scholarly journals Contrasting effects of the alkaloid ricinine on the capacity of Anopheles gambiae and Anopheles coluzzii to transmit Plasmodium falciparum

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Domonbabele F. D. S. Hien ◽  
Prisca S. L. Paré ◽  
Amanda Cooper ◽  
Benjamin K. Koama ◽  
Edwige Guissou ◽  
...  
Keyword(s):  
Growth Rate ◽  
Plasmodium Falciparum ◽  
Anopheles Gambiae ◽  
Ricinus Communis ◽  
Control Agent ◽  
Phenotypic Traits ◽  
Anopheles Coluzzii ◽  
Vector Borne Diseases ◽  
Vector Borne ◽  
The Impact

Abstract Background Besides feeding on blood, females of the malaria vector Anopheles gambiae sensu lato readily feed on natural sources of plant sugars. The impact of toxic secondary phytochemicals contained in plant-derived sugars on mosquito physiology and the development of Plasmodium parasites remains elusive. The focus of this study was to explore the influence of the alkaloid ricinine, found in the nectar of the castor bean Ricinus communis, on the ability of mosquitoes to transmit Plasmodium falciparum. Methods Females of Anopheles gambiae and its sibling species Anopheles coluzzii were exposed to ricinine through sugar feeding assays to assess the effect of this phytochemical on mosquito survival, level of P. falciparum infection and growth rate of the parasite. Results Ricinine induced a significant reduction in the longevity of both Anopheles species. Ricinine caused acceleration in the parasite growth rate with an earlier invasion of the salivary glands in both species. At a concentration of 0.04 g l−1 in An. coluzzii, ricinine had no effect on mosquito infection, while 0.08 g l−1 ricinine-5% glucose solution induced a 14% increase in An. gambiae infection rate. Conclusions Overall, our findings reveal that consumption of certain nectar phytochemicals can have unexpected and contrasting effects on key phenotypic traits that govern the intensity of malaria transmission. Further studies will be required before concluding on the putative role of ricinine as a novel control agent, including the development of ricinine-based toxic and transmission-blocking sugar baits. Testing other secondary phytochemicals in plant nectar will provide a broader understanding of the impact which plants can have on the transmission of vector-borne diseases. Graphical abstract

scholarly journals Contrasting effects of the alkaloid ricinine on the capacity of Anopheles gambiae s.l. to transmit Plasmodium falciparum

2021 ◽  
Author(s):  
Domonbabele François de Sales Hien ◽  
Prisca S. L. Paré ◽  
Amanda Cooper ◽  
Benjamin K. Koama ◽  
Edwige Guissou ◽  
...  
Keyword(s):  
Growth Rate ◽  
Plasmodium Falciparum ◽  
Anopheles Gambiae ◽  
Ricinus Communis ◽  
Control Agent ◽  
Phenotypic Traits ◽  
Anopheles Coluzzii ◽  
Vector Borne Diseases ◽  
Anopheles Gambiae S.L ◽  
The Impact

Abstract Background: Besides feeding on blood, females of the malaria vector Anopheles gambiae s.l. readily feed on natural sources of plant sugars. The impact of toxic secondary phytochemicals contained in plant-derived sugars on mosquito physiology and on the development of Plasmodium parasites remains elusive. The focus of this study was to explore the influence of the alkaloid ricinine, found in the nectar of the castorbean Ricinus communis, on the mosquito ability to transmit Plasmodium falciparum. Methods: Females of Anopheles gambiae and its sibling species Anopheles coluzzii were exposed to ricinine through sugar feeding assays to assess the effect of this phytochemical on mosquito survival, the level of P. falciparum infection, and the growth rate of the parasite. Results: Ricinine induced a significant reduction in the longevity of both Anopheles species. Ricinine caused acceleration in the parasite growth rate with an earlier invasion of the salivary glands in both species. At a concentration of 0.04 g l-1 in An. coluzzii, ricinine had no effect on mosquito infection, while 0.08 g l-1 ricinine-5% glucose solution induced a 14% increase in An. gambiae infection rate. Conclusions: Overall, our findings reveal that consumption of certain nectar phytochemicals can have unsuspected and contrasting effects on key phenotypic traits that govern the intensity of malaria transmission. Further studies will be required before concluding on the putative role of ricinine as a novel control agent, including the development of ricinine-based toxic and transmission-blocking sugar baits. Testing other secondary phytochemicals in plant nectar will provide a broader understanding of the impact, which plants can have on the transmission of vector-borne diseases.

