Clinical characteristics of 134 convalescent patients with COVID-19 in Guizhou, China

Abstract Background Previous studies have focused on the clinical characteristics of hospitalized patients with the novel 2019 coronavirus disease (COVID-19). Limited data are available for convalescent patients. This study aimed to evaluate the clinical characteristics of discharged COVID-19 patients. Methods In this retrospective study, we extracted data for 134 convalescent patients with COVID-19 in Guizhou Provincial Staff Hospital from February 15 to March 31, 2020. Cases were analyzed on the basis of demographic, clinical, and laboratory data as well as radiological features. Results Of 134 convalescent patients with COVID-19, 19 (14.2%) were severe cases, while 115 (85.8%) were non-severe cases. The median patient age was 33 years (IQR, 21.8 to 46.3), and the cohort included 69 men and 65 women. Compared with non-severe cases, severe patients were older and had more chronic comorbidities, especially hypertension, diabetes, and thyroid disease (P < 0.05). Leukopenia was present in 32.1% of the convalescent patients and lymphocytopenia was present in 6.7%, both of which were more common in severe patients. 48 (35.8%) of discharged patients had elevated levels of alanine aminotransferase, which was more common in adults than in children (40.2% vs 13.6%, P = 0.018). A normal chest CT was found in 61 (45.5%) patients during rehabilitation. Severe patients had more ground-glass opacity, bilateral patchy shadowing, and fibrosis. No significant differences were observed in the positive rate of IgG and/or IgM antibodies between severe and non-severe patients. Conclusion Leukopenia, lymphopenia, ground-glass opacity, and fibrosis are common in discharged severe COVID-19 patients, and liver injury is common in discharged adult patients. We suggest physicians develop follow-up treatment plans based on the different clinical characteristics of convalescent patients.

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Clinical characteristics of 134 convalescent patients with COVID-19 in Guizhou, China

10.21203/rs.3.rs-41986/v2 ◽

2020 ◽

Author(s):

Siqin Zhang ◽

Lin Liu ◽

Bin Yang ◽

Rou Li ◽

Jianhua Luo ◽

...

Keyword(s):

Clinical Characteristics ◽

Laboratory Data ◽

Ground Glass Opacity ◽

Ground Glass ◽

The Novel ◽

Positive Rate ◽

Discharged Patients ◽

Treatment Plans ◽

Normal Chest

Abstract Background: Previous studies have focused on the clinical characteristics of hospitalized patients with the novel 2019 coronavirus disease (COVID-19). Limited data are available for convalescent patients. This study aimed to evaluate the clinical characteristics of discharged COVID-19 patients.Methods: In this retrospective study, we extracted data for 134 convalescent patients with COVID-19 in Guizhou Provincial Staff Hospital from February 15 to March 31, 2020. Cases were analyzed on the basis of demographic, clinical, and laboratory data as well as radiological features. Results: Of 134 convalescent patients with COVID-19, 19 (14.2%) were severe cases, while 115 (85.8%) were non-severe cases. The median patient age was 33 years (IQR, 21.8 to 46.3), and the cohort included 69 men and 65 women. Compared with non-severe cases, severe patients were older and had more chronic comorbidities, especially hypertension, diabetes, and thyroid disease (P<0.05). Leukopenia was present in 32.1% of the convalescent patients and lymphocytopenia was present in 6.7%, both of which were more common in severe patients. 48 (35.8%) of discharged patients had elevated levels of alanine aminotransferase, which was more common in adults than in children (40.2% vs 13.6%, P=0.018). A normal chest CT was found in 61 (45.5%) patients during rehabilitation. Severe patients had more ground-glass opacity, bilateral patchy shadowing, and fibrosis. No significant differences were observed in the positive rate of IgG and/or IgM antibodies between severe and non-severe patients.Conclusion: Leukopenia, lymphopenia, ground-glass opacity, and fibrosis are common in discharged severe COVID-19 patients, and liver injury is common in discharged adult patients. We suggest physicians develop follow-up treatment plans based on the different clinical characteristics of convalescent patients.

