Outcomes and prognostic factors of non-HIV patients with pneumocystis jirovecii pneumonia and pulmonary CMV co-infection: A Retrospective Cohort Study

Abstract: The act of crossing an international border for healthcare is a reality in border areas and the flow is in the direction of the city with more human and healthcare resources. Although several prognostic factors related to HIV+ patients are known, the prognostic value of this type of mobility for long term care is still neglected. This study compares the prognosis of HIV patients from three groups, one involved in regional mobility, another in cross-border mobility in search for healthcare and the reference group which is composed by patients living in the same city of the health facility. This is a retrospective cohort study using medical records from a healthcare service in Brazil. Following survival analysis with log-rank test and Cox proportional hazard models, overall survival had no significant difference between patients who were involved in regional (HR = 1.03; 95%CI: 0.69-1.54; p = 0.89) or international (HR = 1.07; 95%CI: 0.58-1.97; p = 0.83) mobility and those who were not. This lack of difference was kept when adjusted for known prognostic factors. In this retrospective cohort study, exposure to both regional and international migration did not have a significant association with the risk of death by any cause in crude or adjusted analyses for already known prognostic factors. This is the first study to consider the prognostic role of cross-border healthcare for HIV patients. Despite these findings, the need of monitoring the extent and the clinical and demographic characteristics of healthcare demand originated in the other side of the border and the use of these data for decision making in health management is emphasized.

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Retrospective cohort study of statin prescribing for primary prevention among people living with HIV

JRSM Cardiovascular Disease ◽

10.1177/20480040211031068 ◽

2021 ◽

Vol 10 ◽

pp. 204800402110310

Author(s):

Joseph A Nardolillo ◽

Joel C Marrs ◽

Sarah L Anderson ◽

Rebecca Hanratty ◽

Joseph J Saseen

Keyword(s):

Cohort Study ◽

Primary Prevention ◽

Statin Therapy ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

People Living With Hiv ◽

Intermediate Risk ◽

Electronic Health Record Data ◽

Hiv Patients ◽

Living With Hiv

Objective To compare statin prescribing rates between intermediate-risk people living with human immunodeficiency virus (HIV; PLWH) and intermediate-risk patients without a diagnosis of HIV for primary prevention of atherosclerotic cardiovascular disease (ASCVD). Methods Retrospective cohort study . Electronic health record data were used to identify a cohort of PLWH aged 40–75 years with a calculated 10-year ASCVD risk between 7.5%-19.9% as determined by the Pooled Cohort Equation (PCE). A matched cohort of primary prevention non-HIV patients was identified. The primary outcome was the proportion of PLWH who were prescribed statin therapy compared to patients who were not living with HIV and were prescribed statin therapy Results 81 patients meeting study criteria in the PLWH cohort were matched to 81 non-HIV patients. The proportion of patients prescribed statins was 33.0% and 30.9% in the PLWH and non-HIV cohorts, respectively (p = 0.74). Conclusion and relevance: This study evaluated statin prescribing in PLWH for primary prevention of ASCVD as described in the 2018 AHA/ACC/Multisociety guideline. Rates of statin prescribing were similar, yet overall low, among intermediate-risk primary prevention PLWH compared to those not diagnosed with HIV.

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Which prognostic factors are important for long-term outcomes in symptomatic obstructive colon cancer? A multi-institutional retrospective cohort study

Journal of Minimally Invasive Surgery ◽

10.7602/jmis.2021.24.3.128 ◽

2021 ◽

Vol 24 (3) ◽

pp. 128-138 ◽

Cited By ~ 1

Author(s):

Chang Hwan Kim ◽

Jung Hoon Bae ◽

Chul Seung Lee ◽

Seung-Rim Han ◽

In Kyu Lee ◽

...

Keyword(s):

Colon Cancer ◽

Cohort Study ◽

Prognostic Factors ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Long Term Outcomes

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Prognostic factors of Candida spp. bloodstream infection in adults: A nine-year retrospective cohort study across tertiary hospitals in Brazil and Spain

The Lancet Regional Health - Americas ◽

10.1016/j.lana.2021.100117 ◽

2021 ◽

pp. 100117

Author(s):

Caroline Agnelli ◽

Maricela Valerio ◽

Emilio Bouza ◽

Jesús Guinea ◽

Teresa Sukiennik ◽

...

Keyword(s):

Cohort Study ◽

Prognostic Factors ◽

Bloodstream Infection ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Candida Spp ◽

Tertiary Hospitals

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Management of patients with pulmonary mycobacteriosis in France: a multicenter retrospective cohort study

BMC Pulmonary Medicine ◽

10.1186/s12890-021-01701-5 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Pascale Bemer ◽

Olivia Peuchant ◽

Hélène Guet-Revillet ◽

Julien Bador ◽

Charlotte Balavoine ◽

...

