL-C or apoB levels could be used to identify individuals who could benefit from more intensive lipid modification.

Vitamin D, Parathyroid Hormone, and Serum Lipid Profiles in a Middle-Aged and Elderly Chinese Population

2014 ◽  
Vol 20 (6) ◽  
pp. 556-565 ◽  
Author(s):  
Wei Chen ◽  
Yuan Sha ◽  
Yun Chen ◽  
Yang Shi ◽  
Da Yin ◽  
...  
Keyword(s):  
Vitamin D ◽  
Parathyroid Hormone ◽  
Chinese Population ◽  
Serum Lipid ◽  
Lipid Profiles ◽  
Middle Aged ◽  
Elderly Chinese

scholarly journals Discordance between apolipoprotein B or non-HDL-cholesterol and LDL-cholesterol in middle-aged and elderly Chinese patients predicts arterial stiffness

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Geyue Qu ◽  
Zhongying Zhang ◽  
Hong Zhu
Keyword(s):  
Arterial Stiffness ◽  
Apolipoprotein B ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Lipoprotein Cholesterol ◽  
Chinese Patients ◽  
Middle Aged ◽  
Residual Cardiovascular Risk ◽  
Elderly Chinese ◽  
The Mean

Abstract Background Discordance of lipid parameters is closely associated with residual cardiovascular risk. This study investigated the discordance between non-high-density lipoprotein cholesterol (non-HDL-C) or apolipoprotein B (apoB) and low-density lipoprotein cholesterol (LDL-C), and assessed arterial stiffness risk. Methods This study included a total of 402 middle-aged and elderly Northern Chinese individuals whose brachial-ankle pulse wave conduction velocity (baPWV), and clinical and biochemical data were measured. Arterial stiffness was defined by inclusion in the upper quartile of the baPWV. All participants were divided into four mutually exclusive concordance/discordance groups based on the lipid goal for high-risk populations, according to the 2019 European Society of Cardiology / European Atherosclerosis Society guidelines. Discordance was defined as LDL-C ≥ 1.81 mmol/L with non-HDL-C <  2.59 mmol/L, or apoB < 0.80 mmol/L, or vice versa. Results The mean age of the participants was 65.9 ± 13.0 years; 59.5% of the participants were male. The mean LDL-C was 2.41 ± 0.81 mmol/L, non-HDL-C: 3.06 ± 0.94 mmol/L, and apoB: 0.84 ± 0.21 mmol/L. LDL-C was observed to be discordant with non-HDL-C (20.1%) and apoB (30.8%). When stratified according to LDL-C levels, the baPWV was greater in those patients with higher non-HDL-C or apoB levels. In the adjusted logistic regression model, low LDL-C and high non-HDL-C or apoB discordance were also associated with the risk of arterial stiffness (OR: 13.412 and OR: 13.054, respectively). Conclusions There was discordance between LDL-C and non-HDL-C, or apoB in middle-aged and elderly Chinese individuals; this was associated with a higher risk of arterial stiffness. Non-HDL-C or apoB levels could be used to identify individuals who may benefit from more comprehensive lipid modification.

scholarly journals Evaluation of non-invasive arterial stiffness parameters and their relationship with physical activity, anthropometric indices and lipid profiles in healthy middle-aged adults: results of the PERSIAN cohort study

2021 ◽  
Author(s):  
Mohammad Nosrati-Oskouie ◽  
Sajjad Arefinia ◽  
Saeed Eslami Hasan Abadi ◽  
Abdolreza Norouzy ◽  
Hamed Khedmatgozar ◽  
...  
Keyword(s):  
Physical Activity ◽  
Arterial Stiffness ◽  
Visceral Fat ◽  
Augmentation Index ◽  
Lipid Profiles ◽  
Fat Free Mass ◽  
Middle Aged ◽  
Anthropometric Indices ◽  
Visceral Fat Area ◽  
Middle Aged Adults

