Quality of life in patients at first time visit for sleep disorders of breathing at a sleep centre

: Melanoma is the most life-threatening and aggressive class of skin malignancies. The incidence of melanoma has steadily increased. Metastatic melanoma is greatly resistant to standard anti-melanomatreatments such as chemotherapy, and 5-year survival rate of cases with melanoma who have metastatic form of disease is less than 10%. The contributing role of apoptosis, angiogenesis and autophagy in the pathophysiology of melanoma has been previously demonstrated. Thus, it is extremely urgent to search for complementary therapeutic approachesthat couldenhance the quality of life of subjects and reduce treatment resistance and adverse effects. Resveratrol, known as a polyphenol component present in grapes and some plants, has anti-cancer properties due to its function as an apoptosis inducer in tumor cells, and anti-angiogenic agent to prevent metastasis. However, more clinical trials should be conducted to prove resveratrol efficacy. : Herein, for first time, we summarize current knowledge of anti-cancerous activities of resveratrol in melanoma.

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Evaluation of the efficacy of hearing aids in older adults: a multiparametric longitudinal study protocol

BMC Geriatrics ◽

10.1186/s12877-021-02033-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Domenico Cuda ◽

Sara Ghiselli ◽

Alessandra Murri

Keyword(s):

Quality Of Life ◽

Older Adults ◽

Speech Perception ◽

Hearing Aids ◽

Assessment Tools ◽

Elderly Subjects ◽

Single Subject ◽

Measurement Tools ◽

First Time

Abstract Background Prevalence of hearing loss increases with age. Its estimated prevalence is 40–50 % in people over 75 years of age. Recent studies agree that declinein hearing threshold contribute to deterioration in sociality, sensitivity, cognition, and quality of life for elderly subjects. The aim of the study presented in this paper is to verify whether or not rehabilitation using first time applied Hearing Aids (HA) in a cohort of old people with hearing impairment improves both speech perception in a noisy environment over time and the overall health-related quality of life. Methods The monocentric, prospective, repeated measurements, single-subject, clinical observational study is to recruit 100 older adults, first-time HA recipients (≥ 65 years).The evaluation protocol is designed to analyze changes in specific measurement tools a year after the first HA usage in comparison with the evaluation before HA fitting. Evaluations will consist of multiparametric details collected through self-report questionnaires completed by the recipients and a series of commonly used audiometric measures and geriatric assessment tools. The primary indicator of changes in speech perception in noise to be used is the Italian version of Oldenburg Satz (OLSA) test whereas the indicator of changes in overall quality of life will be the Assessment of Quality of Life (AQoL) and Hearing Handicap Inventory for the Elderly (HHIE) questionnaires. The Montreal Cognitive Assessment (MoCA) will help in screening the cognitive state of the subjects. Discussion The protocol is designed to make use of measurement tools that have already been applied to the hearing-impaired population in order to compare the effects of HA rehabilitation in the older adults immediately before first HA usage (Pre) and after 1 year of experience (Post). This broad approach will lead to a greater understanding of how useful hearing influences the quality of life in older individuals, and therefore improves potentials for healthy aging. The data is to be analyzed by using an intrasubject endpoint comparison. Outcomes will be described and analyzed in detail. Trial registration This research was retrospectively registered underno. NCT04333043at ClinicalTrials.gov (http://www.clinicaltrials.gov/) on the 26 March 2020. This research has been registered with the Ethics Committee of the Area Vasta Emilia Nord under number 104, date of approval 17/07/2017.

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Sleep Disorders in Adults with Down Syndrome

Journal of Clinical Medicine ◽

10.3390/jcm10143012 ◽

2021 ◽

Vol 10 (14) ◽

pp. 3012

Author(s):

Sandra Giménez ◽

Miren Altuna ◽

Esther Blessing ◽

Ricardo M. Osorio ◽

Juan Fortea

Keyword(s):

Quality Of Life ◽

Mental Health ◽

Down Syndrome ◽

Sleep Disorders ◽

Negative Impact ◽

Current Knowledge ◽

Sleep Disruption ◽

Physical And Mental Health ◽

Future Directions

Sleep disorders, despite being very frequent in adults with Down syndrome (DS), are often overlooked due to a lack of awareness by families and physicians and the absence of specific clinical sleep guidelines. Untreated sleep disorders have a negative impact on physical and mental health, behavior, and cognitive performance. Growing evidence suggests that sleep disruption may also accelerate the progression to symptomatic Alzheimer’s disease (AD) in this population. It is therefore imperative to have a better understanding of the sleep disorders associated with DS in order to treat them, and in doing so, improve cognition and quality of life, and prevent related comorbidities. This paper reviews the current knowledge of the main sleep disorders in adults with DS, including evaluation and management. It highlights the existing gaps in knowledge and discusses future directions to achieve earlier diagnosis and better treatment of sleep disorders most frequently found in this population.

