scholarly journals Anthocyanins increase serum adiponectin in newly diagnosed diabetes but not in prediabetes: a randomized controlled trial

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Liping Yang ◽  
Wenhua Ling ◽  
Yun Qiu ◽  
Yong Liu ◽  
Li Wang ◽  
...  
Keyword(s):  
Fasting Glucose ◽  
Controlled Trial ◽  
Epidemiological Studies ◽  
Serum Adiponectin ◽  
Newly Diagnosed ◽  
Anthropometric Parameters ◽  
Significant Difference ◽  
Before And After ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes

Abstract Background Epidemiological studies have suggested that adiponectin is associated with the development of insulin resistance and type 2 diabetes. This study first examined the effect of purified anthocyanins, a group of dietary flavonoids, on serum adiponectin in patients with prediabetes and newly diagnosed diabetes. Methods A total of 160 patients with prediabetes (n = 90) or newly diagnosed diabetes (n = 70) were randomly assigned to either the anthocyanins group or the placebo group for 12 weeks of intervention. Serum adiponectin, a set of biomarkers related to glucolipid metabolism, anthropometric parameters, dietary intake and physical activity were measured before and after intervention. Results Anthocyanins increased serum adiponectin compared with placebo (net change 0.46 µg/mL, 95% CI [0.03, 0.90], p = 0.038) in the subjects with newly diagnosed diabetes. No significant difference in the change in adiponectin was observed between the two groups either in the overall subjects (0.02 µg/mL [− 0.32, 0.36], p = 0.906) or in prediabetes (− 0.35 µg/mL [− 0.85, 0.16], p = 0.174). Anthocyanins also decreased fasting glucose (− 0.5 mmol/L [− 1, − 0.04], p = 0.035) in the subjects with newly diagnosed diabetes, but no such change was observed in those with prediabetes. Conclusions Anthocyanins supplementation for 12 weeks improved serum adiponectin and fasting glucose in patients with newly diagnosed diabetes, but not in patients with prediabetes. Trial registration ClinicalTrials.gov, NCT02689765. Registered on 6 February 2016, https://clinicaltrials.gov/ct2/show/NCT02689765.

scholarly journals Anthocyanins increase serum adiponectin in newly diagnosed diabetes but not in prediabetes: a randomized controlled trial

2020 ◽  
Author(s):  
LiPing Yang ◽  
Wenhua Ling ◽  
Yun Qiu ◽  
Yong Liu ◽  
Li Wang ◽  
...  
Keyword(s):  
Fasting Glucose ◽  
Controlled Trial ◽  
Epidemiological Studies ◽  
Serum Adiponectin ◽  
Newly Diagnosed ◽  
Anthropometric Parameters ◽  
Significant Difference ◽  
Before And After ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes

Abstract Background Epidemiological studies have suggested that adiponectin is associated with the development of insulin resistance and type 2 diabetes. This study first examined the effect of purified anthocyanins, a group of dietary flavonoids, on serum adiponectin in patients with prediabetes and newly diagnosed diabetes.Methods A total of 160 patients with prediabetes (n=90) or newly diagnosed diabetes (n=70) were randomly assigned to either the anthocyanins group or the placebo group for 12 weeks of intervention. Serum adiponectin, a set of biomarkers related to glucolipid metabolism, anthropometric parameters, dietary intake and physical activity were measured before and after intervention.Results Anthocyanins increased serum adiponectin compared with placebo (net change 0.46 µg/mL, 95% CI [0.03, 0.90], p=0.038) in the subjects with newly diagnosed diabetes. No significant difference in the change in adiponectin was observed between the two groups either in the overall subjects (0.02 µg/mL [-0.32, 0.36], p=0.906) or in prediabetes (-0.35 µg/mL [-0.85, 0.16], p=0.174). Anthocyanins also decreased fasting glucose (-0.5 mmol/L [-1, -0.04], p=0.035) in the subjects with newly diagnosed diabetes, but no such change was observed in those with prediabetes.Conclusions Anthocyanins supplementation for 12 weeks improved serum adiponectin and fasting glucose in patients with newly diagnosed diabetes, but not in patients with prediabetes.

scholarly journals Anthocyanins increase serum adiponectin in newly diagnosed diabetes but not in prediabetes: a randomized controlled trial

