Prognostic Value of Platelet-Lymphocyte Ratio and High-Density Lipoprotein in Patients with Acute Myocardial Infarct

2021 ◽  
Vol 28 (1) ◽  
pp. 46
Author(s):  
Lestari Lestari ◽  
Sulina Yanti Wibawa ◽  
Amaliyah Tahir Lopa ◽  
Darmawaty Rauf
Keyword(s):  
High Density Lipoprotein ◽  
Predictive Value ◽  
Prognostic Value ◽  
Myocardial Infarct ◽  
Density Lipoprotein ◽  
High Density ◽  
Receiver Operating Characteristics ◽  
Operating Characteristics ◽  
Acute Myocardial Infarct ◽  
Lymphocyte Ratio

Acute Myocardial Infarct (AMI) is the main reason for mortality. Platelet to Lymphocyte Ratio (PLR) describesthrombocyte aggregation and inflammation that is linked to cardiovascular disease. High-Density Lipoprotein (HDL) is antiatherogenic.This study aims to analyze the prognostic value of PLR and HDL in patients with AMI. This study was aretrospective observational study by obtaining laboratory results from complete blood count and lipid profiles frominpatients with AMI (STEMI and NSTEMI) medical records during Mei 2019–August 2020. Receiver Operating Characteristics(ROC) analysis was done to get the PLR and HDL cut-off. Prognostic value evaluation was based on sensitivity, specificity,positive and negative predictive value, and accuracy. Results obtained were from 302 subjects with a mean age of 58.4+9.6years old, with most male patients (74.5%). Receiver operating characteristics curve analysis showed an 0.514 Area UnderCurve (AUC) for PLR with p=0.685. High-density lipoprotein ROC was 0.573 with a p=0.033 (p< 0.05), with HDL cut-off = 50.0;sensitivity 72.7%, specificity 32.3%, positive predictive value 63.3%, negative predictive value 42.0% and 57.3% accuracy.Platelet to lymphocyte ratio mean was lower in the HDL <50 group (187.9) compared to the HDL > 50 (210.8), (p=0.009).High-density lipoprotein can be concluded as a potential prognostic factor of acute myocardial infarct. The lower the HDL,the greater the risk for a poor prognosis. A big-scale prospective study should be held to clarify and confirm these findings.

scholarly journals Compared with the monocyte to high-density lipoprotein ratio (MHR) and the neutrophil to lymphocyte ratio (NLR), the neutrophil to high-density lipoprotein ratio (NHR) is more valuable for assessing the inflammatory process in Parkinson’s disease

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Zhu Liu ◽  
Qingli Fan ◽  
Shizheng Wu ◽  
Yaqi Wan ◽  
Yancheng Lei
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
High Density Lipoprotein ◽  
Predictive Value ◽  
Disease Duration ◽  
Density Lipoprotein ◽  
High Density ◽  
Neutrophil To Lymphocyte Ratio ◽  
Control Group ◽  
Lymphocyte Ratio

Abstract Background The inflammatory response plays essential roles in the pathological process and prognosis of Parkinson’s disease (PD). This research investigated the predictive value of the neutrophil to high-density lipoprotein ratio (NHR), neutrophil to lymphocyte ratio (NLR), and monocyte to high-density lipoprotein ratio (MHR) for PD. Methods Patients with PD (n = 98) were divided into three groups according to disease duration: < 6 years (n = 55), 6–10 years (n = 29) and > 10 years (n = 14). Based on the classification system of Hoehn and Yahr, grades 1 ~ 2.5 were considered early-stage PD (n = 44), and grades 3 ~ 5 were considered advanced-stage PD (n = 54). In addition, healthy subjects (n = 98) matched to the above PD patients in the same period were selected as the control group. Differences in the NHR, NLR, MHR and other indicators among the groups were evaluated. Results Smoking, drinking, the neutrophil count and the NHR and NLR were remarkably greater and hypertension, index of body mass, the lymphocyte count, and the levels of cholesterol in total, triglycerides, lipoprotein cholesterol with low density and uric acid were sharply lower in the PD group compared with in the control group. Analysis of multifactor logistic regression indicated that the NHR (odds ratio (adjusted OR) = 1.576, 95% CI: 1.053 ~ 2.358, P = 0.027) and NLR (adjusted OR = 1.734, 95% CI: 1.046 ~ 2.876, P = 0.033) were factors of risk for PD, while the MHR was not significantly correlated with PD. The areas under the receiver operating characteristic (ROC) curve (AUCs) for the prediction of PD by the NHR and NLR were 0.654 (95% CI: 0.583 ~ 0.721, P = 0.0001) and 0.69 (95% CI: 0.62 ~ 0.754, P < 0.0001), respectively, and the optimal cutoff values were 1.848 × 109/mmol and 2.62 × 109/mmol. Spearman’s correlation analysis indicated that the NHR was correlated with the disease duration significantly negatively and that the MHR was positively correlated with disease severity. Conclusions In summary, the NHR not only has strong predictive value for PD but is also closely related to disease duration. The NHR may be a better prediction for the long-period clinical results in PD patients than the MHR and NLR. Trial registration Clinical medical reserach center project of Qinghai Province (2017-SF-L1).

