Association between caregiver quality of life and the care provided to persons with Alzheimer’s disease: protocol for a systematic review

Background: In recent years, several reviews have addressed the effectiveness of dance therapy in dementia, healthy older adults, or the elderly in general. However, reviews regarding the effect of this therapy exclusively on patients diagnosed with Alzheimer’s disease have not been found. Objective: The purpose of this study is to review the available literature describing clinical trials which explore the effects of dancing on psychological and physical outcomes, functionality, cognitive function, and quality of life in patients diagnosed with Alzheimer’s disease. In addition, this review aims to assess the quality of studies that perform dance therapy interventions in these patients. Methods: This study is a systematic review of randomized and non-randomized clinical trials regarding the effect of intervention including a dancing activity in people diagnosed with Alzheimer's disease. Results: In total, the evidence for this review rests on 12 studies with a total of 349 participants. The findings of this mini-review confirm the positive effect of dance therapy on physical and cognitive function, functionality, psychological outcomes, and quality of life in people with Alzheimer's disease. Conclusion: Most of the studies implementing dance as part of the therapeutic treatment has shown to improve or slow the worsening in the quality of life of patients with Alzheimer's disease and their caregivers. Future research focused on these patients should use a more exhaustive methodology and make a more detailed description of these kind of interventions.

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Effects of cognitive stimulation on neuropsychiatric symptoms in elderly with Alzheimer's disease: A systematic review

Dementia & Neuropsychologia ◽

10.1590/s1980-5764-2016dn1003003 ◽

2016 ◽

Vol 10 (3) ◽

pp. 178-184 ◽

Cited By ~ 4

Author(s):

Raiana Lídice Mór Fukushima ◽

Elisangela Gisele do Carmo ◽

Renata do Valle Pedroso ◽

Pollyanna Natalia Micali ◽

Paula Secomandi Donadelli ◽

...

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Elderly Patients ◽

Neuropsychiatric Symptoms ◽

Cognitive Stimulation ◽

Controlled Trials ◽

Inclusion Criteria

ABSTRACT Introduction: Neuropsychiatric symptoms are frequent in Alzheimer's disease and negatively affect patient quality of life. Objective: To assess the effectiveness of cognitive stimulation on neuropsychiatric symptoms in elderly patients with Alzheimer's disease. Methods: The included articles were reviewed between December 2015 and June 2016, and the inclusion criteria were: (1) studies involving older adults diagnosed with Alzheimer's disease; (2) studies published in English, Spanish or Portuguese; (3) studies that determined the effect of cognitive stimulation on neuropsychiatric symptoms in elderly patients with Alzheimer's disease; (4) controlled trials. Results: Out of the total 722, 9 articles matched the inclusion criteria. Depression, apathy and anxiety were the most frequent symptoms. Conclusion: Studies reported significant results post-treatment, suggesting cognitive stimulation can be effective for these neuropsychiatric symptoms, thus improving the quality of life of Alzheimer's disease patients and their caregivers.

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Impact of physical exercise on quality of life of older adults with depression or Alzheimer's disease: a systematic review

Trends in Psychiatry and Psychotherapy ◽

10.1590/2237-6089-2013-0064 ◽

2014 ◽

Vol 36 (3) ◽

pp. 134-139 ◽

Cited By ~ 14

Author(s):

Bianca Boscarino Tavares ◽

Helena Moraes ◽

Andrea Camaz Deslandes ◽

Jerson Laks

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Physical Exercise ◽

The Elderly ◽

Pharmacological Intervention ◽

Older Individuals ◽

Control Groups

INTRODUCTION: Physical exercise has been associated with improvement of quality of live (QoL), but its effect among the elderly with depression and Alzheimer's disease (AD) is still unclear. This systematic review evaluated randomized and controlled studies about the effect of physical exercise on QoL of older individuals with a clinical diagnosis of depression and AD.METHODS:We searched PubMed, ISI, SciELO and Scopus from December 2011 to June 2013 using the following keywords: physical exercise, quality of life, elderly, depression, Alzheimer's disease. Only six studies met inclusion criteria: two examined patients with AD and four, patients with depression.RESULTS: The studies used different methods to prescribe exercise and evaluate QoL, but all had high quality methods. Findings of most studies with individuals with depression suggested that exercise training improved QoL, but studies with patients with AD had divergent results.CONCLUSIONS: Although different methods were used, results suggested that physical exercise is an effective non-pharmacological intervention to improve the QoL of elderly individuals with depression and AD. Future studies should investigate the effect of other factors, such as the use of specific scales for the elderly, controlled exercise prescriptions and type of control groups.

