Quercetin and polycystic ovary syndrome, current evidence and future directions: a systematic review

Background. Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. As a widely used complementary and alternative therapy, acupuncture is increasingly used to treat PCOS. However, the effect of acupuncture in treating PCOS is uncertain, and the mechanisms are unclear. This systematic review aims to determine the efficacy of acupuncture on PCOS in animal preclinical models. Methods. Experimental animal studies of acupuncture in PCOS animal models were searched in PubMed, Web of Science, China National Knowledge Infrastructure, and the Chinese Science and Technology Periodical Database from inception to December 2020. The risk of bias was assessed using the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) risk of bias tool. Results. A total of 358 studies were screened based on the title and abstract, and 31 studies were included. A total of 722 animals were involved, and all studies used either Wistar rats or SD rats. Twenty-six studies used electroacupuncture, 9 studies used manual acupuncture, and 5 of them employed both electroacupuncture and manual acupuncture. A total of 22 acupoints were involved; 7 studies followed the modern acupuncture pattern, and the rest followed classic acupuncture theory. Conclusions. The present review summarizes the current evidence of the effects of acupuncture on PCOS in animal models. Unfortunately, we could not draw a definite conclusion due to the methodological weakness of the included studies and the high heterogeneity. Well-designed studies are needed in the future to fill this gap.

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Faculty Opinions recommendation of Inositol supplementation in women with polycystic ovary syndrome undergoing intracytoplasmic sperm injection: a systematic review and meta-analysis of randomized controlled trials.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.734283508.793559362 ◽

2019 ◽

Author(s):

Fernando Reis

Keyword(s):

Systematic Review ◽

Polycystic Ovary Syndrome ◽

Randomized Controlled Trials ◽

Intracytoplasmic Sperm Injection ◽

Polycystic Ovary ◽

Meta Analysis ◽

Controlled Trials ◽

Ovary Syndrome ◽

Randomized Controlled

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Associations Between Serum Magnesium Concentrations and Polycystic Ovary Syndrome Status: a Systematic Review and Meta-analysis

Biological Trace Element Research ◽

10.1007/s12011-020-02275-9 ◽

2020 ◽

Author(s):

Maedeh Babapour ◽

Hamed Mohammadi ◽

Maryam Kazemi ◽

Amir Hadi ◽

Mahsa Rezazadegan ◽

...

Keyword(s):

Systematic Review ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Meta Analysis ◽

Serum Magnesium ◽

Ovary Syndrome

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Non‐alcoholic fatty liver disease in premenopausal women with polycystic ovary syndrome: A systematic review and meta‐analysis

JGH Open ◽

10.1002/jgh3.12512 ◽

2021 ◽

Vol 5 (4) ◽

pp. 434-445

Author(s):

Mohamed Shengir ◽

Tianyan Chen ◽

Elena Guadagno ◽

Agnihotram V Ramanakumar ◽

Peter Ghali ◽

...

Keyword(s):

Systematic Review ◽

Liver Disease ◽

Polycystic Ovary Syndrome ◽

Fatty Liver Disease ◽

Polycystic Ovary ◽

Meta Analysis ◽

Premenopausal Women ◽

Ovary Syndrome ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

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Relationships Between Biochemical Markers of Hyperandrogenism and Metabolic Parameters in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

Hormone and Metabolic Research ◽

10.1055/a-0806-8281 ◽

2019 ◽

Vol 51 (01) ◽

pp. 22-34 ◽

Cited By ~ 6

Author(s):

Mina Amiri ◽

Fahimeh Tehrani ◽

Razieh Bidhendi-Yarandi ◽

Samira Behboudi-Gandevani ◽

Fereidoun Azizi ◽

...

Keyword(s):

