scholarly journals Age and sex are associated with the plasma lipidome: findings from the GOLDN study

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Emily Slade ◽  
Marguerite R. Irvin ◽  
Kevin Xie ◽  
Donna K. Arnett ◽  
Steven A. Claas ◽  
...  
Keyword(s):  
Lipid Lowering ◽  
Particle Sizes ◽  
Future Studies ◽  
Adult Lifespan ◽  
Age Related ◽  
Lipid Species ◽  
Males And Females ◽  
Age And Sex ◽  
Signal Intensities ◽  
Age Related Changes

Abstract Background Developing an understanding of the biochemistry of aging in both sexes is critical for managing disease throughout the lifespan. Lipidomic associations with age and sex have been reported, but prior studies are limited by measurements in serum rather than plasma or by participants taking lipid-lowering medications. Methods Our study included lipidomic data from 980 participants aged 18–87 years old from the Genetics of Lipid-Lowering Drugs and Diet Network (GOLDN). Participants were off lipid-lowering medications for at least 4 weeks, and signal intensities of 413 known lipid species were measured in plasma. We examined linear age and sex associations with signal intensity of (a) 413 lipid species; (b) 6 lipid classes (glycerolipids, glycerophospholipids, sphingolipids, sterol lipids, fatty acids, and acylcarnitines); and (c) 15 lipid subclasses; as well as with the particle sizes of three lipoproteins. Results Significant age associations were identified in 4 classes, 11 subclasses, 147 species, and particle size of one lipoprotein while significant sex differences were identified in 5 classes, 12 subclasses, 248 species, and particle sizes of two lipoproteins. For many lipid species (n = 97), age-related associations were significantly different between males and females. Age*sex interaction effects were most prevalent among phosphatidylcholines, sphingomyelins, and triglycerides. Conclusion We identified several lipid species, subclasses, and classes that differ by age and sex; these lipid phenotypes may serve as useful biomarkers for lipid changes and associated cardiovascular risk with aging in the future. Future studies of age-related changes throughout the adult lifespan of both sexes are warranted. Trial registration ClinicalTrials.gov NCT00083369; May 21, 2004.

Age-related changes in the TRB and IGH repertoires in healthy adult males and females

2021 ◽  
Author(s):  
Mingxing Gong ◽  
Xueying Li ◽  
Anqi Zheng ◽  
Hongxu Xu ◽  
Shi Xie ◽  
...  
Keyword(s):  
Healthy Adult ◽  
Adult Males ◽  
Age Related ◽  
Males And Females ◽  
Age Related Changes

Sex- and age-related differences in bilirubin concentrations in serum.

1984 ◽  
Vol 30 (8) ◽  
pp. 1380-1382 ◽  
Author(s):  
P Rosenthal ◽  
M Pincus ◽  
D Fink
Keyword(s):  
Serum Bilirubin ◽  
Pearson Correlation ◽  
Age Groups ◽  
Correlation Coefficients ◽  
Bile Pigment ◽  
Age Group ◽  
Age Related ◽  
Liver Functions ◽  
Males And Females ◽  
Age And Sex

Abstract The relation between age and sex and the concentration of bilirubin in serum was evaluated in 6740 men and 11 215 women, ages 13 to 96 years. Mean serum bilirubin concentrations in the men significantly exceeded values in the women over all age groups examined. Further, mean serum bilirubin concentrations were greatest both in males and females in the 19-24 years age group and then declined to former values, which persisted throughout life. Pearson correlation coefficients for bilirubin with liver function indices (albumin and total protein) and with hemoglobin were low in all ages and in both sexes, suggesting that bilirubin concentrations do not correlate with those liver functions not directly concerned with bile pigment processing.

scholarly journals Genetic influence on electrocardiogram time intervals and heart rate in aging mice

2009 ◽  
Vol 296 (6) ◽  
pp. H1907-H1913 ◽  
Author(s):  
Shuqin Xing ◽  
Shirng-Wreng Tsaih ◽  
Rong Yuan ◽  
Karen L. Svenson ◽  
Linda M. Jorgenson ◽  
...  
Keyword(s):  
Heart Rate ◽  
Inbred Strains ◽  
Genetic Influence ◽  
Cardiac Conduction ◽  
Qrs Complex ◽  
Time Intervals ◽  
Age Related ◽  
Males And Females ◽  
Heritability Estimates ◽  
Age Related Changes

