The association of minerals intake in three meals with cancer and all-cause mortality: the U.S. National Health and Nutrition Examination Survey, 2003–2014

Abstract Background Intake time of diet has recently been demonstrated to be associated with the internal clock and circadian pattern. However, whether and how the intake time of minerals would influence the natural course of cancer was largely unknown. Methods This study aimed to assess the association of mineral intake at different periods with cancer and all-cause mortality. A total of 27,455 participants aged 18–85 years old in the National Health and Nutrition Examination Survey were recruited. The main exposures were the mineral intakes in the morning, afternoon and evening, which were categorized into quintiles, respectively. The main outcomes were mortality of cancer and all causes. Results During the 178,182 person-years of follow-up, 2680 deaths, including 601 deaths due to cancer, were documented. After adjusting for potential confounders, compared to the participants who were in the lowest quintile(quintile-1) of mineral intakes at dinner, the participants in the highest quintile intake(quintile-5) of dietary potassium, calcium and magnesium had lower mortality risks of cancer (HRpotassium = 0.72, 95% CI:0.55–0.94, P for trend = 0.023; HRcalcium = 0.74, 95% CI:0.57–0.98, P for trend = 0.05; HRmagnesium = 0.75, 95% CI:0.56–0.99, P for trend = 0.037) and all-cause (HRpotassium = 0.83, 95% CI:0.73–0.94, P for trend = 0.012; HRcalcium = 0.87, 95% CI:0.76–0.99, P for trend = 0.025; HRmagnesium = 0.85, 95% CI:0.74–0.97, P for trend = 0.011; HRcopper = 0.80, 95%CI: 0.68–0.94, P for trend = 0.012). Further, equivalently replacing 10% of dietary potassium, calcium and magnesium consumed in the morning with those in the evening were associated with lower mortality risk of cancer (HRpotassium = 0.94, 95%CI:0.91–0.97; HRcalcium = 0.95, 95%CI:0.92–0.98; HRmagnesium = 0.95, 95%CI: 0.92–0.98). Conclusions This study demonstrated that the optimal intake time of potassium, calcium and magnesium for reducing the risk of cancer and all-cause mortality was in the evening.

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The association of Minerals Intake in Three Meals with Cancer and All-Cause Mortality: The U.S. National Health and Nutrition Examination Survey, 2003-2014

10.21203/rs.3.rs-215291/v1 ◽

2021 ◽

Author(s):

Xiaoqing Xu ◽

Jiaxin Huang ◽

Jiaxu Xu ◽

Wenbo Jiang ◽

Wei Wei ◽

...

Keyword(s):

National Health ◽

Internal Clock ◽

Lower Mortality ◽

Nutrition Examination Survey ◽

Health And Nutrition ◽

Dietary Potassium ◽

All Cause Mortality ◽

Calcium And Magnesium ◽

Risk Of Cancer

Abstract Background: Intake time of diet has recently been demonstrated to be associated with the internal clock and circadian pattern. However, whether and how the intake time of minerals would influence the natural course of cancer was largely unknown. Methods:This study aimed to assess the association of mineral intake at different periods with cancer and all-cause mortality. A total of 27455 participants aged 18-85 years old in the National Health and Nutrition Examination Survey were recruited. The main exposures were the mineral intakes in the morning, afternoon and evening, which were categorized into quintiles, respectively. The main outcomes were mortality of cancer and all causes. Results:During the 178,182 person-years of follow-up, 2680 deaths, including 601 deaths due to cancer, were documented. After adjusting for potential confounders, compared to the participants who were in the lowest quartile(Quartile-1) of mineral intakes at dinner, the participants in the highest quartile intake(Quartile-5) of dietary potassium, calcium and magnesium had lower mortality risks of cancer (HRpotassium=0.72, 95% CI:0.55-0.94; HRcalcium=0.74, 95% CI:0.57-0.98; HRmagnesium=0.75, 95% CI:0.56-0.99) and all-cause (HRpotassium=0.83, 95% CI:0.73-0.94; HRcalcium=0.87, 95% CI:0.76-0.99; HRmagnesium=0.85, 95% CI:0.74-0.97). Further, equivalently replacing 10% of dietary potassium, calcium and magnesium consumed in the morning with those in the evening were associated with lower mortality risk of cancer (HRpotassium=0.94, 95%CI:0.91-0.97; HRcalcium=0.95, 95%CI:0.92-0.98; HRmagnesium=0.95, 95%CI: 0.92-0.98). Conclusions: This study demonstrated that the optimal intake time of potassium, calcium and magnesium for reducing the risk of cancer and all-cause mortality was in the evening.

