scholarly journals Effects of physical exercise on working memory in older adults: a systematic and meta-analytic review

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Cai Zhidong ◽  
Xing Wang ◽  
Jilin Yin ◽  
Dehai Song ◽  
Zhitong Chen
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Physical Exercise ◽  
Publication Bias ◽  
Methodological Quality ◽  
Cognitive Status ◽  
Moderate Intensity ◽  
Exercise Frequency ◽  
Analytic Review

Abstract Background This systematic and meta-analytic review aimed to investigate the effects of physical exercise on the working memory of older adults, and to identify the moderators of these effects. Methods We searched six electronic databases for randomized controlled trials on the effects of physical exercise on working memory that were published before or on May 15, 2020. The PEDro scale was used to evaluate the methodological quality of the included studies. Stata 14.0 software was used to perform the meta-analysis, subgroup analysis, and publication bias testing. Results A total of 28 studies and 2156 participants were included. The methodological quality of the included studies was fair to excellent, and there was no publication bias. Overall, we found that physical exercise had a significant effect on working memory in older adults (standardized mean difference = 0.30, p < 0.0001). The effects of physical exercise on working memory were moderated by exercise frequency, intensity, type, duration, cognitive status, and control subgroup (active/passive), but not by intervention period or age of participant. Conclusion Physical exercise can effectively improve the working memory of older adults. The recommended physical exercise is multi-component exercise or mind–body exercise of moderate intensity for 45–60 min 3 times a week, for more than 6 months.

scholarly journals Dual-Task Exercise to Improve Cognition and Functional Capacity of Healthy Older Adults

2021 ◽  
Vol 13 ◽  
Author(s):  
Naina Yuki Vieira Jardim ◽  
Natáli Valim Oliver Bento-Torres ◽  
Victor Oliveira Costa ◽  
Josilayne Patricia Ramos Carvalho ◽  
Helen Tatiane Santos Pontes ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Exercise Training ◽  
Physical Exercise ◽  
Dual Task ◽  
Cognitive Stimulation ◽  
Moderate Intensity ◽  
Healthy Older Adults ◽  
Physical Exercise Training

BackgroundIt has been suggested that physical inactivity and lack of stimulating cognitive activity are the two most significant modifiable risk factors to impair cognitive function. Although many studies that investigated the cognitive effects of physical exercise and cognitive stimuli in dual-task conditions showed improved cognitive performance, others have not confirmed these findings. The main aim of the present work is to analyze the effects of a dual-task multimodal physical exercise training, at moderate intensity, and cognitive stimulation on cognitive and physical function in healthy older adults.MethodsThis clinical trial was registered on the Brazilian Registry of Clinical Trials (RBR-9zrx3d). Here we tested the effects of a dual-task multimodal physical exercise training, at moderate intensity, on cognitive and physical function and quality of life in community dwelling older adults. The training protocol included 24 group sessions, 2/week, per 75 min. Cognition was assessed using CANTAB automated neuropsychological tests and Functional Capacity to Exercise tests. Performance was compared from baseline to post intervention and to a non-exercise control group using Mixed Linear Model for repeated measures.ResultsControl (CG) and dual-task (DTEx) groups progressed differentially over time on performance of episodic memory, sustained visual attention, functional mobility, cardiorespiratory fitness, lower limbs strength resistance, agility, quality of life and dual-task performance with significant improved DTEx performance. Control group did not show any significant changes on these tests except for showing a reduction in dual-task performance.ConclusionWe suggest that the dual-task combination of multisensory cognitive stimulation and multimodal moderate physical exercise training, twice a week, may be adopted as an effective program to reduce progression of age-related cognitive decline and improve physical fitness and quality of life on healthy older adults.Clinical Trial RegistrationBrazilian Registry of Clinical Trials: https://ensaiosclinicos.gov.br/rg/RBR-9zrx3d -UTN code: U1111-1233-6349.

scholarly journals Effects of Tai Chi Chuan on Cognitive Function in Older Adults with Cognitive Impairment: A Systematic and Meta-Analytic Review

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Zhidong Cai ◽  
Wanting Jiang ◽  
Jilin Yin ◽  
Zhitong Chen ◽  
Jing Wang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Function ◽  
Publication Bias ◽  
Methodological Quality ◽  
Tai Chi ◽  
The Elderly ◽  
Tai Chi Chuan ◽  
Session Time ◽  
Analytic Review

