scholarly journals Insights of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) pandemic: a current review

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Jyoti Choudhary ◽  
Shrivardhan Dheeman ◽  
Vipin Sharma ◽  
Prashant Katiyar ◽  
Santosh Kumar Karn ◽  
...  
Keyword(s):  
Management Strategies ◽  
Rapid Test ◽  
Protein S ◽  
World Health ◽  
Future Research ◽  
Viral Attachment ◽  
Comprehensive Collection ◽  
Test Kit ◽  
Novel Coronavirus ◽  
Health Organization

AbstractCOVID-19, a pandemic of the 21st century caused by novel coronavirus SARS-CoV-2 was originated from China and shallowed world economy and human resource. The medical cures via herbal treatments, antiviral drugs, and vaccines still in progress, and studying rigorously. SARS-CoV-2 is more virulent than its ancestors due to evolution in the spike protein(s), mediates viral attachment to the host’s membranes. The SARS-CoV-2 receptor-binding spike domain associates itself with human angiotensin-converting enzyme 2 (ACE-2) receptors. It causes respiratory ailments with irregularities in the hepatic, nervous, and gastrointestinal systems, as reported in humans suffering from COVID-19 and reviewed in the present article. There are several approaches, have been put forward by many countries under the world health organization (WHO) recommendations and some trial drugs were introduced for possible treatment of COVID-19, such as Lopinavir or Ritonavir, Arbidol, Chloroquine (CQ), Hydroxychloroquine (HCQ) and most important Remdesivir including other like Tocilizumab, Oritavancin, Chlorpromazine, Azithromycin, Baricitinib, etc. RT-PCR is the only and early detection test available besides the rapid test kit (serodiagnosis) used by a few countries due to unreasonable causes. Development of vaccine by several leader of pharmaceutical groups still under trial or waiting for approval for mass inoculation. Management strategies have been evolved by the recommendations of WHO, specifically important to control COVID-19 situations, in the pandemic era. This review will provide a comprehensive collection of studies to support future research and enhancement in our wisdom to combat COVID-19 pandemic and to serve humanity.

scholarly journals Twin Mammals and COVID-19: Life and Science of the Suspects

2020 ◽  
Author(s):  
Naser A. Anjum
Keyword(s):  
World Health Organization ◽  
World Health ◽  
Future Research ◽  
The World ◽  
Potential Link ◽  
Current Outbreak ◽  
The Subject ◽  
Novel Coronavirus ◽  
Health Organization ◽  
The Way

The world is puzzling over the origin of the current outbreak of the coronavirus disease (COVID-19) that is caused by a novel coronavirus-2019 (2019-nCoV). As of 25th March 2020, the World Health Organization has reported 4,14,179 confirmed cases and 18,440 confirmed deaths in total due to COVID-19. To this end, two unique mammals namely bats and pangolins are being investigated for their potential link to COVID-19. However, the evidence so far gathered in this context is far from clear. This paper aimed to: (i) enlighten the major aspects of life of bats and pangolins; (ii) briefly discusses their potential link to COVID-19; and also (iii) to highlight the way forward. The outcomes may contribute to future research on the subject.

scholarly journals Recent Discovery and Development on SARS-CoV-2: A Review of Current Literature

2020 ◽  
Author(s):  
V Deepak Bamola ◽  
Rama Chaudhry
Keyword(s):  
Specific Treatment ◽  
Central China ◽  
World Health ◽  
Diagnostic Tools ◽  
Future Research ◽  
Wuhan City ◽  
Global Challenge ◽  
The World ◽  
Novel Coronavirus ◽  
Health Organization

