Cervical cancer mortality in Peru: regional trend analysis from 2008–2017

Abstract Background Cervical cancer is the third leading cause of cancer-related death among Latin American women. Peru has the sixth highest mortality rate for cervical cancer in the region with regional variations. We aimed to determine overall and regional cervical cancer mortality rates and trends in Peru between 2008 and 2017. Methods We performed an ecological study on the number of deaths by cervical cancer in Peru. Deaths were extracted from the Peruvian Ministry of Health mortality database. Age-standardized mortality rates (ASMR) were estimated per 100,000 women-years using the world standard Segi population. We computed mortality trends using the Joinpoint regression program, estimating the annual percent change (APC). For spatial analysis, GeoDA software was used. Results Peru showed downward trends in the last decade (from 11.62 in 2008 to 9.69 in 2017 (APC = − 2.2, 95% CI: − 4.3, − 0.1, p < 0.05). According to regional-specific analysis, the highest ASMR was in the rainforest region, although this declined from 34.16 in 2008 to 17.98 in 2017 (APC = − 4.3, 95% CI: − 7.2, − 1.3, p < 0.01). Concerning spatial analysis and clustering, the mortality rates from 2008 to 2017 showed a positive spatial autocorrelation and significant clustering (Moran’s I: 0.35, p < 0.001) predominantly in the neighboring North-East departments (Loreto, Ucayali, and San Martin). Conclusions Although mortality trends in the entire population are decreasing, mortality rates remain very high, mainly in the rainforest region. Our results encourage a need for further development and improvement of the current health care delivery system in Peru.

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Cervical cancer mortality trends in Brazil: 1980-2009

Cadernos de Saúde Pública ◽

10.1590/s0102-311x2013000300017 ◽

2013 ◽

Vol 29 (3) ◽

pp. 599-608 ◽

Cited By ~ 10

Author(s):

Carolina Maciel Reis Gonzaga ◽

Ruffo Freitas-Junior ◽

Aline Almeida Barbaresco ◽

Edesio Martins ◽

Bruno Teixeira Bernardes ◽

...

Keyword(s):

Cervical Cancer ◽

Cancer Mortality ◽

Census Data ◽

Mortality Rates ◽

Downward Trend ◽

Mortality Trends ◽

Cervical Cancer Mortality ◽

Geographic Regions ◽

Using Data ◽

Series Study

The objective was to describe time trends in cervical cancer mortality rates in Brazil as a whole and in the country's major geographic regions and States from 1980 to 2009. This was an ecological time series study using data recorded in the Mortality Information System (SIM) and census data collected by the Brazilian Institute of Geography and Statistics (IBGE). Analysis of mortality trends was performed using Poisson regression. Cervical cancer mortality rates in Brazil tended to stabilize. In the geographic regions, a downward trend was observed in the South (-4.1%), Southeast (-3.3%), and Central-West (-1%) and an upward trend in the Northeast (3.5%) and North (2.7%). The largest decreases were observed in the States of São Paulo (5.1%), Rio Grande do Sul, Espírito Santo, and Paraná (-4.0%). The largest increases in mortality trends occurred in Paraíba (12.4%), Maranhão (9.8%), and Tocantins (8.9%). Cervical cancer mortality rates stabilized in the country as a whole, but there was a downward trend in three geographic regions and 10 States, while two geographic regions and another 10 States showed increasing rates.

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Cervical cancer mortality among young women in Latin America and the Caribbean: trend analysis from 1997 to 2030

BMC Public Health ◽

10.1186/s12889-021-12413-0 ◽

2022 ◽

Vol 22 (1) ◽

Author(s):

J. Smith Torres-Roman ◽

Luz Ronceros-Cardenas ◽

Bryan Valcarcel ◽

Janina Bazalar-Palacios ◽

Jorge Ybaseta-Medina ◽

...