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Clinical characteristics of 134 convalescent patients with COVID-19 in Guizhou, China

10.21203/rs.3.rs-41986/v1 ◽

2020 ◽

Author(s):

Siqin Zhang ◽

Lin Liu ◽

Bin Yang ◽

Rou Li ◽

Jianhua Luo ◽

...

Keyword(s):

Clinical Characteristics ◽

Laboratory Data ◽

Ground Glass Opacity ◽

Ground Glass ◽

The Novel ◽

Positive Rate ◽

Discharged Patients ◽

Treatment Plans ◽

Normal Chest

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Analysis of Chest CT Results of Coronavirus Disease 2019 (COVID-19) Patients at First Follow-Up

Canadian Respiratory Journal ◽

10.1155/2020/5328267 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8 ◽

Cited By ~ 1

Author(s):

Lingshan Zhong ◽

Shuo Zhang ◽

Jigang Wang ◽

Xinqian Zhao ◽

Kai Wang ◽

...

Keyword(s):

Ground Glass Opacity ◽

Chest Ct ◽

Ground Glass ◽

Imaging Data ◽

Exclusion Criteria ◽

Pulmonary Lesions ◽

Normal Chest ◽

Time Of Admission ◽

Better Than

Objective. To investigate the dissipation and outcomes of pulmonary lesions at the first follow-up of patients who recovered from moderate and severe cases of COVID-19. Methods. From January 21 to March 3, 2020, a total of 136 patients with COVID-19 were admitted to our hospital. According to inclusion and exclusion criteria, 52 patients who recovered from COVID-19 were included in this study, including 33 moderate cases and 19 severe cases. Three senior radiologists independently and retrospectively analyzed the chest CT imaging data of 52 patients at the last time of admission and the first follow-up after discharge, including primary manifestations, concomitant manifestations, and degree of residual lesion dissipation. Results. At the first follow-up after discharge, 16 patients with COVID-19 recovered to normal chest CT appearance, while 36 patients still had residual pulmonary lesions, mainly including 33 cases of ground-glass opacity, 5 cases of consolidation, and 19 cases of fibrous strip shadow. The proportion of residual pulmonary lesions in severe cases (17/19) was statistically higher than in moderate cases (19/33) ( χ 2 = 5 . 759 , P < 0.05 ). At the first follow-up, residual pulmonary lesions were dissipated to varying degrees in 47 cases, and lesions remained unchanged in 5 cases. There were no cases of increased numbers of lesions, enlargement of lesions, or appearance of new lesions. The dissipation of residual pulmonary lesions in moderate patients was statistically better than in severe patients (Z = −2.538, P < 0.05 ). Conclusion. Clinically cured patients with COVID-19 had faster dissipation of residual pulmonary lesions after discharge, while moderate patients had better dissipation than severe patients. However, at the first follow-up, most patients still had residual pulmonary lesions, which were primarily ground-glass opacity and fibrous strip shadow. The proportion of residual pulmonary lesions was higher in severe cases of COVID-19, which required further follow-up.

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Clinical Characteristics of Coronavirus Disease 2019 in Hainan, China

10.1101/2020.03.19.20038539 ◽

2020 ◽

Cited By ~ 10

Author(s):

Shijiao Yan ◽

Xingyue Song ◽

Feng Lin ◽

Haiyan Zhu ◽

Xiaozhi Wang ◽

...

Keyword(s):

