scholarly journals Follicular lymphoid hyperplasia of the posterior maxillary site presenting as uncommon entity: a case report and review of the literature

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Masato Watanabe ◽  
Ai Enomoto ◽  
Yuya Yoneyama ◽  
Michihide Kohno ◽  
On Hasegawa ◽  
...  
Keyword(s):  
Lymphoid Hyperplasia ◽  
Germinal Centers ◽  
Resected Specimen ◽  
Unusual Site ◽  
Case Presentation ◽  
Lymphoid Follicles ◽  
Complete Surgical Resection ◽  
Left Posterior ◽  
Nodular Growth ◽  
Oral And Maxillofacial Region

Abstract Background Follicular lymphoid hyperplasia (FLH) is characterized by an increased number and size of lymphoid follicles. In some cases, the etiology of FLH is unclear. FLH in the oral and maxillofacial region is an uncommon benign entity which may resemble malignant lymphoma clinically and histologically. Case presentation We report the case of a 51-year-old woman who presented with an asymptomatic firm mass in the left posterior maxillary site. Computed tomography scan of her head and neck showed a clear circumscribed solid mass measuring 28 × 23 mm in size. There was no evidence of bone involvement. Incisional biopsy demonstrated benign lymphoid tissue. The patient underwent complete surgical resection. Histologically, the resected specimen showed scattered lymphoid follicles with germinal centers and predominant small lymphocytes in the interfollicular areas. Immunohistochemically, the lymphoid follicles were positive for CD20, CD79a, CD10, CD21, and Bcl6. The germinal centers were negative for Bcl2. Based on these findings, a diagnosis of benign FLH was made. There was no recurrence at 1 year postoperatively. Conclusions We diagnosed an extremely rare case of FLH arising from an unusual site and whose onset of entity is unknown. Careful clinical and histopathological evaluations are essential in making a differential diagnosis from a neoplastic lymphoid proliferation with a nodular growth pattern.

scholarly journals THE EFFECT OF LYMPHOCYTOSIS INDUCED WITH EMBRYONIC EXTRACT ON THE COURSE OF EXPERIMENTAL TUBERCULOSIS IN RABBITS

1932 ◽  
Vol 56 (2) ◽  
pp. 173-183 ◽  
Author(s):  
Kenneth C. Smithburn
Keyword(s):  
Chick Embryo ◽  
Lymph Nodes ◽  
Blood Cells ◽  
Lymphoid Hyperplasia ◽  
Germinal Centers ◽  
Experimental Tuberculosis ◽  
Embryo Extract ◽  
Chick Embryo Extract ◽  
Tuberculosis In Children ◽  
Immature Cells

1. Chick embryo extract given intravenously did not favorably influence the course of experimental tuberculosis in rabbits, although it did cause lymphocytosis and lymphoid hyperplasia. 2. The tuberculous animals treated with chick embryo extract showed lower values for hemoglobin and red blood cells than tuberculous controls inoculated from the same suspension. 3. Under the conditions of these experiments an increase in the number of young, immature cells in the lymph nodes was accompanied by more extensive tuberculous lesions in the lymph nodes and especially in the germinal centers of the nodes. A possible analogy to lymphatic tuberculosis in children is suggested. 4. The observations of previous investigators on the progression and later regression of lesions in experimental tuberculosis have been confirmed. The distribution, character, and extent of lesions have been studied and are presented in tabular form. 5. The presence and significance of tuberculous thrombi in the lungs are discussed.

scholarly journals Unusual Site for a White Nodule on the Palatine Tonsil: Presentation, Differential Diagnosis, and Discussion

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Ashwag Yagoub Aloyouny
Keyword(s):  
Differential Diagnosis ◽  
Clinical Presentation ◽  
Surgical Intervention ◽  
Fungal Infections ◽  
The Body ◽  
Palatine Tonsil ◽  
Unusual Site ◽  
Case Presentation ◽  
Lymphoepithelial Cysts ◽  
Malignant Lesions

