scholarly journals Down-regulation of microRNA-342-5p or Up-regulation of Wnt3a Inhibits Angiogenesis and Maintains Atherosclerotic Plaque Stability in Atherosclerosis Mice

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Haixia Sun ◽  
Jinhua Feng ◽  
Yan Ma ◽  
Ding Cai ◽  
Yulu Luo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Lipid ◽  
Regulatory Mechanisms ◽  
Aortic Tissue ◽  
Lipid Levels ◽  
High Fat ◽  
Plaque Stability ◽  
Aortic Plaque ◽  
Functional Studies ◽  
And Oxidative Stress

AbstractEvidence has demonstrated that microRNA-342-5p (miR-342-5p) is implicated in atherosclerosis (AS), but little is known regarding its intrinsic regulatory mechanisms. Here, we aimed to explore the effect of miR-342-5p targeting Wnt3a on formation of vulnerable plaques and angiogenesis of AS. ApoE−/− mice were fed with high-fat feed for 16 w to replicate the AS vulnerable plaque model. miR-342-5p and Wnt3a expression in aortic tissues of AS were detected. The target relationship between miR-342-5p and Wnt3a was verified. Moreover, ApoE−/− mice were injected with miR-342-5p antagomir and overexpression-Wnt3a vector to test their functions in serum lipid levels, inflammatory and oxidative stress-related cytokines, aortic plaque stability and angiogenesis in plaque of AS mice. miR-342-5p expression was enhanced and Wnt3a expression was degraded in aortic tissues of AS mice and miR-342-5p directly targeted Wnt3a. Up-regulating Wnt3a or down-regulating miR-342-5p reduced blood lipid content, inflammatory and oxidative stress levels, the vulnerability of aortic tissue plaque and inhibited angiogenesis in aortic plaque of AS mice. Functional studies show that depleting miR-342-5p can stabilize aortic tissue plaque and reduce angiogenesis in plaque in AS mice via restoring Wnt3a.

Effect of high fluoride and high fat on serum lipid levels and oxidative stress in rabbits

2014 ◽  
Vol 38 (3) ◽  
pp. 1000-1006 ◽  
Author(s):  
Liyan Sun ◽  
Yanhui Gao ◽  
Wei Zhang ◽  
Hui Liu ◽  
Dianjun Sun
Keyword(s):  
Oxidative Stress ◽  
Serum Lipid ◽  
Lipid Levels ◽  
High Fat ◽  
Serum Lipid Levels ◽  
High Fluoride ◽  
And Oxidative Stress

Effect of Armillaria mellea on Blood Lipid Levels and Antioxidant Enzymes Activity in High Fat Mice

2014 ◽  
Vol 884-885 ◽  
pp. 423-428
Author(s):  
Yan Hui Yang ◽  
Guo Qiang Zheng ◽  
Juan Tang ◽  
Yue Meng Wang ◽  
Chuan Wang Zhu ◽  
...  
Keyword(s):  
Antioxidant Enzymes ◽  
High Fat Diet ◽  
Blood Lipid ◽  
Lipid Levels ◽  
Model Group ◽  
High Fat ◽  
Treatment Groups ◽  
Armillaria Mellea ◽  
And Oxidative Stress ◽  
Blood Lipid Levels

The effect of Armillaria mellea on blood lipid levels and oxidative stress in mice fed on high-fat diet was investigated. Animals were allocated to the Armillaria mellea polysaccharides-treatment groups (I, II) and Armillaria mellea oligosaccharides-treatment groups (I, II). All mice were fed with high-fat diet for 40 days but control mice with basic diet. TC, TG, HDL-c, LDL-c were measured by enzymatic and colorimetric methods. The same, MDA,SOD, GSH-PX were measured. Results showed that administration of Armillaria mellea polysaccharides and oligosaccharides significantly increased antioxidant enzymes GSH-Px activities and decreased TC, TG, LDL-c, MDA level in mice (P < 0.05) compared with model group. In conclusion Armillaria mellea polysaccharides and oligosaccharides were able to protect mices antioxidative and improve abnormal blood lipid levels.

scholarly journals Galangin Resolves Cardiometabolic Disorders through Modulation of AdipoR1, COX-2, and NF-κB Expression in Rats Fed a High-Fat Diet

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 769
Author(s):  
Patoomporn Prasatthong ◽  
Sariya Meephat ◽  
Siwayu Rattanakanokchai ◽  
Juthamas Khamseekaew ◽  
Sarawoot Bunbupha ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cardiac Tissue ◽  
Sprague Dawley ◽  
High Fat ◽  
Impaired Liver Function ◽  
Impaired Liver ◽  
Cardiometabolic Disorders ◽  
Cox 2 ◽  
Factor Α ◽  
And Oxidative Stress

Galangin is a natural flavonoid. In this study, we evaluated whether galangin could alleviate signs of metabolic syndrome (MS) and cardiac abnormalities in rats receiving a high-fat (HF) diet. Male Sprague–Dawley rats were given an HF diet plus 15% fructose for four months, and they were fed with galangin (25 or 50 mg/kg), metformin (100 mg/kg), or a vehicle for the last four weeks. The MS rats exhibited signs of MS, hypertrophy of adipocytes, impaired liver function, and cardiac dysfunction and remodeling. These abnormalities were alleviated by galangin (p < 0.05). Interleukin-6 and tumor necrosis factor-α concentrations and expression were high in the plasma and cardiac tissue in the MS rats, and these markers were suppressed by galangin (p < 0.05). These treatments also alleviated the low levels of adiponectin and oxidative stress induced by an HF diet in rats. The downregulation of adiponectin receptor 1 (AdipoR1) and cyclooxygenase-2 (COX-2) and the upregulation of nuclear factor kappa B (NF-κB) expression were recovered in the galangin-treated groups. Metformin produced similar effects to galangin. In conclusion, galangin reduced cardiometabolic disorders in MS rats. These effects might be linked to the suppression of inflammation and oxidative stress and the restoration of AdipoR1, COX-2, and NF-κB expression.

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