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Association between selenium intake, diabetes, and mortality in adults: findings from National Health and Nutrition Examination Survey (NHANES) 2003-2014

British Journal Of Nutrition ◽

10.1017/s000711452100177x ◽

2021 ◽

pp. 1-24

Author(s):

Bushra Hoque ◽

Zumin Shi

Keyword(s):

National Health ◽

Cox Regression ◽

Inverse Association ◽

Nutrition Examination Survey ◽

Health And Nutrition ◽

Hazard Ratios ◽

The Us ◽

All Cause Mortality ◽

Cvd Mortality

Abstract Selenium (Se) is a trace mineral that has antioxidant and anti-inflammatory properties. This study aimed to investigate the association between Se intake, diabetes, all-cause and cause-specific mortality in a representative sample of US adults. Data from 18,932 adults who attended the 2003-2014 National Health and Nutrition Examination Survey (NHANES) were analysed. Information on mortality was obtained from the US mortality registry updated to 2015. Multivariable logistic regression and Cox regression were used. Cross-sectionally, Se intake was positively associated with diabetes. Comparing extreme quartiles of Se intake, the odds ratio (OR) for diabetes was 1.44 (95% CI: 1.09–1.89). During a mean of 6.6 years follow-up, there were 1627 death (312 CVD, 386 cancer). High intake of Se was associated with a lower risk of all-cause mortality. When comparing the highest with the lowest quartiles of Se intake, the hazard ratios (HRs) for all-cause, CVD mortality, cancer mortality and other mortality were: 0.77 (95% CI 0.59-1.01), 0.62 (95% CI, 0.35-1.13), 1.42 (95% CI, 0.78-2.58) and 0.60 (95% CI,0.40-0.80), respectively. The inverse association between Se intake and all-cause mortality was only found among white participants. In conclusion, Se intake was positively associated with diabetes but inversely associated with all-cause mortality. There was no interaction between Se intake and diabetes in relation to all-cause mortality.

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Cocaine Use and the Likelihood of Cardiovascular and All-Cause Mortality: Data from the Third National Health and Nutrition Examination Survey Mortality Follow-Up Study (P07.031)

Neurology ◽

10.1212/wnl.78.1_meetingabstracts.p07.031 ◽

2012 ◽

Vol 78 (Meeting Abstracts 1) ◽

pp. P07.031-P07.031 ◽

Cited By ~ 1

Author(s):

A. Qureshi ◽

M. Suri

Keyword(s):

National Health ◽

Mortality Data ◽

Nutrition Examination Survey ◽

Cocaine Use ◽

The Third ◽

Follow Up Study ◽

Health And Nutrition ◽

All Cause Mortality

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Associations between elevated kidney and liver biomarker ratios, metabolic syndrome and all-cause and coronary heart disease (CHD) mortality: analysis of the U.S. National Health and Nutrition Examination Survey (NHANES)

BMC Cardiovascular Disorders ◽

10.1186/s12872-021-02160-w ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Akinkunle Oye-Somefun ◽

Jennifer L. Kuk ◽

Chris I. Ardern

Keyword(s):