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Alzheimer’s disease severity and its association with patient and caregiver quality of life in Japan: results of a community-based survey

BMC Geriatrics ◽

10.1186/s12877-018-0831-2 ◽

2018 ◽

Vol 18 (1) ◽

Cited By ~ 7

Author(s):

William Montgomery ◽

Amir Goren ◽

Kristin Kahle-Wrobleski ◽

Tomomi Nakamura ◽

Kaname Ueda

Keyword(s):

Quality Of Life ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Disease Severity ◽

Community Based ◽

Caregiver Quality

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Validación de la escala Quality of Life in Alzheimer’s Disease (QOL-AD) en pacientes mexicanos con demencia tipo Alzheimer, vascular y mixta

Revista de Neurología ◽

10.33588/rn.5102.2009648 ◽

2010 ◽

Vol 51 (02) ◽

pp. 72 ◽

Cited By ~ 3

Author(s):

Oscar Rosas Carrasco ◽

Laura del Pilar Torres Arreola ◽

María de Guadalupe Guerra Silla ◽

Sara Torres Castro ◽

Luis Miguel Gutiérrez Robledo

Keyword(s):

Quality Of Life ◽

Alzheimer’S Disease ◽

Alzheimer's Disease

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Assessing the Relationship between Health Utilities, Quality of Life, and Health Care Costs in Alzheimer's Disease: The CATIE-AD Study

Current Alzheimer Research ◽

10.2174/1567210197155522050 ◽

2010 ◽

Vol 999 (999) ◽

pp. 1-10

Author(s):

Edward Alan Miller ◽

Robert A. Rosenheck ◽

Lon S. Schneider

Keyword(s):

Quality Of Life ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Health Care ◽

Health Care Costs ◽

Health Utilities ◽

The Relationship ◽

Care Costs

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Assessing Alzheimer's disease patients' quality of life: Discrepancies between patient and caregiver perspectives

Alzheimer s & Dementia ◽

10.1016/j.jalz.2015.09.003 ◽

2015 ◽

Vol 12 (4) ◽

pp. 427-437 ◽

Cited By ~ 19

Author(s):

Sandrine Andrieu ◽

Nicola Coley ◽

Yves Rolland ◽

Christelle Cantet ◽

Catherine Arnaud ◽

...

Keyword(s):

Quality Of Life ◽

Alzheimer’S Disease ◽

Alzheimer's Disease

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CLINICAL AND COST-EFFECTIVENESS OF DONEPEZIL, RIVASTIGMINE, AND GALANTAMINE FOR ALZHEIMER'S DISEASE

International Journal of Technology Assessment in Health Care ◽

10.1017/s026646230200034x ◽

2002 ◽

Vol 18 (3) ◽

pp. 497-507 ◽

Cited By ~ 48

Author(s):

Andrew Clegg ◽

Jackie Bryant ◽

Tricia Nicholson ◽

Linda McIntyre ◽

Sofie De Broe ◽

...

Keyword(s):

Quality Of Life ◽

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cost Effectiveness ◽

Global Health ◽

Cochrane Library ◽

The Impact ◽

Health Cognition ◽

Economic Studies

Objectives: Systematic review of the clinical and cost-effectiveness of donepezil, rivastigmine, and galantamine for people suffering from Alzheimer's disease.Methods: Sixteen electronic databases (including MEDLINE, the Cochrane Library, and Embase) and bibliographies of related papers were searched for published/unpublished English language studies, and experts and pharmaceutical companies were consulted for additional information. Randomized controlled trials (RCTs) and economic studies were selected. Clinical effectiveness was assessed on measurement scales assessing progression of Alzheimer's disease on the person's global health, cognition, functional ability, behavior and mood, and quality of life. Cost-effectiveness was presented as incremental cost per year spent in a nonsevere state (by Mini Mental Health State Examination) or quality-adjusted life-year.Results: Twelve of 15 RCTs included were judged to be of good quality. Although donepezil had beneficial effects in Alzheimer's patients on global health and cognition, rivastigmine on global health, and galantamine on global health, cognition, and functional scales, these improvements were small and may not be clinically significant. Measures of quality of life and behavior and mood were rarely assessed. Adverse effects were usually mild and transient. Cost-effectiveness base case estimates ranged from £2,415 savings to £49,476 additional cost (1997 prices) per unit of effect for donepezil and a small savings for rivastigmine. Estimates were not considered robust or generalizable.Conclusions: Donepezil, rivastigmine, and galantamine appear to have some clinical effect for people with Alzheimer's disease, although the extent to which these translate into real differences in everyday life remains unclear. Due to the nature of current economic studies, cost-effectiveness remains uncertain and the impact on different care sectors has been inadequately investigated. Further research is needed to establish the actual benefits of acetylcholinesterase inhibitors (AChEls) for people with Alzheimer's disease and their caregivers, the relationship of these changes to clinical management, and careful prospective evaluation of resource and budgetary consequences.

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