scholarly journals Evidence use in E-cigarettes debates: scientific showdowns in a ‘wild west’ of research

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Katherine E. Smith ◽  
Theresa Ikegwuonu ◽  
Heide Weishaar ◽  
Shona Hilton
Keyword(s):  
Sociology Of Science ◽  
Research Quality ◽  
Middle Ground ◽  
Economic Interests ◽  
Scientific Authority ◽  
Policy Paradigm ◽  
Policy Debates ◽  
The Uk ◽  
Policy Communities ◽  
New Evidence

Abstract Background Against a backdrop of declining tobacco use, e-cigarette markets are growing. The UK now has a higher percentage of e-cigarette users than any other European country. These developments have prompted fierce discussions in scientific, advocacy and policy communities about how best to respond. This article is one of the first to examine the role of evidence in these debates. Methods We analysed 121 submissions to two Scottish policy consultations on e-cigarettes (in 2014 and 2015) and undertook interviews with 26 key informants in 2015–2016, following up with a sub-set in 2019–2020. All data were thematically coded, and our analysis was informed by insights from policy studies and the sociology of science. Results First, we affirm previous research in suggesting that e-cigarettes appeared to have triggered a breakdown of old public health alliances. Second, we demonstrate that, amid concerns about research quality and quantity, actors are guided by normative outlooks (and/or economic interests) in their assessments of evidence. Third, we show that, despite describing e-cigarette debates as contentious and polarised, actors engaging in Scottish policy debates exhibit a spectrum of views, with most interviewees occupying an uncertain ‘middle ground’ that is responsive to new evidence. Fourth, we suggest that the perceived divisiveness of e-cigarette debates is attributed to recurrent media simplifications and tensions arising from the behaviours of some actors with settled positions working to promote particular policy responses (including by strategically enrolling supportive evidence). Fifth, we argue that the actions of these actors are potentially explained by the prospect that e-cigarettes could usher in a new tobacco ‘policy paradigm’. Finally, we show how scientific authority is employed as a tool within these debates. Conclusions E-cigarette debates are likely to reconcile only if a clear majority of participants in the uncertain ‘middle ground’ settle on a more fixed position. Our results suggest that many participants in Scottish e-cigarette debates occupy this ‘middle ground’ and express concerns that can be empirically assessed, implying evidence has the potential to play a more important role in settling e-cigarette debates than previous research suggests.

scholarly journals A semi-supervised approach for rapidly creating clinical biomarker phenotypes in the UK Biobank using different primary care EHR and clinical terminology systems

JAMIA Open ◽  
2020 ◽  
Author(s):  
Spiros Denaxas ◽  
Anoop D Shah ◽  
Bilal A Mateen ◽  
Valerie Kuan ◽  
Jennifer K Quint ◽  
...  
Keyword(s):  
Primary Care ◽  
Proportional Hazards ◽  
Biomarker Discovery ◽  
Data Extraction ◽  
Cox Proportional Hazards ◽  
Research Quality ◽  
Uk Biobank ◽  
Expert Review ◽  
Cox Proportional Hazards Models ◽  
The Uk

Abstract Objectives The UK Biobank (UKB) is making primary care electronic health records (EHRs) for 500 000 participants available for COVID-19-related research. Data are extracted from four sources, recorded using five clinical terminologies and stored in different schemas. The aims of our research were to: (a) develop a semi-supervised approach for bootstrapping EHR phenotyping algorithms in UKB EHR, and (b) to evaluate our approach by implementing and evaluating phenotypes for 31 common biomarkers. Materials and Methods We describe an algorithmic approach to phenotyping biomarkers in primary care EHR involving (a) bootstrapping definitions using existing phenotypes, (b) excluding generic, rare, or semantically distant terms, (c) forward-mapping terminology terms, (d) expert review, and (e) data extraction. We evaluated the phenotypes by assessing the ability to reproduce known epidemiological associations with all-cause mortality using Cox proportional hazards models. Results We created and evaluated phenotyping algorithms for 31 biomarkers many of which are directly related to COVID-19 complications, for example diabetes, cardiovascular disease, respiratory disease. Our algorithm identified 1651 Read v2 and Clinical Terms Version 3 terms and automatically excluded 1228 terms. Clinical review excluded 103 terms and included 44 terms, resulting in 364 terms for data extraction (sensitivity 0.89, specificity 0.92). We extracted 38 190 682 events and identified 220 978 participants with at least one biomarker measured. Discussion and conclusion Bootstrapping phenotyping algorithms from similar EHR can potentially address pre-existing methodological concerns that undermine the outputs of biomarker discovery pipelines and provide research-quality phenotyping algorithms.