2020 ◽  
Author(s):  
LiPing Yang ◽  
Wenhua Ling ◽  
Yun Qiu ◽  
Yong Liu ◽  
Li Wang ◽  
...  
Keyword(s):  
Fasting Glucose ◽  
Controlled Trial ◽  
Epidemiological Studies ◽  
Serum Adiponectin ◽  
Dietary Intakes ◽  
Newly Diagnosed ◽  
Anthropometric Parameters ◽  
Significant Difference ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes

Abstract Background Epidemiological studies have suggested that adiponectin is associated with the development of insulin resistance and type 2 diabetes. This study first examined the effect of purified anthocyanins, a group of dietary flavonoids, on serum adiponectin in patients with prediabetes and newly diagnosed diabetes.Methods A total of 160 patients with prediabetes (n=90) or newly diagnosed diabetes (n=70) were randomly assigned to either the anthocyanins group or the placebo group for 12 weeks intervention. Serum adiponectin, a set of biomarkers related to glucolipid metabolism, anthropometric parameters, dietary intakes and physical activities were measured before and after intervention.Results Anthocyanins increased serum adiponectin compared with placebo (net change 0.46 ug/mL, 95%CI [0.03, 0.90], p=0.038) in the subjects with newly diagnosed diabetes. No significant difference in the change of adiponectin was observed between the two groups either in the overall subjects (0.02 ug/mL [-0.32, 0.36], p=0.906) or in prediabetes (-0.35 ug/mL [-0.85, 0.16], p=0.174). Anthocyanins also decreased fasting glucose (-0.5 mmol/L [-1, -0.04], p=0.035) in the subjects with newly diagnosed diabetes, and no such change was observed in those with prediabetes.ConclusionsAnthocyanins supplementation for 12 weeks improved serum adiponectin and fasting glucose in patients with newly diagnosed diabetes, but not in patients with prediabetes.

scholarly journals Increased Arterial Stiffness in Prediabetic Subjects Recognized by Hemoglobin A1c with Postprandial Glucose but Not Fasting Glucose Levels

2019 ◽  
Vol 8 (5) ◽  
pp. 603
Author(s):  
Chung-Hao Li ◽  
Feng-Hwa Lu ◽  
Yi-Ching Yang ◽  
Jin-Shang Wu ◽  
Chih-Jen Chang
Keyword(s):  
Arterial Stiffness ◽  
Hemoglobin A1c ◽  
Pulse Wave ◽  
Glycated Hemoglobin ◽  
Fasting Glucose ◽  
Postprandial Glucose ◽  
Newly Diagnosed ◽  
Glucose Levels ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes

Previous studies exploring the association between arterial stiffness and prediabetes remain controversial. This study aimed to investigate the association of the different domains of prediabetes categorized by glycated hemoglobin A1c (A1c) 5.7–6.4%, impaired fasting glucose (IFG), fasting plasma glucose of 5.6–6.9 mmol/L, and impaired glucose tolerance (IGT), two-hour post-load glucose of 7.8–11.0 mmol/L, on arterial stiffness. These were measured by brachial–ankle pulse-wave velocity (baPWV). We enrolled 4938 eligible subjects and divided them into the following nine groups: (1) normoglycemic; (2) isolated A1c 5.7–6.4%; (3) isolated IFG; (4) IFG with A1c 5.7–6.4%; (5) isolated IGT; (6) combined IGT and IFG with A1c <5.7%; (7) IGT with A1c 5.7–6.4%; (8) combined IGT and IFG with A1c 5.7–6.4%; and (9) newly diagnosed diabetes (NDD). The baPWV values were significantly high in subjects with NDD (β = 47.69, 95% confidence interval (CI) = 29.02–66.37, p < 0.001), those with IGT with A1c 5.7–6.4% (β = 36.02, 95% CI = 19.08–52.95, p < 0.001), and those with combined IGT and IFG with A1c 5.7–6.4% (β = 27.72, 95% CI = 0.68–54.76, p = 0.044), but not in the other subgroups. These findings suggest that increased arterial stiffness was found in prediabetes individuals having an A1c 5.7–6.4% with IGT, but not IFG. Isolated A1c 5.7–6.4% and isolated IGT were not associated with elevated arterial stiffness.

scholarly journals No evidence of long-term disruption of glycometabolic control after SARS-CoV-2 infection