This systematic and meta-analytic review aimed to investigate the effects of Tai Chi Chuan (TCC) on the cognitive function of the elderly with cognitive impairment and to analyze the moderators of these effects. We searched eight electronic databases for randomized controlled trials on the effects of TCC on cognitive function, published up to June 14, 2020. The PEDro scale was used to evaluate the methodological quality of the included literature. Stata14.0 software was used for meta-analysis, subgroup analysis, and publication bias testing. A total of 19 studies and 1,970 samples were included. The methodological quality of the included literature was fair to good, and there was no publication bias. Overall, the research shows that the effect of TCC on the elderly with cognitive impairment is statistically significant (SMD = 0.31, p < 0.0001 ). Five of the cognitive function subdomains were significant moderators [Q (5) = 15.66, p = 0.008 ], and the effect size (ES) was the largest for global cognitive function (SMD = 0.41), followed by executive function (SMD = 0.33), memory (SMD = 0.31), and verbal fluency (SMD = 0.27). Regarding the exercise prescription variables, results were significantly moderated by the length of exercise training [Q (2) = 6.00, p = 0.05 ], with ESs largest for moderate length (SMD = 0.41), followed by short length (SMD = 0.40) and long length (SMD = 0.29). However, the results were not moderated by session time or frequency. TCC can improve multiple cognitive functions of the elderly with cognitive impairment. The intervention effects are moderated by exercise length, but not by exercise session time and frequency.

scholarly journals Benefits of Physical Exercise Training on Cognition and Quality of Life in Frail Older Adults

2012 ◽  
Vol 68 (3) ◽  
pp. 400-404 ◽  
Author(s):  
F. Langlois ◽  
T. T. M. Vu ◽  
K. Chasse ◽  
G. Dupuis ◽  
M.-J. Kergoat ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Exercise Training ◽  
Physical Exercise ◽  
Frail Older Adults ◽  
Physical Exercise Training

Intergenerational Montessori Program for Adults With Memory Concerns

2021 ◽  
pp. 1-10
Author(s):  
Michelle Bourgeois ◽  
Jennifer Brush
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Cognitive Status ◽  
After School ◽  
Program Participation ◽  
After School Program ◽  
Memory Concerns ◽  
Neutral Affect ◽  
With Memory

Purpose This study evaluated the effects of an intergenerational Montessori after-school program on the engagement, affect, and quality of life of older adults with memory concerns and on the attitudes of children toward older adults. Method Eleven older adults were paired with 11 children to participate in a 45-min after-school activity program. Observations of engagement and affect during the interactions were collected 3 times a week for 4 weeks. The older adults' engagement and affect also were observed during 45-min planning/discussion sessions without the children present before their arrival to the program. Results Results revealed significant differences in older adults' engagement and positive affect when the children were present. Significant pre–post improvements in reported quality of life and maintenance of cognitive status were associated with program participation. Children demonstrated more active than passive engagement and more happy than neutral affect during activity sessions. Four of the seven children improved their positive ratings of older adults. Conclusions This program documented success in improving engagement and affect in older adults with mild memory concerns while engaging with children. Future studies with a larger sample of participants with varying degrees of memory impairment are needed to investigate the potential of this promising program.

scholarly journals Memory-Related Frontal Brainwaves Predict Transition to Mild Cognitive Impairment in Healthy Older Individuals Five Years Before Diagnosis

2020 ◽  
pp. 1-11
Author(s):  
Yang Jiang ◽  
Juan Li ◽  
Frederick A. Schmitt ◽  
Gregory A. Jicha ◽  
Nancy B. Munro ◽  
...  
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Memory Performance ◽  
Memory Task ◽  
Cognitive Status ◽  
Older Individuals ◽  
Increased Risk ◽  
Differentiation Pattern

Background: Early prognosis of high-risk older adults for amnestic mild cognitive impairment (aMCI), using noninvasive and sensitive neuromarkers, is key for early prevention of Alzheimer’s disease. We have developed individualized measures in electrophysiological brain signals during working memory that distinguish patients with aMCI from age-matched cognitively intact older individuals. Objective: Here we test longitudinally the prognosis of the baseline neuromarkers for aMCI risk. We hypothesized that the older individuals diagnosed with incident aMCI already have aMCI-like brain signatures years before diagnosis. Methods: Electroencephalogram (EEG) and memory performance were recorded during a working memory task at baseline. The individualized baseline neuromarkers, annual cognitive status, and longitudinal changes in memory recall scores up to 10 years were analyzed. Results: Seven of the 19 cognitively normal older adults were diagnosed with incident aMCI for a median 5.2 years later. The seven converters’ frontal brainwaves were statistically identical to those patients with diagnosed aMCI (n = 14) at baseline. Importantly, the converters’ baseline memory-related brainwaves (reduced mean frontal responses to memory targets) were significantly different from those who remained normal. Furthermore, differentiation pattern of left frontal memory-related responses (targets versus nontargets) was associated with an increased risk hazard of aMCI (HR = 1.47, 95% CI 1.03, 2.08). Conclusion: The memory-related neuromarkers detect MCI-like brain signatures about five years before diagnosis. The individualized frontal neuromarkers index increased MCI risk at baseline. These noninvasive neuromarkers during our Bluegrass memory task have great potential to be used repeatedly for individualized prognosis of MCI risk and progression before clinical diagnosis.

