scholarly journals Distribution of inflammatory phenotypes among patients with asthma in Jilin Province, China: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Bingqing Shi ◽  
Wei Li ◽  
Hongna Dong ◽  
Mengting Xu ◽  
Yuqiu Hao ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Inflammatory Cell ◽  
Cross Sectional Study ◽  
Jilin Province ◽  
Cell Phenotype ◽  
Blood Collection ◽  
Sectional Study ◽  
Cross Sectional ◽  
Cell Counts ◽  
Inflammatory Phenotypes

Abstract Background The inflammatory phenotypes of asthma predict the treatment response and prognosis. The phenotype distributions differ depending on the geographical region. This study aimed to assess the distribution of different inflammatory phenotypes among asthma patients in Jilin Province, China. Methods A total of 255 patients with asthma were recruited from Jilin Province, China for this cross-sectional study. Each patient underwent sputum induction following clinical assessment and peripheral blood collection. Inflammatory phenotypes were classified according to the inflammatory cell counts in the sputum. Results Paucigranulocytic asthma (PGA) was the most common inflammatory phenotype (52.2%), followed by eosinophilic asthma (EA, 38.3%), mixed granulocytic asthma (MGA, 5.2%), and neutrophilic asthma (NA, 4.3%). NA was more common among patients over 45 years old and those who were treated with higher doses of inhaled corticosteroids (ICS), but was less common following antibiotics treatment (p < 0.05). The proportion of patients with EA decreased as the ICS treatment dose and time increased (p = 0.038). Patients with uncontrolled asthma had higher numbers of sputum eosinophils and neutrophils (p < 0.05). Patients with severe asthma had a higher percentage of sputum neutrophils (p < 0.05). A greater proportion of patients with NA had severe asthma (60%) compared to those with EA (18.2%) (p = 0.016). Conclusions The most common asthma inflammatory cell phenotype in Jilin Province, China is PGA, followed by EA, MGA, and NA. The low prevalence of NA in Jilin Province compared to other countries and also other regions in China might be due to excessive antibiotic use and irregular ICS treatment in this region.

The needs and well‐being of severe asthma and COPD carers: A cross‐sectional study

Respirology ◽  
2021 ◽  
Author(s):  
Eleanor C. Majellano ◽  
Vanessa L. Clark ◽  
Peter G. Gibson ◽  
Juliet M. Foster ◽  
Vanessa M. McDonald
Keyword(s):  
Severe Asthma ◽  
Well Being ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals The Identification and Description of Severe Asthma Patients in a Cross-Sectional Study —the Ideal Study

2016 ◽  
Vol 137 (2) ◽  
pp. AB103 ◽  
Author(s):  
Robert Y. Suruki ◽  
Necdet Gunsoy ◽  
Ji-Yeon Shin ◽  
Jonas Daugherty ◽  
Linda Nelsen ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Asthma Patients ◽  
Ideal Study ◽  
The Ideal

scholarly journals Prevalence and distribution of hypertension and related risk factors in Jilin Province, China 2015: a cross-sectional study

BMJ Open ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. e020126 ◽  
Author(s):  
Junduo Wu ◽  
Tianyi Li ◽  
Xianjing Song ◽  
Wei Sun ◽  
Yangyu Zhang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Body Mass ◽  
Alcohol Drinking ◽  
Cross Sectional Study ◽  
Jilin Province ◽  
Sectional Study ◽  
Cross Sectional ◽  
Related Risk ◽  
Modifiable Factors

ObjectiveThis study aimed to investigate the prevalence and distribution of hypertension and its related factors in Jilin province, China.DesignA cross-sectional study in four cities and four rural counties in Jilin as part of a national Chinese study.Participants and settingA total of 15 206 participants who were ≥15 years old and were selected using a stratified multistage random sampling method.Main outcome measuresThe prevalence of hypertension.ResultsThe prevalence of hypertension in Jilin province was 24.7%. Moreover, the prevalence of hypertension increased with age in both sexes, and was higher in men than in women. The modifiable factors that were associated with hypertension were body mass index, smoking and alcohol drinking. The risk factors identified are similar to those in southern China, except smoking, which has no association with hypertension prevalence in the South.ConclusionsAge, sex, body mass index, smoking and alcohol drinking were risk factors of hypertension. Control of these related risk factors, especially smoking, may be helpful in the treatment and management of hypertension in Jilin province.

scholarly journals Sputum Induction in Children and Adolescents with Problematic Severe Asthma: Success Rate, Safety and Tolerability

