scholarly journals Management of acute respiratory diseases in the pediatric population: the role of oral corticosteroids

2017 ◽  
Vol 43 (1) ◽  
Author(s):  
Renato Cutrera ◽  
Eugenio Baraldi ◽  
Luciana Indinnimeo ◽  
Michele Miraglia Del Giudice ◽  
Giorgio Piacentini ◽  
...  
Keyword(s):  
Respiratory Diseases ◽  
Pediatric Population ◽  
Oral Corticosteroids ◽  
Acute Respiratory Diseases

THE BIOLOGICAL ROLE OF VITAMIN D

Vestnik ◽  
2021 ◽  
pp. 169-172
Author(s):  
Д.Т. Джатдоева ◽  
А.А. Гочияев ◽  
М.Б. Семенов ◽  
З.М. Каппушева
Keyword(s):  
Vitamin D ◽  
Respiratory Diseases ◽  
Postoperative Recovery ◽  
The Body ◽  
Uv Treatment ◽  
Protective Properties ◽  
Acute Respiratory Diseases ◽  
The Moment ◽  
Positive Effect

В статье рассматриваются заболевания, зависящие от уровня витамина D в организме, возможные методы коррекции его уровня и их последствия. Рассматривается зависимость организма -как единого целого от уровня данного витамина в крови. На данный момент во всем мире наблюдается глобальный дефицит витамина D, у всех пациентов, которые сдают данный анализ, которое так же было выявлено на фоне глобальной пандемии “COVID-19”. Влияние витамина D на иммунитет абсолютно точно доказано, и поэтому его дефицитное состояние может ухудшать течение различных заболеваний. Также витамин D выступает в качестве гормона, недостаток которого приводит к патологиям сердечно-сосудистой системы, рахиту, остеопорозу, сахарному диабету, ожирению и другим серьезным заболеваниям. Неоднократно рассматривалось влияние его уровня на постоперационное восстановление. В статье так же приводятся методы коррекции посредством UV в зимнее время, которое как показали данные является опасной. В статье описываются нейродегенеративные расстройства, на которых оказывает огромное влияние уровень данного витамина и его профилактика. Проанализировано влияние его уровня на здоровье пациенток в постменопаузе, приводящее к нежелательным последствиям в том числе и остеопорозу. Приведены примеры влияния на защитные свойства ротовой полости при пародонте и кариесе. Описывается влияние на процесс течения острых респираторных заболеваний у детей, а также влияние на течение болезни при сахарном диабете. The article discusses diseases that depend on the level of vitamin D in the body, possible methods of correcting its level and their consequences. The dependence of the body on the level of this vitamin in the blood is considered. At the moment, there is a global vitamin D deficiency worldwide, which was revealed during the global COVID-19 pandemic. The positive effect of vitamin D on the immune system has been proven, and therefore its deficiency can worsen the course of various diseases. Vitamin D also acts as a hormone, the lack of which leads to pathologies of the cardiovascular system, rickets, osteoporosis, diabetes, obesity, and other serious diseases. The influence of its level on postoperative recovery is also considered. In addition, the article provides methods of correction by means of UV treatment in winter, which, as the data has shown, is dangerous. The article describes neurodegenerative disorders, which are greatly influenced by the level of this vitamin and its prevention. The influence of its level on the health of postmenopausal patients, leading to undesirable consequences, including osteoporosis, is analyzed. Examples of the effect on the protective properties of the oral cavity in periodontal disease and caries are given. The article describes the effect on the course of acute respiratory diseases in children, as well as the effect on the course of the disease in diabetes mellitus.

scholarly journals Application of RT-PCR for diagnosis of respiratory syncytial virus and human metapneumovirus infections in Bulgaria, 2006-7 and 2007-8

2009 ◽  
Vol 14 (23) ◽  
Author(s):  
S Pavlova ◽  
T Hadzhiolova ◽  
P Abadjieva ◽  
R Kotseva
Keyword(s):  
Respiratory Syncytial Virus ◽  
Respiratory Diseases ◽  
National Laboratory ◽  
Human Metapneumovirus ◽  
Rt Pcr ◽  
Chain Reaction ◽  
Acute Respiratory Diseases ◽  
Polymerase Chain ◽  
Syncytial Virus

