scholarly journals The relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy: the data from TSN-GOLD working group

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Kenan Turgutalp ◽  
Egemen Cebeci ◽  
Aydin Turkmen ◽  
Ulver Derici ◽  
Nurhan Seyahi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Staining Intensity ◽  
Oxford Classification ◽  
Mesangial Proliferation ◽  
Renal Prognosis ◽  
Blood Pressures ◽  
Prognostic Risk Factors ◽  
The Relationship ◽  
Glomerular Damage

Abstract Background Galactose-deficient IgA1 (Gd-IgA1) has an increased tendency to form immunocomplexes with IgG in the serum, contributing to IgAN pathogenesis by accumulating in the glomerular mesangium. Several studies showed that glomerular IgG deposition in IgAN is an important cause of mesangial proliferation and glomerular damage. This study aims to determine the association of the positivity of IgG and the intensity of IgG staining with a poor renal prognosis. Methods A total of 943 IgAN patients were included in the study. Glomerular IgG staining negative and positive patients were compared using Oxford classification scores, histopathological evaluations, proteinuria, eGFR, albumin, blood pressures. IgG positive patients were classified as (+), (++), (+++) based on their staining intensity, and the association with the prognostic criteria was also evaluated. Results 81% (n = 764) of the patients were detected as IgG negative, while 19% (n = 179) were positive. Age, gender, body mass index, blood pressure, proteinuria, eGFR, uric acid values were similar in IgG positive and negative patients who underwent biopsy (p > 0.05). Intensity of glomerular IgG positivity was not found to be associated with diastolic and systolic blood pressure, urea, uric acid, age, eGFR, albumin, proteinuria (p > 0.05 for all, r = − 0.084, r = − 0.102, r = − 0.006, r = 0.062, r = 0.014, r = − 0.044, r = − 0.061, r = − 0.066, r = 0.150, respectively). There was no difference for histopathological findings between IgG (+), IgG (++), IgG (+++) groups (for all, p > 0.05). Conclusion Glomerular IgG negativity and positivity detected by routine IFM in IgAN patients is not associated with poor renal prognostic risk factors.

scholarly journals Relationship between severity of hypertension and renal impairment in preeclampsia

2018 ◽  
Vol 11 (3) ◽  
pp. 213
Author(s):  
Khairun Nahar ◽  
Ferdousi Islam ◽  
Naila Atik Khan
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Uric Acid ◽  
Renal Impairment ◽  
Serum Creatinine ◽  
Preeclamptic Patient ◽  
Blood Pressures ◽  
Mild Preeclampsia ◽  
The Mean ◽  
The Relationship

<p class="Abstract">The aim of this study was to determine the relationship between the severity of hypertension and renal impairment in preeclampsia. This study was conducted on 92 diagnosed cases of mild (n=42) and severe (n=50) preeclampsia patients from August 2010 to July 2011. All the patients were almost identical in terms of age and socioeconomic status. The results of the study showed that the mean serum creatinine and uric acid levels were significantly high in severe preeclampsia patient compared to mild preeclampsia and both systolic and diastolic blood pressures had the positive and significant effects on the serum creatinine and uric acid levels. In conclusion, impairment of renal function has the positive and significant relationship with the severity of blood pressure in the preeclamptic patient.</p>

P0490IS THE SEVERITY OF GLOMERULAR IGG STAINING IN PATIENT WITH IGA NEPHROPATHY USEFUL FOR PREDICTING POOR RENAL PROGNOSIS? THE DATA FROM TSN-GOLD WORKING GROUP

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Kenan Turgutalp ◽  
Egemen Cebeci ◽  
Aydin Turkmen ◽  
Ülver Derici ◽  
Nurhan Seyahi ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Iga Nephropathy ◽  
Working Group ◽  
Prognostic Indicators ◽  
Glomerular Diseases ◽  
Baseline Evaluation ◽  
Renal Prognosis ◽  
Blood Pressures ◽  
Circulating Autoantibodies ◽  
The Relationship