Keyword(s):

Cervical Cancer ◽

Latin America ◽

Young Women ◽

Cancer Mortality ◽

Mortality Rates ◽

World Health ◽

Mortality Trends ◽

Cervical Cancer Mortality ◽

The World ◽

The Caribbean

Abstract Background Cervical cancer continues to show a high burden among young women worldwide, particularly in low- and middle-income countries. Limited data is available describing cervical cancer mortality among young women in Latin America and the Caribbean (LAC). The purpose of this study was to examine the mortality trends of cervical cancer among young women in LAC and predict mortality rates to 2030. Methods Deaths from cervical cancer were obtained from the World Health Organization mortality database. Age-standardized mortality rates per 100,000 women-years were estimated in women aged 20–44 years using the world standard population for 16 countries (and territories) in LAC from 1997 to 2017. We estimated the average mortality rates for the last 4 years (2014–2017). Joinpoint regression models were used to identify significant changes in mortality trends. Nordpred method was used for the prediction of the mortality rates to 2030. Results Between 2014 and 2017, Paraguay and Venezuela had the highest mortality rates of cervical cancer, whereas Puerto Rico had the lowest rates. Overall, most of the LAC countries showed downward trends of cervical cancer mortality over the entire period. Significant decreases were observed in Chile (Average annual percent change [AAPC]: − 2.4%), Colombia (AAPC: − 2.0%), Cuba (AAPC: − 3.6%), El Salvador (AAPC: − 3.1%), Mexico (AAPC: − 3.9%), Nicaragua (AAPC: − 1.7%), Panama (AAPC: − 1.7%), and Peru (AAPC: − 2.2%). In contrast, Brazil (AAPC: + 0.8%) and Paraguay (AAPC: + 3.7%) showed significant upward trends. By 2030, mortality rates are not predicted to further decrease in some LAC countries, including Argentina, Paraguay, and Venezuela. Conclusions Mortality trends of cervical cancer among young women have large variability in LAC countries. Cervical cancer screening programs have a high priority for the region. Primary and secondary prevention in the community are necessary to accelerate a reduction of cervical cancer mortality by 2030.

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Disparities in cervical and breast cancer mortality in Brazil

Revista de Saúde Pública ◽

10.1590/s0034-8910.2014048005214 ◽

2014 ◽

Vol 48 (3) ◽

pp. 459-467 ◽

Cited By ~ 35

Author(s):

Vania Reis Girianelli ◽

Carmen Justina Gamarra ◽

Gulnar Azevedo e Silva

Keyword(s):

Breast Cancer ◽

Cervical Cancer ◽

Cancer Mortality ◽

Breast Cancer Mortality ◽

Mortality Rates ◽

Capital City ◽

Economic Research ◽

Annual Percent Change ◽

Increased Risk ◽

Cervical Cancer Mortality

OBJECTIVE To analyze cervical and breast cancer mortality in Brazil according to socioeconomic and welfare indicators. METHODS Data on breast and cervical cancer mortality covering a 30-year period (1980-2010) were analyzed. The data were obtained from the National Mortality Database, population data from the Brazilian Institute of Geography and Statistics database, and socioeconomic and welfare information from the Institute of Applied Economic Research. Moving averages were calculated, disaggregated by capital city and municipality. The annual percent change in mortality rates was estimated by segmented linear regression using the joinpoint method. Pearson’s correlation coefficients were conducted between average mortality rate at the end of the three-year period and selected indicators in the state capital and each Brazilian state. RESULTS There was a decline in cervical cancer mortality rates throughout the period studied, except in municipalities outside of the capitals in the North and Northeast. There was a decrease in breast cancer mortality in the capitals from the end of the 1990s onwards. Favorable socioeconomic indicators were inversely correlated with cervical cancer mortality. A strong direct correlation was found with favorable indicators and an inverse correlation with fertility rate and breast cancer mortality in inner cities. CONCLUSIONS There is an ongoing dynamic process of increased risk of cervical and breast cancer and attenuation of mortality because of increased, albeit unequal, access to and provision of screening, diagnosis and treatment.