Clinical Characteristics ◽

Early Stage ◽

Laboratory Data ◽

Ground Glass Opacity ◽

The Elderly ◽

Rt Pcr ◽

Rapid Spread ◽

The World ◽

Imported Cases ◽

Discharged Patients

AbstractBackgroundSince January 2020, coronavirus disease 2019 (Covid-19) has spread rapidly and developing the pandemic model around the world. Data have been needed on the clinical characteristics of the affected patients in an imported cases as model in island outside Wuhan.MethodsWe conducted a retrospective study included all 168 confirmed cases of Covid-19 in Hainan province from 22 January 2020 to 13 March 2020. Cases were confirmed by real-time RT-PCR and were analysed for demographic, clinical, radiological and laboratory data.ResultsOf 168 patients, 160 have been discharged, 6 have died and 2 remain hospitalized. The median age was 51.0 years and 51.8% were females. 129 (76.8%) patients were imported cases, and 118 (70.2%), 51 (30.4%) and 52 (31%) of patients lived in Wuhan or traveled to Wuhan, had contact with Covid-19 patients, or had contact with Wuhan residents, respectively. The most common symptoms at onset of illness were fever (65.5%), dry cough (48.8%) and expectoration (32.1%). On admission, ground-glass opacity was the most common radiologic finding on chest computed tomography (60.2%). The elderly people with diabetes, hypertension and CVD are more likely to develop severe cases. Follow-up of 160 discharged patients found that 20 patients (12.5%) had a positive RT-PCR test results of pharyngeal swabs or anal swabs or fecal.ConclusionsIn light of the rapid spread of Covid-19 around the world, early diagnosis and quarantine is important to curb the spread of Covid-19 and intensive treatments in early stage is to prevent patients away from critical condition.

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Clinical Characteristics and Risk Factors of Mortality Among Severe COVID-19 Patients

10.21203/rs.3.rs-166002/v1 ◽

2021 ◽

Author(s):

Reham Mohamed Elmorshedy ◽

Maha Mohamed El-kholy ◽

Alaa Eldin AbdelMoniem ◽

Shimaa Abbas Hassan ◽

Samiaa Hamdy Sadek

Keyword(s):

Risk Factors ◽

Clinical Characteristics ◽

Laboratory Data ◽

Ground Glass Opacity ◽

Older Age ◽

Ground Glass ◽

Neutrophil Lymphocyte Ratio ◽

Lymphocyte Ratio ◽

Increased Risk ◽

D Dimer

Abstract Background:The novel corona virus is attacking several millions of people worldwide, resulting in death of almost a million and a half-humans. The rational of the current study was to detect clinical characteristics of severe COVID- 19 patients, and assessment of risk factors for death.Methodology:This retrospective cohort study included all laboratory confirmed COVID-19 patients with severe disease admitted to critical care unit in June and July 2020. All recorded data were collected,which included clinincal, radiological, and laboratory data, in addition to the outcome and duration of ICU stay.Statistical analysis was performed for obtaining descriptive information, comparison between living and dead patients,in addition to regression analysis to identify risk factors for mortality.Results:One hundred and three patients were included in the current study;cough and fever were the most common clinical presentations, and bilateral ground glass opacity was the most common radiological presentation. Patients had elevated values of neutrophils, neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), serum ferritin, CRP, and D-dimer, also had longer ICU stay ,with reduced values of lymphocytes, and PaO2/FIO2 ratio. Most of these variables were more exaggerated in dead patients compared to living ones. Older age, lower values of PaO2/FIO2 ratio, and higher values of neutrophils, NLR, and D-dimer were predictors for death.Conclusion: Cough, fever and bilateral ground glass opacity were the most common clinical and radiological presentation of severe COVID 19. Older age, lower value of PaO2/FIO2 ratio, and higher values of D- dimer, neutrophil and NLR were risk factors associated with increased risk of mortality.

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Follow-up Chest CT findings from discharged patients with severe COVID-19: an 83-day observational study

10.21203/rs.3.rs-27359/v1 ◽

2020 ◽

Author(s):

Tianhe Ye ◽

Yanqing Fan ◽

Jiacheng Liu ◽

Chongtu Yang ◽

Songjiang Huang ◽

...

Keyword(s):

