scholarly journals Cocaine and amphetamine-regulated transcript prepropeptide gene (CARTPT) polymorphism interacts with Diet Quality Index-International (DQI-I) and Healthy Eating Index (HEI) to affect hypothalamic hormones and cardio-metabolic risk factors among obese individuals

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Mahsa Mahmoudi-Nezhad ◽  
Mahdieh Abbasalizad Farhangi ◽  
Houman Kahroba
Keyword(s):  
Risk Factors ◽  
Gene Polymorphism ◽  
Healthy Eating ◽  
Diet Quality ◽  
Quality Index ◽  
Healthy Eating Index ◽  
Metabolic Risk ◽  
Diet Quality Index ◽  
Healthy Obese ◽  
Apparently Healthy

Abstract Background Epidemiologic studies show that cocaine- and amphetamine-regulated transcript prepropeptide (CARTPT) gene polymorphism modifies diet-obesity relationships. However, the interaction between CARTPT gene polymorphism and diet quality indices have not been investigated yet. The current study was aimed to evaluate the interaction between major dietary indices including Diet Quality Index-International (DQI-I) and Healthy Eating Index (HEI)-2015 and CARTPT gene rs2239670 variants among apparently healthy obese Iranians. Methods This cross-sectional study was carried out by employing 288 apparently healthy obese adults aged 20–50 years with a BMI of 30–40 kg/m2. Diet quality was evaluated by Diet Quality Index-International (DQI-I) and Healthy Eating Index-2015 (HEI-2015) using a 132-items semi-quantitative validated food frequency questionnaire. The CARTPT gene rs2239670 polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR–RFLP) technique. Blood concentrations of glycemic markers, lipid profile, α-melanocyte stimulating hormone (MSH) and agouti-related peptide (AgRP) were also measured. ANCOVA multivariate interaction model was used to analyze gene-diet interactions. Results The significant interactions were identified between CARTPT gene polymorphism and HEI, affecting BMR (PInteraction = 0.003), serum glucose (PInteraction = 0.009) and high density lipoprotein cholesterol HDL concentrations (PInteraction = 0.03) after adjusting for the effects of sex and age. Also we found gene-diet interaction between CARTPT genotypes and DQI-I in terms of fat mass (FM; PInteraction = 0.02), waist circumference (WC; PInteraction < 0.001), body mass index (BMI; PInteraction < 0.001), basal metabolic rate (BMR, PInteraction < 0.001), serum fasting glucose (PInteraction < 0.01) and AgRP (PInteraction = 0.05) in individuals even after adjusting for potential confounders. Conclusion Current study showed the effects of interaction between CARTPT genotype with adherence to HEI and DQI-I scores on obesity-related anthropometric and metabolic risk-factors.

scholarly journals The interaction between brain-derived neurotrophic factor (BDNF) Val66met polymorphism and dietary indices, The Healthy Eating Index (HEI), The Diet Quality Index-International (DQI-I) , and Phytochemical index (PI) , on anthropometric indices, inflammatory, and oxidative stress markers in patient with type2 diabetes

2021 ◽  
Author(s):  
Zeinab Naeini ◽  
Negin Aghazadeh ◽  
Elmira Karimi ◽  
Zahra Esmaeily ◽  
Faezeh Abaj ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Healthy Eating ◽  
Diet Quality ◽  
Quality Index ◽  
Healthy Eating Index ◽  
Quality Indices ◽  
Val66met Polymorphism ◽  
Diet Quality Index ◽  
Bdnf Val66met Polymorphism ◽  
And Oxidative Stress