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Quality of life in adolescents and young adults with CHD is not reduced: a systematic review and meta-analysis

Cardiology in the Young ◽

10.1017/s104795111500181x ◽

2015 ◽

Vol 26 (3) ◽

pp. 415-425 ◽

Cited By ~ 12

Author(s):

Morten Schrøder ◽

Kirsten A. Boisen ◽

Jesper Reimers ◽

Grete Teilmann ◽

Jesper Brok

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Young Adults ◽

Meta Analysis ◽

Adolescents And Young Adults ◽

Analysis Model ◽

Significant Difference ◽

Newcastle Ottawa Scale ◽

First Time

AbstractPurposeWe performed a systematic review and meta-analysis of observational studies assessing quality of life in adolescents and young adults born with CHD compared with age-matched controls.MethodsWe carried out a systematic search of the literature published in Medline, Embase, PsychINFO, and the Cochrane Library’s Database (1990–2013); two authors independently extracted data from the included studies. We used the Newcastle–Ottawa scale for quality assessment of studies. A random effects meta-analysis model was used. Heterogeneity was assessed using the I2-test.ResultsWe included 18 studies with 1786 patients. The studies were of acceptable-to-good quality. The meta-analysis of six studies on quality of life showed no significant difference – mean difference: −1.31; 95% confidence intervals: −6.51 to +3.89, I2=90.9% – between adolescents and young adults with CHD and controls. Similar results were found in 10 studies not eligible for the meta-analysis. In subdomains, it seems that patients had reduced physical quality of life; however, social functioning was comparable or better compared with controls.ConclusionFor the first time in a meta-analysis, we have shown that quality of life in adolescents and young adults with CHD is not reduced when compared with age-matched controls.

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Effects of sleep disorders and sedative–hypnotic medications on health-related quality of life in dialysis patients

International Urology and Nephrology ◽

10.1007/s11255-018-2018-3 ◽

2018 ◽

Vol 51 (1) ◽

pp. 163-174

Author(s):

Chenfei Zheng ◽

Jinglin Xu ◽

Chaosheng Chen ◽

Fan Lin ◽

Rongrong Shao ◽

...

Keyword(s):

Quality Of Life ◽

Sleep Disorders ◽

Health Related Quality ◽

Dialysis Patients ◽

Related Quality ◽

Health Related

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Quality of life and the prevalence of urinary incontinence after surgical treatment for gynecologic cancer

10.21203/rs.2.11879/v1 ◽

2019 ◽

Author(s):

Noriko Nakayama ◽

Tetsuya Tsuji ◽

Makoto Aoyama ◽

Takafumi Fujino ◽

Meigen Liu

Keyword(s):

Quality Of Life ◽

Risk Factors ◽

Stress Incontinence ◽

Gynecologic Cancer ◽

Cesarean Sections ◽

Mixed Incontinence ◽

Post Surgery ◽

Significant Difference ◽

First Time

Abstract Purpose To examine the rates, causes, and impact on quality of life (QOL) of urinary storage symptoms after gynecologic cancer surgery. Methods A questionnaire survey, including Japanese-language versions of the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF), Overactive Bladder Symptom Score (OABSS), and Incontinence Impact Questionnaire-7 (IIQ-7), was distributed to gynecologic cancer patients who underwent hysterectomy between 2008 and 2013. Results Of the 145 patients analyzed, 49 (33.8%) had urinary incontinence (UI) pre-surgery and 76 (52.4%) had UI post-surgery, including 34 (35.4%) first-time UI patients, with a significant difference between pre- and post-surgery. Of the 49 subjects with UI pre-surgery, 43 (87.7%) had stress incontinence, while of the 76 patients with UI post-surgery, 44 (57.1%) had stress incontinence, and 24 (31.2%) had mixed incontinence. Seven (4.8%) subjects had overactive bladder (OAB) pre-surgery, whereas 19 (13.1%) had OAB symptoms post-surgery (including 15 first-time OAB patients), with a significant difference between pre- and post-surgery. IIQ-7 scores were markedly higher for patients with mixed incontinence post-surgery than for those with stress incontinence, indicating a lower QOL. Logistic regression analysis identified the number of Cesarean sections and days of urinary bladder catheterization as risk factors for postoperative UI. Conclusions UI and OAB rates were higher after gynecologic cancer surgery than in the general female population. The mixed incontinence rate was markedly higher post-surgery; QOL was low for such patients due to the combination of urgency and stress incontinence. Multiple Cesarean sections and urinary bladder catheterization post-surgery were risk factors for post-surgical UI.

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Effects of various factors on sleep disorders and quality of life in Parkinson’s disease

Acta Neurologica Belgica ◽

10.1007/s13760-015-0478-0 ◽

2015 ◽

Vol 115 (4) ◽

pp. 615-621 ◽

Cited By ~ 4

Author(s):

Srdjana Telarovic ◽

Dragana Mijatovic ◽

Irma Telarovic

Keyword(s):

Quality Of Life ◽

Parkinson’S Disease ◽

Parkinson's Disease ◽

Sleep Disorders

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Relationship between Sleep Disorders and Health Related Quality of Life—Results from the Georgia SOMNUS Study

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph15081588 ◽

2018 ◽

Vol 15 (8) ◽

pp. 1588 ◽

Cited By ~ 10

Author(s):

Nato Darchia ◽

Nikoloz Oniani ◽

Irine Sakhelashvili ◽

Mariam Supatashvili ◽

Tamar Basishvili ◽

...

