Association between plasma fatty acids and inflammatory markers in patients with and without insulin resistance and in secondary prevention of cardiovascular disease, a cross-sectional study

ObjectivesCardiovascular disease (CVD) and metabolic diseases are growing concerns among patients with HIV infection as a consequence of the improving survival of this population. We aimed to assess the relationship between CVD risk and insulin resistance in a group of black African individuals with HIV infection.MethodsThis cross-sectional study involved patients with HIV infection aged 30–74 years and followed up at the Yaoundé Central Hospital, Cameroon. Absolute CVD risk was calculated using the Framingham and the DAD CVD risk equations while the HOMA-IR index was used to assess insulin resistance (index ≥2.1).ResultsA total of 452 patients (361 women; 80%) were screened. The mean age was 44.4 years and most of the respondents were on antiretroviral therapy (88.5%). The median 5-year cardiovascular risk was 0.7% (25th−75th percentiles: 0.2–2.0) and 0.6% (0.3–1.3) according to the Framingham and DAD equations respectively. Of all participants, 47.3% were insulin resistant. The Framingham equation derived absolute CVD risk was significantly associated with insulin resistance; while no linear association was found using the DAD equation.ConclusionThe relationship between cardiovascular risk and insulin resistance in black African patients with HIV infection seems to depend on the cardiovascular risk equation used.

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Knowledge of cardiovascular disease risk factors and practice of primary prevention of cardiovascular disease by Community Pharmacists in Nigeria: a cross-sectional study

International Journal of Clinical Pharmacy ◽

10.1007/s11096-018-0744-3 ◽

2018 ◽

Vol 40 (6) ◽

pp. 1587-1595 ◽

Cited By ~ 3

Author(s):

Casmir E. Amadi ◽

Folasade O. Lawal ◽

Amam C. Mbakwem ◽

Jayne N. Ajuluchukwu ◽

David A. Oke

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Primary Prevention ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

Community Pharmacists ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Prevention Of Cardiovascular Disease

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Correction to: Knowledge of cardiovascular disease risk factors and practice of primary prevention of cardiovascular disease by Community Pharmacists in Nigeria: a cross-sectional study

International Journal of Clinical Pharmacy ◽

10.1007/s11096-019-00903-6 ◽

2019 ◽

Vol 42 (1) ◽

pp. 293-293

Author(s):

Casmir E. Amadi ◽

Folasade O. Lawal ◽

Amam C. Mbakwem ◽

Jayne N. Ajuluchukwu ◽

David A. Oke

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Primary Prevention ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

Community Pharmacists ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Prevention Of Cardiovascular Disease

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Association between polyunsaturated fatty acids and inflammatory markers in patients in secondary prevention of cardiovascular disease

Nutrition ◽

10.1016/j.nut.2016.12.006 ◽

2017 ◽

Vol 37 ◽

pp. 30-36 ◽

Cited By ~ 13

Author(s):

Ângela Cristine Bersch-Ferreira ◽

Geni Rodrigues Sampaio ◽

Marcella Omena Gehringer ◽

Maria Beatriz Ross-Fernandes ◽

Cristiane Kovacs ◽

...

Keyword(s):

Cardiovascular Disease ◽

Fatty Acids ◽

Secondary Prevention ◽

Polyunsaturated Fatty Acids ◽

Inflammatory Markers ◽

Prevention Of Cardiovascular Disease

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Relationship between Testosterone, Insulin Resistance, Inflammatory Markers and Obesity Parameters in Overweight and Obese Adolescents and Adult Males - A Cross-Sectional Study

Journal of Evidence Based Medicine and Healthcare ◽

10.18410/jebmh/2021/161 ◽

2021 ◽

Vol 8 (13) ◽

pp. 823-829

Author(s):

Rahul Valsaraj ◽

Nilanjan Sengupta ◽

Arjun Baidya ◽

Soumik Goswami ◽

Pranab Kumar Sahana

Keyword(s):