To bee or not to beet with neonicotinoids

2021 ◽  
Vol 23 (2) ◽  
pp. 103-109
Author(s):  
Lynda M. Warren
Keyword(s):  
Sugar Beet ◽  
Weather Conditions ◽  
The European Union ◽  
Environmental Standards ◽  
Economic Interests ◽  
Precautionary Approach ◽  
The United Kingdom ◽  
Commercial Sugar ◽  
The Uk ◽  
First Time

In January 2021 the UK government granted an application for authorisation to use thiamethoxam, a neonicotinoid pesticide, to protect commercial sugar beet crops from attack by viruses transmitted by aphids. This was the first time such an authorisation had been granted in the United Kingdom (UK) and there were concerns that it signalled a weakening of environmental standards now that the UK was no longer part of the European Union. In fact, similar authorisations had been granted by several European Member States in the last 2 years, despite the ban on the use of neonicotinoids introduced in 2018. Nevertheless, the reasons for granting the authorisation do suggest that the balance between adopting a precautionary approach to environmental protection and taking emergency action to protect economic interests may have shifted. It was acknowledged that the proposed mitigation to safeguard bees and other wildlife was not entirely satisfactory. In the end, due to unforeseen weather conditions it meant that the pesticide is not necessary, which in itself demonstrates that short-term emergency measures are unsuitable for dealing with the problem. If the sugar beet industry is to continue to prosper in the UK, it will need to be managed in a way that provides resistance to virus infection without the use of controversial chemicals.

‘Feels like I'm doing it on my own’: Examining the Synchronicity between Policy Responses and the Circumstances and Experiences of Mortgage Borrowers in Arrears

2011 ◽  
Vol 11 (1) ◽  
pp. 117-129 ◽  
Author(s):  
Alison Wallace
Keyword(s):  
Policy Framework ◽  
State Support ◽  
Safety Nets ◽  
Mortgage Debt ◽  
Policy Responses ◽  
The Uk ◽  
New Evidence

The previous administration introduced several measures to prevent mortgage possessions, some of which were modestly effective. However, these hastily introduced initiatives were insufficient to bridge the gap between a fragmented policy framework and borrowers’ circumstances and experiences of managing mortgage debt. The present restructuring of welfare and regulation represents a unique window to address these long-standing policy omissions in relation to sustainable homeownership in the UK. However, in the context of weakening state support, it is uncertain how or indeed whether, the opportunity to reform mortgage safety nets will be grasped. This article reflects upon the continuing misalignment of policy with borrowers’ circumstances and experiences of mortgage arrears using new evidence from this downturn.

scholarly journals TOP-DOWN OR BOTTOM-UP? EMPLOYING A MIDDLE-GROUND APPROACH IN DESIGNING A UK ACADEMIC WRITING COURSE FOR ADVANCED CHINESE GRADUATES

2020 ◽  
pp. 095
Author(s):  
Ivo Ganchev
Keyword(s):  
Design Process ◽  
Academic Writing ◽  
Course Design ◽  
Middle Ground ◽  
Top Down ◽  
Bottom Up ◽  
Postgraduate Study ◽  
Writing Course ◽  
Second Tier ◽  
The Uk