Keyword(s):

Quality Of Life ◽

Sleep Quality ◽

Sleep Disorders ◽

Developing World ◽

Short Form ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Insomnia Severity

The extent to which sleep disorders are associated with impairment of health-related quality of life (HRQoL) is poorly described in the developing world. We investigated the prevalence and severity of various sleep disorders and their associations with HRQoL in an urban Georgian population. 395 volunteers (20–60 years) completed Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, STOP-Bang questionnaire, Insomnia Severity Index, Beck Depression Inventory-Short Form, and Short Form Health Survey (SF-12). Socio-demographic data and body mass index (BMI) were obtained. The prevalence of sleep disorders and their association with HRQoL was considerable. All SF-12 components and physical and mental component summaries (PCS, MCS) were significantly lower in poor sleepers, subjects with daytime sleepiness, apnea risk, or insomnia. Insomnia and apnea severity were also associated with lower scores on most SF-12 dimensions. The effect of insomnia severity was more pronounced on MCS, while apnea severity—on PCS. Hierarchical analyses showed that after controlling for potential confounding factors (demographics, depression, BMI), sleep quality significantly increased model’s predictive power with an R2 change (ΔR2) by 3.5% for PCS (adjusted R2 = 0.27) and by 2.9% for MCS (adjusted R2 = 0.48); for the other SF-12 components ΔR2 ranged between 1.4% and 4.6%. ESS, STOP-Bang, ISI scores, all exerted clear effects on PCS and MCS in an individual regression models. Our results confirm and extend the findings of studies from Western societies and strongly support the importance of sleep for HRQoL. Elaboration of intervention programs designed to strengthen sleep-related health care and thereof HRQoL is especially important in the developing world.

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Impact of ocrelizumab on patient-reported fatigue and quality of life in patients with relapsing multiple sclerosis treated for the first time with ocrelizumab

http://isrctn.com/ ◽

10.1186/isrctn55332718 ◽

2021 ◽

Author(s):

Clinical Trials

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Patient Reported ◽

First Time ◽

Relapsing Multiple Sclerosis

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The prevalence of common sleep disorders in young adults: a descriptive population-based study

SLEEP ◽

10.1093/sleep/zsaa072 ◽

2020 ◽

Vol 43 (10) ◽

Cited By ~ 2

Author(s):

Nigel McArdle ◽

Sarah V Ward ◽

Romola S Bucks ◽

Kathleen Maddison ◽

Anne Smith ◽

...

Keyword(s):

Quality Of Life ◽

Young Adults ◽

Sleep Disorders ◽

Sleep Disorder ◽

Restless Legs Syndrome ◽

Survey Methods ◽

Apnea Hypopnea Index ◽

Restless Legs ◽

Obstructive Sleep

Abstract Sleep disorders in adults are associated with adverse health effects including reduced quality of life and increased mortality. However, there is little information on sleep disorders in young adults. A cross-sectional observational study was undertaken in 1,227 young adults participating in the Western Australian Pregnancy (Raine) Study (2012–2014) to describe the prevalence of common sleep disorders. In-laboratory polysomnography (PSG) and validated survey methods were used, including the Epworth Sleepiness Scale, Pittsburgh Sleep Symptom Questionnaire-Insomnia, and International Restless Legs Syndrome Study Group criteria. A total of 1,146 participants completed a core questionnaire, 1,051 completed a sleep-focused questionnaire and 935 had analyzable PSG data. Participants had a mean age of 22.2 years and female to male ratio of 1.1 to 1. The respective sleep disorder prevalences in females and males were: obstructive sleep apnea (OSA) (apnea-hypopnea index [AHI]: ≥5 events/hour) 14.9% (95% CI: 11.8–18.5) and 26.9% (95% CI: 22.9–31.2); chronic insomnia, 19.3% (95% CI: 16.7–23.9) and 10.6% (95% CI: 8.3–13.9); restless legs syndrome, 3.8% (95% CI: 2.4–5.6) and 1.9% (95% CI: 0.9–3.4); and abnormal periodic leg movements during sleep (>5 movements/hour), 8.6% (95% CI: 6.3–11.5) and 9.6% (95% CI: 7.1–12.7). There were statistically significant differences in prevalence between sexes for OSA and insomnia, which persisted after adjustment for body mass index and education. In those with complete data on all sleep-related assessments (n = 836), at least one sleep disorder was present in 41.0% of females and 42.3% of males. Sleep disorders are very common in young adults. Health practitioners should be aware of these high prevalences, as early identification and treatment can improve quality of life and may reduce later morbidity and mortality.

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