scholarly journals Evaluation of open search methods based on theoretical mass spectra comparison

2021 ◽  
Vol 22 (S2) ◽  
Author(s):  
Albane Lysiak ◽  
Guillaume Fertin ◽  
Géraldine Jean ◽  
Dominique Tessier

Abstract Background Mass spectrometry remains the privileged method to characterize proteins. Nevertheless, most of the spectra generated by an experiment remain unidentified after their analysis, mostly because of the modifications they carry. Open Modification Search (OMS) methods offer a promising answer to this problem. However, assessing the quality of OMS identifications remains a difficult task. Methods Aiming at better understanding the relationship between (1) similarity of pairs of spectra provided by OMS methods and (2) relevance of their corresponding peptide sequences, we used a dataset composed of theoretical spectra only, on which we applied two OMS strategies. We also introduced two appropriately defined measures for evaluating the above mentioned spectra/sequence relevance in this context: one is a color classification representing the level of difficulty to retrieve the proper sequence of the peptide that generated the identified spectrum ; the other, called LIPR, is the proportion of common masses, in a given Peptide Spectrum Match (PSM), that represent dissimilar sequences. These two measures were also considered in conjunction with the False Discovery Rate (FDR). Results According to our measures, the strategy that selects the best candidate by taking the mass difference between two spectra into account yields better quality results. Besides, although the FDR remains an interesting indicator in OMS methods (as shown by LIPR), it is questionable: indeed, our color classification shows that a non negligible proportion of relevant spectra/sequence interpretations corresponds to PSMs coming from the decoy database. Conclusions The three above mentioned measures allowed us to clearly determine which of the two studied OMS strategies outperformed the other, both in terms of number of identifications and of accuracy of these identifications. Even though quality evaluation of PSMs in OMS methods remains challenging, the study of theoretical spectra is a favorable framework for going further in this direction.

Author(s):  
Gustavo Rafael Escobar Delgado ◽  
Anicia Katherine Tarazona Meza ◽  
Andy Einstein García García

The research analyzes the relationship between factors of resilience and academic performance in disabled students studying at the Technical University of Manabí. It is a correlational descriptive study conducted with a population of 88 disabled students, of which two groups were selected, one with high academic performance and the other with low performance. A questionnaire was designed and applied to determine the level of quality of life and risk factors of adolescents. Resilience was measured with the SV-RES scale created for the Latin American population.


2021 ◽  
Vol 3 (1) ◽  
pp. 21-24
Author(s):  
Ali Humardani ◽  
Yuly Peristiowati ◽  
Agusta D. Ellina

Handling emergency cases must not only be carried out quickly but also must be precise. Standard Operating Procedures (SOP) is one of the instruments to measure the quality of service. the number of patient visits that can affect the quality of service. Triage is a way of sorting patients based on therapy needs and available resources. Therapy is based on ABC conditions (Airway, with cervical spine control, Breathing, and Circulation with bleeding control). On the other hand, the COVID-19 pandemic greatly affects the response time, impacting the number of patient visits. Response time is the time between the beginning of a request being responded to in other words it can be called response time. A good response time for patients is 5 minutes. The purpose of this study was to identify the relationship between the number of patient visits and the accuracy of triage implementation and response time. The electronic database used is PubMed, Springer, and Google Scholar with a search strategy using the PICO (patient, intervention, comparison, and outcome) method.


2021 ◽  
Vol 25 (4) ◽  
pp. 13-22
Author(s):  
Mohammed A. Rashid ◽  
◽  
Nagam O. Kariem ◽  

This study was intended to evaluate the quality of some bottled waters available in Iraqi market, by testing their physical, chemical and biological characteristics. These samples produced by four companies during the period of December- 2016 to April-2017. The selected companies had the biggest sells and were under the trade names of AlluLua, Ala, Alwafi, and Venesia. The results showed that most bottled waters samples characteristics were in compliance with Iraqi and international standards, with some superiority in water quality for the trade mark Allulua upon the other companies, but the trade mark Ala was at the end of the list of quality rank. All the tested samples showed clean bacteriological results for coliforms as pollution indicators and fecal coliforms (all tests MPN was less than 1.1). The other physical and chemical characteristics showed pH range of 6.21 ~ 7.7, TDS of 12.81 ~ 126.88 mg/L, Ca of 0.24 ~ 25.5 mg/L, Mg of 3.2 ~ 13.1 mg/L, Na of 0.92 ~ 23 mg/L, K of 0 ~ 0.39 mg/L, Hardness of 3.8 ~ 38.2 mg/L, and chloride of 3.55 ~ 35.5 mg/L.


1999 ◽  
Author(s):  
Y. Zhang ◽  
X. Daniel Fang

Abstract A new measure for evaluating fit quality of mating parts via Fit Capability Indices (FCIs) is introduced as an interface between fit quality and process control of the mating parts. Fit Capability Analysis method is discussed based on the relationship between FCIs and Process Capability Indices (PCIs). A new statistical tolerancing approach for assuring predetermined fit quality is developed on the basis of fit quality evaluation measures and fit capability analysis, which can be used as a guideline to process design and process monitoring of the mating parts.