Symptom Onset ◽

Virus Disease ◽

Ground Glass Opacity ◽

Chest Ct ◽

Ct Scans ◽

Ground Glass ◽

Ct Findings ◽

Lung Abnormalities ◽

Discharged Patients

Abstract Background: Chest computed tomography (CT) has been used to be a monitoring measure to assess the severity of lung abnormalities in corona virus disease 19 (COVID-19). Up to date, there has been no reports about follow-up chest CT findings from discharge patients with severe COVID-19. This study aims to describe the change pattern of radiological abnormalities from admission, to discharge, and to the last chest CT follow-up through an 83-day retrospective observation, and focuses on follow-up chest CT findings in discharged patients with severe COVID-19.Methods: Twenty-nine discharged patients (17 males, 12 females; median age, 56 years, IQR, 47-67) confirmed with severe COVID-19 from 13 January to 15 February were enrolled in this study. A total of 80 chest CT scans was performed from admission to the last follow-up. Images were mainly evaluated for ground-glass opacity, consolidation, parenchymal bands, and crazy-paving pattern. A semi-quantitative CT scoring system was used for estimating lung abnormalities of each lobe.Results: All patients received nasal cannula or/and high-flow mask oxygen therapy. Admission occurred 9 days (IQR, 5-13) after symptom onset. The median in-hospital period was 18 days (IQR, 11-26). The last follow-up chest CT was performed 66 days (IQR, 61-77) after symptom onset. Total CT scores in follow-up decreased significantly compared to that of performed in-hospital ([3, IQR, 0-5] to [13, IQR, 10-16], P < 0.001). Predominant patterns on follow-up chest CT performed 64 days after symptom onset were subpleural parenchymal bands (47%, 9/19) and complete radiological resolution (37%, 7/19). Consolidation absorbed earlier than ground-glass opacity did, and subpleural parenchymal bands were the longest-lasting feature during radiological resolution.Conclusions: Radiological abnormalities in patients of severe COVID-19 could be completely absorbed with no residual lung injury in more than two months’ follow-up. Serial chest CT scans could be used as a monitoring modality to help clinician better understand the disease course.

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Stepwise progression from ground-glass opacity towards invasive adenocarcinoma: Long-term follow-up of radiological findings

Lung Cancer ◽

10.1016/j.lungcan.2007.09.001 ◽

2008 ◽

Vol 60 (2) ◽

pp. 298-301 ◽

Cited By ~ 21

Author(s):

Hiroshi Soda ◽

Yoichi Nakamura ◽

Katsumi Nakatomi ◽

Nanae Tomonaga ◽

Hiroyuki Yamaguchi ◽

...

Keyword(s):

Ground Glass Opacity ◽

Ground Glass ◽

Radiological Findings ◽

Invasive Adenocarcinoma ◽

Long Term Follow Up

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Acute Megakaryocytic Leukemia with or Without Acquired Trisomy 21 in 15 Pediatric Patients

10.21203/rs.3.rs-107199/v1 ◽

2020 ◽

Author(s):

Wenzhi ZHANG ◽

Hui LI ◽

Jingzhen LIU ◽

Jiawei XU ◽

Jinjin HAO ◽

...

Keyword(s):

Trisomy 21 ◽

Poor Prognosis ◽

Clinical Characteristics ◽

Pediatric Patients ◽

Laboratory Data ◽

Clinical Manifestations ◽

The Other ◽

Hematopoietic Stem ◽

Acute Megakaryocytic Leukemia

Abstract The knowledge of clinical characteristics and prognosis of pediatric acute megakaryocytic leukemia (AMKL) with or without acquired +21 was limited. We reported 15 AMKL pediatric patients without Down Syndrome (four cases with acquired +21 and 11 cases without acquired +21) with the clinical manifestations, laboratory data, and prognosis. The clinical features and laboratory data between patients with acquired +21 and patients without acquired +21 are similar. As for prognosis, three of the 11 cases without acquired +21 obtained complete remission (CR) after 1st induction. The median follow-up time of the 11 cases was 9 months. Among four cases with acquired +21, one case gave up treatment during 1st induction, one obtained CR after 1st induction and was still alive after 49 months of follow-up. One case obtained CR after 2nd induction and was still alive for 15 months of follow-up after bone marrow transplantation, the other patient was planning for allogeneic hematopoietic stem cell transplantation (HSCT) without CR. The median follow-up time of the four cases was 12 months. None relapsed in our study. In conclusion, acquired trisomy 21 may not be an indicator for poor prognosis. Cytogenetics analysis can help us for diagnosis stratification, prognostic judgment and individualized treatment of AMKL.