scholarly journals The preablation monocyte/ high density lipoprotein ratio predicts the late recurrence of paroxysmal atrial fibrillation after radiofrequency ablation

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
She-an Chen ◽  
Man-man Zhang ◽  
Meifang Zheng ◽  
Fei Liu ◽  
Lei Sun ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Radiofrequency Ablation ◽  
High Density Lipoprotein ◽  
Predictive Value ◽  
Density Lipoprotein ◽  
Late Recurrence ◽  
High Density ◽  
Significant Difference ◽  
Af Recurrence

Abstract Background The monocyte/high-density lipoprotein ratio (MHR) has emerged as a promising alternative biomarker in the fields of cardiovascular disease and atrial fibrillation (AF). This retrospective study was aimed to explore the predictive value of the MHR for the late recurrence of AF after radiofrequency ablation. Methods From April 2015 to October 2018, patients with paroxysmal AF who had undergone radiofrequency catheter ablation at Subei People’s Hospital of Jiangsu Province were enrolled in our study. All the participants were observed until November 2019 after the procedure. During the postoperative follow up, the patients were categorized into the recurrence group and maintenance of sinus rhythm group based on who had experienced AF recurrence. Results One hundred twenty-five patients were diagnosed with paroxysmal AF, with an average age of 61.2 ± 9.3 years. Forty-seven patients had developed late recurrence during a mean follow up of 25.1 ± 12.0 months. The AF recurrence event rates were significantly increased in the highest MHR tertile compared with those in the lowest MHR tertile (22.0% vs. 57.1%; P < 0.05). On multivariate logistic regression analysis, the preablation MHR (OR = 1.34; 95% CI = 1.12 ~ 1.60; P = 0.001) and left atrial diameter (LAD) (OR = 1.21, 95% CI = 1.08 ~ 1.35; P = 0.001) were independent risk factors predicting the recurrence of AF after radiofrequency ablation. Furthermore, receiver operating characteristic (ROC) curve analysis revealed that the area under the curve (AUC) of the MHR was 0.712 (95% CI = 0.618 ~ 0.806; P = 0.000) and that of LAD was 0.739 (95% CI = 0.653 ~ 0.814; P = 0.000). Z-test found no significant difference between the MHR and LAD regarding the AUC (Z = 0.451; P = 0.652). Conclusion An elevated preablation MHR was associated with an increased risk of the postoperative recurrence of AF. Additionally, the MHR independently predicted the late recurrence of paroxysmal AF after radiofrequency ablation, with the same predictive value as LAD.

scholarly journals Association of High Density Lipoprotein with Platelet to Lymphocyte and Neutrophil to Lymphocyte Ratios in Coronary Artery Disease Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Jayesh H. Prajapati ◽  
Sibasis Sahoo ◽  
Tushar Nikam ◽  
Komal H. Shah ◽  
Bhumika Maheriya ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
High Density Lipoprotein ◽  
Young Patients ◽  
Density Lipoprotein ◽  
High Density ◽  
Lymphocyte Ratio ◽  
Coronary Syndrome ◽  
Low Hdl ◽  
Artery Disease

