scholarly journals Optimization of a Cisplatin Model of Chemotherapy-Induced Peripheral Neuropathy in Mice: Use of Vitamin C and Sodium Bicarbonate Pretreatments to Reduce Nephrotoxicity and Improve Animal Health Status

2014 ◽  
Vol 10 ◽  
pp. 1744-8069-10-56 ◽  
Author(s):  
Josée Guindon ◽  
Liting Deng ◽  
Baochang Fan ◽  
Jim Wager-Miller ◽  
Andrea G Hohmann
Keyword(s):  
Health Status ◽  
Peripheral Neuropathy ◽  
Vitamin C ◽  
Sodium Bicarbonate ◽  
Animal Health

Taxane-induced peripheral neuropathy and quality of life in breast cancer patients

2020 ◽  
Vol 26 (6) ◽  
pp. 1421-1428
Author(s):  
Ebrahim Salehifar ◽  
Ghasem Janbabaei ◽  
Abbas Alipour ◽  
Nasim Tabrizi ◽  
Razieh Avan
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Health Status ◽  
Peripheral Neuropathy ◽  
Global Health ◽  
Cancer Patients ◽  
Physical Functioning ◽  
Role Functioning ◽  
Breast Cancer Patients

Purpose Taxane-induced peripheral neuropathy (TIPN) is a common and bothersome toxicity. This study aimed to determine the incidence and severity of TIPN in patients with breast cancer and to investigate the relationship between TIPN and quality of life. Methods A total of 82 breast cancer patients with TIPN symptoms were included in this study. The criteria of National Cancer Institute-Common Terminology Criteria for Adverse Events (NCI-CTCAE v4.03) and the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire (QLQ-C30, version 3.0) were used to evaluate grading of sensory neuropathy and quality of life, respectively. Analysis of the data was done by IBM SPSS statistics version 23. Results A total of 346 patients received taxane-based chemotherapy and 82 patients (23.7%) experience TIPN. The mean (SD) global health status/quality of life, physical functioning, role functioning, and pain subscales were 60.63 (5.26), 80.64 (9.05), 81.77 (10.41), and 43.88 (11.27), respectively. There were significant negative correlations between global health status/quality of life, physical functioning, and role functioning subscales with the grade of neuropathy (r = −0.33, −0.80, and −0.61, respectively) and positive correlation between pain subscale and the grade of neuropathy (r = 0.70). Conclusion This study shows a clear association between TIPN and worsened quality of life. These findings emphasize on detecting and management of TIPN in an effort to improve the quality of life of breast cancer patients.

scholarly journals Structural homology and expression tendency of the natural immune response of the terminal complement components to inoculations in pigs: a review

2013 ◽  
Vol 58 (No. 1) ◽  
pp. 1-9
Author(s):  
D.V.A. Khoa
Keyword(s):  
Health Status ◽  
Candidate Genes ◽  
Production Systems ◽  
Animal Health ◽  
Mammalian Species ◽  
Protein A ◽  
Retinol Binding Protein ◽  
Classical Pathway ◽  
Complement Components ◽  
Terminal Complement

The transmission of infectious agents from domestic animals to humans is a matter of particular concern at present. Inoculation can enhance the defences of each individual animal but only in the short term. Certainly, it will be of immense benefit if biotechnology and genetic techniques are applied to farm animal breeding and selection programs to improve productivity, performance and health status as well as for the construction of sustainable animal production systems and promotion of animal welfare. In recent years, efforts to drive candidate genes like cytokines, haptoglobin, complement system, C-reactive protein, a 2-macroglobulin, retinol binding protein, transcortin, and etc. associated with immune traits have successfully been studied in human and different animal species. Here, we compared the molecular structure and evaluated the expression tendency of the haemolytic complement activity (HCA) of porcine candidate genes encoding the terminal complement components (TCC) C6–9. The results suggested that (1) high homology of complement genes among mammalian species may open new ways in cure/ treatment of disease; (2) Muong Khuong animals (Vietnamese potbelly pig) have a great genetic potential to improve the health status of pigs; and (3) HCA in the classical pathway can be developed further by different activation modes, with the potential improvement of animal health.

scholarly journals Pengaruh pemberian probiotik Lactobacillus helveticus Rosell-52 dan Lactobacillus rhamnosus Rosell-11 terhadap kadar limfosit lanjut usia

2014 ◽  
Vol 3 (1) ◽  
pp. 13-19
Author(s):  
Retno Wahyuningsih ◽  
Darmono SS ◽  
Ani Margawati
Keyword(s):  
Health Status ◽  
Vitamin E ◽  
Vitamin A ◽  
Vitamin C ◽  
Lactobacillus Rhamnosus ◽  
The Elderly ◽  
Lactobacillus Helveticus ◽  
Control Group ◽  
Quality Of Sleep