2021 ◽  
Author(s):  
Andrea Laurenzi ◽  
Amelia Caretto ◽  
Chiara Molinari ◽  
Alessia Mercalli ◽  
Raffaella Melzi ◽  
...  
Keyword(s):  
Public Health ◽  
Health Problem ◽  
Fasting Glucose ◽  
Fasting Blood Glucose ◽  
Public Health Problem ◽  
Newly Diagnosed ◽  
Markers Of Inflammation ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes

Abstract Purpose To assess whether dysglycaemia diagnosed during SARS-CoV-2 pneumonia may become a potential public health problem after resolution of the infection. In an adult cohort with suspected COVID-19 pneumonia, we integrated glucose data upon hospital admission with fasting blood glucose (FBG) in the year prior to COVID-19 and during post-discharge follow-up. Methods From February 25th to May 15th 2020 660 adults with suspected COVID-19 pneumonia were admitted to the San Raffaele Hospital (Milan, Italy). Through structured interviews / medical record reviews we collected demographics, clinical features and laboratory tests upon admission and additional data during hospitalization or after discharge and in the previous year. Upon admission, we classified participants according to ADA criteria as having: a) pre-existing diabetes; b) newly diagnosed diabetes; c) hyperglycaemia not in the diabetes range; d) normoglycaemia. FBG prior to admission and during follow-up were classified as normal or impaired fasting glucose and fasting glucose in the diabetes range. Results In patients with confirmed COVID (n=589) the proportion with pre-existing or newly diagnosed diabetes, hyperglycaemia not in the diabetes range and normoglycaemia was 19.6%, 6.7%, 43.7% and 30.0%, respectively. Patients with dysglycaemia associated to COVID-19 had increased markers of inflammation and organs’ injury and poorer clinical outcome compared to those with normoglycemia. After the infection resolved, the prevalence of dysglycaemia reverted to pre-admission frequency. Conclusions COVID-19 associated dysglycaemia is unlikely to become a lasting public health problem. Alarmist claims on the diabetes risk after COVID-19 pneumonia should be interpreted with caution.

scholarly journals WC is better than BMI as a predictor of diabetes and pre diabetes in Hindu priests of India

2014 ◽  
Vol 6 (1) ◽  
pp. 91-94
Author(s):  
Booloo Sharma ◽  
Devajit Sarmah
Keyword(s):  
Statistical Correlation ◽  
Medical Attention ◽  
Newly Diagnosed ◽  
Medical Sciences ◽  
Significant Difference ◽  
Measurable Parameter ◽  
Screening Study ◽  
Diagnosed Diabetes ◽  
Newly Diagnosed Diabetes ◽  
Better Than

Background & Objective: Over a period of time great emphasis has been made to prevent diabetes and its complications, and BMI have evolved into a reliable indicator for predicting the incidence of diabetes mellitus. But for a common man BMI is difficult to understand and calculate and there is a need for a more easily acceptable, understandable and measurable parameter as a predictor for diabetes risks. WC is one such parameter and the study tries to establish a correlation between (WC) and FBS with an aim to establish WC as a predictor of diabetes risks. Methods: From our ongoing diabetes screening study 220 Hindu priests were selected. This includes 55 newly diagnosed diabetes, 55 newly diagnosed pre-diabetes and 110 age matched controls. BMI, WC and FBS were calculated. A statistical correlation was established between BMI and FBS and between WC and FBS. The upper limit above which the risk association became statistically significant (P < 0.005) with pre-diabetes and diabetes were considered to be the cutoff for normal values. Results & Conclusion: The WC was 31.77 ± 2.63, 35.82 ± 1.04 and 41.07 ± 2.24 inches in controls, pre-diabetes and diabetes respectively. A statistically significant difference (P < 0.005) for WC was found between controls and pre-diabetes and diabetes. Normal cut off for waist circumference among the Hindu priest is <35 inches or <90 centimeters. Also, statistically significant correlation was established between BMI and FBS and between WC and FBS however, correlation between WC and FBS is better than the former. WC more or less correlates with the pant/pyjama/trouser size, and almost everybody is aware of their pant size. Since WC is a more understandable term for the layman and which can be measured and tracked by the layman themselves, WC could be used as a better and more beneficial predictor of diabetes risk. Simply monitoring the pant size can make the layman understand when to ring the alarm and take medical attention or modify lifestyles.DOI: http://dx.doi.org/10.3126/ajms.v6i1.10097 Asian Journal of Medical Sciences Vol.6(1) 2015 91-94

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