Metabolic Syndrome ◽

Coronary Heart Disease ◽

Heart Disease ◽

National Health ◽

Nutrition Examination Survey ◽

Health And Nutrition ◽

Increased Risk ◽

All Cause Mortality ◽

The U.S

Abstract Background We examined the relationship between ratios of select biomarkers of kidney and liver function on all-cause and coronary heart disease (CHD) mortality, both in isolation, and in combination with metabolic syndrome (MetS), among adults (20 + years, n = 10,604). Methods Data was derived from the U.S. National Health and Nutrition Examination Survey (1999–2016) including public-use linked mortality follow-up files through December 31, 2015. Results Select biomarker ratios of kidney (UACR or albuminuria and BUN-CR) and liver (AST-ALT and GGT-ALP) function in isolation and in combination with MetS were associated with all-cause and CHD mortality. Compared to individuals with neither elevated biomarker ratios nor MetS (HR = 1.00, referent), increased risk of all-cause mortality was observed in the following groups: MetS with elevated UACR (HR, 95% CI = 2.57, 1.99–3.33), MetS with elevated AST-ALT (HR = 2.22, 1.61–3.07), elevated UACR without MetS (HR = 2.12, 1.65–2.72), and elevated AST-ALT without MetS (HR = 1.71, 1.35–2.18); no other biomarker ratios were associated with all-cause mortality. For cause-specific deaths, elevated risk of CHD mortality was associated with MetS with elevated UACR (HR = 1.67, 1.05–2.67), MetS with elevated AST-ALT (HR = 2.80, 1.62–4.86), and elevated BUN-CR without MetS (HR = 2.12, 1.12–4.04); no other biomarker ratios were associated with CHD mortality. Conclusion Future longitudinal studies are necessary to examine the utility of these biomarker ratios in risk stratification for chronic disease management.

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Association of serum levels of antioxidant micronutrients with mortality in US adults: National Health and Nutrition Examination Survey 1999–2002

Public Health Nutrition ◽

10.1017/s1368980020004619 ◽

2020 ◽

pp. 1-10

Author(s):

Noah C Peeri ◽

Weiwen Chai ◽

Robert V Cooney ◽

Meng-Hua Tao

Keyword(s):

Vitamin E ◽

National Health ◽

Nutrition Examination Survey ◽

Health And Nutrition ◽

All Cause Mortality ◽

Specific Mortality ◽

Race Ethnicity ◽

Risk Of Cancer ◽

Reduced Risk ◽

Cvd Mortality

Abstract Objective: To examine associations between serum antioxidant levels and mortality (all-cause, cancer and CVD) among US adults. Design: We examined the risk of death from all-cause and cause-specific mortality associated with serum antioxidant (vitamin E and carotenoids) and vitamin A levels using Cox regression models to estimate hazards ratios (HR) and 95 % CI. Setting: The National Health and Nutrition Examination Survey (NHANES) 1999–2002 was followed up through 31 December 2015. Participants: The NHANES 1999–2002 cohort included 8758 participants aged ≥ 20 years. Serum carotenoid levels were only assessed for the 1999–2000 cycle. Therefore, sample size for each assessed antioxidant ranged from 4633 to 8758. Results: Serum vitamin E level was positively associated with all-cause mortality (HR = 1·22, 95 % CI 1·04, 1·43, highest v. lowest quartile). No other antioxidants were associated with mortality in overall analysis. In race/ethnicity-specific analyses, high vitamin E and α-tocopherol levels were associated with increased risk of all-cause mortality among non-Hispanic Whites. Among non-Hispanic Blacks, serum α-tocopherol level was associated with decreased risk of cancer mortality (HR = 0·30, 95 % CI 0·12, 0·75, third v. first quartile) and total carotenoid levels with reduced risk of CVD mortality (HR = 0·26; 95 % CI 0·07, 0·97, second v. lowest quartile). Hispanics with high β-carotene levels had reduced risk of CVD mortality. Conclusions: Serum antioxidant levels may be related to mortality; these associations may differ by race/ethnicity and appeared to be non-linear for all-cause and cause-specific mortality. Further studies are needed to confirm our results.

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Hypotension and survival: diagnostic criteria in Russian and United States population

Russian Journal of Cardiology ◽

10.15829/1560-4071-2021-4365 ◽

2021 ◽

Vol 26 (5) ◽

pp. 4365

Author(s):

V. G. Vilkov ◽

Yu. A. Balanova ◽

A. V. Kapustina ◽

G. A. Muromtseva ◽

S. A. Shalnova

Keyword(s):