Origin and spread of current novel coronavirus raised serious concerns among stakeholders around the globe. Different speculations which may unfold the mystery in the future are taking roots, but now there is no globally acceptable opinion about the origin and spread of this novel coronavirus. It is reported that Wuhan city of Hubei Province of central China was the epicenter of this outbreak of novel coronavirus. However, initial inadequate preventive measures allowed the infection to cross the borders of China and that pull the world into a drastic public health and economic crisis. This novel coronavirus disease now named as COVID-19 by World Health Organization (WHO) and the responsible coronavirus is named as ‘severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)’. The spread of SARS-CoV-2 is alarming even after five months of inception and WHO further warns the world to be prepared for more intense spread of COVID-19. Different diagnostic tools to detect SARS-CoV-2 are being used around the globe, but the identification of asymptomatic carriers of the disease is a serious challenge in countering the COVID-19 pandemic. There is no specific treatment available, only preventive, symptomatic and supportive treatments are being used for clinical management of COVID-19. The available knowledge is limited therefore any escalation of information on the disease will help to combat with this global challenge of COVID-19. In this review, we have discussed and summarized the available multi-factorial information and recent updates on the SARS-CoV-2 which can support future research and may help in the strategic management of currentCOVID-19 pandemic. The articles available online before 30 April 2020 on bioRxiv, medRxiv, ChemRxiv, Google scholar and PubMed have been assessed for compilation of this review. Information on the official portal of WHO, CDC, ICMR etc were also assessed and used with due credit.

scholarly journals COVID-19: A Conundrum to Decipher

2020 ◽  
Author(s):  
Vishwajit Deshmukh ◽  
Satyendra C. Tripathi ◽  
Arvind Pandey ◽  
Vaishnavi Deshmukh ◽  
Ashlesh Patil ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Medical Condition ◽  
Management Strategies ◽  
Respiratory Illness ◽  
World Health ◽  
Chronic Medical Condition ◽  
Severe Illness ◽  
Life Threatening ◽  
Novel Coronavirus ◽  
Health Organization

OBJECTIVE: Recent worldwide outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of respiratory coronavirus disease 2019 (COVID-19), is a current, ongoing life-threatening crisis and international public health emergency. The early diagnosis and management of the disease remains a major challenge. In this review, we aim to summarize the updated epidemiology, causes, clinical manifestation and diagnosis, as well as prevention and control of the novel coronavirus SARS-CoV-2.MATERIALS AND METHODS: A broad search of the literature was performed in “PubMed” “Medline” “Web of knowledge”, and “Google Scholar” World Health Organization-WHO” using the keywords “severe acute respiratory syndrome coronavirus”, “2019-nCoV”, “COVID-19, “SARS”, “SARS-CoV-2” “Epidemiology” “Transmission” “Pathogenesis” “Clinical Characteristics”. We reviewed and documented the information obtained from literature on epidemiology, pathogenesis and clinical appearances of SARS-CoV-2 infection.RESULTS: The global cases of COVID-19 as of April 2, 2020 have risen to more than 900,000 and morbidity has reached more than 47,000. The incidence rate for COVID-19 has been predicted to be higher than the previous outbreaks of other coronavirus family members, including those of SARS-CoV and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). The main clinical presentation of SARS-CoV-2 infection ranges from asymptomatic stages to severe lower respiratory infection in the form of pneumonia. Most of the patients also presented with fever, cough, sore throat, headache, fatigue, myalgia and breathlessness.Individuals at higher risk for severe illness include elderly people and patients with a weakened immune system or that are suffering from a underlying chronic medical condition like hypertension, diabetes, cancer, respiratory illness or cardiovascular diseases.CONCLUSIONS: SARS-Cov-2 has emerged as a worldwide threat, currently affecting 170 countries and territories across the globe. There is still much to be understood regarding SARS-CoV-2 about its virology, epidemiology and clinical management strategies; this knowledge will be essential to both manage the current pandemic and to conceive comprehensive measures to prevent such outbreaks in the future.

scholarly journals Prevalence of COVID-19 amongst returning Students of University of Port Harcourt, Port Harcourt, Rivers State, Nigeria