Abstract Background and Aims In IgA nephropathy (IgAN), which is characterized by mesangial IgA accumulation, there is the formation of circulating autoantibodies against galactose deficient IgA1s (Gd-IgA1). IgG / Gd-IgA1 immunocomplexes accumulate in the glomerular mesangium and play a role in the pathogenesis of IgAN. Recent studies have suggested a relationship between glomerular IgG deposition and the severity of glomerular inflammation. However, detection of the presence and severity of IgG in routine immunofluorescence microscopy (IFM) may fail. This study aims to investigate whether IgG positivity detected by IFM is associated with poor renal prognostic indicators and whether renal prognosis can be predicted according to IgG positivity. Method 4399 patients who were enrolled between May 2009-June 2019 in database of Turkish Society of Nephrology, Glomerular Diseases Working Group (TSN-GOLD) including 44 centers were evaluated. After exclusion criteria, 994 primary IgAN patients were included in the study. Glomerular IgG negative and positive patients were compared by means of Oxford classification scores, histopathological evaluations, proteinuria, creatinine, albumin, blood pressures. IgG positive patients were divided into subgroups according to the grade of the IFM positivity. The relationship between IgG positivity and poor prognosis criteria were evaluated. Results Demographic and biochemical findings of glomerular IgG positive and negative patients at the time of biopsy are shown in Table 1. No difference was found between the groups. There was no difference in the demographic and biochemical findings at the time of biopsy in IgG subgroup analyses (Table 2). There was no difference between the histopathological and Oxford MEST scores of the subgroups. Glomerular IgG positivity was not associated with diastolic blood pressure, systolic blood pressure, urea, uric acid, age, eGFR, albumin, proteinuria (p&gt; 0.05 for all, r= -0.084, r= -0.102, r= -0.006, r=0.062, r= 0.014, r= -0.044, r= -0.061, r= -0.066, r= 0.150, respectively). Conclusion Glomerular IgG positivity detected by routine IFM in IgAN is not associated with poor renal prognostic indicators. It is difficult to predict renal prognosis by looking at the severity of IgG positivity at the baseline evaluation.

Antenatal corticosteroid therapy and blood pressure at 14 years of age in preterm children

2000 ◽  
Vol 98 (2) ◽  
pp. 137-142 ◽  
Author(s):  
L. W. DOYLE ◽  
G. W. FORD ◽  
N. M. DAVIS ◽  
C. CALLANAN
Keyword(s):  
Blood Pressure ◽  
Corticosteroid Therapy ◽  
Animal Species ◽  
Antenatal Corticosteroid ◽  
Antenatal Corticosteroids ◽  
Preterm Children ◽  
Clinical Hypertension ◽  
Blood Pressures ◽  
The Relationship ◽  
Mercury Sphygmomanometer

Antenatal corticosteroid therapy substantially improves the survival rate of preterm infants, with few side effects. Higher blood pressure in adulthood has been described in several animal species after exposure to antenatal corticosteroids, but there are no similar reports in humans. The objective of the present study was to determine the relationship between exposure to antenatal corticosteroid therapy and blood pressure at 14 years of age. This was a cohort study of 210 preterm survivors with birthweights of < 1501 g born in the Royal Women's Hospital, Melbourne, between 1 January 1977 and 31 March 1982. Blood pressure was measured in 177 subjects (84.3%) at 14 years of age with a standard mercury sphygmomanometer. Children exposed to antenatal corticosteroids (n = 89) had higher systolic and diastolic blood pressures than those not exposed to corticosteroids (n = 88) [mean difference (95% confidence interval) (mmHg): systolic, 4.1 (0.1–8.0); diastolic, 2.8 (0.05–5.6)]. However, few had blood pressure in the hypertensive range. It is concluded that antenatal corticosteroid therapy is associated with higher systolic and diastolic blood pressures in adolescence, and might lead to clinical hypertension in survivors well beyond birth.

The Relationship between Religious Activities and Blood Pressure in Older Adults

1998 ◽  
Vol 28 (2) ◽  
pp. 189-213 ◽  
Author(s):  
Harold G. Koenig ◽  
Linda K. George ◽  
Judith C. Hays ◽  
David B. Larson ◽  
Harvey J. Cohen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
High Blood Pressure ◽  
Religious Activity ◽  
Religious Activities ◽  
The Bible ◽  
Lower Blood ◽  
Religious Services ◽  
Blood Pressures ◽  
The Relationship