United States ◽

Risk Factors ◽

National Health ◽

Population Studies ◽

Nutrition Examination Survey ◽

Health And Nutrition ◽

United States Population ◽

Severe Hypotension ◽

All Cause Mortality

Aim. Based on Russian and United States population studies, to determine the criterion for distinguishing between normal and low blood pressure (BP), which is the most significant for predicting all-cause mortality.Material and methods. We used data from prospective Russian studies of 14730 men aged 19-82 years (9307 deaths per 342309 person-years of followup) and 6141 women aged 18-72 years (2101 deaths per 158727 person-years of follow-up), and two United States population studies: the First National Health and Nutrition Examination Survey (NHANES I) in conjunction with the NHANES I Epidemiologic Followup Study, and the Second National Health and Nutrition Examination Survey (NHANES II) in conjunction with the NHANES II Mortality Study. The total American cohort included only white subjects: 8618 men aged 25-75 years (3130 deaths per 121794 person-years of follow-up) and 11135 women 25-75 years (2465 deaths per 176676 person-years of follow-up). Primary examinations were carried out in 1971-1982, while the latest information on the subjects’ survival status was obtained in 2017 (Russia) and 1992 (USA). KaplanMeier curves and Cox proportional hazards models were created; all-cause death was taken into account as an outcome.Results. Survival analysis using Cox models, in which, in addition to BP levels, sex, age and risk factors were taken into account, showed that in persons with a pronounced BP decrease, survival is worse in comparison with those with normal BP. Mean dynamic BP, unfavorable for all-cause mortality, was below 70 and 68 mm Hg and 76 and 72 mm Hg in men and women in the Russian and US cohorts, respectively.Conclusion. Not only hypertension, but also severe hypotension is associated with increased all-cause mortality compared to normal BP. Survival decrease is manifested in severe hypotension, subject to sex and adjustment for age and risk factors.

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Serum Antioxidant Status and Cause-Specific Mortality in US Adults: Results from the National Health and Nutrition Examination Survey (NHANES) 1999–2002

Current Developments in Nutrition ◽

10.1093/cdn/nzaa061_103 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 1475-1475

Author(s):

Noah Peeri ◽

Meng-Hua Tao ◽

Weiwen Chai

Keyword(s):

Vitamin E ◽

Vitamin A ◽

Nutrition Examination Survey ◽

Health And Nutrition ◽

Increased Risk ◽

All Cause Mortality ◽

Risk Of Cancer ◽

Β Carotene ◽

Cvd Mortality

Abstract Objectives Oxidative stress is one of the most important risk factors of non-communicable diseases. Studies on the association of serum antioxidants with mortality in a representative sample of US adults are still limited with inconsistent results. The objective of this study was to examine associations between serum concentrations of antioxidants (vitamins A and E, γ-tocopherol, total carotenoids, and β-carotene) and mortality among US adults. Methods The study cohort included adults aged ≥20 years who participated in the National Health and Nutrition Examination Survey (NHANES) 1999–2002, with measured serum antioxidants and mortality follow-up through December 31st, 2015 (N = 10,291). Outcomes were all-cause, cancer, and cardiovascular (CVD) mortality. Cox Proportional Hazards modelling was used to estimate adjusted hazards ratios (aHR) and 95% confidence intervals (CIs) for associations between serum antioxidant levels and mortality. Results Median follow-up was 14.2 years, with 2708 deaths, 556 from CVD, and 471 from cancer. Overall, a high level of vitamin E (>1529.5 ug/dL) was associated with increased risk of all-cause mortality (aHR: 1.3; 95% CI: 1.10, 1.54), while a low carotenoid level (<46.73 ug/dL) was associated with increased risk of all-cause mortality (aHR: 1.25; 95% CI: 0.88, 1.43). Vitamin A, γ-tocopherol, and β-carotene were not associated with mortality. The positive association between vitamin E and all-cause mortality was stronger among non-Hispanic whites (aHR: 1.37; 95% CI: 1.15, 1.65). Among Hispanics, compared to participants with vitamin A levels between 48.41–58.93 (ug/dL), participants in the highest vitamin A quartile (>70.54 ug/dL) had increased risk of all-cause and CVD mortality, while the third quartile (58.94–70.54 ug/dL) had reduced risk of cancer mortality. Among non-Hispanic blacks, total carotenoid levels between 63.60–87.24 (ug/dL) were negatively associated with all-cause mortality and vitamin E levels between 1154.57–1529.54 (ug/dL) were associated with decreased risk of cancer mortality, while high vitamin A levels were associated with increased CVD mortality. Conclusions Findings suggest that optimal levels of serum antioxidants may protect against mortality, with differences between race/ethnicity. Further studies in minority populations are warranted to confirm the findings. Funding Sources N/A.

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