Abstract Background: Although many studies suggest an association between BDNF Val66Met with eating disorders and obesity especially in type 2 diabetes mellitus (T2DM), the interaction between BDNF Val66Met polymorphism and diet quality indices in diabetic patients have not been investigated yet. The current study was aimed to evaluate the interaction between the diet quality indices including Healthy Eating Index (HEI), Diet Quality Index-International (DQI-I), Phytochemical Index (PI) and BDNF Val66Mat (rs6265) polymorphism on markers of inflammation, and oxidative stress in T2DM patients.Methods: This current cross-sectional study was conducted on 634 Iranian T2DM patients aged 35–65 years of both genders were randomly recruited. Dietary intakes was estimated by a food frequency questionnaire (FFQ) with 148 food items. All participants were categorized into three categories, based on DQI, HEI, and PI scores. The interactions were tested using analysis of covariance (ANCOVA) in adjusted and unadjusted models.Results: There were significant gene-diet interactions between BDNF Val66Met polymorphism and HEI, DQI, and PI scores in modulating body mass index (BMI) and waist circumference (WC) values. Our results showed that higher scores for all diet-quality indices were significantly associated with a lower BMI and WC values after adjustment (P Interactions < 0.05). We also observed a significant interaction between the DQI scores and Val66Met polymorphism on level of superoxide dismutase (SOD) (p-interaction= 0.01). The highest quartile of DQI was associated with elevated level of SOD in the Val/Met and Met/Met genotype group. Moreover, the interaction between the DQI scores and Val66Met polymorphism on total antioxidant capacity (TAC) tended to be significant.Conclusions: Higher scores for all diet-quality indices were significantly associated with a lower BMI and WC values. There were significant differences for PTX and PGF2A among HEI tertiles. The interaction between the polymorphism and DQI on TAC and SOD levels were significant.

scholarly journals Consensus among experts on healthy eating and diet quality index

2020 ◽  
Vol 25 (7) ◽  
pp. 2551-2560
Author(s):  
Simone dos Anjos Caivano ◽  
Semíramis Martins Álvares Domene
Keyword(s):  
Healthy Eating ◽  
Diet Quality ◽  
Quality Index ◽  
Healthy Eating Index ◽  
Risk Markers ◽  
Diet Quality Index ◽  
Quality Markers ◽  
Minimum Score ◽  
Meat And Eggs ◽  
Milk And Dairy Products

Abstract The article aims to achieve a consensus about Healthy Eating and Diet Quality Index to enable a validation study on the Diet Quality Index. Experts were identified among authors of articles published from 2010 to 2015 that presented the key worlds healthy eating index and diet quality index. The query was carried out by combining the Delphi technique with the Likert method. To determine a consensus, at least three of the following criteria had to be met: minimum score in each statement (≥ 3,00); standard deviation (< 1,5); frequency of agreement (≥ 51%) and differences between interquartile ranges (< 1,0). Topics regarding Highly palatable foods, oilseeds, and Meat and eggs did not arrived at a consensus in the first round. Experts proposed new themes: Gluten, Meal frequency, Alcohol consumption, and Including nutrients in the diet quality index. Although quality and risk markers in diet are periodically studied, it was only possible to reach consensus on subjects such as fruits, vegetables, milk and dairy products, legumes, and oilseeds as quality markers after theoretical justification. Processed and ready-to-eat foods, highly palatable foods, excessive sweets and fats, and alcohol were readily identified as risk factors.

scholarly journals The interaction between brain-derived neurotrophic factor (BDNF) Val66met polymorphism and dietary indices, The Healthy Eating Index (HEI), The Diet Quality Index-International (DQI-I), and Phytochemical index (PI), on anthropometric indices, inflammatory, and oxidative stress markers in patient with type2 diabetes

2021 ◽  
Author(s):  
Fariba Koohdani ◽  
Zeinab Naeini ◽  
Negin Aghazadeh ◽  
Elmira Karimi ◽  
Zahra Esmaeily ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Healthy Eating ◽  
Diet Quality ◽  
Quality Index ◽  
Healthy Eating Index ◽  
Quality Indices ◽  
Val66met Polymorphism ◽  
Diet Quality Index ◽  
Bdnf Val66met Polymorphism ◽  
And Oxidative Stress