2005 ◽  
pp. 161-181 ◽  
Author(s):  
Stuart J. Barnes ◽  
Richard Vidgen

Understanding the customer is a key aspect of developing any e-commerce offering. In doing so, organizations can improve their offerings over time and benchmark against competitors and best practice in any industry. eQual is a method for assessing the quality of Web sites. The eQual instrument has evolved via a process of iterative refinement in different e-commerce domains. Two of the studies conducted have examined online bookshops as a domain for e-commerce quality evaluation, one based on eQual 2.0 and the other on eQual 4.0. In this chapter we aim to examine these studies, and, as a result, to evaluate the use of the instrument and the benchmarking of the bookshops on two separate occasions. Of particular note are whether the findings are consistent across the two studies and the implications of the findings for e-commerce practice. Finally, the paper rounds off with some conclusions and directions for further research.


1991 ◽  
Vol 22 (1) ◽  
pp. 13-24 ◽  
Author(s):  
William White ◽  
Paul J. Handal

This study systematically examined the relationship between death anxiety and mental health/distress and controlled for methodological problems present in the literature. Specifically, two measures of death anxiety were used-both had recommended cut-off scores for high death anxiety. Both positive and negative aspects of adjustment were assessed, and a valid clinically meaningful cut-off score for distress was employed. Results revealed high death-anxious females were statistically and clinically more distressed and were significantly less satisfied with life than low death-anxious females. Similar results were obtained for males on one death-anxiety measure; a similar trend was found on the other measure. Discussion focuses on the interpretation of results.


2020 ◽  
Vol 61 (4) ◽  
pp. 418-436
Author(s):  
Shira Offer

Using egocentric network data from the University of California Social Networks Study (1,136 respondents; 11,536 alters), this study examines how difficult ties—an unexplored form of social negativity—are associated with well-being. Findings show that well-being is affected by the quality of the relationship rather than its presence in the network. Having a nondifficult partner is associated with lower loneliness compared to having no partner, but having no partner and having a difficult partner are related to similar levels of loneliness. Likewise, having difficult adult children and having no adult children are associated with reporting greater psychological distress than having nondifficult adult children. Consistent with the stress process model, the negative association of a difficult partner with well-being is buffered when that partner is otherwise supportive and when the other ties in the network are supportive. However, that association is amplified when the other ties are also difficult.


2020 ◽  
Vol 6 (1) ◽  
pp. 7
Author(s):  
Alessia Donato

Several studies have analyzed the relationship between the firms’ technological diversification and the innovation performance outcomes. We use information coming from patents portfolio of a sample of firms that operate in a nanotechnology sector and analyze the effect, in this relationship, of the use of scientific knowledge in the development of patented inventions. We find, firstly, that the trend of the quality of innovation with the technological diversification of a firm appears similar to a Gaussian with positive asymmetry. Secondly, we find that with the increase in the percentage of the used science by year, in one side, firms appear to obtain the maximum impact of the innovation, in average, with a less technological diversification in the patent’s portfolio and, in the other side, innovations with more impact are obtained in average.


2020 ◽  
Vol 47 (2) ◽  
pp. 169-189
Author(s):  
André Krebber

Abstract This article explores Theodor W. Adorno’s recovery of natural beauty in Aesthetic Theory against the background of current debates in environmental aesthetics and evinces the relationship of his reading of natural beauty to his critique of the domination of nature. From there, a critique of natural domination can be issued through the artwork. Whereas Adorno specifies that artworks do not relate to natural beauty in a positive, pseudomorphotic sense, they nevertheless inherit a quality of natural beauty as presenting to humans what is not reducible to the human. Within the specific historical context of an environmental crisis, then, a case is finally made for art as an area of ecological critique that recovers the artwork and nature from both the artwork’s reduction to a propagandistic tool and its idealistic enlisting for reinstating a bourgeois ideal of nature.


2013 ◽  
Vol 83 (6) ◽  
pp. 1043-1048 ◽  
Author(s):  
Irfan Dawoodbhoy ◽  
Elsa K. Delgado-Angulo ◽  
Eduardo Bernabé

ABSTRACT Objective: To assess the relationship between malocclusion severity and quality of life in children. Materials and Method: Two hundred and seventy-eight children aged 11 to 14 years were recruited voluntarily from the Dental and Maxillofacial Centre of the Almana General Hospital in Alkhobar, Saudi Arabia. The children were asked to fill out the Arabic version of the Child Perception Questionnaire for 11- to 14-year-old children (CPQ11–14) and were then clinically examined to determine the severity of their malocclusion using the Dental Aesthetic Index (DAI). Multivariate analysis of variance was used to compare the four domains and the total CPQ11–14 scores between the four DAI severity groups. Results: Significant differences were found between DAI severity groups for the four domains and the total CPQ11–14 scores. Although children with very severe (handicapping) malocclusion had significantly higher domain and total CPQ11–14 scores than all the other groups (differences of up to 6 and 22 units, respectively, compared to children with no/minor malocclusion), there were no differences between those with no/minor, definite, and severe malocclusion. Conclusion: These findings suggest that only very severe malocclusion had an impact on the quality of life of the participants. Orthodontists should focus not only on clinical measures of malocclusion but should also consider the impact of severe malocclusion on patients' quality of life.


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