Chronic multisite pain in major depression and bipolar disorder: cross-sectional study of 149,611 participants in UK Biobank

ObjectivesTo assess the magnitude of internalised stigma and associated factors among patients with bipolar disorder attending the outpatient department of Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia.DesignInstitution-based cross-sectional study design.SettingAmanuel Mental Specialized Hospital, Addis Ababa, Ethiopia.ParticipantsWe recruited about 418 participants using systematic sampling technique for an interview during the study period.MeasurementData were collected by face-to-face interviews. Internalized Stigma of Mental Illness scale was used to measure internalised stigma. The Rosenberg Self-Esteem Scale and the Oslo-3 Social Support were instruments used to assess the associated factors. Bivariate and multivariate logistic regressions were performed to identify factors associated with the outcome variable. ORs with 95% CI were computed to determine the level of significance.ResultsThe magnitude of internalised stigma was 24.9% (95% CI: 21.2% to 28.9%). In the multivariate analysis, unemployed (adjusted OR (AOR)=2.3, 95% CI: 1.0 to 5.0), unable to read and write (AOR=3.3, 95% CI: 1.05 to 10.7), poor social support (AOR=5.3, 95% CI: 1.9 to 15.0), ≥4 previous hospitalisations due to bipolar disorder (AOR=2.6, 95% CI: 1.1 to 6.1) and low self-esteem (AOR=2.4, 95% CI: 1.1 to 5.1) had a significant association with internalised stigma.ConclusionsOne in four patients with bipolar disorder reported high internalised stigma. Unemployment, low educational status, low self-esteem, poor social support and being hospitalised more than three times before were significantly associated with internalised stigma. Thus, a stigma-reduction programme focusing on self-esteem improvement and psychological health of patients to increase their stigma resistance to counteracting effects of internalised stigma is essential.

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Cam morphology is associated with radiographic hip osteoarthritis and hip pain in men but not in women: findings from a cross-sectional study in UK biobank

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2021.02.385 ◽

2021 ◽

Vol 29 ◽

pp. S291-S292

Author(s):

B. Faber ◽

R. Ebsim ◽

F. Saunders ◽

M. Frysz ◽

C. Lindner ◽

...

Keyword(s):

Hip Osteoarthritis ◽

Cross Sectional Study ◽

Hip Pain ◽

Uk Biobank ◽

Sectional Study ◽

Cross Sectional ◽

Cam Morphology

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Review for "Sex differences in the association of photoperiod with hippocampal subfield volumes in older adults: A cross‐sectional study in the UK Biobank cohort"

10.1002/brb3.1593/v2/review2 ◽

2020 ◽

Author(s):

Julian Macoveanu

Keyword(s):

Older Adults ◽

Sex Differences ◽

Cross Sectional Study ◽

Uk Biobank ◽

Sectional Study ◽

Cross Sectional ◽

The Uk

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Cardiometabolic disease and features of depression and bipolar disorder: Population-based, cross-sectional study

The British Journal of Psychiatry ◽

10.1192/bjp.bp.114.157784 ◽

2016 ◽

Vol 208 (4) ◽

pp. 343-351 ◽

Cited By ~ 16

Author(s):

Daniel J. Martin ◽

Zia Ul-Haq ◽

Barbara I. Nicholl ◽

Breda Cullen ◽

Jonathan Evans ◽

...

Keyword(s):

Cardiovascular Disease ◽

Bipolar Disorder ◽

Mood Disorder ◽

Psychotropic Medication ◽

Large Population ◽

Population Sample ◽

Cross Sectional Study ◽

Cardiometabolic Disease ◽

Sectional Study ◽

Cross Sectional

BackgroundThe relative contribution of demographic, lifestyle and medication factors to the association between affective disorders and cardiometabolic diseases is poorly understood.AimsTo assess the relationship between cardiometabolic disease and features of depresion and bipolar disorder within a large population sample.MethodCross-sectional study of 145 991 UK Biobank participants: multivariate analyses of associations between features of depression or bipolar disorder and five cardiometabolic outcomes, adjusting for confounding factors.ResultsThere were significant associations between mood disorder features and ‘any cardiovascular disease’ (depression odds ratio (OR) = 1.15, 95% CI 1.12–1.19; bipolar OR = 1.28, 95% CI 1.14–1.43) and with hypertension (depression OR = 1.15, 95% CI 1.13–1.18; bipolar OR = 1.26, 95% CI 1.12–1.42). Individuals with features of mood disorder taking psychotropic medication were significantly more likely than controls not on psychotropics to report myocardial infarction (depression OR = 1.47, 95% CI 1.24–1.73; bipolar OR = 2.23, 95% CI 1.53–3.57) and stroke (depression OR = 2.46, 95% CI 2.10–2.80; bipolar OR = 2.31, 95% CI 1.39–3.85).ConclusionsAssociations between features of depression or bipolar disorder and cardiovascular disease outcomes were statistically independent of demographic, lifestyle and medication confounders. Psychotropic medication may also be a risk factor for cardiometabolic disease in individuals without a clear history of mood disorder.