Objective: To examine the relationship between religious activities and blood pressure in community-dwelling older adults. Method: Blood pressure and religious activities were assessed in a probability sample of 3,963 persons age sixty-five years or older participating in the Duke EPESE survey. Participants were asked if their doctor had ever informed them that they had high blood pressure and if they were currently taking medication for high blood pressure. After the interview, systolic and diastolic blood pressures were measured following a standardized protocol. Data were available for three waves of the survey (1986, 1989–90, and 1993–94). Analyses were stratified by age (65–74 vs. over 75) and by race (Whites vs. Blacks) and were controlled for age, race, gender, education, physical functioning, body mass index, and, in longitudinal analyses, blood pressure from the previous wave. Results: Cross-sectional analyses revealed small (1–4 mm Hg) but consistent differences in measured systolic and diastolic blood pressures between frequent (once/wk) and infrequent (< once/wk) religious service attenders. Lower blood pressures were also observed among those who frequently prayed or studied the Bible (daily or more often). Blood pressure differences were particularly notable in Black and younger elderly, in whom religious activity at one wave predicted blood pressures three years later. Among participants who both attended religious services and prayed or studied the Bible frequently, the likelihood of having a diastolic blood pressure of 90 mm Hg or higher was 40 percent lower than found in participants who attended religious services infrequently and prayed or studied the Bible infrequently (OR 0.60, 95% CI, 0.48–0.75, p < .0001). Among participants told they had high blood pressure, religiously active persons were more likely to be taking their blood pressure medication; this could not, however, explain the differences in blood pressure observed. While most religious activity was associated with lower blood pressure, those who frequently watched religious TV or listened to religious radio actually had higher blood pressures. Conclusions: Religiously active older adults tend to have lower blood pressures than those who are less active. This applies to attendance at religious services and private religious activities, but not to religious media. Physiological mechanisms are discussed.

Relationship of Age and Blood Pressure to Baroreflex Sensitivity and Arterial Compliance in Man

1976 ◽  
Vol 51 (s3) ◽  
pp. 357s-360s ◽  
Author(s):  
O. S. Randall ◽  
M. D. Esler ◽  
G. F. Bulloch ◽  
A. S. Maisel ◽  
C. N. Ellis ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Systolic Blood Pressure ◽  
Negative Correlation ◽  
Baroreflex Sensitivity ◽  
Arterial Compliance ◽  
Significant Negative Correlation ◽  
Arterial Distensibility ◽  
Blood Pressures ◽  
Relationship Of ◽  
The Relationship

1. The relationship between baroreflex sensitivity (BRS) and arterial compliance index (ACI) has been investigated (a) in paired subjects matched in one instance for systolic blood pressure with differing ages, and (b) in another instance matched for age with differing systolic blood pressures. 2. There was a significant negative correlation between BRS and age and between ACI and age in the twelve systolic blood pressure-matched subjects. 3. A significant negative correlation of systolic blood pressure with both BRS and ACI was observed in the fourteen age-matched subjects. 4. Both BRS and ACI appear to decrease with increasing age and systolic blood pressure. This decrease in BRS is probably due at least in part to the observed reduction in arterial distensibility.

scholarly journals Sex-specific in the relationship between hyperuricemia and pulse pressure in non-diabetic Korean adults: the 2017 Korean National Health and Nutrition Examination Survey

2021 ◽  
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Confidence Interval ◽  
National Health ◽  
Pulse Pressure ◽  
Nutrition Examination Survey ◽  
Korean Adults ◽  
Health And Nutrition ◽  
The Relationship ◽  
Significant Factors

Background and objective: The present study assesses the relationship between hyperuricemia and pulse pressure (PP) in non-diabetic Korean adults. Material and methods: Data from 5122 subjects (2251 men and 2871 women) in the seventh Korean National Health and Nutrition Examination Survey (KNHANES VII-2, 2017) were analyzed. Results: Systolic blood pressure (SBP) and PP were significant factors determining the odds ratios (ORs) for hyperuricemia (uric acid ≥7.0 mg/dL in men or ≥6.0 mg/dL in women) in men and the overall population. In women, SBP, diastolic blood pressure (DBP), and PP were not significant factors determining the OR for hyperuricemia. After adjusting for related variables, the OR of hyperuricemia was significantly higher in the high PP group (PP >60.0 mmHg) for men (OR, 1.760; 95% confidence interval [CI], 1.152--2.688) and the overall population (OR, 1.557; 95% CI, 1.132--2.140) compared with the normal PP group, but this trend was not seen in women (OR, 1.060; 95% CI, 0.646--1.740). Conclusions: Hyperuricemia was positively associated with PP in non-diabetic Korean men but not in women.

Blood Pressure and Chemistry: Some Correlations and Apparent Correlations

1984 ◽  
Vol 21 (4) ◽  
pp. 257-260 ◽  
Author(s):  
J B Whitfield ◽  
N G Martin
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
Plasma Calcium ◽  
Plasma Albumin ◽  
Men And Women ◽  
Plasma Uric Acid ◽  
Plasma High Density ◽  
Blood Pressures

The reported correlation between plasma calcium and blood pressure has been investigated in 412 young men and women. In this sample, it seemed to be due to a stronger correlation between blood pressure and plasma albumin. Blood pressures were also significantly correlated with plasma high-density lipoprotein in men and with plasma uric acid in women.

