scholarly journals Comprehensive analysis of prognostic alternative splicing signature in cervical cancer

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Dong Ouyang ◽  
Ping Yang ◽  
Jing Cai ◽  
Si Sun ◽  
Zehua Wang
Keyword(s):  
Cervical Cancer ◽  
Alternative Splicing ◽  
Comprehensive Analysis

scholarly journals Splicing Genomics Events in Cervical Cancer: Insights for Phenotypic Stratification and Biomarker Potency

Genes ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 130
Author(s):  
Flavia Zita Francies ◽  
Sheynaz Bassa ◽  
Aristotelis Chatziioannou ◽  
Andreas Martin Kaufmann ◽  
Zodwa Dlamini
Keyword(s):  
Cervical Cancer ◽  
Alternative Splicing ◽  
Cancer Progression ◽  
Molecular Mechanisms ◽  
Therapy Resistance ◽  
Splicing Factors ◽  
Aberrant Splicing ◽  
Molecular Alteration ◽  
Common Cancer ◽  
Potential Biomarkers

Gynaecological cancers are attributed to the second most diagnosed cancers in women after breast cancer. On a global scale, cervical cancer is the fourth most common cancer and the most common cancer in developing countries with rapidly increasing mortality rates. Human papillomavirus (HPV) infection is a major contributor to the disease. HPV infections cause prominent cellular changes including alternative splicing to drive malignant transformation. A fundamental characteristic attributed to cancer is the dysregulation of cellular transcription. Alternative splicing is regulated by several splicing factors and molecular changes in these factors lead to cancer mechanisms such as tumour development and progression and drug resistance. The serine/arginine-rich (SR) proteins and heterogeneous ribonucleoproteins (hnRNPs) have prominent roles in modulating alternative splicing. Evidence shows molecular alteration and expression levels in these splicing factors in cervical cancer. Furthermore, aberrant splicing events in cancer-related genes lead to chemo- and radioresistance. Identifying clinically relevant modifications in alternative splicing events and splicing variants, in cervical cancer, as potential biomarkers for their role in cancer progression and therapy resistance is scrutinised. This review will focus on the molecular mechanisms underlying the aberrant splicing events in cervical cancer that may serve as potential biomarkers for diagnosis, prognosis, and novel drug targets.

scholarly journals Comprehensive analysis of alternative splicing in rice and comparative analyses with Arabidopsis

BMC Genomics ◽  
2006 ◽  
Vol 7 (1) ◽  
Author(s):  
Matthew A Campbell ◽  
Brian J Haas ◽  
John P Hamilton ◽  
Stephen M Mount ◽  
C Robin Buell
Keyword(s):  
Alternative Splicing ◽  
Comprehensive Analysis ◽  
Comparative Analyses

scholarly journals Comprehensive Analysis of Prognostic Alternative Splicing Signatures in Endometrial Cancer

2020 ◽  
Vol 11 ◽  
Author(s):  
Peigen Chen ◽  
Junxian He ◽  
Huixia Ye ◽  
Senwei Jiang ◽  
Yunhui Li ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Alternative Splicing ◽  
Comprehensive Analysis

scholarly journals Comprehensive analysis of mutually exclusive alternative splicing inC. elegans

Worm ◽  
2014 ◽  
Vol 3 (1) ◽  
pp. e28459 ◽  
Author(s):  
Hidehito Kuroyanagi ◽  
Satomi Takei ◽  
Yutaka Suzuki
Keyword(s):  
Alternative Splicing ◽  
Comprehensive Analysis

scholarly journals Comprehensive Analysis of Alternative Splicing in Digitalis purpurea by Strand-Specific RNA-Seq

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e106001 ◽  
Author(s):  
Bin Wu ◽  
Fengmei Suo ◽  
Wanjun Lei ◽  
Lianfeng Gu
Keyword(s):  
Alternative Splicing ◽  
Comprehensive Analysis ◽  
Rna Seq ◽  
Digitalis Purpurea

scholarly journals The Catastrophic HPV/HIV Dual Viral Oncogenomics in Concert with Dysregulated Alternative Splicing in Cervical Cancer