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Associations between residual depressive symptoms, cognition, and functioning in patients with euthymic bipolar disorder: results from the FACE-BD cohort

The British Journal of Psychiatry ◽

10.1192/bjp.bp.117.201335 ◽

2017 ◽

Vol 211 (6) ◽

pp. 381-387 ◽

Cited By ~ 18

Author(s):

Paul Roux ◽

Aurélie Raust ◽

Anne-Sophie Cannavo ◽

Valérie Aubin ◽

Bruno Aouizerate ◽

...

Keyword(s):

Bipolar Disorder ◽

Depressive Symptoms ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Cognitive Component ◽

Cognitive Components ◽

The Face ◽

Sources Of Variation ◽

The Relationship

BackgroundThe relationship between residual depressive symptoms, cognition and functioning in patients with euthymic bipolar disorder is a subject of debate.AimsTo assess whether cognition mediates the association between residual depressive symptoms and functioning in patients with bipolar disorder who were euthymic.MethodWe included 241 adults with euthymic bipolar disorder in a multicentre cross-sectional study. We used a battery of tests to assess six cognition domains. A path analysis was then used to perform a mediation analysis of the relationship between residual depressive symptoms, cognitive components and functioning.ResultsOnly verbal and working memory were significantly associated with better functioning. Residual depressive symptoms were associated with poorer functioning. No significant relationship was found between residual depressive symptoms and any cognitive component.ConclusionsCognition and residual depressive symptoms appear to be two independent sources of variation in the functioning of people with euthymic bipolar disorder.

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Affective temperaments are associated with specific clusters of symptoms and psychopathology: A cross-sectional study on bipolar disorder inpatients in acute manic, mixed, or depressive relapse

Journal of Affective Disorders ◽

10.1016/j.jad.2013.06.041 ◽

2013 ◽

Vol 151 (2) ◽

pp. 540-550 ◽

Cited By ~ 31

Author(s):

Felice Iasevoli ◽

Alessandro Valchera ◽

Emanuela Di Giovambattista ◽

Massimo Marconi ◽

Maria Paola Rapagnani ◽

...

Keyword(s):

Bipolar Disorder ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Affective Temperaments

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Association of elder abuse, crime victimhood and perceived neighbourhood safety with major depression among older adults in India: a cross-sectional study using data from the LASI baseline survey (2017–2018)

BMJ Open ◽

10.1136/bmjopen-2021-055625 ◽

2021 ◽

Vol 11 (12) ◽

pp. e055625

Author(s):

T Muhammad ◽

Trupti Meher ◽

T V Sekher

Keyword(s):

Older Adults ◽

Major Depression ◽

Violent Crime ◽

Elder Abuse ◽

Cross Sectional Study ◽

Secondary Outcome ◽

Older Individuals ◽

Sectional Study ◽

Cross Sectional ◽

Perceived Safety

ObjectiveThe study aims to explore the associations of elder abuse, crime victimhood and perceived safety with depression among older adults and examine the interactive effects of sex and place of residence in those associations.DesignA cross-sectional study was conducted using a large survey data.Setting and participantsThe study used data from the Longitudinal Ageing Study in India wave 1 (2017–2018). The effective sample size was 31 464 older adults (aged 60 years or older).Primary and secondary outcome measuresThe outcome variable was major depression, calculated using Short Form Composite International Diagnostic Interview. Descriptive statistics along with bivariate and multivariate analyses were performed to fulfil the objectives.Results5.22% of the older adults (n=1587) experienced abuse in the past 1 year. 1.33% of the older individuals (n=402) were victims of a violent crime, and 14.30% (n=1886) perceived an unsafe neighbourhood. Also, 8.67% of the older adults (n=2657) were suffering from depression. Older adults who were abused had 2.5 odds of suffering from depression (adjusted OR (AOR): 2.47, CI: 1.96 to 3.10) and victims of a violent crime were 84% more likely to be depressed (AOR: 1.84, CI: 1.15 to 2.95) compared with their counterparts. Besides, older individuals who perceived as living in unsafe neighbourhood were 61% more likely to be depressed (AOR: 1.61, CI: 1.34 to 1.93) compared with their counterparts. In the interaction analysis, older women who reported abuse had higher odds of suffering from depression (AOR: 3.27; CI: 2.34 to 4.57) compared with older men who were not abused. Similar result was found in older adults reporting abuse and residing in rural areas (AOR: 3.01, CI: 2.22 to 4.07) compared with those urban residents reporting no abuse.ConclusionsHealthcare providers should pay more attention to the mental health implications of elder abuse, crime victimhood and perceived safety to grasp the underlying dynamics of the symptomology of late-life depression.

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