Background. We aimed to evaluate a relationship between platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) with high density lipoprotein (HDL) cholesterol levels in coronary artery disease (CAD) patients.Methods. A total of 354 patients with angiographically confirmed coronary blockages were enrolled in the study. Hematological indices and lipid profiling data of all the patients were collected.Results. We have observed significant association between HDL and PLR (P=0.008) and NLR (P=0.009); however no significant relationship was obtained with HDL and isolated platelet (P=0.488), neutrophil (P=0.407), and lymphocyte (P=0.952) counts in CAD patients. The association was subjected to gender specific variation as in males PLR (P=0.024) and NLR (P=0.03) were highly elevated in low HDL patients, whereas in females the elevation could not reach the statistically significant level. The PLR (217.47 versus 190.3;P=0.01) and NLR (6.33 versus 5.10;P=0.01) were significantly higher among the patients with acute coronary syndrome. In young patients the PLR (P=0.007) and NLR (P=0.001) were inversely associated with HDL, whereas in older population only NLR (P=0.05) had showed a significant association.Conclusion. We conclude that PLR and NLR are significantly elevated in CAD patients having low HDL levels.

scholarly journals Compared with Monocyte to High-Density Lipoprotein Ratio (MHR) and Neutrophil to Lymphocyte Ratio (NLR),Neutrophil to High-Density Lipoprotein Ratio (NHR) is more Valuable in the Inflammatory Process of Parkinson's Disease

2021 ◽  
Author(s):  
Qingli Fan ◽  
Zhu Liu ◽  
Shizheng Wu ◽  
Yancheng Lei
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
High Density Lipoprotein ◽  
Early Stage ◽  
Density Lipoprotein ◽  
High Density ◽  
Neutrophil To Lymphocyte Ratio ◽  
Control Group ◽  
Course Of Disease ◽  
Lymphocyte Ratio

Abstract Background: Inflammatory response plays an important role in the pathologic process and prognosis of Parkinson's disease (PD).We investigated the relationship between the neutrophil to high-density lipoprotein ratio (NHR),neutrophil to lymphocyte ratio (NLR),and monocyte to high-density lipoprotein ratio (MHR) on the prediction of PD and its course and severity.Methods: Patients with Parkinson's disease were selected (n=101) and divided into three groups according to the onset cycle:<6 years (n=64),6-10 years (n=23) and > 10 years(n=14).And according to Hoehn and Yahr classification: 1~2.5 is the early stage (n=55);Grades 3~5 are divided into two groups (n=46).In addition, healthy subjects (n=97) matched with the above pd patients in the same period were selected as the control group.In this way, the influence of NHR, NLR, MHR and other indicators on corresponding groups is evaluated.Results: Neutrophils, NHR and NLR in PD group were significantly higher than those in control group. nevertheless, lymphocyte, total cholesterol, low density lipoprotein and hemoglobin were significantly lower than those in the control group. Multi-factor logistic regression analysis indicated that NHR (odds ratio (OR)=1.456,95%CI:1.007~2.104,P=0.046) and NLR(OR=1.663,95%CI:1.101~2.513,P=0.016) were risk factors for Parkinson's disease, while MHR had no significant correlation with Parkinson's disease. The AUC(area under the ROC curve) of PD predicted by NHR and NLR were 0.648(95%CI:0.572~0.724,P=0.0003) and 0.718 (95%CI:0.646~0.790,P<0.0001),respectively, and the critical values for optimal diagnosis were3.104×109/mmol and 1.939×109/mmol. Spearman analysis showed that NHR was significantly negatively correlated with the course of disease.Conclusions: In summary, NHR not only has strong predictive value for PD disease, but also is closely related to the course of disease. NHR levels may be better predictors of long-term clinical outcomes in PD patients than MHR and NLR.

scholarly journals Triglyceride/High-Density Lipoprotein Cholesterol Ratio is associated with the mortality of COVID-19: An Observational Study