Abstract Background: Although many studies suggest an association between BDNF Val66Met with eating disorders and obesity especially in type 2 diabetes mellitus (T2DM), the interaction between BDNF Val66Met polymorphism and diet quality indices in diabetic patients have not been investigated yet. The current study was aimed to evaluate the interaction between the diet quality indices including Healthy Eating Index (HEI), Diet Quality Index-International (DQI-I), Phytochemical Index (PI) and BDNF Val66Mat (rs6265) polymorphism on markers of inflammation, and oxidative stress in T2DM patients.Methods: This current cross-sectional study was conducted on 634 Iranian T2DM patients aged 35–65 years of both genders were randomly recruited. Dietary intakes was estimated by a food frequency questionnaire (FFQ) with 148 food items. All participants were categorized into three categories, based on DQI, HEI, and PI scores. The interactions were tested using analysis of covariance (ANCOVA) in adjusted and unadjusted models.Results: There were significant gene-diet interactions between BDNF Val66Met polymorphism and HEI, DQI, and PI scores in modulating body mass index (BMI) and waist circumference (WC) values. Our results showed that higher scores for all diet-quality indices were significantly associated with a lower BMI and WC values after adjustment (P Interactions < 0.05). We also observed a significant interaction between the DQI scores and Val66Met polymorphism on level of superoxide dismutase (SOD) (p-interaction= 0.01). The highest quartile of DQI was associated with elevated level of SOD in the Val/Met and Met/Met genotype group. Moreover, the interaction between the DQI scores and Val66Met polymorphism on total antioxidant capacity (TAC) tended to be significant.Conclusions: Higher scores for all diet-quality indices were significantly associated with a lower BMI and WC values. There were significant differences for PTX and PGF2A among HEI tertiles. The interaction between the polymorphism and DQI on TAC and SOD levels were significant.

scholarly journals Nutrient profiling and adherence to components of the UK national dietary guidelines association with metabolic risk factors for CVD and diabetes: Airwave Health Monitoring Study

2018 ◽  
Vol 119 (6) ◽  
pp. 695-705 ◽  
Author(s):  
Rebeca Eriksen ◽  
Rachel Gibson ◽  
Kathryn Lamb ◽  
Yvonne McMeel ◽  
Anne-Claire Vergnaud ◽  
...  
Keyword(s):  
Risk Factors ◽  
Waist Circumference ◽  
Diet Quality ◽  
Health Monitoring ◽  
Quality Index ◽  
Cardiometabolic Risk ◽  
Epidemiological Studies ◽  
Metabolic Risk ◽  
Point Increase ◽  
Monitoring Study

AbstractCVD is the leading cause of death worldwide. Diet is a key modifiable component in the development of CVD. No official UK diet quality index exists for use in UK nutritional epidemiological studies. The aims of this study are to: (i) develop a diet quality index based on components of UK dietary reference values (DRV) and (ii) determine the association between the index, the existing UK nutrient profile (NP) model and a comprehensive range of cardiometabolic risk markers among a British adult population. A cross-sectional analysis was conducted using data from the Airwave Health Monitoring Study (n 5848). Dietary intake was measured by 7-d food diary and metabolic risk using waist circumference, BMI, blood lipid profile, glycated Hb (HbA1c) and blood pressure measurements. Diet quality was assessed using the novel DRV index and NP model. Associations between diet and cardiometabolic risk were analysed via multivariate linear models and logistic regression. A two-point increase in NP score was associated with total cholesterol (β −0·33 mmol/l, P<0·0001) and HbA1c (β −0·01 %, P<0·0001). A two-point increase in DRV score was associated with waist circumference (β −0·56 cm, P<0·0001), BMI (β −0·15 kg/m2, P<0·0001), total cholesterol (β −0·06 mmol/l, P<0·0001) and HbA1c (β −0·02 %, P=0·002). A one-point increase in DRV score was associated with type 2 diabetes (T2D) (OR 0·94, P=0·01) and obesity (OR 0·95, P<0·0001). The DRV index is associated with overall diet quality and risk factors for CVD and T2D, supporting its application in nutritional epidemiological studies investigating CVD risk in a UK population.