Insulin Resistance ◽

Inflammatory Markers ◽

Cross Sectional Study ◽

Model Assessment ◽

Adult Males ◽

Sectional Study ◽

Cross Sectional ◽

Obese Adolescent ◽

Waist Hip Ratio ◽

Hs Crp

BACKGROUND Obesity is a global pandemic in adolescent and adult population. Although changes in hypothalamic-pituitary-gonadal (HPG) axis with obesity is well known, there is dearth of literature from Eastern India especially with its relationship to obesity parameters, insulin resistance (IR) & inflammatory markers. We wanted to study the changes in total testosterone (TT), sex hormone binding globulin (SHBG) and calculated free testosterone (cFT) with parameters of obesity [body mass index (BMI), waist, hip, neck, wrist circumference and waist-hip ratio], insulin resistance [homeostatic model assessment (HOMA) – insulin resistance (HOMA-IR) and (HOMA2-IR) and inflammation (adiponectin and high sensitivity C-reactive protein, hs-CRP)] in overweight and obese (OWOB) adolescent and adult males. METHODS An institution based cross-sectional study was done from January 2018 to January 2020 consisting of 323 male participants including adolescent and adults presenting to or being referred for overweight or obesity to the Department of Endocrinology and non-obese volunteers. RESULTS TT was lower in OWOB groups (adolescents - 216.6 ± 82.2 vs. 259.0 ± 111.1 ng / dl; P = < 0.0001, adults - 392.3 ± 131.4 vs. 500.24 ± 137.8 ng / dl; P = < 0.0001) compared to nonobese. Luteinizing hormone (LH), SHBG and cFT was also significantly lower in OWOB groups. Obesity parameters (except waist-hip ratio), HOMA-IR, HOMA2-IR and adiponectin correlated with TT, SHBG and cFT in OWOB adults and only TT in OWOB adolescents. Hs-CRP correlated with TT, SHBG and cFT in OWOB adults. CONCLUSIONS Testosterone was found to have a significant correlation with parameters of obesity, insulin resistance, and inflammation in overweight and obese adolescent and adult males. KEYWORDS Overweight, Obesity, Insulin Resistance, Testosterone, Hypogonadism

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Polymorphisms of the TNF-α gene interact with plasma fatty acids on inflammatory biomarker profile: a population-based, cross-sectional study in São Paulo, Brazil

British Journal Of Nutrition ◽

10.1017/s0007114517001416 ◽

2017 ◽

Vol 117 (12) ◽

pp. 1663-1673 ◽

Cited By ~ 5

Author(s):

Erica Oki ◽

Marina N. Norde ◽

Antônio A. F. Carioca ◽

José M. P. Souza ◽

Inar A. Castro ◽

...

Keyword(s):

Fatty Acids ◽

Population Based ◽

Cross Sectional Study ◽

Sao Paulo ◽

Inflammatory Biomarkers ◽

Sectional Study ◽

Cross Sectional ◽

Plasma Fatty Acids ◽

Inflammatory Biomarker ◽

Tnf Α

AbstractThe aim of the present study was to investigate the relationship of four TNF-α SNP with inflammatory biomarkers and plasma fatty acids (FA), and the interaction among them in a population-based, cross-sectional study in São Paulo, Brazil. A total of 281 subjects, aged >19 and <60 years, participated in a cross-sectional, population-based study performed in Brazil. The following SNP spanning the TNF-α gene were genotyped: -238G/A (rs361525), -308G/A (rs1800629), -857C/T (rs1799724) and -1031T/C (rs1799964). In all, eleven plasma inflammatory biomarkers and plasma FA profile were determined. To analyse the interaction between TNF-α SNP and plasma FA, a cluster analysis was performed to stratify individuals based on eleven inflammatory biomarkers into two groups used as outcome: inflammatory (INF) and non-inflammatory clusters. The -238A allele carriers had higher TNF-α (P=0·033), IL-6 (P=0·013), IL-1β (P=0·037), IL-12 (0·048) and IL-10 (P=0·010) than the GG genotype. The -308A allele carriers also had lower levels of plasma palmitoleic acid (P=0·009), oleic acid (P=0·039), total MUFA (P=0·014), stearoyl-CoA desaturase (SCD) activity index-16 (P=0·007), SCD-18 (P=0·020) and higher levels of PUFA (P=0·046) and DHA (P=0·044). Significant interactions modifying the risk of belonging to the INF cluster were observed with inflammatory cluster as outcome between -857C/T and plasma α-linolenic acid (P=0·026), and also between -308G/A and plasma stearic acid (P=0·044) and total SFA (P=0·040). Our study contributes to knowledge on TNF-α SNP and their association with inflammatory biomarker levels, plasma FA and the interaction among them, of particular interest for the Brazilian population.

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