2021 ◽  
Author(s):  
Fei Peng ◽  
Shangjie Wu ◽  
Si Lei ◽  
Quan Zhang ◽  
Yanjun Zhong
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Blood Cells ◽  
Hematological Parameters ◽  
White Blood Cells ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Operating Characteristics ◽  
Cholesterol Ratio

Abstract (1) Background: Triglyceride to high density lipoprotein cholesterol (TG/HDL-c) ratio is crucial when researching metabolic and vascular diseases, and its involvement in COVID-19 was sparsely elaborated on. The purpose of the study was to explore if there were any associations between the TG/HDL-c ratio and COVID-19 prognosis; (2) Methods: A total of 262 COVID-19 patients were retrospectively investigated. The clinical features and baseline hematological parameters were recorded and analyzed; (3) Results: Compared with the survivors, the non-survivors of COVID-19 had significantly higher levels of white blood cells (4.7 vs. 13.0 ×109/L; P < 0.001), neutrophils (3.0 vs. 11.6×109/L; P < 0.001), C-reactive proteins (15.7 vs. 76.7 mg/L; P < 0.001) and TG/HDL-c ratio (1.4 vs. 2.5; P = 0.001). The receiver operating characteristics curve [area under the curve, 0.731; 95% confidence interval, 0.609–0.853; P = 0.001] suggested that the TG/HDL-c ratio could predict the mortality of COVID-19. Moreover, the TG/HDL-c ratio was positively correlated with white blood cells (r = 0.255, P < 0.001), neutrophils (r = 0.243, P < 0.001) and C-reactive proteins (r = 0.170, P < 0.006); (4) Conclusions: Our study demonstrated that TG/HDL-c ratio may potentially be a predictive marker for mortality in COVID-19 patients.

Abstract 12156: Greater Regression of Coronary Atherosclerosis With the Pre-Beta High-Density Lipoprotein Mimetic CER-001 in Patients With More Extensive Plaque Burden

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Yu Kataoka ◽  
Jordan Andrews ◽  
MyNgan Duong ◽  
Tracy Nguyen ◽  
Nisha Schwarz ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Plaque Burden ◽  
Operating Characteristics ◽  
Chi Square ◽  
Coronary Syndrome ◽  
Imaging Characteristics ◽  
Atheroma Volume ◽  
Plaque Regression

Introduction: Infusing high-density lipoprotein (HDL) has been shown to promote plaque regression in patients with acute coronary syndrome (ACS). The factors associated with a greater propensity to regression have not been elucidated. We hypothesized greater plaque regression with HDL infusion would be observed in patients with greater baseline plaque burden. Methods: The CHI-SQUARE study compared the effect of infusing the pre-beta HDL mimetic CER-001 (3 to 12 mg/kg) versus placebo weekly for 5 weeks in patients with a recent ACS on plaque burden using serial intravascular ultrasound. Receiver operating characteristics curve analysis determined that a baseline percent atheroma volume (PAV) ≥30% optimally associated with greater regression. Clinical and imaging characteristics were compared in patients with baseline PAV <30% (n=74) or ≥30% (n=271). Results: There were no differences between the groups apart from greater use of statin in patients with baseline PAV ≥30% (100 v. 90%, p=0.01). Patients with a greater baseline PAV were more likely to demonstrate echolucency (20 v. 9%, p=0.02) and ultrasound attenuation (21 v. 7%, p=0.01), consistent with lipidic and inflammatory material. On serial evaluation, PAV decreased with CER-001 infusion in patients with baseline PAV ≥30% by -0.27% (p=0.01 v. baseline), but not in those with baseline PAV <30% (+0.43%, p=0.15 v. baseline, p=0.01 between plaque burden groups). The greatest PAV regression was observed with infusing CER-001 3 mg/kg in patients with baseline PAV ≥30% by 0.96% (p=0.04 v. baseline, p=0.02 v. placebo) (Table), but not in those patients with baseline PAV <30% (+0.08%, p=0.55 v. baseline, p=0.004 for comparison between plaque burden groups). Conclusions: Greater plaque regression with CER-001 3 mg/kg was observed in ACS patients with greater atheroma burden and more vulnerable features. The findings identify ACS patients with high-risk plaque features most likely to benefit from HDL mimetic therapy.

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