2021 ◽  
Vol 11 (3) ◽  
pp. 213-219
Author(s):  
Henrrietta Ogadimma Asuzu-Samuel ◽  
Amanda Adanma Samuel ◽  
Sonia Oghenefejiri Jemifor ◽  
Osuo-Owene Karibo ◽  
Clinton Ubulom Awajigbanam
Keyword(s):  
Demographic Data ◽  
Hospital Setting ◽  
Returning Students ◽  
World Health ◽  
Screening Tests ◽  
Antigen Test ◽  
Port Harcourt ◽  
Test Kit ◽  
Novel Coronavirus ◽  
Health Organization

The causative agent of a mysterious pneumonia was identified as clustered of unexplained pneumonia, was identified as a novel coronavirus in Wuhan, China and was named coronavirus disease 2019 (COVID-19) by the World Health Organization. There are thousands of infectious individuals worldwide and millions of deaths. A total number of 248 subjects (124 males and 124 females) of returning students of some Faculties of University of Port Harcourt were used. Questionnaire were used to collect some demographic data from the subjects while Standard Q COVID-19 Antigen Test Kit methods were applied for the screening. The subjects that gave consent were made to sit down comfortably with their head tilted back and nasal samples collected with COVID-19 swab stick. The swab was inserted into an extraction buffer tube and squeezed at the sides to extract the liquid. 4 drops of the extracted specimen were applied to the well of the Standard Q COVID-19 Antigen Test Kit. The result was read in 20 minutes and was recorded. All the results of the study read negative. This showed zero prevalence of COVID-19 disease amongst the returning students of University of Port Harcourt. This could be as a result of age, environmental factor or strong COVID-19 preventive measures within the campus. Nevertheless, continuous observance of COVID-19 preventive protocols, further COVID-19 screening tests amongst the staff and in a hospital, setting is strongly recommended.

scholarly journals Regulatory response to pandemics in a developing country- the case of COVID-19 and the Ghana food and drugs authority (Ghana FDA)

2020 ◽  
Vol 8 (4) ◽  
pp. 61-65
Author(s):  
Delese Afia Amoakoa Darko ◽  
Olivia Agyekumwaa Boateng
Keyword(s):  
World Health ◽  
Single Infection ◽  
Health Technologies ◽  
Test Kit ◽  
The World ◽  
Post Market ◽  
Drug Supply Chain ◽  
Novel Coronavirus ◽  
Health Organization ◽  
The Right

The emergence of the novel coronavirus (COVID-19) has demonstrated the challenge of a single infection to health systems across the globe. The World Health Organization (WHO) declared COVID-19 as a pandemic on 11th March 2020, pointing at the time to the over 118,000 cases of the coronavirus illness in over 110 countries around the world and the sustained risk of further global spread. Congruent to this declaration by the WHO, countries were expected to accelerate their individual efforts amidst striking the right balance between protecting health and preventing economic or social disruption. In response to the pandemic, regulatory authorities of food and drugs in various countries are also recognizing the new demands and obligations that the pandemic has brought and taking measures to meet them and provide the much-needed support.  The Ghana Food and Drugs Authority (FDA) has taken various accelerated actions to meet the local demands in managing COVID-19. The regulatory interventions not only aim to facilitate the authorization of medicines and health technologies, sensitize the public on disease prevention and ensure the uninterrupted availability of medical and food supplies but also seek to inspire and boost local industrial potential. The Ghana FDA’s efforts are multifaceted and include propping the Drug Supply Chain, expeditious testing of essential COVID-19 medicines, facilitating efforts at COVID-19 test kit evaluation, active post market surveillance and public sensitization on preventive measures. The outcomes of the FDA response have informed ample opportunities that can be leveraged on now and beyond the pandemic and sensitized the Authority on the need to simulate possible emergencies and be better prepared in future happenings.