Background: Arterial stiffness (AS) indicates the initial stage of cardiovascular disease (CVD), which associated with modifiable and lifestyle risk factors. We aimed to examine the association of AS with anthropometric indices, lipid profiles, and physical activity. Methods: 658 healthy middle-aged adults selected and anthropometric indices (body mass index (BMI), waist circumferences (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), neck circumferences (NC), a body shape index (ABSI), body roundness index (BRI), body-fat mass (BFM), visceral-fat, fat-free mass(FFM), lipid profiles, and PA were measured. Arterial Stiffness measured by carotid-femoral pulse wave velocity (cf-PWV) and central augmentation index (cAIx). Results: Our results show, cf-PWV positively associated with TGs (β = 0.10, p = 0.01) and in anthropometric indices corelated with, WC (β = 0.11, p = 0.02), WHR (β = 0.09, p = 0.03), WHtR (β = 0.1, p = 0.02), and BRI (β = 0.09, p = 0.04). cAIx was independently positive association with cholesterol (β = 0.08, p = 0.03), WC (β = 0.1, p = 0.03), WHR (β = 0.09, p = 0.02), ABSI (β = 0.09, p = 0.01), BRI (β = 0.08, p = 0.05), visceral-fat area (β = 0.09, p = 0.03) and BFM (β = 0.08, p = 0.04) and negatively associated with PA (β = -0.08, p = 0.03). Conclusions: WC, WHR, and BRI were associated with both cf-PWV and cAIx. TGs and WHtR associated with cf-PWV, while cAIx was associated with ABSI, so improving these indices may be helpful to prevent CVD.

scholarly journals Links between arterial stiffness and bone mineral density in middle-aged and elderly Chinese individuals: a cross-sectional study

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e029946 ◽  
Author(s):  
Meng Zhang ◽  
Lijuan Bai ◽  
Jing Kang ◽  
Jing Ge ◽  
Wen Peng
Keyword(s):  
Bone Mineral Density ◽  
Arterial Stiffness ◽  
Bone Mineral ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Middle Aged ◽  
Mineral Density ◽  
Cross Sectional ◽  
Elderly Chinese ◽  
History Of

ObjectivesTo explore whether bone mineral density (BMD) is associated with arterial stiffness in middle-aged and elderly people with an advanced arterial stiffness index as indicated by the cardio-ankle vascular index (CAVI).DesignA cross-sectional study.SettingThis study was conducted from September 2015 to May 2017 at the geriatrics department of a provincial medical centre in China.ParticipantsA total of 580 patients aged 50 and over were enrolled in the study. The mean age of the group was 64.82±11.4 years, and 63.1% were male.Primary outcome measuresAssociations of age with CAVI values and BMD. Associations between BMD and CAVI values.ResultsWith increasing age, CAVI values gradually increased (p<0.001) and the femoral neck (FN) and total hip (TH) BMD gradually decreased (p<0.001, all). In the bivariate correlation analyses between the covariates and CAVI values, age and CAVI values showed the greatest positive correlation (r=0.631, p<0.001), and CAVI values were negatively correlated with FN BMD (r=−0.229, p<0.001) and TH BMD (r=−0.218, p<0.001). In the linear regression analyses, TH BMD (B=−1.812 (95% CI −2.475 to −1.149), p<0.001) and FN BMD (B=−1.968 (95% CI −2.651 to −1.284), p<0.001) were negatively correlated with CAVI values. After adjusting for age, gender, body mass index, smoking, history of cardiovascular or cerebrovascular disease, history of diabetes mellitus, systolic blood pressure, high-density lipoprotein cholesterol, blood uric acid, fibrinogen and estimated glomerular filtration rate, only TH BMD was still negatively correlated with CAVI values (B=−0.843 (95%CI −1.454 to −0.232), p=0.007). However, there was no consistent and significant correlation between lumbar spine BMD and CAVI values.ConclusionIn this cross-sectional study, a significant correlation between TH BMD and CAVI values was observed in middle-aged and elderly Chinese inpatients. However, our cohort was a small sample of inpatients, and prospective studies from more centres are expected.

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