Distinct effects of acute exercise and breaks in sitting on working memory and executive function in older adults: a three-arm, randomised cross-over trial to evaluate the effects of exercise with and without breaks in sitting on cognition

2019 ◽  
Vol 54 (13) ◽  
pp. 776-781 ◽  
Author(s):  
Michael J Wheeler ◽  
Daniel J Green ◽  
Kathryn A Ellis ◽  
Ester Cerin ◽  
Ilkka Heinonen ◽  
...  
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Executive Function ◽  
Light Intensity ◽  
Visual Learning ◽  
Moderate Intensity ◽  
Moderate Intensity Exercise ◽  
Intermittent Light ◽  
Time Points ◽  
Serum Bdnf

BackgroundSedentary behaviour is associated with impaired cognition, whereas exercise can acutely improve cognition.ObjectiveWe compared the effects of a morning bout of moderate-intensity exercise, with and without subsequent light-intensity walking breaks from sitting, on cognition in older adults.MethodsSedentary overweight/obese older adults with normal cognitive function (n=67, 67±7 years, 31.2±4.1 kg/m2) completed three conditions (6-day washout): SIT (sitting): uninterrupted sitting (8 hours, control); EX+SIT (exercise + sitting): sitting (1 hour), moderate-intensity walking (30 min), uninterrupted sitting (6.5 hours); and EX+BR (exercise + breaks): sitting (1 hour), moderate-intensity walking (30 min), sitting interrupted every 30 min with 3 min of light-intensity walking (6.5 hours). Cognitive testing (Cogstate) was completed at four time points assessing psychomotor function, attention, executive function, visual learning and working memory. Serum brain-derived neurotrophic growth factor (BDNF) was assessed at six time points. The 8-hour net area under the curve (AUC) was calculated for each outcome.ResultsWorking memory net AUC z-score·hour (95% CI) was improved in EX+BR with a z-score of +28 (−26 to +81), relative to SIT, −25 (−79 to +29, p=0.04 vs EX+BR). Executive function net AUC was improved in EX+SIT, −8 (− 71 to +55), relative to SIT, −80 (−142 to −17, p=0.03 vs EX+SIT). Serum BDNF net AUC ng/mL·hour (95% CI) was increased in both EX+SIT, +171 (−449 to +791, p=0.03 vs SIT), and EX+BR, +139 (−481 to +759, p=0.045 vs SIT), relative to SIT, −227 (−851 to +396).ConclusionA morning bout of moderate-intensity exercise improves serum BDNF and working memory or executive function in older adults, depending on whether or not subsequent sitting is also interrupted with intermittent light-intensity walking.Trial registration numberACTRN12614000737639.

scholarly journals EFFECT OF PHYSICAL EXERCISE ON COGNITION IN ADULT DAY PARTICIPANTS

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S652-S653
Author(s):  
Bradford Stucki ◽  
Ben Katz ◽  
Jonathan Briganti ◽  
Ila Schepisi ◽  
Shannon Jarrott
Keyword(s):  
Older Adults ◽  
Physical Exercise ◽  
Effective Means ◽  
Cognitive Status ◽  
Data Set ◽  
Moderation Effect ◽  
Exercise Interventions ◽  
Mini Mental Status Exam ◽  
Exercise Regimen ◽  
Exercise Activity

Abstract Aerobic exercise has been demonstrated to be one of the most effective means of improving cognition in older adults. However, less is known about how exercise programs may improve cognition in older adults participating in Adult Day Service (ADS) programs. We analyzed a ten-year longitudinal data set from the Virginia Tech ADS center. We limited our analyses to individuals for whom we had two time points of the Mini-Mental Status Exam (MMSE) (n=142; average age = 78.48; 63 female, average days at center = 347; SD=432.71). Participants in the center completed approximately 30 minutes of physical exercise each day of attendance. The exercise regimen was largely composed of aerobic chair exercise, stretching, and lifting. Facilitator ratings of engagement with the exercise activity between the two test administrations were used to create an average engagement score for each participant. Multiple regression analyses were conducted using engagement as a predictor and change in MMSE as an outcome; no significant relationship was identified between exercise engagement and change in cognitive status. However, a moderation analysis conducted with diagnosis of Alzheimer’s disease (AD) or dementia as a predictor, change in MMSE as an outcome, and exercise engagement as a moderator revealed a significant moderation effect (p = .001). Greater exercise engagement was associated with improvements on the MMSE, but only for individuals without a diagnosis of AD or dementia. Given that many ADS programs serve individuals both with and without AD or dementia, these findings may inform more personalized exercise interventions at ADS centers.

