Hyperphosphatemia as an independent risk factor for coronary artery calcification progression in peritoneal dialysis patients

Background.Coronary artery calcification (CAC) contributes to high risk of cardiocerebrovascular diseases in dialysis patients. However, the risk factors for CAC initiation in peritoneal dialysis (PD) patients are not known clearly.Methods.Adult patients with baseline CaCS = 0 and who were followed up for at least 3 years or until the conversion from absent to any measurable CAC detected were included in this observational cohort study. Binary logistic regression was performed to identify the risk factors for CAC initiation in PD patients.Results.70 patients recruited to our study were split into a noninitiation group (n=37) and an initiation group (n=33) according to the conversion of any measurable CAC during their follow-up or not. In univariate analysis, systolic blood pressure, serum phosphorus, fibrinogen, hs-CRP, serum creatinine, and triglycerides were positively associated with the initiation of CAC, while the high density lipoprotein and nPCR did the opposite function. Multivariate analysis revealed that hyperphosphatemia and hs-CRP were the independent risk factors for CAC initiation after adjustments.Conclusions.Hyperphosphatemia and hs-CRP were the independent risk factors for CAC initiation in PD patients. These results suggested potential clinical strategies to prevent the initiation of CAC in PD patients.

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Anticalcifying nanoparticle antibody titer is an independent risk factor for coronary artery calcification

Coronary Artery Disease ◽

10.1097/mca.0b013e3283487d7f ◽

2011 ◽

Vol 22 (6) ◽

pp. 394-400 ◽

Cited By ~ 3

Author(s):

Cansin Tulunay Kaya ◽

Fatih Sinan Ertas ◽

Taner Hasan ◽

Basar Candemir ◽

Cagdas Ozdol ◽

...

Keyword(s):

Risk Factor ◽

Coronary Artery ◽

Antibody Titer ◽

Coronary Artery Calcification ◽

Independent Risk Factor

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Triglyceride to High-Density Lipoprotein Ratio can predict coronary artery calcification

Pakistan Journal of Medical Sciences ◽

10.12669/pjms.38.3.5290 ◽

2022 ◽

Vol 38 (3) ◽

Author(s):

Beilei Wang ◽

Jinsheng Hua ◽

Likun Ma

Keyword(s):

Blood Pressure ◽

Risk Factor ◽

Coronary Artery ◽

Coronary Angiography ◽

High Density Lipoprotein ◽

Coronary Artery Calcification ◽

Independent Risk Factor ◽

Density Lipoprotein ◽

High Density ◽

Angiotensin Receptor

Objectives: We assessed the TG/HDL-C ratio as a predictor for the presence of coronary artery calcifications (CACs). Methods: We collected demographic characteristics (age and gender), physical examination (height, weight, BMI, SBP, DBP), comorbidities, medication use, and laboratory variables Triglyceride to High-Density Lipoprotein (TG, HDL-C, TG/HDL-C, UA, TBG, 25-OH-VitD3); and we used coronary angiography to determine the presence of CACs. We performed univariate and multivariate analyses to evaluate the correlation between the TG/HDL-C ratio and CACs and established a predictive model. Results: CAC was present in 121 patients (25.80%). The levels of TG and TG/HDL-C ratio in the CAC group were higher than those in the non-CAC group, while the level of HDL-C in the CAC group was lower than that in the non-CAC group. The univariate analysis showed that the TG/HDL-C ratio was associated with CAC (OR, 0.021; 95% CI, 0.008 to 0.052; P<0.001), and the multivariate analysis indicated that the ratio was an independent risk factor for CAC (OR, 4.088; 95% CI, 2.787-5.996; P<0.001). Using the ratio to establish a prediction model, the area under the ROC curve was 0.814 (95% CI, 0.775-0.853; P<0.001), suggesting that the TG/HDL-C ratio has a high diagnostic efficiency. The diagnostic threshold was 1.037, and the corresponding sensitivity and specificity were 89.3% and 60.5%, respectively. Conclusion: The Triglyceride to High-Density Lipoprotein TG/HDL-C ratio is an independent risk factor for CAC with good diagnostic efficacy. Abbreviations: TG: Triglycerides, HDL-C: High-Density Lipoprotein, CAC: Coronary Artery Calcifications, BMI: Body Mass Index, SBP: Systolic Blood Pressure, DBP: Diastolic Blood Pressure, UA: Uric Acid, FBG: Fasting Blood Glucose, 25-OH-VitD3: 25-Hydroxyvitamin D3, ACEI: Angiotensin-Converting Enzyme Inhibitors, ARB: Angiotensin Receptor Blockers, CCB: Calcium Channel Blockers, ARNI: Angiotensin Receptor-Neprilysin Inhibitor, CAG: Coronary Angiography, AUCROC: Area Under the Receiver Operating Curve. doi: https://doi.org/10.12669/pjms.38.3.5290 How to cite this:Wang B, Hua J, Ma L. Triglyceride to High-Density Lipoprotein Ratio can predict coronary artery calcification. Pak J Med Sci. 2022;38(3):---------. doi: https://doi.org/10.12669/pjms.38.3.5290 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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The Relationship between Epicardial Adipose Tissue and Coronary Artery Calcification in Peritoneal Dialysis Patients