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Predicting the 30-day Adverse Outcomes of Non-Critical New-Onset COVID-19 Patients in Emergency Departments based on their Lung CT Scan Findings; A Pilot Study for Derivation an Emergency Scoring Tool

Frontiers in Emergency Medicine ◽

10.18502/fem.v5i4.6691 ◽

2021 ◽

Author(s):

Alireza Jalali ◽

Ehsan Karimialavijeh ◽

Parto Babaniamansour ◽

Ehsan Aliniagerdroudbari ◽

Sepideh Babaniamansour

Keyword(s):

Ct Scan ◽

Prediction Models ◽

Ground Glass Opacity ◽

Adverse Outcomes ◽

Ground Glass ◽

Global Health Issue ◽

Discharged Patients ◽

History Of ◽

Scoring Tool ◽

New Onset

Introduction: Coronavirus Disease (COVID‐19) has become the most important global health issue, and chest computed tomography (CT) scan can help determine the severity of the infection. Objectives: This study aimed to provide an emergency scoring tool for predicting 30-day adverse outcomes in non-critical new-onset COVID-19 patients. Methods: This derivation study was conducted on new-onset COVID-19 patients presenting to the emergency department of an urban teaching hospital in Tehran, Iran, between 20 February and 20 March 2020. The total lobe severity score (TSS), age, history of comorbidities, and 30-day adverse outcomes (death, ICU admission or intubation) were taken into account to produce three prediction models. Results: Overall, 137 patients were included in the study. Their mean age was 59.9±16.8 years and 62% were male. The ground glass nodule, patch B/punctate ground-glass opacity, fibrous stripes, and air bronchogram sign with perihilar distribution, bilateral and ≥ 2 affected lobes were the most common findings. The mean TSS (model 1) was significantly higher in patients with an adverse outcome (9.4±3.2) compared to the discharged patients (7.2±3.3) (p<0.001, AUC: 0.703, sensitivity: 64.4% and specificity: 74.1%). The optimal cut-off point of model 2 (TSS and age) had the following parameters: AUC: 0.721, sensitivity: 71.2% and specificity: 67.2%. The optimal cut-off point of model 3 (TSS, age, comorbidities) had: AUC: 0.755, sensitivity: 79.7% and specificity: 65.5%. The discrimination achieved with model 3 based on Bonferroni’s test was significantly better than that achieved with TSS (p<0.001). Conclusion: TSS combined with age and history of at least one comorbidity had a better predictive value for adverse outcomes with a cut-off point above 8.

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Spontaneous regression of pulmonary pure ground-glass opacity with progression of a solid component during a 40-month follow-up

Chest Disease Reports ◽

10.4081/cdr.2011.e14 ◽

2011 ◽

Vol 1 (1) ◽

pp. 14

Author(s):

Nobuaki Ochi ◽

Nagio Takigawa ◽

Masayuki Yasugi ◽

Daijiro Harada ◽

Hiromichi Yamane ◽

...

Keyword(s):

Early Stage ◽

Lung Nodule ◽

Ground Glass Opacity ◽

Solid Component ◽

Smoking History ◽

Ground Glass ◽

Bronchioloalveolar Carcinoma ◽

In Situ Carcinoma ◽

Fibrotic Scar

A 75-year-old man with a 50 pack-year smoking history underwent a right upper lobectomy due to an early stage lung adenocarcinoma. Simultaneously, pure ground-glass opacity (GGO) on the left upper lobe measuring 6.7 mm in diameter was detected on computed tomography (CT), which was considered atypical adenomatous hyperplasia, a bronchioloalveolar carcinoma, or focal organizing pneumonia/fibrosis. Eighteen months later, the diameter of the lesion increased to 9.0 mm. The lesion further enlarged to 10.4 mm with a small solid component within the GGO at 28 months after the initial CT scan. At the 33- month follow-up, the lesion had decreased in size and a solid component was prominent. Forty months after the initial CT, the lesion seemed to be a fibrotic scar. To the best of our knowledge, no studies have reported a pure GGO progressing with a solid component that regressed spontaneously over such a long period. Although this case seems rare, physicians should be aware that a lung nodule compatible with progression from in situ carcinoma to invasive carcinoma on CT could resolve over 24 months.

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