scholarly journals Association between Ag-RP, alpha-MSH and cardiovascular risk factors regarding adherence to Diet Quality Index- International (DQI-I) among obese individuals

2021 ◽  
Author(s):  
Mahsa Mahmoudinezhad ◽  
Mahdieh Abbasalizad Farhangi
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Diet Quality ◽  
Quality Index ◽  
Cardiometabolic Risk ◽  
Resistance Index ◽  
Cardiometabolic Risk Factors ◽  
Model Assessment ◽  
Diet Quality Index ◽  
Adherence To Diet

Introduction: Obesity is a strong promoter of cardiometabolic risk factors and is associated with several chronic comorbidities. Recently, the role of α-melanocyte stimulating hormone (α-MSH) and agouti related peptide (Ag-RP) in regulation of energy balance has attracted much attention. In current study, we evaluated the association between α-MSH and Ag-RP with cardiometabolic factors among obese individuals with different adherence to Diet Quality Index-International (DQI-I) values. Methods: In this research, 188 obese adults aged between 20 and 50 years old and body mass index (BMI) between 30 and 40 kg/m2 were recruited. Dietary intakes of participants and DQI-I calculation was performed using a semi-quantitative food frequency questionnaire (FFQ) with 132 food items. Serum glucose, lipids, insulin, and plasma α-MSH and Ag-RP levels were measured using ELISA kits. Homeostasis model assessment for insulin resistance index (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI) were also calculated. Results: Among those with the lowest adherence to DQI-I, Ag-RP was positively associated with systolic blood pressure (SBP) (P = 0.03) among males, which was associated with waist circumference (WC) (P = 0.01) and diastolic blood pressure (DBP) (P = 0.01). Moreover, among males with low and moderate adherence to DQI-I, α-MSH was positively associated with insulin (P = 0.04), weight (P = 0.03), WC (P < 0.01), SDP (P = 0.02) and DBP (P = 0.01). Also, Ag-RP showed a positive association with BMI values (R2 = 0.03; P = 0.03). Conclusion: According to our findings, in obese subjects with poor to moderate adherence to DQI-I, Ag-RP and α-MSH were in positive correlation with cardiometabolic risk factors. These findings further clarify the clinical importance of these parameters as prognostic factors of cardiometabolic abnormalities.

scholarly journals Diet quality, excess body weight and cardiometabolic risk factors in adolescents living in São Paulo, Brazil and in the USA: differences and similarities

2020 ◽  
pp. 1-11 ◽  
Author(s):  
Jaqueline L Pereira ◽  
Josiemer Mattei ◽  
Carmen R Isasi ◽  
Linda Van Horn ◽  
Mercedes R Carnethon ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Weight ◽  
Healthy Eating ◽  
Diet Quality ◽  
Whole Grains ◽  
Sao Paulo ◽  
Healthy Eating Index ◽  
Excess Body Weight ◽  
São Paulo ◽  
The Usa