Cardiorenal Medicine ◽

10.1159/000335495 ◽

2012 ◽

Vol 2 (1) ◽

pp. 43-51 ◽

Cited By ~ 21

Author(s):

Kultigin Turkmen ◽

Orhan Ozbek ◽

Hatice Kayikcioğlu ◽

Mehmet Kayrak ◽

Yalcin Solak ◽

...

Keyword(s):

Adipose Tissue ◽

Peritoneal Dialysis ◽

Coronary Artery ◽

Coronary Artery Calcification ◽

Epicardial Adipose Tissue ◽

Dialysis Patients ◽

The Relationship

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Vitamin D Status Is an Independent Risk Factor for Global Cognitive Impairment in Peritoneal Dialysis Patients

PLoS ONE ◽

10.1371/journal.pone.0143782 ◽

2015 ◽

Vol 10 (12) ◽

pp. e0143782 ◽

Cited By ~ 12

Author(s):

Gui-Ling Liu ◽

Hai-Chen Pi ◽

Li Hao ◽

Dan-Dan Li ◽

Yong-Gui Wu ◽

...

Keyword(s):

Vitamin D ◽

Risk Factor ◽

Cognitive Impairment ◽

Peritoneal Dialysis ◽

Independent Risk Factor ◽

Vitamin D Status ◽

Dialysis Patients

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Shortage of Appendicular Skeletal Muscle is an Independent Risk Factor for Mortality in Peritoneal Dialysis Patients

Peritoneal Dialysis International ◽

10.3747/pdi.2016.00019 ◽

2017 ◽

Vol 37 (1) ◽

pp. 78-84 ◽

Cited By ~ 4

Author(s):

Sanli Jin ◽

Qian Lu ◽

Chunyan Su ◽

Dong Pang ◽

Tao Wang

Keyword(s):

Skeletal Muscle ◽

Risk Factor ◽

Peritoneal Dialysis ◽

Energy Intake ◽

Independent Risk Factor ◽

Proportional Hazards Model ◽

Dialysis Patients ◽

Appendicular Skeletal Muscle ◽

The Mean

BackgroundLimited data are available on clinical outcomes among peritoneal dialysis patients with shortage of appendicular skeletal muscle (ASM). In this study, we tested the hypothesis that the shortage of ASM is an independent risk factor for mortality in continuous ambulatory peritoneal dialysis (CAPD) patients.MethodsAdult patients undergoing CAPD between March and August 2007 in a single center in China were recruited in this prospective cohort study. Body composition, protein/energy intake, clinical, and biochemical data were collected at baseline, 6 months, and 12 months. End points were all-cause mortality by 12 September 2014. The mean follow-up time was 60.21 (± 24.45) months (11.00 – 89.00).ResultsCompared with the baseline, the mean value of ASM in CAPD patients decreased at 12 months (19.40 ± 5.60 vs 21.85 ± 6.14, p < 0.001). According to the estimation of patient survival by Kaplan-Meier, patients with a shortage of ASM had a worse survival rate than those with normal ASM (χ2= 16.588, p < 0.001). In the Cox's proportional hazards model, patients’ survival was independently associated with a shortage of ASM (hazard ratio [HR] = 2.318, p = 0.024, 95% confidence interval [CI] = 1.116 – 4.812). Standard daily protein intake (stDPI) and standard daily energy intake (stDEI) in patients with a shortage of ASM were significantly lower than those in patients with normal ASM in the first follow-up year ( t = 2.067, p = 0.041; t = 3.673, p = 0.001).ConclusionsA shortage of ASM is an independent risk factor for mortality in CAPD patients. Further studies are needed to demonstrate that nutritional intervention helps with improving muscle mass and, consequently, the survival of CAPD patients.

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