scholarly journals Effect of naturally occurring Wolbachia in Anopheles gambiae s.l. mosquitoes from Mali on Plasmodium falciparum malaria transmission

2017 ◽  
Vol 114 (47) ◽  
pp. 12566-12571 ◽  
Author(s):  
Fabio M. Gomes ◽  
Bretta L. Hixson ◽  
Miles D. W. Tyner ◽  
Jose Luis Ramirez ◽  
Gaspar E. Canepa ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Anopheles Gambiae ◽  
Malaria Transmission ◽  
Deleterious Effect ◽  
Plasmodium Falciparum Malaria ◽  
Anopheles Coluzzii ◽  
Naturally Occurring ◽  
Anopheles Gambiae S.L ◽  
Cat Fleas ◽  
Sporozoite Infection

A naturally occurring Wolbachia strain (wAnga-Mali) was identified in mosquitoes of the Anopheles gambiae complex collected in the Malian villages of Dangassa and Kenieroba. Phylogenetic analysis of the nucleotide sequence of two 16S rRNA regions showed that wAnga-Mali clusters with Wolbachia strains from supergroup A and has the highest homology to a Wolbachia strain isolated from cat fleas (Ctenocephalides). wAnga-Mali is different from two Wolbachia strains previously reported in A. gambiae from Burkina Faso (wAnga_VK5_STP and wAnga_VK5_3.1a). Quantitative analysis of Wolbachia and Plasmodium sporozoite infection in field-collected mosquitoes indicates that the prevalence and intensity of Plasmodium falciparum sporozoite infection is significantly lower in Wolbachia-infected females. The presence of Wolbachia in females from a laboratory Anopheles coluzzii (A. gambiae, M form) colony experimentally infected with P. falciparum (NF54 strain) gametocyte cultures slightly enhanced oocyst infection. However, Wolbachia infection significantly reduced the prevalence and intensity of sporozoite infection, as observed in the field. This indicates that wAnga-Mali infection does not limit early stages of Plasmodium infection in the mosquito, but it has a strong deleterious effect on sporozoites and reduces malaria transmission.

scholarly journals THE IMPACT OF GLOBAL WARMING ON THE PUBLIC HEALTH INCREASING THE BACTERIAL CAUSING INFECTIOUS DISEASES PERFORMED BY EXPERIMENT: VECTOR-BORNE DISEASES INSECTS, TAIF, KSA

2017 ◽  
Vol 5 (5) ◽  
pp. 42-53
Author(s):  
Sherifa Mostafa M. Sabra ◽  
Samar Ahamed
Keyword(s):  
Public Health ◽  
Global Warming ◽  
Infectious Diseases ◽  
Vector Borne Diseases ◽  
The Public ◽  
Colony Forming Unit ◽  
Tapinoma Sessile ◽  
Vector Borne ◽  
The Mean ◽  
The Impact

The search conducted on "The impact of global warming (GW) on the public health (PH) increasing the bacterial causing infectious diseases (IDs) performed by experiment: Vector-borne diseases (VBDs) insects, Taif, KSA", the experiment used ants (Taif Tapinoma sessile), prepared, arranged appropriate nests and adjusted the temperature at (20, 25, 30, 35, 40 and 45°C), for a week of each zone. It revealed the behaviour as (normal, semi-normal and ab-normal), the mean of mortality rates were between (0-53.3%). The bacterial contents measured by the turbidity indicated the presence of multiplication, were between (0.109-0.328). The bacterial growth degrees by sings were between (+ - +++++) and percent between (12-100%). Colony Forming Unit/ml (CFU/ml) confined between (1.8X102-15.0X102)/mL. Through this experiment it turned out the GW had a significant role on the PH, helped the proliferation of bacterial pathogens that caused IDS. The conclusion wiped from the experiment that the extent degrees of GW disadvantages on the PH. The PH workers must take the "Preventive Health Prophylaxis Measures" (PHPMs) to protect the individuals from IDs by eliminating the VBDs of various types, monitoring the immunological situation of individuals, provided the vaccinations of IDs and preparing for complete PHPMs against any changes in the PH.

