Early natural killer cell counts in blood predict mortality in severe sepsis

This study was designed to test whether a single 50-mg dose of the opioid antagonist naltrexone hydrochloride, ingested 60 min before 2 h of moderate-intensity exercise (i.e., 65% peak O2consumption), influenced the exercise-induced augmentation of peripheral blood natural killer cell cytolytic activity (NKCA). Ten healthy male subjects were tested on four occasions separated by intervals of at least 14 days. A rested-state control trial was followed by three double-blind exercise trials [placebo (P), naltrexone (N), and indomethacin] arranged according to a random block design. The indomethacin exercise trial is discussed elsewhere (S. G. Rhind, G. A. Gannon, P. N. Shek, and R. J. Shepherd. Med. Sci. Sports Exerc. 30: S20, 1998). For both the P and N trials, plasma levels of β-endorphin were increased ( P < 0.05) at 90 and 120 min of exercise but returned to resting (preexercise) levels 2 h postexercise. CD3−CD16+CD56+NK cell counts and NKCA were significantly ( P < 0.05) elevated at each 30-min interval of exercise compared with correspondingly timed resting control values. However, there were no differences in NK cell counts or NKCA between P and N trials at any time point during the two trials. Changes in NKCA reflected mainly changes in NK cell count ( r = 0.72; P < 0.001). The results do not support the hypothesis that the enhancement of NKCA during prolonged submaximal aerobic exercise is mediated by β-endorphin.

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Association of Anger Expression-Out with NK Cell Counts in Colorectal Cancer Patients

Acta Médica Portuguesa ◽

10.20344/amp.9573 ◽

2018 ◽

Vol 31 (3) ◽

pp. 152

Author(s):

Estela Kakoo-Brioso ◽

Luís Costa ◽

Sílvia Ouakinin

Keyword(s):

Colorectal Cancer ◽

Natural Killer Cell ◽

Cell Count ◽

Natural Killer ◽

Cancer Patients ◽

Psychological Factors ◽

Killer Cell ◽

Anger Expression ◽

Cell Counts ◽

Colorectal Cancer Patients

Introduction: There is growing evidence describing the relation between psychological factors and the progression of colorectal cancer. Several mechanisms have been proposed but the one showing more promising evidence relies on the modulation of the antitumoral immune response by psychological factors, particularly through natural killer cells. We aimed to study the relation between natural killer cell count and anxiety, depression and anger state, trait and expression in 54 pre-surgical colorectal cancer patients.Material and Methods: We measured peripheral blood natural killer cell count and applied the State-Trait Anger Expression Inventory and the Hospital Anxiety and Depression Scale to 54 pre-surgical colorectal cancer patients. We used the Mann-Whitney U test and the Kruskal-Wallis test when appropriate to compare independent groups.Results: Patients with higher Anger Expression-Out had lower natural killer cell numbers than patients with lower Anger Expression-Out (p value = 0.008). No relation was found between natural killer cell levels and Anger State, Anger Trait, or Anger Expression-In. No difference in natural killer cell count was found between patients with and without clinical anxiety or depression.Discussion: These results suggest that, in colorectal cancer patients, natural killer cell counts are influenced by Anger Expression-Out, but not by clinical anxiety or depression.Conclusion: The unregulated emotional expression might be a conditioning factor of innate immunity. Additional studies are needed to further investigate this relation and to ascertain the clinical impact of therapeutic interventions regarding emotional regulation on the anti-tumoral immune response.

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The relationship of natural killer cell counts, perforin mRNA and CD2 expression to post-exercise natural killer cell activity in humans

Acta Physiologica Scandinavica ◽

10.1046/j.1365-201x.2002.00958.x ◽

2002 ◽

Vol 174 (4) ◽

pp. 317-325 ◽

Cited By ~ 13

Author(s):

M. P. MILES ◽

L. T. MACKINNON ◽

D. S. GROVE ◽

N. I. WILLIAMS ◽

J. A. BUSH ◽

...

Keyword(s):

Natural Killer Cell ◽

Natural Killer ◽

Natural Killer Cell Activity ◽

Killer Cell ◽

Cell Activity ◽

Post Exercise ◽

Cell Counts ◽

Killer Cell Activity ◽

Relationship Of ◽

The Relationship

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Toll-like receptor 2 gene polymorphisms, pulmonary tuberculosis, and natural killer cell counts

BMC Medical Genetics ◽

10.1186/1471-2350-11-17 ◽

2010 ◽

Vol 11 (1) ◽

Cited By ~ 37

Author(s):

Yung-Che Chen ◽

Chang-Chun Hsiao ◽

Chung-Jen Chen ◽

Chien-Hung Chin ◽

Shih-Feng Liu ◽

...

Keyword(s):

Natural Killer Cell ◽

Pulmonary Tuberculosis ◽

Natural Killer ◽

Gene Polymorphisms ◽

Killer Cell ◽

Toll Like Receptor ◽

Cell Counts ◽

Toll Like Receptor 2

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Dendritic and Natural Killer Cell Subsets Associated with Stable or Declining CD4+Cell Counts in Treated HIV‐1–Infected Children

The Journal of Infectious Diseases ◽

10.1086/429300 ◽

2005 ◽

Vol 191 (9) ◽

pp. 1451-1459 ◽

Cited By ~ 37

Author(s):

L. Azzoni ◽

R. M. Rutstein ◽

J. Chehimi ◽

M. A. Farabaugh ◽

A. Nowmos ◽

...

Keyword(s):

Natural Killer Cell ◽

Natural Killer ◽

Killer Cell ◽

Cell Counts ◽

Cd4 Cell Counts ◽

Cd4 Cell ◽

Hiv 1

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Natural Killer Cell Counts Are Not Different between Patients with Post-Lyme Disease Syndrome and Controls

Clinical and Vaccine Immunology ◽

10.1128/cvi.00167-09 ◽

2009 ◽

Vol 16 (8) ◽

pp. 1249-1250 ◽

Cited By ~ 38

Author(s):

Adriana Marques ◽

Margaret R. Brown ◽

Thomas A. Fleisher

Keyword(s):

Natural Killer Cells ◽

Lyme Disease ◽

Natural Killer Cell ◽

Healthy Volunteers ◽

Natural Killer ◽

Killer Cell ◽

Killer Cells ◽

Chronic Lyme Disease ◽

Cell Counts

ABSTRACT It has been reported that patients with “chronic Lyme disease” have a decreased number of natural killer cells, as defined by the CD57 marker. We performed immunophenotyping in 9 individuals with post-Lyme disease syndrome, 12 who recovered from Lyme disease, and 9 healthy volunteers. The number of natural killer cells was not significantly different between the groups.

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