Understanding the genetic influence on ECG time intervals and heart rate (HR) is important for identifying the genes underlying susceptibility to cardiac arrhythmias. The objective of this study was to determine the genetic influence on ECG parameters and their age-related changes in mice. ECGs were recorded in lead I on 8 males and 8 females from each of 28 inbred strains at the ages of 6, 12, and 18 mo. Significant interstrain differences in the P-R interval, QRS complex duration, and HR were found. Age-related changes in the P-R interval, QRS complex duration, and HR differed among strains. The P-R interval increased with age in 129S1/SvlmJ females. The QRS complex duration decreased with age in C57BR/J males and DBA2/J females but increased in NON/ShiLtJ females. HR decreased in C57L/J females and SM/J and P/J males but increased in BALB/cByJ males. Differences between males and females were found for HR in SJL/J mice and in the P-R interval in 129S1/SvlmJ mice. Broad-sense heritability estimates of ECG time intervals and HR ranged from 0.31 for the QRS complex duration to 0.52 for the P-R interval. Heritability estimates decreased with age for the P-R interval. Our study revealed that genetic factors play a significant role on cardiac conduction activity and age-related changes in ECG time intervals and HR.

Changes with age of mammary glands in male and female soft-furred rat, Millardia meltada, in relation to prolactin and testosterone

1994 ◽  
Vol 28 (1) ◽  
pp. 35-43
Author(s):  
H. Nagasawa ◽  
T. Mori ◽  
S. Sakamoto ◽  
S. Sassa ◽  
Y. Yamamuro ◽  
...  
Keyword(s):  
Enzyme Activities ◽  
De Novo ◽  
Serum Levels ◽  
Mammary Glands ◽  
Ventral Prostate ◽  
Male And Female ◽  
Age Related ◽  
Males And Females ◽  
Salvage Pathways ◽  
Age Related Changes

The soft-furred rat, millardia ( Millardia meltada), is characterized by the development of androgen-dependent mammary tumours only in males. The age-related changes of the activities of thymidylate synthetase (TS) and thymidine kinase (TK), which contribute to DNA synthesis through de novo and salvage pathways, respectively, and structure in the mammary glands were studied in both males and females of this species between 5-28 months of age. While TK activity had no relation to age, TS activity decreased with age in males. In the females, TK activity increased with age, but not TS activity. These enzyme activities were generally higher in females than in males. The mammary glands of both sexes consisted of fine ducts with small end-buds and the glands of males contained mostly black pigments at any age examined. In either males or females, serum levels of prolactin and testosterone related little with age, DNA synthesizing enzyme activities or structure of the mammary glands. Furthermore, elevation by pituitary grafting of circulating prolactin affected neither DNA synthesizing enzyme activities nor structure of mammary glands in both sexes. The histological structures of adrenal, testis, ovary, ventral prostate and uterus of millardia were essentially similar to those of mice or rats.

scholarly journals Ageing and thermal performance in the sub-Antarctic wingless fly Anatalanta aptera (Diptera: Sphaeroceridae): older is better

2009 ◽  
Vol 6 (3) ◽  
pp. 346-349 ◽  
Author(s):  
L. Lalouette ◽  
P. Vernon ◽  
H. Amat ◽  
D. Renault
Keyword(s):  
Thermal Performance ◽  
Recovery Period ◽  
Age Groups ◽  
Thermal Conditions ◽  
Subsequent Recovery ◽  
Old Adults ◽  
Adult Lifespan ◽  
Age Related ◽  
Males And Females ◽  
First Time

Senescence is a progressive biological process expressed in behavioural, morphological, physiological, biochemical and cellular age-related changes. Age-associated alterations in activity are regularly found in insects when examining whole-organism senescence over the adult lifespan. In addition, overall stress resistance usually decreases with senescence. In the present study, we measured the critical thermal minimum (CT min ) and the subsequent recovery period over the lifespan of the sub-Antarctic wingless fly, Anatalanta aptera . Experiments were conducted on males and females in seven age groups: newly emerged, 1.5-, 5-, 7-, 13-, 15- and 18-month-old adults. Surprisingly, CT min decreased significantly with ageing in A. aptera , from −3.8 ± 0.5°C just after the emergence to −5.6 ± 0.7°C in the 18-month-old flies. The subsequent recovery period remained similar between the seven groups tested. Our unexpected results contradict the previous data collected in other insects. We have demonstrated for the first time that ageing may improve rather than impair locomotor activity during unfavourable thermal conditions. It raises questions and challenges the literature dealing with ageing. These fascinating results also question the underpinning mechanisms involved in the improvement of the thermal performance with ageing in A. aptera .

scholarly journals International relevance of Two Measures of Awareness of Age-Related Change (AARC)