Waterborne Diseases and Climate Change: Impact and Implications

2018 ◽  
pp. 469-484
Author(s):  
Maha Bouzid
Keyword(s):  
Climate Change ◽  
Developing Countries ◽  
Disease Transmission ◽  
Waterborne Diseases ◽  
Vector Borne Diseases ◽  
Significant Burden ◽  
Change Impact ◽  
Vector Borne ◽  
The Impact ◽  
Adaptation Options

Waterborne diseases are caused by a multitude of pathogens and associated with a significant burden in both developed and developing countries. While the assessment of the adverse impacts of climate change on human heath from infectious diseases has mainly focused on vector-borne diseases, waterborne diseases prevalence and transmission patterns are also likely to be impacted by environmental change. This chapter will outline relevant waterborne pathogens, summarise the impact of climate change on disease transmission and explore climate change adaptation options in order to reduce the increased burden of waterborne diseases.

How to model the impact of climate change on vector-borne diseases?

2021 ◽  
pp. 26-31
Author(s):  
Cyril Caminade
Keyword(s):  
Climate Change ◽  
Risk Assessment ◽  
Mathematical Models ◽  
Future Climate ◽  
Future Climate Change ◽  
Climate Change Risk ◽  
Vector Borne Diseases ◽  
Impact Of Climate Change ◽  
Vector Borne ◽  
The Impact

Abstract This expert opinion provides an overview of mathematical models that have been used to assess the impact of climate change on ticks and tick-borne diseases, ways forward in terms of improving models for the recent context and broad guidelines for conducting future climate change risk assessment.

Waterborne Diseases and Climate Change

2017 ◽  
pp. 1041-1055
Author(s):  
Maha Bouzid
Keyword(s):  
Climate Change ◽  
Developing Countries ◽  
Disease Transmission ◽  
Waterborne Diseases ◽  
Waterborne Pathogens ◽  
Vector Borne Diseases ◽  
Significant Burden ◽  
Vector Borne ◽  
The Impact ◽  
Adaptation Options

Waterborne diseases are caused by a multitude of pathogens and associated with a significant burden in both developed and developing countries. While the assessment of the adverse impacts of climate change on human heath from infectious diseases has mainly focused on vector-borne diseases, waterborne diseases prevalence and transmission patterns are also likely to be impacted by environmental change. This chapter will outline relevant waterborne pathogens, summarise the impact of climate change on disease transmission and explore climate change adaptation options in order to reduce the increased burden of waterborne diseases.

scholarly journals Assessing the acoustic behaviour of Anopheles gambiae (s.l.) dsxF mutants: implications for vector control

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Matthew P. Su ◽  
Marcos Georgiades ◽  
Judit Bagi ◽  
Kyros Kyrou ◽  
Andrea Crisanti ◽  
...  
Keyword(s):  
Anopheles Gambiae ◽  
Population Control ◽  
Beat Frequency ◽  
Phenotypic Traits ◽  
Gene Drive ◽  
Anopheles Gambiae S.L ◽  
Female Genotype ◽  
Female Specific ◽  
The Impact ◽  
Dose Dependent

Abstract Background Release of gene-drive mutants to suppress Anopheles mosquito reproduction is a promising method of malaria control. However, many scientific, regulatory and ethical questions remain before transgenic mosquitoes can be utilised in the field. At a behavioural level, gene-drive carrying mutants should be at least as sexually attractive as the wildtype populations they compete against, with a key element of Anopheles copulation being acoustic courtship. We analysed sound emissions and acoustic preference in a doublesex mutant previously used to collapse Anopheles gambiae (s.l.) cages. Methods Anopheles rely on flight tones produced by the beating of their wings for acoustic mating communication. We assessed the impact of disrupting a female-specific isoform of the doublesex gene (dsxF) on the wing beat frequency (WBF; measured as flight tone) of males (XY) and females (XX) in homozygous dsxF− mutants (dsxF−/−), heterozygous dsxF− carriers (dsxF+/−) and G3 dsxF+ controls (dsxF+/+). To exclude non-genetic influences, we controlled for temperature and wing length. We used a phonotaxis assay to test the acoustic preferences of mutant and control mosquitoes. Results A previous study showed an altered phenotype only for dsxF−/− females, who appear intersex, suggesting that the female-specific dsxF allele is haplosufficient. We identified significant, dose-dependent increases in the WBF of both dsxF−/− and dsxF+/− females compared to dsxF+/+ females. All female WBFs remained significantly lower than male equivalents, though. Males showed stronger phonotactic responses to the WBFs of control dsxF+/+ females than to those of dsxF+/− and dsxF−/− females. We found no evidence of phonotaxis in any female genotype. No male genotypes displayed any deviations from controls. Conclusions A prerequisite for anopheline copulation is the phonotactic attraction of males towards female flight tones within mating swarms. Reductions in mutant acoustic attractiveness diminish their mating efficiency and thus the efficacy of population control efforts. Caged population assessments may not successfully reproduce natural mating scenarios. We propose to amend existing testing protocols to better reflect competition between mutants and target populations. Our findings confirm that dsxF disruption has no effect on males; for some phenotypic traits, such as female WBFs, the effects of dsxF appear dose-dependent rather than haplosufficient.