scholarly journals Twin Mammals and COVID-19: Life and Science of the Suspects

2020 ◽  
Author(s):  
Naser A. Anjum
Keyword(s):  
World Health Organization ◽  
World Health ◽  
Future Research ◽  
The World ◽  
Potential Link ◽  
Current Outbreak ◽  
The Subject ◽  
Novel Coronavirus ◽  
Health Organization ◽  
The Way

The world is puzzling over the origin of the current outbreak of the coronavirus disease (COVID-19) that is caused by a novel coronavirus-2019 (2019-nCoV). As of 26th March 2020, the World Health Organization has reported 46,2,684 confirmed cases and 20,834 confirmed deaths in total due to COVID-19. To this end, two unique mammals namely bats and pangolins are being investigated for their potential link to COVID-19. However, the evidence so far gathered in this context is far from clear. This paper aimed to: (i) enlighten the major aspects of life of bats and pangolins; (ii) briefly discusses their potential link to COVID-19; and also (iii) to highlight the way forward. The outcomes may contribute to future research on the subject.

scholarly journals COVID-19: A Conundrum to Decipher

2020 ◽  
Author(s):  
Vishwajit Deshmukh ◽  
Satyendra C. Tripathi ◽  
Arvind Pandey ◽  
Vaishnavi Deshmukh ◽  
Ashlesh Patil ◽  
...  
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Medical Condition ◽  
Management Strategies ◽  
Respiratory Illness ◽  
World Health ◽  
Chronic Medical Condition ◽  
Life Threatening ◽  
Novel Coronavirus ◽  
Health Organization ◽  
And Control

OBJECTIVE: Recent outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), another member of coronavirus family is an ongoing worldwide life-threatening crisis. The early diagnosis and management of the disease remains a major challenge. In this review, we aim to summarize the updated epidemiology, causes, clinical manifestation and diagnosis, as well as prevention and control of the novel coronavirus SARS-CoV-2. MATERIALS AND METHODS: A broad search of the literature was performed in “PubMed” “Medline” “Web of knowledge”, and “Google Scholar” World Health Organization-WHO” using the key words “severe acute respiratory syndrome coronavirus”, “SARS”, “SARS-CoV-2” “Epidemiology” “Transmission” “Pathogenesis” “Clinical Characteristics”. We reviewed and documented the information attained from literature on epidemiology, pathogenesis and clinical appearances of SARS-CoV-2 infection. RESULTS: The global cases of COVID-19 till 30th March 2020 have rose more than 700,000 and morbidity has gone more than 37,000. The infection rate for COVID-19 has been predicted to be higher than the previous outbreaks of same family members, that includes the SARS-CoV and Middle East Respiratory Syndrome Coronavirus (MERS-CoV). The main clinical presentation ranges from asymptomatic stages to severe lower respiratory infection in the form of pneumonia. Most of the patients also presented with fever, cough, sore throat, headache, fatigue, myalgia and breathlessness. High risk includes elderly people and patients with weak immune system or suffering from chronic medical condition like hypertension, diabetes, cancer, respiratory illness and cardiovascular diseases. CONCLUSIONS: SARS-Cov-2 has emerged as a worldwide threat, affecting almost each and every country on globe. As there is still growing understanding of SARS-CoV-2 in relation to its virology, epidemiology and clinical management strategies, we need to learn our lessons to conceive comprehensive measures to prevent such outbreaks in future.

scholarly journals Overview of the Management of COVID-19 Efficacy and Doubts

2020 ◽  
pp. 47-53
Author(s):  
O. A. Ayodeji ◽  
C. N. Stanley ◽  
P. C. Stanley
Keyword(s):  
Management Strategies ◽  
Respiratory Illness ◽  
Psychosocial Treatment ◽  
World Health ◽  
Pharmacological Treatments ◽  
Control And Prevention ◽  
Comprehensive Search ◽  
Current Outbreak ◽  
Novel Coronavirus ◽  
Health Organization