Introduction. Palatine tonsils are part of the mucosa-associated lymphoid tissue, located in the oropharyngeal region. Although these tissues protect the body from foreign intruders, they are more prone to infections due to their anatomical structure and location. For instance, the differential diagnosis of a white lesion on the palatine tonsil can range from benign to malignant lesions. Oral lymphoepithelial cysts commonly arise as painless, yellowish nodules on the floor of the mouth and the ventral or lateral surface of the tongue. Case Presentation. This paper presents a rare case of an unusual site of a lymphoepithelial cyst (LEC) in the oral cavity. The lesion was located in the tonsil of a 20-year-old woman with a chief complaint of a painless, white lump in the back of the mouth for nine months. Discussion. The differential diagnosis of a white lesion on the palatine tonsil is caused by several factors, such as bacterial, viral, and fungal infections; trauma; stones; cysts; abscess; or cancer. In this case, both the clinical presentation and extra- and intraoral examinations were highly associated with LEC. Oral LEC etiopathogenesis is uncertain, and several theories have been proposed to discuss the causes of LEC. In addition, oral LEC could be monitored without surgical intervention if the nodule is asymptomatic. Conclusion. We emphasize the importance of a thorough clinical examination of oral and oropharyngeal lesions, which are usually neglected.

Angiolymphoid Hyperplasia With Eosinophilia Associated With Pregnancy: A Case Report and Review of the Literature

2005 ◽  
Vol 129 (9) ◽  
pp. 1168-1171 ◽  
Author(s):  
Neda Zarrin-Khameh ◽  
James E. Spoden ◽  
Ruc M. Tran
Keyword(s):  
Case Reports ◽  
Inflammatory Cells ◽  
Germinal Centers ◽  
Second Trimester ◽  
Review Of The Literature ◽  
Lymphoid Follicles ◽  
Oral Contraceptive Pills ◽  
Angiolymphoid Hyperplasia With Eosinophilia ◽  
Angiolymphoid Hyperplasia ◽  
Contraceptive Pills

Abstract A case of angiolymphoid hyperplasia with eosinophilia (ALH) is reported in a 33-year-old woman who developed an auricular nodule during the second trimester of her pregnancy. Angiolymphoid hyperplasia with eosinophilia usually occurs on the head and neck of young adults and is more common in women than in men. Characteristic histologic features of ALH present in this case included proliferation of thick-walled blood vessels lined by prominent endothelial cells, infiltration of the interstitium by chronic inflammatory cells (mainly eosinophils), and presence of lymphoid follicles with germinal centers. The auricular tumor was completely excised. Thirteen months after excision, the patient remains tumor free. Although there are not many case reports on ALH during pregnancy or involving use of oral contraceptive pills, sex hormones may play a role in the pathogenesis of ALH. This hypothesis, in the context of cases previously described in the literature, and the differential diagnosis of ALH are discussed.

scholarly journals Protruded duodenal tumor arising from Santorini’s duct of the pancreas: a rare case of intraductal papillary mucinous neoplasm mimicking a duodenal polypoid tumor

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Haruna Komatsubara ◽  
Hiroyuki Kato ◽  
Daisuke Noguchi ◽  
Kazuyuki Gyoten ◽  
Aoi Hayasaki ◽  
...  
Keyword(s):  
Intraductal Papillary Mucinous Neoplasm ◽  
Rare Case ◽  
Resected Specimen ◽  
Case Presentation ◽  
Duodenal Tumor ◽  
Mucinous Neoplasm ◽  
First Case ◽  
Enhanced Ct ◽  
Duodenal Lumen ◽  
Polypoid Tumor

Abstract Background We experienced a rare case of intraductal papillary mucinous neoplasm arising from Santorini’s duct (SD) forming a tumor protruding into the duodenum . Case presentation A 71-year-old woman was incidentally diagnosed with a 3 cm type Isp polypoid tumor in the second portion of the duodenum at another hospital. Enhanced CT and endoscopic ultrasound revealed that the origin of this protruding tumor was arising from SD and that the tumor mimicked a pedunculated duodenal tumor. Our preoperative diagnosis was a malignant pancreatic tumor arising from SD with invasion into the duodenum. She underwent a subtotal stomach-preserving pancreaticoduodenectomy, and the resected specimen showed a 25 mm tumor protruding into the duodenum with a villous surface. The pathological findings revealed that the tumor was intraductal papillary mucinous adenoma (IPMA) arising from SD. Conclusions To the best of our knowledge, this is the first case of IPMA protruding into the duodenal lumen from SD, although most of the tumors arising from SD have been reported to be malignant.

scholarly journals Sirolimus for the Treatment of Airway Obstruction due to Indolent T-Lymphoblastic Proliferation