2020 ◽  
Author(s):  
Serena Sabatini ◽  
Obioha C Ukoumunne ◽  
Clive Ballard ◽  
Allyson Brothers ◽  
Roman Kaspar ◽  
...  
Keyword(s):  
Cognitive Functioning ◽  
Convergent Validity ◽  
Demographic Variables ◽  
Cognitive Health ◽  
Age Related ◽  
Males And Females ◽  
University Degree ◽  
Gains And Losses ◽  
Functioning Subscale ◽  
Age Related Changes

Abstract Background: A questionnaire assessing awareness of positive and negative age-related changes (AARC gains and losses) was developed in the US and Germany. We validated the short form of the measure (AARC-10 SF) and the cognitive functioning subscale from the 50-item version of the AARC (AARC-50) questionnaire in the UK population aged 50 and over.Methods: Data from 14,797 participants in the “blind for review” cohort were used to explore and confirm the psychometric properties of the AARC measures including: validity of the factor structure; reliability; measurement invariance across males and females and across individuals with and without a university degree; and convergent validity with measures of self-perception of aging and mental, physical, and cognitive health. We also explored the relationship between demographic variables and AARC.Results: We confirmed the two-factor structure (gains and losses) of the AARC-10 SF and the AARC-50 cognitive functioning subscale. Both scales showed good reliability and convergent validity. The meaning of AARC gains and losses was the same across males and females and across individuals with and without a university degree. Items composing AARC scales had the same meaning across individuals with and without a university degree. Items composing the AARC-50 cognitive functioning subscale had the same meaning across males and females. Two items in the AARC-10 SF had different meaning across males and females. Demographic variables significantly predicted AARC gains and losses.Conclusions: The AARC-10 SF and AARC-50 cognitive functioning subscale can help to identify UK individuals who perceive age-related changes in their mental, physical, and cognitive health.

scholarly journals Sex-Specific Retinal Anomalies Induced by Chronic Social Defeat Stress in Mice

2021 ◽  
Vol 15 ◽  
Author(s):  
Eric Arsenault ◽  
Andrée-Anne Lavigne ◽  
Samaneh Mansouri ◽  
Anne-Marie Gagné ◽  
Kimberley Francis ◽  
...  
Keyword(s):  
Social Defeat ◽  
Oscillatory Potentials ◽  
Social Defeat Stress ◽  
Major Depressive ◽  
Retinal Activity ◽  
Age Related ◽  
Chronic Social Defeat Stress ◽  
Before And After ◽  
Males And Females ◽  
Age Related Changes

Major depressive disorder (MDD) is one of the most common consequences of chronic stress. Still, there is currently no reliable biomarker to detect individuals at risk to develop the disease. Recently, the retina emerged as an effective way to investigate psychiatric disorders using the electroretinogram (ERG). In this study, cone and rod ERGs were performed in male and female C57BL/6 mice before and after chronic social defeat stress (CSDS). Mice were then divided as susceptible or resilient to stress. Our results suggest that CSDS reduces the amplitude of both oscillatory potentials and a-waves in the rods of resilient but not susceptible males. Similar effects were revealed following the analysis of the cone b-waves, which were faster after CSDS in resilient mice specifically. In females, rod ERGs revealed age-related changes with no change in cone ERGs. Finally, our analysis suggests that baseline ERG can predict with an efficacy up to 71% the expression of susceptibility and resilience before stress exposition in males and females. Overall, our findings suggest that retinal activity is a valid biomarker of stress response that could potentially serve as a tool to predict whether males and females will become susceptible or resilient when facing CSDS.

scholarly journals Charting human subcortical maturation with in vivo 7 T MRI

2021 ◽  
Author(s):  
S. Miletić ◽  
P.-L. Bazin ◽  
S.J.S. Isherwood ◽  
M. C. Keuken ◽  
A. Alkemade ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Neurodegenerative Diseases ◽  
Resonance Imaging ◽  
Subcortical Structures ◽  
Adult Lifespan ◽  
Age Related ◽  
Age Related Changes ◽  
Standard Magnetic Resonance Imaging

AbstractThe human subcortex comprises hundreds of unique structures. Subcortical functioning is crucial for behavior, and disrupted subcortical function is observed in common neurodegenerative diseases. Despite their importance, human subcortical structures continue to be difficult to study in vivo. Here, we zoom in on 17 prominent subcortical structures, by describing their approximate iron and myelin contents and thickness, and by providing detailed accounts of their age-related changes across the normal adult lifespan. The results provide compelling insights into the highly heterogeneous morphometry and intricate age-related variations of these structures. They also show that the locations of these structures shift across the lifespan, which is of direct relevance for the use of standard magnetic resonance imaging atlases. The results further our understanding of subcortical morphometry and neuroimaging properties, and of normal aging processes which ultimately can improve understanding of neurodegeneration.

Sign in / Sign up

Export Citation Format

Share Document