Coronavirus disease 2019 (COVID-19) is defined as an illness caused by a novel coronavirus now called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2. It was first identified during an outbreak of respiratory illness cases in Wuhan City, Hubei Province, China. Management of COVID-19 is still unspecific as there are no vaccine or specific antiviral drugs are available for its treatment. This paper reviews the management efficacy and doubt of COVID-19. Methods: A comprehensive search from relevant literatures, World Health Organization (W.H.O), Centre for Disease Control and prevention (CDC) official websites and announcements was performed between 1 March 2020 to 10:30 am 22 April 2020 (Nigerian time). A latest summary of 2019- nCoV and the current outbreak was drawn. Conclusion: The covid-19 pandemic is spreading rapidly and several researchers are making efforts to discover drugs for its treatment. Chloroquine phosphate, vaccines and other forms of management strategies have been employed. However, preventive measures like social distancing, washing of hands with soap and water, wearing of face masks and psychosocial treatment should be adopted while waiting for pharmacological treatments.

scholarly journals Considerations for assessing the impact of the COVID-19 pandemic on mental health in Australia

2020 ◽  
Vol 54 (11) ◽  
pp. 1067-1071 ◽  
Author(s):  
Eric J Tan ◽  
Denny Meyer ◽  
Erica Neill ◽  
Andrea Phillipou ◽  
Wei Lin Toh ◽  
...  
Keyword(s):  
Mental Health ◽  
Well Being ◽  
World Health ◽  
Vulnerable Groups ◽  
Future Research ◽  
First Case ◽  
Essential Services ◽  
Novel Coronavirus ◽  
Health Organization ◽  
The Impact

During this unprecedented novel coronavirus (COVID-19) pandemic, there is an urgent need for empirical data to characterise its impact on the mental health and well-being of Australians. In this viewpoint, we outline a number of considerations for research on this topic, highlighting areas necessitating special attention, consideration of particular vulnerable groups and the need for longitudinal studies to track mental health fluctuations in the general population. We conclude by introducing the COLLATE (COvid-19 and you: mentaL heaLth in AusTralia now survEy) project, outlining its aims, addressing some considerations raised herein and detailing avenues for future research. Since the World Health Organization (WHO) declared the novel coronavirus (COVID-19) outbreak a Public Health Emergency of International Concern (PHEIC) on 30 January 2020 (WHO, 2020), the COVID-19 pandemic has caused major upheaval both in Australia and globally. While the search for a vaccine continues, current efforts towards tackling the virus and limiting contagion in several nations have focused on social distancing and the shutdown of non-essential services. In Australia, the first case was reported on 13 January 2020 (COVID-19 National Incident Room Surveillance Team, 2020), the first death occurred on 24 February and a spate of progressive restrictions were enforced throughout the 2 weeks leading up to 31 March 2020 (COVID-19 National Incident Room Surveillance Team, 2020a).

Current updates on COVID-19 - A review

2020 ◽  
Vol 10 (1) ◽  
pp. 1-8
Author(s):  
Ghotekar D S ◽  
Vishal N Kushare ◽  
Sagar V Ghotekar
Keyword(s):  
World Health Organization ◽  
Common Cold ◽  
Respiratory Diseases ◽  
Gastrointestinal Diseases ◽  
Hubei Province ◽  
World Health ◽  
The World ◽  
The Common ◽  
Novel Coronavirus ◽  
Health Organization

Coronaviruses are a family of viruses that cause illness such as respiratory diseases or gastrointestinal diseases. Respiratory diseases can range from the common cold to more severe diseases. A novel coronavirus outbreak was first documented in Wuhan, Hubei Province, China in December 2019. The World Health Organization (WHO) has declared the coronavirus disease 2019 (COVID-19) a pandemic. A global coordinated effort is needed to stop the further spread of the virus. A novel coronavirus (nCoV) is a new strain that has not been identified in humans previously. Once scientists determine exactly what coronavirus it is, they give it a name (as in the case of COVID-19, the virus causing it is SARS-CoV-2).

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