We describe here the results of respiratory syncytial virus (RSV) detection by reverse transcription polymerase chain reaction (RT-PCR) during two consecutive seasons, from December 2006 to February 2007 and from October 2007 to March 2008, performed in the National Laboratory of Influenza and Acute Respiratory Diseases, Bulgaria. A total number of 278 nasopharyngeal samples obtained from hospitalised children up to the age of five years were investigated for these two seasons. During the first season, the aetiological role of RSV was confirmed in 56 of 148 samples (37.8%) compared to 11 of 130 samples (8.5%) during the second season. Since the beginning of January 2008, RT-PCR for the detection of the recently identified human metapneumovirus (HMPV) has also been introduced in Bulgaria. This virus has been demonstrated as the aetiological agent in 13 out of 81 samples (16%) from children of the same age group. The use of RT-PCR allows the detection of a broader spectrum of viruses causing respiratory diseases, as well as better discrimination of the aetiological agents in clinically similar cases.

scholarly journals PECULIARITIES OF ACUTE RESPIRATORY DISEASES IN PATIENTS WITH ATOPY

2015 ◽  
pp. 57-62
Author(s):  
L. O. Ponezheva ◽  
Zh. B. Ponezheva ◽  
A. N. Kupchenko
Keyword(s):  
Immune Deficiency ◽  
Chronic Inflammation ◽  
Clinical Efficacy ◽  
Transfer Factor ◽  
Respiratory Diseases ◽  
Respiratory Infections ◽  
Respiratory Viruses ◽  
Causative Agents ◽  
Acute Respiratory Diseases

In the work identified clinical and immunological characteristics of the course of ARVI patients with atopy and assessed the clinical efficacy of transfer factor in patients with severe immune deficiency. Emphasized the role of respiratory infections as the most important triggers of exacerbations of atopy and causes more severe and prolonged course. Describes the mechanisms of how respiratory viruses potentiate chronic inflammation and remodeling of the airways. The role of the causative agents of ARVI in patients with atopy deserve more practical attention towards and optimization of therapy.

scholarly journals Epidemiology of S. Pneumoniae-associated Pneumonias and the Analysis of Effectiveness of Vaccination against Pneumococcal Infection in Children under the Age of Six

2018 ◽  
Vol 17 (1) ◽  
pp. 25-32 ◽  
Author(s):  
A. V. Somova ◽  
V. V. Romanenko ◽  
A. A. Golubkova
Keyword(s):  
Respiratory Diseases ◽  
Pneumococcal Infection ◽  
Epidemiologic Study ◽  
Early Period ◽  
Incidence Rates ◽  
Community Acquired Pneumonia ◽  
Etiologic Role ◽  
Acute Respiratory Diseases ◽  
The Town

Pneumococcal infection is one of the main causes of acute respiratory diseases and exacerbation of chronic ones. In order to study the prevalence of community-acquired pneumonia, the etiologic role of S. pneumoniaе and effectiveness of vaccination among children under the age of 6 in the town of industrial cities, we conducted a non-interventional epidemiologic study of serotypes of circulating pneumococci and their compliance with the declared composition of vaccines recommended for prevention of pneumococcal infection in children. We also studied incidence rates of community-acquired pneumonias among children under the age of five vaccinated against pneumococcal infection, depending on the schedule and beginning of immunization. Our findings indicate a significant role of pneumococcus in the etiology of community-acquired pneumonias among children under the age of 17 (24.14%).The established spectrum of serotypes of pneumococcus from nasopharyngial swabs in children under the age of 17 with community-acquired pneumonia in the town of this city showed that such serotypes as 19F, 14, 9V/A, 15A/F, 6A/B/C, 3, and 23F contributed the most to the development of pneumonia (79.97%). Pneumococcus serotypes found corresponded to the composition of PCV13 in 76.36% of cases and to that of PCV10 – in 67.27%. Proven the effectiveness of the vaccine, the rate of epidemiologic effectiveness was 48.7% in relation to pneumonia of any etiology. Shown the largest epidemiological effectiveness (54.8%) of vaccination in children vaccinated in an early period (under the age of 1). 

scholarly journals Is Human Bocavirus Infection Associated with Gastroenteritis in Children? An Updated Systematic Review and Meta-analysis

2021 ◽  
Author(s):  
Minyi Zhang ◽  
Minyi Liang ◽  
Qiushuang Li ◽  
Juxian Xian ◽  
Fei Wu ◽  
...  
Keyword(s):  
Respiratory Diseases ◽  
Web Of Science ◽  
Meta Analysis ◽  
Human Bocavirus ◽  
Pathogenic Role ◽  
Increased Risk ◽  
Genotype 2 ◽  
Acute Respiratory Diseases ◽  
Tract Infections