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Eric Moughames ◽  
Ana P. Kiess ◽  
Lee M. Akst ◽  
Antoine Azar
Keyword(s):  
Lymph Node ◽  
Adverse Effects ◽  
Cervical Lymph Node ◽  
Lymphoid Hyperplasia ◽  
Clinical Findings ◽  
Base Region ◽  
Case Presentation ◽  
Effective Role ◽  
T Lymphoblasts

Introduction. Indolent T-lymphoblastic proliferation (iT-LBP) is a rare nonmalignant entity that presents as a proliferation of T-lymphoblasts. We report a first such case with a recurrent laryngeal obstruction presentation that was successfully controlled with Sirolimus. Case presentation. This is the case of a 29-year-old female who presented with a recurrent significant lymphoid hyperplasia in the adenoid and tongue base region as well as a right cervical lymph node. After repeated adenoidectomies and tonsillectomies, and based on pathological and clinical findings she was diagnosed with iT-LBP. Trials of radiotherapy and immunotherapy with cyclosporine and rituximab all failed to control the progression of the disease. Sirolimus was finally able to restrict the growth and improve her symptoms. Conclusion. While It-LBP does not usually require treatment, it is important to report cases in which treatment was crucial for the survival of the patient, and the effective role of Sirolimus in doing so, without any major adverse effects.

scholarly journals The monoclonality of human B-cell lymphomas.

1977 ◽  
Vol 145 (4) ◽  
pp. 1014-1028 ◽  
Author(s):  
R Levy ◽  
R Warnke ◽  
R F Dorfman ◽  
J Haimovich
Keyword(s):  
B Cell ◽  
Lymphoid Hyperplasia ◽  
Cell Populations ◽  
Reactive Lymphoid Hyperplasia ◽  
Frozen Sections ◽  
B Cell Lymphomas ◽  
Lymphoid Follicles ◽  
Human Lymphoma ◽  
Double Label ◽  
Human B Cell

Human tissues involved with lymphoma have been examined in frozen sections for immunoglobulin-bearing cells by a technique involving double-label immunofluorescence with mixed anti-kappa and anti-lambda antibodies. F (ab')2 fragments of purified antibodies were employed to avoid any binding via Fc receptors. B cell lymphomas were shown to be composed of monoclonal populations of Ig bearing cells, whereas normal or reactive lymphoid follicles contained a mosaic of Ig-bearing cells derived from multiple clones. Nodules of lymphoma were often surrounded by normal polyclonal B cell populations. We anticipates that the approach described here will be useful in the diagnosis of lymphoma, differentiating it from reactive lymphoid hyperplasia by the demostration of monoclonality. In addition, it should provide a sensitive and reliable tool for investigating the immunobiology of human lymphoma.

Benign Lymphoid Hyperplasia of the Tongue Masquerading as Carcinoma: Case Report and Literature Review

2005 ◽  
Vol 6 (3) ◽  
pp. 111-119 ◽  
Author(s):  
Sunitha Carnelio ◽  
Gabriel Rodrigues
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Lymphoid Hyperplasia ◽  
Germinal Centers ◽  
Major Surgery ◽  
Benign Lymphoid Hyperplasia ◽  
Mononuclear Infiltrate ◽  
Carcinoma Of The Tongue

Abstract Lymphoid hyperplasia of the tongue is a very rare benign lymphoproliferative lesion that closely resembles carcinoma or lymphoma, clinically or histopathologically. A case of benign lymphoid hyperplasia (BLH) of the tongue is reported. Clinically this lesion presented as a painless ulcer, which mimicked carcinoma of the tongue. Microscopy showed typical histologic features of multiple germinal centers with a rim of small mature lymphocytes together with a mixed, mainly mononuclear infiltrate which clinched the diagnosis of benign lymphoid hyperplasia. This diagnosis averted extensive investigations and major surgery. The etiology of these lesions is unknown. Their distinction from carcinoma and lymphoma is discussed. Citation Carnelio S, Rodrigues G. Benign Lymphoid Hyperplasia of the Tongue Masquerading as Carcinoma: Case Report and Literature Review. J Contemp Dent Pract 2005 August;(6)3:111-119.

scholarly journals A Case Presentation of Gastrointestinal Stromal Tumor of Duodenum

2021 ◽  
Vol 5 (1) ◽  
pp. 49-53
Author(s):  
Aamir Ghazanfar ◽  
Afifa Asghar ◽  
Farrukh Zaman ◽  
Hassan Mumtaz ◽  
Shahzeb Habib ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Abdominal Distension ◽  
Stromal Tumor ◽  
Palpable Mass ◽  
Case Presentation ◽  
Complete Surgical Resection ◽  
Abdominal Examination ◽  
Duodenal Gists ◽  
The Right ◽  
Common Mesenchymal Tumor

A gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. It is caused by the mutation in KIT and PDGFRα genes. It constitutes <1% of all gastrointestinal tumors. Duodenal GISTs constitute 4.5% of all GISTs. We report a 61-year-old lady, presented with generalized abdominal pain, vomiting, abdominal distension, and nausea for the last 3 years. Physical exam-ination showed a pallor and on abdominal examination, a large palpable mass was extending from the pelvis to the right upper quadrant of the abdomen. The CT scan showed a large heterogeneously echogenic mass in the abdomen and pelvis with no lymphadenopathy and distant metastasis in this region. Laparotomy showed a large globular mass extending from the pelvis to the right upper quadrant of the abdomen adherent to the wall of a third part of the duodenum. Complete surgical resection of tumor done with an intact capsule. Microscopic examination showed neoplastic spindle cells with tumor necrosis. An immunohistochemical study confirmed GIST.

scholarly journals Primary mediastinal seminoma with florid follicular lymphoid hyperplasia: a case report and review of the literature

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Charlotte Holmes ◽  
Peh Sun Loo ◽  
Sion Barnard
Keyword(s):  
Germ Cell Tumors ◽  
Median Sternotomy ◽  
Surgical Excision ◽  
Lymphoid Hyperplasia ◽  
Radiological Imaging ◽  
Review Of The Literature ◽  
Case Presentation ◽  
Oncological Treatment ◽  
Mediastinal Tumours ◽  
Mediastinal Seminoma

Abstract Background First described in 1955 Primary mediastinal seminomas are rare. Only 1–4% of mediastinal tumours are germ cell tumors; majority of which are teratomas. They typically present in men aged between 20 and 40 years. Very few cases are reported in the literature. Florid follicular lymphoid hyperplasia can obscure the malignant cells and is a rarer finding still. We present a rare case of a 48 year old man with a primary mediastinal seminoma with florid follicular lymphoid hyperplasia; found following excision of a clinically presumed thymoma. Case presentation A 48 year old man was referred for excision of a thymic mass. The presumed diagnosis was a thymoma; following preoperative investigations. The mass was incidentally found on a radiological imaging. However, the patient did report mid-sternal discomfort on lying flat and breathlessness. The patient underwent a thymectomy via a partial median sternotomy with good recovery. Histological assessment was that the mass was in fact a primary mediastinal seminoma with florid follicular lymphoid hyperplasia. A primary testicular malignancy was excluded and the patient required no further oncological treatment. Conclusions Only 11 cases have previously been reported of primary mediastinal seminoma with florid follicular lymphoid hyperplasia. Although rare, a primary mediastinal seminoma should be considered as a differential diagnosis for presentations with a thymic mass. Tumour markers can be helpful, however are only positive in third of cases. Ultrasound imaging of the gonads is essential to exclude a primary gonadal lesion. Pure seminomas are radiotherapy and chemotherapy sensitive however the mainstay treatment of primary mediastinal seminomas remains surgical excision. Radiotherapy is reserved postoperatively for incomplete surgical margins.

scholarly journals Thyroglossal cyst at unusual site: a rare case presentation

2019 ◽  
Vol 5 (5) ◽  
pp. 1419
Author(s):  
Toshi Janardan ◽  
Jas Simran Singh Bhatia
Keyword(s):  
Young Male ◽  
Thyroglossal Duct Cyst ◽  
Excision Biopsy ◽  
Thyroglossal Cyst ◽  
Unusual Site ◽  
Duct Cyst ◽  
Case Presentation ◽  
Thyroglossal Duct ◽  
Superior Mediastinum ◽  
Base Of The Tongue

<p>Thyroglossal duct cyst is a congenital lesion in the anterior side of neck which results from embryonic remnant of the descending thyroglossal duct. It may get enlarge by infection, inflammation or mucous retention but can be found anywhere in the midline from the base of the tongue to thyroid gland. Most commonly it is present infrahyoid only. In this case, it is present at an unusual site at suprasternal region. A young male presented in the OPD with a single, non-tender swelling in the midline at suprasternal region, almost reaching upto superior mediastinum. After radiological examination and histopathological excision biopsy, it came out to be thyroglossal cyst. No recurrence had occurred.</p>

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