2015 ◽  
Vol 8 (1) ◽  
pp. 7-13
Author(s):  
Cristiane de Abreu T. Ricci ◽  
Laura Maria de Lima B. F. Lasmar ◽  
Paulo M. Pitrez ◽  
Raimundo F. Mascarenhas ◽  
Paulo A. M. Camargos
Keyword(s):  
Success Rate ◽  
Severe Asthma ◽  
Pediatric Patients ◽  
Isotonic Saline ◽  
Cross Sectional Study ◽  
Forced Expiratory Volume ◽  
Sputum Induction ◽  
Cross Sectional ◽  
Inflammatory Processes ◽  
Inflammatory Phenotypes

Background: In problematic severe asthma (PSA), inflammatory phenotypes can by identified by assessing cellularity in induced sputum (IS) samples. However, there have been few studies employing sputum induction (SI) in pediatric patients. Objectives: To assess the success rate, safety and tolerability of SI, as well as IS sample cellularity, in pediatric PSA patients. Methods: We conducted a cross-sectional study involving 44 pediatric PSA patients. We collected IS samples using inhalations of nebulized saline solution. On the basis of the post-bronchodilator forced expiratory volume in one second (FEV1, % of predicted), we administered nebulization with 4.5% hypertonic saline (for patients with an FEV1 ≥ 60%) or 0.9% isotonic saline (for those with an FEV1 < 60%). We classified IS samples as satisfactory if there was ≤ 20% squamous cell contamination and cell viability was > 50%. Results: The observed success rate was 75% (95% CI: 60-86). Most of the patients provided satisfactory samples, although multiple SI sessions were required in some cases (27%). In comparison with the IS samples containing > 20% squamous cells, those containing ≤ 20% showed significantly more neutrophils (P = 0.02) and eosinophils (P = 0.03). The most common adverse events were mild wheezing (in 14%) and salty taste (in 9%). In 8% of the sessions, there was a ≥ 20% decrease in FEV1. Conclusion: In our sample of pediatric patients with PSA, sputum induction was safe and generally well tolerated, suggesting that it could be useful in the assessment of inflammatory processes in such patients.

scholarly journals Comparison between CT and RT-PCR in a cohort of symptomatic patients with suspected COVID-19 pneumonia during the outbreak peak in Italy

2020 ◽  
Author(s):  
Giulia Besutti ◽  
Paolo Giorgi Rossi ◽  
Valentina Iotti ◽  
Lucia Spaggiari ◽  
Riccardo Bonacini ◽  
...  
Keyword(s):  
Cross Sectional Study ◽  
Ground Glass ◽  
Reference Standard ◽  
Sectional Study ◽  
Rt Pcr ◽  
Cross Sectional ◽  
Oxygen Saturation Level ◽  
Blood Tests ◽  
Cell Counts ◽  
Italian Cohort

Abstract Objective: To assess sensitivity and specificity of CT vs RT-PCR for the diagnosis of COVID-19 pneumonia in a prospective Italian cohort of symptomatic patients during the outbreak peak.Methods: In this cross-sectional study we included all consecutive patients who presented to the ER between March 13th and 23rd for suspected COVID-19 and underwent both CT and RT-PCR within 3 days. Using a structured report, radiologists prospectively classified CTs in highly suggestive, suggestive, and non-suggestive of COVID-19 pneumonia. Ground-glass, consolidation, and visual extension of parenchymal changes were collected. Three different RT-PCR-based reference standard definitions were used. Oxygen saturation level, CRP, LDH, and blood cell counts were collected and compared between CT/RT-PCR classes.Results: The study included 696 patients (41.4% women; age 59±15.8 years): 423/454 (93%) patients with highly suggestive CT, 97/127 (76%) with suggestive CT, and 31/115 (27%) with non-suggestive CT had positive RT-PCR. CT sensitivity ranged from 73% to 77% and from 90% to 94% for high and low positivity threshold, respectively. Specificity ranged from 79% to 84% for high positivity threshold and was about 58% for low positivity threshold. PPV remained ≥90% in all cases. Ground-glass was more frequent in patients with positive RT-PCR in all CT classes. Blood tests were significantly associated with RT-PCR and CT classes. Leukocytes, lymphocytes, neutrophils, and platelets decreased, CRP and LDH increased from non-suggestive to suggestive CT classes.Conclusions: During the outbreak peak, CT presented high PPV and may be considered a good reference to recognize COVID-19 patients while waiting for RT-PCR confirmation.

scholarly journals Airway Microbiome in Different Inflammatory Phenotypes of Asthma: A Cross-Sectional Study in Northeast China

2019 ◽  
Vol 16 (3) ◽  
pp. 477-485 ◽  
Author(s):  
Zhiqiang Pang ◽  
Guoqiang Wang ◽  
Peter Gibson ◽  
Xuewa Guan ◽  
Weijie Zhang ◽  
...  
Keyword(s):  
Northeast China ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Airway Microbiome ◽  
Inflammatory Phenotypes
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