scholarly journals Reviewing working memory training gains in healthy older adults: A meta-analytic review of transfer for cognitive outcomes

2019 ◽  
Vol 103 ◽  
pp. 163-177 ◽  
Author(s):  
Ana C. Teixeira-Santos ◽  
Célia S. Moreira ◽  
Rosana Magalhães ◽  
Carina Magalhães ◽  
Diana R. Pereira ◽  
...  
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Cognitive Outcomes ◽  
Working Memory Training ◽  
Memory Training ◽  
Healthy Older Adults ◽  
Analytic Review

Review: Multiple sclerosis and physical exercise: recommendations for the application of resistance-, endurance- and combined training

2008 ◽  
Vol 14 (1) ◽  
pp. 35-53 ◽  
Author(s):  
U. Dalgas ◽  
E. Stenager ◽  
T. Ingemann-Hansen
Keyword(s):  
Multiple Sclerosis ◽  
Physical Exercise ◽  
Endurance Training ◽  
Exercise Prescription ◽  
Moderate Intensity ◽  
Physiological Profile ◽  
Combined Training ◽  
Beneficial Effects ◽  
Training Modality

This review summarizes the existing knowledge regarding the effects of physical exercise in patients suffering from multiple sclerosis (MS). Furthermore, recommendations are given regarding exercise prescription for MS patients and for future study directions. Previously, MS patients were advised not to participate in physical exercise. During recent years, it has been increasingly acknowledged that exercise benefits MS patients. The requirement for exercise in MS patients is emphasized by their physiological profile, which probably reflects both the effects of the disease per se and the reversible effects of an inactive lifestyle. To date the effects of exercise have only been studied in moderately impaired MS patients with an EDSS score of less than 7. Evidence exists for recommending participation in endurance training at low to moderate intensity, as the existing literature demonstrates that MS patients can both tolerate and benefit from this training modality. Also, resistance training of moderate intensity seems to be well tolerated and to have beneficial effects on MS patients, but the methodological quality of the existing evidence is in general low and the number of studies is limited. Only two studies have evaluated the effects of combined resistance- and endurance training, making solid conclusions regarding this training modality impossible. Multiple Sclerosis 2008; 14: 35—53. http://msj.sagepub.com

Subjective cognitive impairment and quality of life: a systematic review

2017 ◽  
Vol 29 (12) ◽  
pp. 1965-1977 ◽  
Author(s):  
Nikki L. Hill ◽  
Caroline McDermott ◽  
Jacqueline Mogle ◽  
Elizabeth Munoz ◽  
Nicole DePasquale ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Cognitive Impairment ◽  
Methodological Quality ◽  
Empirical Work ◽  
Weight Of Evidence ◽  
Empirical Literature ◽  
Cross Sectional ◽  
Subjective Cognitive Impairment

ABSTRACTBackground:Older adults with subjective cognitive impairment (SCI) experience increased affective symptoms, reduced engagement in a range of activities, as well as more functional problems when compared to those without SCI. These associations suggest that SCI may be detrimental to older adults’ quality of life (QoL). The purpose of this paper is to advance understanding of the SCI–QoL relationship through a comprehensive review of the empirical literature relating SCI and QoL.Methods:A systematic literature review was conducted in CINAHL, PsycINFO, and PubMed per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria. Eligible articles were appraised using the weight of evidence (WoE) framework to evaluate methodological quality, methodological relevance, and topic relevance. A narrative synthesis of results was conducted, based on conceptual definitions of QoL.Results:Eleven articles were identified that met eligibility criteria. WoE ratings ranged from low to high scores. Studies reviewed reported that the presence, greater frequency, or greater severity of SCI is associated with lower QoL regardless of methodological quality rating, sample characteristics (e.g. geographic location, clinical vs. community settings), study design (e.g. cross-sectional vs. longitudinal), and operationalization of SCI or QoL.Conclusion:Across studies, QoL was negatively associated with SCI. However, a frequent limitation of the reviewed literature was the mismatch between the conceptual and operational definitions of SCI and QoL. Similarly, SCI measures varied in quality across the reviewed literature. This suggests future empirical work should focus on the appropriate strategies for conceptually and operationally defining these constructs.

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