Keyword(s):

Cohort Study ◽

Prognostic Factors ◽

Mycobacterium Avium ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Cox Regression ◽

Nontuberculous Mycobacteria ◽

Great Variability ◽

Microbiological Characteristics ◽

Smear Negative

Abstract Background Recent studies report very low adherence of practitioners to ATS/IDSA recommendations for the treatment of nontuberculous mycobacteria pulmonary disease (NTM-PD), as well as a great variability of practices. Type of management could impact prognosis. Methods To evaluate management and prognosis of patients with NTM-PD cases with respect to ATS recommendations, we conducted a multicenter retrospective cohort study (18 sentinel sites distributed throughout France), over a period of six years. We collected clinical, radiological, microbiological characteristics, management and outcome of the patients (especially death or not). Results 477 patients with NTM-PD were included. Respiratory comorbidities were found in 68% of cases, tuberculosis sequelae in 31.4% of patients, and immunosuppression in 16.8% of cases. The three most common NTM species were Mycobacterium avium complex (60%), M. xenopi (20%) and M. kansasii (5.7%). Smear-positive was found in one third of NTM-PD. Nodulobronchiectatic forms were observed in 54.3% of cases, and cavitary forms in 19.1% of patients. Sixty-three percent of patients were treated, 72.4% of patients with smear-positive samples, and 57.5% of patients with smear-negative samples. Treatment was in adequacy with ATS guidelines in 73.5%. The 2-year mortality was 14.4%. In the Cox regression, treatment (HR = 0.51), age (HR = 1.02), and M. abscessus (3.19) appeared as the 3 significant independent prognostic factors. Conclusion These findings highlight the adequacy between French practices and the ATS/IDSA guidelines. Treatment was associated with a better survival.

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Retrospective cohort study of prognostic factors in patients with oral cavity and oropharyngeal squamous cell carcinoma

Head & Neck ◽

10.1002/hed.23914 ◽

2015 ◽

Vol 38 (4) ◽

pp. 536-541 ◽

Cited By ~ 14

Author(s):

José F. Carrillo ◽

Liliana C. Carrillo ◽

Ana Cano ◽

Margarita C. Ramirez-Ortega ◽

Jorge G. Chanona ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cohort Study ◽

Prognostic Factors ◽

Oral Cavity ◽

Cell Carcinoma ◽

Squamous Cell ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Oropharyngeal Squamous Cell Carcinoma

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Clinicopathologic characteristics, laboratory parameters, treatment protocols, and outcomes of pancreatic cancer: a retrospective cohort study of 1433 patients in China

PeerJ ◽

10.7717/peerj.4893 ◽

2018 ◽

Vol 6 ◽

pp. e4893 ◽

Cited By ~ 6

Author(s):

Shuisheng Zhang ◽

Xiaozhun Huang ◽

Yuan Tian ◽

Saderbieke Aimaiti ◽

Jianwei Zhang ◽

...

Keyword(s):

Pancreatic Cancer ◽

Cohort Study ◽

Prognostic Factors ◽

Lymph Node ◽

Distant Metastasis ◽

Retrospective Cohort Study ◽

Retrospective Cohort ◽

Clinicopathologic Characteristics ◽

Treatment Protocols ◽

Laboratory Parameters

Objectives The prognosis of people with pancreatic cancer is extremely unfavorable. However, the prognostic factors remain largely undefined. We aimed to perform comprehensive analyses of clinicopathologic characteristics, laboratory parameters, and treatment protocols for exploring their role as prognostic factors of pancreatic cancer. Methods Patients diagnosed with pancreatic cancer and hospitalized at the China National Cancer Center between April 2006 and May 2016 were enrolled in this retrospective cohort study. Clinicopathologic characteristics, laboratory parameters, and treatment protocols were compared among patients at different stages of the disease. The association between these factors and overall survival (OS) was analyzed using the Kaplan–Meier method and Cox proportional hazards model. Results The present study included 1,433 consecutive patients with pancreatic cancer. Median OS was 10.6 months (95% confidence interval [CI] 9.8–11.3 months), with 1-, 3-, and 5-year survival rates of 43.7%, 14.8%, and 8.8%, respectively. Cox multivariate analysis findings identified the following factors as independent predictors of OS: gender (female vs male, hazard ratio 0.72, 95% CI [0.54–0.95]); elevated total bilirubin (TBil; 1.82, 1.34–2.47); elevated carbohydrate antigen 19-9 (CA19-9; 1.72, 1.17–2.54); tumor being located in pancreatic body and tail (1.52, 1.10–2.10); advanced T stage (T3-4 vs T1-2, 1.62, 1.15–2.27); lymph node metastasis (1.57, 1.20–2.07); distant metastasis (1.59, 1.12–2.27); the presence of surgical resection (0.53, 0.34–0.81); and the presence of systemic chemotherapy (0.62, 0.45–0.82). Conclusions Being male, elevated TBil and carcinoembryonic antigen, tumor being located in pancreatic body and tail, advanced T stage, lymph node and distant metastasis, the absence of surgical resection, and the absence of systematic chemotherapy were associated with worse OS in patients with pancreatic cancer.

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