scholarly journals Potassium iodide, but not potassium iodate, as a potential protective agent against oxidative damage to membrane lipids in porcine thyroid

2013 ◽  
Vol 6 (1) ◽  
pp. 10 ◽  
Author(s):  
Magdalena Milczarek ◽  
Jan Stepniak ◽  
Andrzej Lewinski ◽  
Malgorzata Karbownik-Lewinska
Keyword(s):  
Oxidative Damage ◽  
Potassium Iodide ◽  
Membrane Lipids ◽  
Protective Agent ◽  
Potassium Iodate

Melatonin reduces high levels of lipid peroxidation induced by potassium iodate in porcine thyroid

2019 ◽  
pp. 1-7 ◽  
Author(s):  
Paulina Iwan ◽  
Jan Stepniak ◽  
Malgorzata Karbownik-Lewinska
Keyword(s):  
Lipid Peroxidation ◽  
Oxidative Damage ◽  
Membrane Lipids ◽  
Chemical Properties ◽  
Iodine Concentration ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Protective Effects ◽  
Potassium Iodate ◽  
Hormone Synthesis

Abstract. Iodine is essential for thyroid hormone synthesis. Under normal iodine supply, calculated physiological iodine concentration in the thyroid is approx. 9 mM. Either potassium iodide (KI) or potassium iodate (KIO3) are used in iodine prophylaxis. KI is confirmed as absolutely safe. KIO3 possesses chemical properties suggesting its potential toxicity. Melatonin (N-acetyl-5-methoxytryptamine) is an effective antioxidant and free radical scavenger. Study aims: to evaluate potential protective effects of melatonin against oxidative damage to membrane lipids (lipid peroxidation, LPO) induced by KI or KIO3 in porcine thyroid. Homogenates of twenty four (24) thyroids were incubated in presence of either KI or KIO3 without/with melatonin (5 mM). As melatonin was not effective against KI-induced LPO, in the next step only KIO3 was used. Homogenates were incubated in presence of KIO3 (200; 100; 50; 25; 20; 15; 10; 7.5; 5.0; 2.5; 1.25 mM) without/with melatonin or 17ß-estradiol. Five experiments were performed with different concentrations of melatonin (5.0; 2.5; 1.25; 1.0; 0.625 mM) and one with 17ß-estradiol (1.0 mM). Malondialdehyde + 4-hydroxyalkenals (MDA + 4-HDA) concentration (LPO index) was measured spectrophotometrically. KIO3 increased LPO with the strongest damaging effect (MDA + 4-HDA level: ≈1.28 nmol/mg protein, p < 0.05) revealed at concentrations of around 15 mM, thus corresponding to physiological iodine concentrations in the thyroid. Melatonin reduced LPO (MDA + 4-HDA levels: from ≈0.97 to ≈0,76 and from ≈0,64 to ≈0,49 nmol/mg protein, p < 0.05) induced by KIO3 at concentrations of 10 mM or 7.5 mM. Conclusion: Melatonin can reduce very strong oxidative damage to membrane lipids caused by KIO3 used in doses resulting in physiological iodine concentrations in the thyroid.

scholarly journals Large-Scale Production of Salt Fortified with Iodine and Iron

1996 ◽  
Vol 17 (1) ◽  
pp. 1-6 ◽  
Author(s):  
S. Ranganathan ◽  
Vinodini Reddy ◽  
P. Ramamoorthy
Keyword(s):  
Potassium Iodide ◽  
Large Scale ◽  
Ferrous Sulphate ◽  
Sodium Hexametaphosphate ◽  
Common Salt ◽  
Scale Production ◽  
Mixing Process ◽  
Potassium Iodate ◽  
Large Scale Production ◽  
Dry Mixing

A new dry-mixing process for producing iodine- and iron-fortified salt on a large scale (20 30 metric tons per shift) was developed in salt factories at Valinokkam and Hyderabad, India. Common salt is mixed with 1% sodium hexametaphosphate, 0.5% ferrous sulphate heptahydrate, and 0.0055% potassium iodide or 0.007% potassium iodate in a ribbon blender. Dry mixing is superior to spray mixing and is associated with no operational problems. The fortified salt produced by this method retains the original colour of the unfortified salt, and the distribution of iodine and iron is uniform. The acceptability of the fortified salt is satisfactory, as various food preparations using the product are indistinguishable in colour, taste, and flavour from those containing unfortified salt