scholarly journals Narrative Review on Health-EDRM Primary Prevention Measures for Vector-Borne Diseases

2020 ◽  
Vol 17 (16) ◽  
pp. 5981 ◽  
Author(s):  
Emily Chan ◽  
Tiffany Sham ◽  
Tayyab Shahzada ◽  
Caroline Dubois ◽  
Zhe Huang ◽  
...  
Keyword(s):  
Primary Prevention ◽  
Keyword Search ◽  
Risk Mitigation ◽  
World Health ◽  
Limiting Factors ◽  
Prevention Measures ◽  
Vector Borne Diseases ◽  
Vector Borne ◽  
Health Organization ◽  
The Impact

Climate change is expanding the global at-risk population for vector-borne diseases (VBDs). The World Health Organization (WHO) health emergency and disaster risk management (health-EDRM) framework emphasises the importance of primary prevention of biological hazards and its value in protecting against VBDs. The framework encourages stakeholder coordination and information sharing, though there is still a need to reinforce prevention and recovery within disaster management. This keyword-search based narrative literature review searched databases PubMed, Google Scholar, Embase and Medline between January 2000 and May 2020, and identified 134 publications. In total, 10 health-EDRM primary prevention measures are summarised at three levels (personal, environmental and household). Enabling factor, limiting factors, co-benefits and strength of evidence were identified. Current studies on primary prevention measures for VBDs focus on health risk-reduction, with minimal evaluation of actual disease reduction. Although prevention against mosquito-borne diseases, notably malaria, has been well-studied, research on other vectors and VBDs remains limited. Other gaps included the limited evidence pertaining to prevention in resource-poor settings and the efficacy of alternatives, discrepancies amongst agencies’ recommendations, and limited studies on the impact of technological advancements and habitat change on VBD prevalence. Health-EDRM primary prevention measures for VBDs require high-priority research to facilitate multifaceted, multi-sectoral, coordinated responses that will enable effective risk mitigation.

Effects of climate change on vector-borne diseases: an updated focus on West Nile virus in humans

2019 ◽  
Vol 3 (2) ◽  
pp. 143-152 ◽  
Author(s):  
Shlomit Paz
Keyword(s):  
Climate Change ◽  
West Nile Virus ◽  
The West ◽  
West Nile ◽  
Local Conditions ◽  
Transmission Season ◽  
Vector Borne Diseases ◽  
Vector Borne ◽  
The Impact ◽  
Impacts Of Climate Change

Abstract One of the main impacts of climate change on health is the influence on vector-borne diseases (VBDs). During the last few years, yearly outbreaks of the West Nile virus (WNV) have occurred in many locations, providing evidence of ongoing transmission. Currently, it is the most widely distributed arbovirus in the world. Increases in ambient temperature have impacts on WNV transmission. Indeed, clear associations were found between warm conditions and WNV outbreaks in various areas. The impact of changes in rainfall patterns on the incidence of the disease is influenced by the amount of precipitation (increased rainfall, floods or droughts), depending on the local conditions and the differences in the ecology and sensitivity of the species of mosquito. Predictions indicate that for WNV, increased warming will result in latitudinal and altitudinal expansions of regions climatically suitable for transmission, particularly along the current edges of its transmission areas. Extension of the transmission season is also predicted. As models show that the current climate change trends are expected to continue, it is important to reinforce WNV control efforts and increase the resilience of population health. For a better preparedness, any assessment of future transmission of WNV should consider the impacts of the changing climate.

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