Systematic Review ◽

Polycystic Ovary Syndrome ◽

Biochemical Markers ◽

Polycystic Ovary ◽

Meta Analysis ◽

Metabolic Parameters ◽

High Density Lipoproteins ◽

Total Testosterone ◽

Ovary Syndrome ◽

Increased Risk

AbstractWhile several studies have documented an increased risk of metabolic disorders in patients with polycystic ovary syndrome (PCOS), associations between androgenic and metabolic parameters in these patients are unclear. We aimed to investigate the relationships between biochemical markers of hyperandrogenism (HA) and metabolic parameters in women with PCOS. In this systematic review and meta-analysis, a literature search was performed in the PubMed, Scopus, Google Scholar, ScienceDirect, and Web of Science from 2000 to 2018 for assessing androgenic and metabolic parameters in PCOS patients. To assess the relationships between androgenic and metabolic parameters, meta-regression analysis was used. A total number of 33 studies involving 9905 patients with PCOS were included in this analysis. The associations of total testosterone (tT) with metabolic parameters were not significant; after adjustment for age and BMI, we detected associations of this androgen with low-density lipoproteins cholesterol (LDL-C) (β=0.006; 95% CI: 0.002, 0.01), high-density lipoproteins cholesterol (HDL-C) (β=–0.009; 95% CI: –0.02, –0.001), and systolic blood pressure (SBP) (β=–0.01; 95% CI: –0.03, –0.00). We observed a positive significant association between free testosterone (fT) and fasting insulin (β=0.49; 95% CI: 0.05, 0.91); this association remained significant after adjustment for confounders. We also detected a reverse association between fT and HDL-C (β=–0.41; 95% CI: –0.70, –0.12). There was a positive significant association between A4 and TG (β=0.02; 95% CI: 0.00, 0.04) after adjustment for PCOS diagnosis criteria. We also found significant negative associations between A4, TC, and LDL-C. Dehydroepiandrosterone sulfate (DHEAS) had a positive association with LDL-C (β=0.02; 95% CI: 0.001, 0.03) and a reverse significant association with HDL-C (β=–0.03; 95% CI: –0.06, –0.001). This meta-analysis confirmed the associations of some androgenic and metabolic parameters, indicating that measurement of these parameters may be useful for predicting metabolic risk in PCOS patients.

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Risk of coronary heart disease and risk of stroke in women with polycystic ovary syndrome: A systematic review and meta-analysis

International Journal of Cardiology ◽

10.1016/j.ijcard.2014.06.079 ◽

2014 ◽

Vol 176 (2) ◽

pp. 486-487 ◽

Cited By ~ 36

Author(s):

Sarah A. Anderson ◽

John A. Barry ◽

Paul J. Hardiman

Keyword(s):

Systematic Review ◽

Coronary Heart Disease ◽

Heart Disease ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Meta Analysis ◽

Ovary Syndrome

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The effect of obesity on polycystic ovary syndrome: a systematic review and meta-analysis

Obesity Reviews ◽

10.1111/j.1467-789x.2012.01053.x ◽

2012 ◽

Vol 14 (2) ◽

pp. 95-109 ◽

Cited By ~ 179

Author(s):

S. S. Lim ◽

R. J. Norman ◽

M. J. Davies ◽

L. J. Moran

Keyword(s):

Systematic Review ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Meta Analysis ◽

Ovary Syndrome

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Recombinant FSH in alternative doses or versus urinary gonadotrophins for ovulation induction in subfertility associated with polycystic ovary syndrome: a systematic review based on a Cochrane review

Human Reproduction ◽

10.1093/humrep/deg229 ◽

2003 ◽

Vol 18 (6) ◽

pp. 1143-1149 ◽

Cited By ~ 32

Author(s):

M. van Wely

Keyword(s):

Systematic Review ◽

Polycystic Ovary Syndrome ◽

Ovulation Induction ◽

Polycystic Ovary ◽

Cochrane Review ◽

Recombinant Fsh ◽

Ovary Syndrome

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The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review

Acta Endocrinologica ◽

10.1530/eje-13-0617 ◽

2013 ◽

Vol 169 (6) ◽

pp. 853-865 ◽

Cited By ~ 57

Author(s):

Y H M Krul-Poel ◽

C Snackey ◽

Y Louwers ◽

P Lips ◽

C B Lambalk ◽

...

Keyword(s):

Systematic Review ◽

Vitamin D ◽

Clinical Trials ◽

Polycystic Ovary Syndrome ◽

Polycystic Ovary ◽

Vitamin D Status ◽

Regression Analyses ◽

Metabolic Disturbances ◽

Ovary Syndrome ◽

Weighted Means

ContextMetabolic disturbances, in particular, insulin resistance (IR) and dyslipidemia, are common in women suffering from polycystic ovary syndrome (PCOS). Evidence is accumulating that vitamin D status may contribute to the development of metabolic disturbances in PCOS.ObjectiveThe aim of this study was to carry out a systematic review addressing the association between vitamin D status, vitamin D receptor polymorphisms, and/or polymorphisms related to vitamin D metabolism and metabolic disturbances in women with PCOS.Design and methodsA systematic search of electronic databases was carried out up to January 2013 for observational studies and clinical trials in women suffering from PCOS with outcome measures that were related to vitamin D status. We conducted univariate and multivariate regression analyses of the weighted means to gain insights into the association between vitamin D, BMI, and IR based on existing literature.ResultsWe found 29 eligible trials with inconsistency in their results. One well-designed randomized controlled trial has been carried out until now. Univariate regression analyses of the weighted means revealed vitamin D to be a significant and independent predictor of IR in both PCOS and control women. The significance disappeared after adjustment for BMI in PCOS women.ConclusionsCurrent evidence suggests an inverse association between vitamin D status and metabolic disturbances in PCOS. Owing to the heterogeneity of the studies, it is hard to draw a definite conclusion. The causal relationship between vitamin D status and metabolic disturbances in PCOS remains to be determined in well-designed placebo-controlled randomized clinical trials.

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