Blood pressure, hemodynamic, and thermal responses after cycling exercise

1993 ◽  
Vol 75 (1) ◽  
pp. 240-245 ◽  
Author(s):  
S. P. Brown ◽  
H. Li ◽  
L. F. Chitwood ◽  
E. R. Anderson ◽  
D. Boatwright
Keyword(s):  
Blood Pressure ◽  
Repeated Measures ◽  
Venous Return ◽  
Lower Limbs ◽  
O2 Uptake ◽  
Cycling Exercise ◽  
Vasodilatory Response ◽  
Repeated Measures Analysis ◽  
Blood Pressures ◽  
The Relationship

Seated recovery [at 5, 15, 20, 40, and 60 min (R5,15,20,40,60)] body temperature (T) and blood pressure were examined after 45 min of cycling exercise (54 +/- 5% maximal O2 uptake) in 12 normotensive males to study the relationship between postexercise thermal and hemodynamic responses. Data were analyzed with a repeated-measures analysis of variance. Systolic (SBP, R15,20,40; P < 0.01) and mean arterial (MAP, R15,20; P < 0.05) blood pressures were significantly lower, but diastolic blood pressure (DBP) was unchanged. Heart rate (R5,15,20, P < 0.001) was above that measured at rest. Decreases in mean skin T (Tsk, R15,20,60; P < 0.01) and increases in core T (Tc, R5,15,20; P < 0.01) were found. Significant negative correlations averaging -0.68 (R15,20,40) and -0.69 (R15,20,40) were demonstrated for Tsk and SBP and MAP, respectively. Increases in thigh Tsk (R5,15,20; P < 0.00001) and decreases in calf (R15,20,40,60; P < 0.00001) and chest (Tchest, R5,15,20,40; P < 0.00001) Tsk were found. Significant negative correlations averaging -0.67 (R5,15,20,40) and -0.71 (R20,40,60) were demonstrated for Tchest and SBP and MAP, respectively. Inverse relationships between various regional Ts and blood pressure and the increased R Tc suggest a vasodilatory response in the visceral organs and/or lower limbs leading to a pooling of blood and transient decreases in blood pressure by a reduced venous return, although not affecting stroke volume and cardiac output.

scholarly journals Effect of short-term blood pressure variability on functional outcome after intra-arterial treatment in acute stroke patients with large-vessel occlusion

2019 ◽  
Author(s):  
Tianli Zhang ◽  
Weirong Li ◽  
Xiaolong Wang ◽  
Chao Wen ◽  
Feng Zhou ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Variability ◽  
Area Under The Curve ◽  
Large Vessel ◽  
Multivariable Logistic Regression Analysis ◽  
Large Vessel Occlusion ◽  
Short Term ◽  
Vessel Occlusion ◽  
Blood Pressures ◽  
The Relationship

Abstract Background: Endovascular treatment (EVT) is advocated for acute ischemic stroke with large-vessel occlusion (LVO), but perioperative periods are challenging.This study investigated the relationship between post-EVT short-term blood pressure variability (BPV) and early outcomes in LVO patients. Methods: We retrospectively reviewed 72 LVO patients undergoing EVT between June 2015 and June 2018. Hourly systolic and diastolic blood pressures (SBP and DBP, respectively) were recorded in the first 24 hours post-EVT. BPV were evaluated as standard deviation (SD), coefficient of variation (CV), and successive variation (SV) separately for SBP and DBP. Patients were categorized into favorable (mRS 0-2) and unfavorable (mRS 3-6) outcome groups based on 3-month modified Rankin Scale (mRS) scores. Results: For 58.3% patients with favorable outcomes, median National Institutes of Health Stroke Scale and Alberta Stroke Program Early CT scores on admission were 14 and 8, respectively. The maximum SBP ([154.3±16.8] vs. [163.5±15.6], P=0.02), systolic CV ([8. 8%±2.0%] vs. [11.0%±1.8%], P<0.001), SV ([11.4±2.3] vs. [14.6±2.0], P<0.001), and SD ([10.5±2.4] vs. [13.8±3.9], P<0.001) were lower in patients with favorable outcomes. On multivariable logistic regression analysis, systolic SV (OR: 4.273, 95% CI: 1.030 to 17.727, P=0.045) independently predicted unfavorable prognosis (area under the curve = 0.868 [95% CI: 0.781 to 0.955, P<0.001]. Sensitivity and specificity were 93.3% and 73.8%, respectively, showing excellent value for 3-month-poor-outcome predictions. Conclusions: Decreased maximum SBP and systolic CV, SV, and SD following intra-arterial therapies result in favorable 3-month outcomes. Systolic SV may be a novel predictor of functional prognosis in LVO patients.

Sign in / Sign up

Export Citation Format

Share Document