Background: Infectious disease remains a health problem for the elderly. The elderly are susceptible to infection,because the body's ability to fight infection decreases immunity. The immune status can be improved through the effortsof immunization, and nutrition. However the elderly are not sufficient to meet the nutritional needs of food, so probioticcould support nutritional adequacy.Objective: Analyze the effect of probiotic Lactobacillus helveticus Rosell-52 and Lactobacillus rhamnosus Rosell-11 onlevels of lymphocytes in the elderly in Tresna Elderly Social Institution Puspakarma Mataram, West Nusa Tenggara.Methods: This was quasi-experimental study, randomized pre-post control group design. The population is elderly aged60-75 years, involving 45 subjects were divided randomly into two groups, namely the treatment groups givenprobiotics and the control group was given a placebo. Probiotics were given for 4 weeks, with the provision of onecapsule a day. Immunity status in this study was lymphocytes. Data examined included the intake of nutrients (protein,vitamin A, vitamin C, vitamin E, Fe, Zn), health status, quality of sleep, and levels of lymphocytes in the elderly. Datawere analyzed using bivariate with different test Independent sample t-test, Mann-Whitney U test, Spearman, Pearson,and Paired t-test.Results: Increasing number of lymphocytes were significantly in the treatment group (χ ± SD: 1.84 ± 1.85) and in thecontrol group (0.95 ± 5.0). There is no relationship between intake (protein, vitamin A, vitamin C, vitamin E, Fe, Zink),physical health status, and quality of sleep with levels of lymphocytes.Conclusion: Probiotics in 4 weeks is proven to increase the number of lymphocytes in the elderly.

scholarly journals Food consumption, its aspects and consequences

2000 ◽  
Vol 18 (No. 4) ◽  
pp. 148-152
Author(s):  
J. Hrubý
Keyword(s):  
Time Series ◽  
Health Status ◽  
Vitamin A ◽  
Vitamin C ◽  
Food Consumption ◽  
Economic Factor ◽  
Food Prices ◽  
Nutrition Status ◽  
Milk Consumption ◽  
Food Policies

Food consumption recording is a social need because the consumption is an indicator of the nutrition status that means the health status, of the population, and an economic factor. Food consumption trends in the nineties are characterized by a steep fall of most kinds of foods, mainly from animal sources. It is not necessary to adjust this fact with respect to recent data of the time series. Four commodities show a positive increase. The trend of food consumption is bound up with more slowly increasing incomes of the population than was the increase in food prices after their liberalization. The consequences of consumption trends do not imply any deterioration of nutrition status because nutrition requirements have been met except calcium and vitamin A supply due to a decrease in milk consumption, and except vitamin C, still a deficient element although its supply has substantially increased. A systematic attention should be focused on the population nutrition through nutrition and food policies.

Measuring general animal health status: Development of an animal health barometer

2015 ◽  
Vol 118 (4) ◽  
pp. 341-350 ◽  
Author(s):  
Pieter Depoorter ◽  
Xavier Van Huffel ◽  
Herman Diricks ◽  
Hein Imberechts ◽  
Jeroen Dewulf ◽  
...  
Keyword(s):  
Health Status ◽  
Animal Health

scholarly journals Prawo o zdrowiu zwierząt

2020 ◽  
pp. 41-52
Author(s):  
Izabela Lipińska
Keyword(s):  
Health Status ◽  
Infectious Diseases ◽  
Animal Health ◽  
Legal Regulation ◽  
Farm Animals ◽  
Animal Disease ◽  
Fully Integrated ◽  
Animal Disease Control ◽  
The Subject ◽  
Health Legislation

The subject of the article is the issues related to the implementation of EU legal solutions concerning the protection of the health of farm animals, while the purpose of the considerations is to evaluate the legal regulation adopted to implement the package of measures aimed at animal health that have been in place since 2013, and propose the direction of necessary changes in the national legislation in this area. The new animal health legislation entails the amendment or repeal of a number of national provisions on animal disease control, in particular those which were transpositions of directives and EU decisions now repealed. The legal instruments provided for in the regulation are expected to contribute to the achievement of a fully integrated internal market and to prevent the spread of infectious diseases, provided that the existing animal health status is maintained as far as possible.

scholarly journals Impact of Cadmium Intoxication on Health Status, Rumen and Blood Constituents in Egyptian Ossimi Sheep

2021 ◽  
Vol 10 (2) ◽  
pp. 102-106
Keyword(s):  
Drinking Water ◽  
Health Status ◽  
Rumen Fluid ◽  
Animal Health ◽  
Ammonia Nitrogen ◽  
Strong Positive Correlation ◽  
Toxic Heavy Metals ◽  
Animal Blood ◽  
Antioxidant Markers ◽  
The Impact

Toxic heavy metals particularly Cadmium (Cd) have a hazardous impact on animal health and productivity because of their ill-degradability and bio-accumulation for long periods. This study carried out on 52 Ossimi sheep belonging to Giza Governorate, including 12 sheep considered as control (kept in a private farm) and 40 sheep grazed on an area polluted with cadmium. Drinking water, animal blood and rumen fluid samples were collected from all sheep. Complete blood, rumen and serum constituents were analyzed. Iron, copper, zinc, oxidant, and antioxidant markers were evaluated and Cd levels in water, rumen fluid and serum were investigated to show the impact of Cd on those parameters. Physical examination revealed significant disturbance in health status of Cd-exposed sheep. Rumen fluid examination showed significant increase in rumen pH, significant decrease in rumen ammonia-nitrogen, TVFAs, AST, ALT, GGT, Ca and Ph. Blood constituent revealed significant alteration as significant decrease in RBCs count, Hb, PCV, MCHC and TLC as well as impaired hepatic and renal function and significant decrease of antioxidant markers. These alterations associated with strong positive correlation between these altered parameters and cadmium level in drinking water, rumen fluid and blood samples which markedly increased more than permissible limits; these results should be put in consideration in interpretation of affected animals' status and during treatment and control of cadmium exposed sheep cases as well as consumption of such animals' meat and offal is not recommended.

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