Abstract Objective: To compare diet quality and its association with excess body weight (EBW: overweight/obesity), central adiposity (CA) and CVD risk factors (CVDR) among adolescents from Brazil and USA. Design: Data from two cross-sectional surveys: Health Survey of São Paulo (ISA-Nutrition) and Hispanic Community Health Study/Study of Latino Youth (SOL-Youth). Dietary intake was assessed from 24-h recalls, and diet quality using the Alternate Healthy Eating Index-2010 (AHEI) developed in the USA and the Revised Brazilian Healthy Eating Index (BHEI-R). CVDR was defined as ≥3 of: obesity, elevated blood pressure, dyslipidaemia, high plasma glucose and insulin resistance. Adjusted OR for EBW, CA and CVDR by diet quality were tested using logistic regression. Setting: São Paulo, Brazil; and Chicago, IL; Miami, FL; Bronx, NY; San Diego, CA. Participants: Adolescents (12–16 years) living in São Paulo (n 189) and USA (n 787). Results: ISA-Nutrition individuals with EBW (v. without) had marginally lower (unhealthier) scores for whole grains using BHEI-R and sugary beverages using AHEI. SOL-Youth individuals with EBW had lower scores of nuts/legumes using AHEI, and Na using BHEI-R, but higher scores of whole grains and dairy using BHEI-R. In ISA-Nutrition, BHEI-R was inversely associated with EBW (OR = 0·87; 95 % CI 0·80, 0·95) and CVDR (OR = 0·89; 95 % CI 0·80, 0·98). In SOL-Youth, AHEI was inversely associated with EBW (OR = 0·93; 95 % CI 0·87, 0·99). Conclusions: Dietary improvements should be made by adolescents in both USA and Brazil. Healthier diet quality as measured with the country-specific index was associated with lower odds of EBW in Brazilian and USA-Hispanic/Latino adolescents, and with lower CVDR in Brazilian adolescents.

scholarly journals The Relationship Between Healthy Eating Index-2015 and Cardiometabolic Risk Factors in People with Long-Standing Spinal Cord Injury

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 540-540
Author(s):  
Jia Li ◽  
Aynur Demirel ◽  
Andres Azuero ◽  
Amie McLain ◽  
Ceren Yarar-Fisher
Keyword(s):  
Risk Factors ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Healthy Eating ◽  
Diet Quality ◽  
Cardiometabolic Risk ◽  
Healthy Eating Index ◽  
Effect Sizes ◽  
Cord Injury ◽  
The Relationship

Abstract Objectives The Healthy Eating Index (HEI)-2015 is a measure of diet quality in reference to the 2015 Dietary Guidelines for Americans. We examined the relationship between HEI-2015 and several indices of cardiometabolic risk factors among individuals with chronic spinal cord injury (SCI) (&gt;3 years after injury). Methods Twenty-four participants without type 2 diabetes were included (45 ± 12 y, 8F/16 M, 9 Tetraplegia/15 Paraplegia, time since injury: 20 ± 13 y). All participants underwent a 2-hour oral glucose tolerance test (OGTT), a Dual-energy X-ray absorptiometry scan (DXA), and 3 24-hour multiple-pass dietary recalls. HEI-2015 was calculated using the dietary recall data. To build the regression model, firstly, principal component (PC) analysis was used to reduce the number of covariates from 3 (level of injury, gender, percentage body fat estimated from the DXA) to 2 PCs. Multiple linear regression analyses were run to predict indices of lipid metabolism and glucose homeostasis as well as C-reactive protein (CRP) from the HEI and the 2 PC scores. Results The average HEI-2015 score was lower for participants with SCI compared to the general American population (48 ± 11 vs. 59, P &lt; 0.05). The regression models for fasting glucose (FG), Cholesterol, HDL, LDL, and CRP had moderate to large effect sizes (adjusted R2 &gt; 13%), indicating good explanatory ability of the predictors. Small or limited effect sizes were observed for other models (glucose tolerance, fasting insulin, triaglycerides, and Matsuda index, adjusted R2 &lt; 13% for all). Furthermore, the HEI accounted for a moderate amount of variation in FG as evidenced by partial Omega-squared of 13%. Each 10-point increase of the HEI was associated with a 3.3 mg/dL decrease in FG concentrations. However, HEI accounted for a limited amount of variations in other indices (ωP2 &lt; 5% for all). Conclusions Our exploratory analyses suggest that HEI-2015 has limited effects on blood lipids and CRP but may be associated with lower FG concentrations in our sample group. Future larger studies are warranted to delineate the relationship between diet quality and cardiometabolic health outcomes in individuals with SCI. Funding Sources The National Institute on Disability, Independent Living, and Rehabilitation Research.

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