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Poisson Regression with Misclassified Counts: Application to Cervical Cancer Mortality Rates

Journal of the Royal Statistical Society Series C (Applied Statistics) ◽

10.2307/2347906 ◽

1991 ◽

Vol 40 (1) ◽

pp. 81 ◽

Cited By ~ 29

Author(s):

A. S. Whittemore ◽

G. Gong

Keyword(s):

Cervical Cancer ◽

Cancer Mortality ◽

Poisson Regression ◽

Mortality Rates ◽

Cervical Cancer Mortality

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Analysis of cervical cancer mortality rate trends in Natal-RN, Brazil, between 2000 and 2012

Revista de Salud Pública ◽

10.15446/rsap.v21n2.68893 ◽

2019 ◽

Vol 21 (2) ◽

pp. 161-167

Author(s):

Paulo Roberto Medeiros Azevedo ◽

Joyce Bezerra Rocha ◽

Thales Allyrio Araújo de Medeiros Fernandes ◽

José Veríssimo Fernandes

Keyword(s):

Cervical Cancer ◽

Cancer Mortality ◽

Empirical Bayes ◽

Family Income ◽

Screening Program ◽

Mortality Rates ◽

P Value ◽

Average Family ◽

Historical Series ◽

Cervical Cancer Mortality

Objective To describe cervical cancer mortality rates and their corresponding trends, and to analyze the spatial correlations of this type of cancer in Natal-RN, Brazil, between 2000 and 2012.Materials and Methods The simple linear regression model, the empirical Bayes method and the Global Moran's index were used for the statistical analysis.Results The mortality coefficient of cervical cancer in Natal, standardized by age range, was 5.5 per 100 000 women. All historical series for the coefficients studied were classifiedas stable. The Global Moran's index obtained was 0.048, with a p-value for the spatial test correlation between neighborhoods of 0.300. The average family income by neighborhood showed no significant correlation to cervical cancer mortality rates.Conclusion This study found a temporal stabilization and spatial independence trend of cervical cancer mortality rates in women from Natal, as well as the absence of correlationbetween these rates and the average family income of the of the participating women distributed by neighborhoods. In view of this, changes in the public policies should be made aimed at preventing the disease; adopting these measures could positively impact the screening program, improving the coverage of Pap smears and immunization campaigns against HPV, in order to reverse this trend and achieve a reduction of mortality rates.

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Hysterectomy‐corrected cervical cancer mortality rates in Denmark during 2002‐2015: A registry‐based cohort study

Acta Obstetricia Et Gynecologica Scandinavica ◽

10.1111/aogs.13608 ◽

2019 ◽

Vol 98 (8) ◽

pp. 1063-1069 ◽

Cited By ~ 6

Author(s):

Anne Hammer ◽

Johnny Kahlert ◽

Patti E. Gravitt ◽

Anne F. Rositch

Keyword(s):

Cervical Cancer ◽

Cohort Study ◽

Cancer Mortality ◽

Mortality Rates ◽

Cervical Cancer Mortality

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Cervical cancer mortality trends in Brazil, 1981-2006

Cadernos de Saúde Pública ◽

10.1590/s0102-311x2010001200018 ◽

2010 ◽

Vol 26 (12) ◽

pp. 2399-2407 ◽

Cited By ~ 15

Author(s):

Gulnar Azevedo e Silva ◽

Vania Reis Girianelli ◽

Carmen Justina Gamarra ◽

Maria Teresa Bustamante-Teixeira

Keyword(s):

Cervical Cancer ◽

Cancer Mortality ◽

Malignant Neoplasm ◽

The State ◽

Downward Trend ◽

Mortality Trends ◽

Female Population ◽

The North ◽

Cervical Cancer Mortality ◽

Screening Coverage

The aim of this study was to describe cervical cancer mortality trends in Brazil for the period 1981-2006. Cervical cancer mortality was corrected on the basis of proportional redistribution of the deaths from "malignant neoplasm of uterus, part unspecified". Time trends were evaluated by means of simple linear regression. After correction, cervical cancer ranked second among the leading causes of death from cancer in the female population up to 2005, with a downward trend for the country as a whole, a decline in the State capitals, and a stable trend in the municipalities in the interior. A downward trend was confirmed in the State capitals in all geographic regions of the country. In the municipalities in the interior, there was an increase in the North and Northeast regions, a decline in the Southeast and South, and a stable trend in the Central-West. Although uneven, the decline began to take consistent shape in the country. Even better results could be achieved by investing in the expansion of screening coverage, especially among the populations at greatest risk.

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