This article documents the academic writing course design process for advanced Chinese learners aiming to pursue postgraduate degrees in business-related fields at their respective target universities in the UK. Four holders of BA degrees in the social sciences from second tier universities in Beijing were tested, surveyed and observed in detail to design a non-terminal twenty-hour pre-sessional writing course (ten two-hour sessions) to assist in their preparation for postgraduate study. All students held offers from Russell Group universities in the UK and had covered the IELTS requirement (6.5-7.0) for admission there prior to signing up for the EAP course discussed in this paper. The aim of the course is to enhance the students’ academic skills and improve their performance in the following year when they attend UK universities. The course design process is informed by two sets of principles, incorporating both a top-down and a bottom-up perspective. The former is framed within an understanding of EAP as academic, rather than language training. The latter is based on needs analysis of student-specific weaknesses explored through the use of a questionnaire, a diagnostic writing test and in-class observations. Both perspectives feed into the course goals and objectives which serve as a basis for the course rationale. Aiming to bridge the gap between Chinese undergraduate and UK postgraduate study, the course combines textbooks with authentic materials and formative with summative assessment. Reflections on major constraints and limitations are provided throughout the process. This documented case of academic writing course design aims to reveal challenges faced by EAP practitioners working with UK and Chinese institutions, and to present a middle ground approach to resolving tensions between top-down and bottom-up pressures in the context of course design for advanced Chinese graduates.

At what cost?

2021 ◽  
Vol 23 (4) ◽  
pp. 14-16
Author(s):  
Sue Cowley
Keyword(s):  
Social Mobility ◽  
Government Funding ◽  
Current Situation ◽  
Policy Debates ◽  
The World ◽  
The Uk ◽  
The Impact

With childcare in the UK now being some of the most expensive in the world, questions about the sustainability of settings and the impact of funding on social mobility are at the centre of policy debates. Sue Cowley takes a look at the current situation with government funding and assesses the impact of the 30 hours entitlement.

The Role of the Directors

2021 ◽  
pp. 125-194
Author(s):  
Eva Micheler
Keyword(s):  
Public Interest ◽  
Company Law ◽  
Economic Interests ◽  
Financial Reports ◽  
The Public ◽  
Company Directors ◽  
The Board Of Directors ◽  
The Law ◽  
The Uk

This chapter describes the role of the directors. The duties of the directors are owed to the company and while the shareholders are the primary indirect beneficiaries of those duties, the law integrates the interests of creditors and also of wider society. The law is primarily focused on ensuring compliance with the Companies Act and the constitution rather than with the enhancement of economic interests. The Company Directors Disqualification Act 1986 serves as a mechanism through which the public interest is integrated into company law, while the UK Corporate Governance Code adds a further procedural dimension to the operation of the board of directors. The chapter then looks at how the idea of designing remuneration in a way that guides the directors to act either for the benefit of the shareholder or for the benefit of the company is flawed and has served as a motor justifying increasing rewards without bringing about commensurate increases in performance. It also analyses the duties of the directors to keep accounting records and to produce financial reports.

Crisis, What Crisis?

2020 ◽  
pp. 1-16
Author(s):  
Geoffrey Meen ◽  
Christine Whitehead
Keyword(s):  
Housing Policy ◽  
Global Financial Crisis ◽  
The Political ◽  
Fiscal Policies ◽  
Policy Debates ◽  
Key Policy ◽  
The Global Financial Crisis ◽  
The Uk ◽  
Analytical Approaches ◽  
Housing Outcomes

The opening chapter provides an overview of the topics covered in the book, set in the context of the key policy debates that have taken place in recent years, not just in the UK but across countries facing similar issues. The chapter introduces the analytical approaches to be used. The methods are primarily those of economists – including modern as well as traditional techniques - but recognise the insights of other disciplines and the political constraints under which housing operates. The chapter stresses that housing cannot be divorced from the macroeconomy and monetary and fiscal policies are often more important to housing outcomes than policies directly aimed at housing. But housing also influences the economy which, particularly since the Global Financial Crisis, has added further constraints on housing policy.

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