Background: Human bocavirus (HBoV) figures as an increased risk factor of respiratory and gastrointestinal tract infections among children. A great deal of data is available to support the pathogenic role of HBoV in acute respiratory diseases. However, the association between HBoV infection and gastroenteritis remains controversial due to the ambiguous results. The present work aims to clarify the role of HBoV as a cause of gastroenteritis in children. Methodology/Principal findings: A systematic search of the literature was carried out from 1 January 2016 to 29 August 2021 in Embase, PubMed, Scopus, Web of Science, and the Chinese bibliographic database of biomedicine (CBM). Data from included studies were analyzed by use of a random-effects model. The pooled estimates of HBoV prevalence among all cases of gastroenteritis were generated and stratified by potential confounders. The pooled odds ratio (OR) and 95% confidence interval (CI) were computed for HBoV infection in relation to the risk of gastroenteritis. The overall prevalence of HBoV in children with gastroenteritis (9.1%, 95% CI: 6.7-11.8%) was considerably higher than that detected in children without gastroenteritis (4.0%, 95% CI: 1.1-8.5%). HBoV prevalence tended to be higher in cases of gastroenteritis under five years of age (12.1%, 95% CI: 6.8-18.7%). The highest frequency of HBoV was found in Egypt (57.8%, 95% CI: 47.7-67.6%). The predominant genotypes of HBoV circulating in children with gastroenteritis were genotype 1 (HBoV1, 3.8%, 95% CI: 2.7-5.2%) and genotype 2 (HBoV2, 2.4%, 95% CI: 1.3-3.7%). HBoV infection was significantly associated with an increased risk of gastroenteritis in children (OR 1.620, 95% CI: 1.023-2.566). Conclusion: The HBoV prevalence in pediatric cases of gastroenteritis is higher than that in children without gastroenteritis, demonstrating an increasing global burden of gastroenteritis in children caused by HBoV infection. Targeted intervention to reduce the HBoV burden should be established.

scholarly journals Mitochondrial dysfunction in lung ageing and disease

2020 ◽  
Vol 29 (157) ◽  
pp. 200165 ◽  
Author(s):  
Suzanne M. Cloonan ◽  
Kihwan Kim ◽  
Pauline Esteves ◽  
Thomas Trian ◽  
Peter J. Barnes
Keyword(s):  
Mitochondrial Dysfunction ◽  
Respiratory Diseases ◽  
Experimental Models ◽  
Cell Populations ◽  
Targeted Therapeutics ◽  
Related Research ◽  
The Past ◽  
Acute Respiratory Diseases ◽  
Diseased Lung

Mitochondrial biology has seen a surge in popularity in the past 5 years, with the emergence of numerous new avenues of exciting mitochondria-related research including immunometabolism, mitochondrial transplantation and mitochondria-microbe biology. Since the early 1960s mitochondrial dysfunction has been observed in cells of the lung in individuals and in experimental models of chronic and acute respiratory diseases. However, it is only in the past decade with the emergence of more sophisticated tools and methodologies that we are beginning to understand how this enigmatic organelle regulates cellular homeostasis and contributes to disease processes in the lung. In this review, we highlight the diverse role of mitochondria in individual lung cell populations and what happens when these essential organelles become dysfunctional with ageing and in acute and chronic lung disease. Although much remains to be uncovered, we also discuss potential targeted therapeutics for mitochondrial dysfunction in the ageing and diseased lung.

Evaluation of clinical efficacy of Derinat® in form of spray in practice of district therapist

2019 ◽  
Vol 1 (9) ◽  
pp. 38-46
Author(s):  
A. P. Babkin ◽  
A. A. Zuikova ◽  
O. N. Krasnorutskaya ◽  
Yu. A. Kotova ◽  
D. Yu. Bugrimov ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Respiratory Diseases ◽  
Viral Infections ◽  
Pharmacological Action ◽  
The Body ◽  
Natural Resistance ◽  
Acute Respiratory Diseases ◽  
T Helpers ◽  
T Killers ◽  
Stimulation Of

The widespread worldwide spread of acute respiratory diseases is an urgent problem in health care. Expressed polyetiology of respiratory diseases does not allow to limit the use of specific vaccine preparations and dictates the need to use to combat them a variety of non-specific means that stimulate the natural resistance of the human body. The main pharmacological action of sodium deoxyribonucleate is the stimulation of phagocytic activity of T-helpers and T-killers, increasing the functional activity of neutrophils and monocytes/ macrophages, providing regeneration and repair processes in the epithelial component of antiviral protection of the body. Based on the above, the study of the clinical efficacy of Derinat® in the form of spray in the treatment of acute respiratory viral infections is relevant.

Sign in / Sign up

Export Citation Format

Share Document