Rofecoxib Increases Susceptibility of Human LDL and Membrane Lipids to Oxidative Damage: A Mechanism of Cardiotoxicity

2006 ◽  
Vol 47 (Supplement 1) ◽  
pp. S7-S14 ◽  
Author(s):  
R. Preston Mason ◽  
Mary F. Walter ◽  
Hyesun P. McNulty ◽  
Samuel F. Lockwood ◽  
Jungsoo Byun ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Membrane Lipids

scholarly journals Exogenous Application of Melatonin Improves Drought Tolerance in Coffee by Regulating Photosynthetic Efficiency and Oxidative Damage

2021 ◽  
Vol 146 (1) ◽  
pp. 24-32
Author(s):  
Sylvia Cherono ◽  
Charmaine Ntini ◽  
Misganaw Wassie ◽  
Mohammad Dulal Mollah ◽  
Mohammad A. Belal ◽  
...  
Keyword(s):  
Drought Stress ◽  
Drought Tolerance ◽  
Oxidative Damage ◽  
Photosynthetic Efficiency ◽  
Crop Yields ◽  
Foliar Spray ◽  
Chlorophyll Degradation ◽  
Guaiacol Peroxidase ◽  
Protective Agent ◽  
Exogenous Application

The protective role of melatonin in plants under abiotic stress has been reported, but little information is available on its mitigation effect on coffee (Coffea arabica) plants. The objective of this study was to determine the effect of exogenous application of 100 µM melatonin in coffee leaves under 3 months of drought stress treatment. Melatonin was found to alleviate the drought-induced damage in coffee through reducing the rate of chlorophyll degradation, electrolyte leakage, malonaldehyde content, and activating various antioxidant enzymes, such as catalase, guaiacol peroxidase, and superoxide dismutase. Melatonin application suppressed the expression of chlorophyll degradation gene PAO encoding pheophorbide a oxygenase, and upregulated the expression of photosynthetic gene RBCS2 encoding ribulose-1,5-bisphosphate oxygenase (Rubisco) protein, and a drought-related gene AREB encoding abscisic acid-responsive element binding protein. The photosynthetic efficiency of photosystem II under dark adaptation was also improved upon melatonin application in drought-stressed plants. Our results showed that both foliar spray and direct soil application of melatonin could improve drought tolerance by regulating photosynthetic efficiency and oxidative damage in C. arabica seedlings. This study provides insights in application of melatonin as a protective agent against drought stress in improvement of crop yields.

scholarly journals Susceptibility of tamarin (Saguinus labiatus) red blood cell membrane lipids to oxidative stress: implications for wasting marmoset syndrome

1986 ◽  
Vol 20 (2) ◽  
pp. 140-147 ◽  
Author(s):  
J. M. C. Gutteridge ◽  
L. F. Taffs ◽  
C. M. Hawkey ◽  
C. Rice-Evans
Keyword(s):  
Oxidative Stress ◽  
Blood Cell ◽  
Oxidative Damage ◽  
Red Blood Cell ◽  
Membrane Lipids ◽  
Wasting Disease ◽  
Breeding Colony ◽  
Degree Of Certainty ◽  
Saguinus Labiatus ◽  
Increased Susceptibility

Captive Callitrichids frequently suffer a fatal wasting disease, wasting marmoset syndrome (WMS), of unexplained cause. This paper describes studies on the erythrocytes from animals in a breeding colony of tamarins ( Saguinus labiatus), in which deaths from anaemia and wasting were occurring, to seek evidence for biochemical changes which could lead to oxidative damage and premature cell lysis. In only one animal of 33 studied did the red blood cell lipids show an increased susceptibility to oxidative damage. This animal, with some degree of certainty, could be diagnosed as having WMS. It was concluded that evidence for a primary deficiency of antioxidants as a cause of unexplained deaths, or WMS, in the colony could not at present be substantiated.

Potassium Iodate and Its Comparison to Potassium Iodide As a Blocker of 131I Uptake by the Thyroid in Rats

1993 ◽  
Vol 65 (5) ◽  
pp. 545-549 ◽  
Author(s):  
D. N. Pahuja ◽  
M. G. R. Rajan ◽  
A. V. Borkar ◽  
A. M. Samuel
Keyword(s):  
Potassium Iodide ◽  
Potassium Iodate ◽  
131I Uptake
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