2021 ◽  
Vol 22 (18) ◽  
pp. 10115
Author(s):  
Rahaba Marima ◽  
Rodney Hull ◽  
Georgios Lolas ◽  
Konstantinos N. Syrigos ◽  
Minah Kgoebane-Maseko ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Alternative Splicing ◽  
Hiv Infection ◽  
Highly Active Antiretroviral Therapy ◽  
Therapeutic Potential ◽  
Public Health Problem ◽  
Hiv Infections ◽  
Vital Role ◽  
African Women ◽  
Splicing Machinery

Cervical cancer is a public health problem and has devastating effects in low-to-middle-income countries (LTMICs) such as the sub-Saharan African (SSA) countries. Infection by the human papillomavirus (HPV) is the main cause of cervical cancer. HIV positive women have higher HPV prevalence and cervical cancer incidence than their HIV negative counterparts do. Concurrent HPV/HIV infection is catastrophic, particularly to African women due to the high prevalence of HIV infections. Although various studies show a relationship between HPV, HIV and cervical cancer, there is still a gap in the knowledge concerning the precise nature of this tripartite association. Firstly, most studies show the relationship between HPV and cervical cancer at genomic and epigenetic levels, while the transcriptomic landscape of this relationship remains to be elucidated. Even though many studies have shown HPV/HIV dual viral pathogenesis, the dual molecular oncoviral effects on the development of cervical cancer remains largely uncertain. Furthermore, the effect of highly active antiretroviral therapy (HAART) on the cellular splicing machinery is unclear. Emerging evidence indicates the vital role played by host splicing events in both HPV and HIV infection in the development and progression to cervical cancer. Therefore, decoding the transcriptome landscape of this tripartite relationship holds promising therapeutic potential. This review will focus on the link between cellular splicing machinery, HPV, HIV infection and the aberrant alternative splicing events that take place in HIV/HPV-associated cervical cancer. Finally, we will investigate how these aberrant splicing events can be targeted for the development of new therapeutic strategies against HPV/HIV-associated cervical cancer.

scholarly journals Systematic profiling of alternative splicing signature reveals prognostic predictor for cervical cancer

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Yue-Xin Hu ◽  
Ming-Jun Zheng ◽  
Wen-Chao Zhang ◽  
Xiao Li ◽  
Rui Gou ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Alternative Splicing ◽  
Prognostic Markers ◽  
Univariate Analysis ◽  
Enrichment Analysis ◽  
High Morbidity ◽  
Diagnosis And Prognosis ◽  
Different Types ◽  
Genome Level ◽  
Prediction Of Prognosis

Abstract Aim Cervical cancer is a common malignant carcinoma of the gynecological tract with high morbidity and mortality. Therefore, it is crucial to elucidate the pathogenesis, prevention, diagnosis and prognosis of cervical cancer by searching for the involved key genes. Method In this study, the alternative splicing (AS) events of 253 patients with cervical cancer were analyzed, and 41,766 AS events were detected in 9961 genes. Univariate analysis was performed to screen prognostic AS events. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was used to identify the pathways in which these AS events were involved. Results We found that exon skip (ES) is the main AS event in patients with cervical cancer. There was pronounced consistency between the genes involved in overall survival and those involved in recurrence. At the same time, we found that a gene may exhibit several different types of AS events, and these different AS events may be related to prognosis. Four characteristic genes, HSPA14, SDHAF2, CAMKK2 and TM9SF1, that can be used as prognostic markers for cervical cancer were selected. Conclusion: The importance of AS events in the development of cervical cancer and prediction of prognosis was revealed by a large amount of data at the whole genome level, which may provide a potential target for cervical cancer treatment. We also provide a new method for exploring the pathogenesis of cervical cancer to determine clinical treatment and prognosis more accurately.

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