scholarly journals Thyroid hormone: sex-dependent role in nervous system regulation and disease

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Shounak Baksi ◽  
Ajay Pradhan
Keyword(s):  
Nervous System ◽  
Thyroid Hormone ◽  
Steroid Hormones ◽  
Visual Processing ◽  
Nervous System Development ◽  
The Body ◽  
Male And Female ◽  
Neuronal Signaling ◽  
Specific Manner ◽  
Female Specific

AbstractThyroid hormone (TH) regulates many functions including metabolism, cell differentiation, and nervous system development. Alteration of thyroid hormone level in the body can lead to nervous system-related problems linked to cognition, visual attention, visual processing, motor skills, language, and memory skills. TH has also been associated with neuropsychiatric disorders including schizophrenia, bipolar disorder, anxiety, and depression. Males and females display sex-specific differences in neuronal signaling. Steroid hormones including testosterone and estrogen are considered to be the prime regulators for programing the neuronal signaling in a male- and female-specific manner. However, other than steroid hormones, TH could also be one of the key signaling molecules to regulate different brain signaling in a male- and female-specific manner. Thyroid-related diseases and neurological diseases show sex-specific incidence; however, the molecular mechanisms behind this are not clear. Hence, it will be very beneficial to understand how TH acts in male and female brains and what are the critical genes and signaling networks. In this review, we have highlighted the role of TH in nervous system regulation and disease outcome and given special emphasis on its sex-specific role in male and female brains. A network model is also presented that provides critical information on TH-regulated genes, signaling, and disease.

scholarly journals Tyrosine kinase inhibition produces specific alterations in axon guidance in the grasshopper embryo

Development ◽  
1998 ◽  
Vol 125 (20) ◽  
pp. 4121-4131 ◽  
Author(s):  
K.P. Menon ◽  
K. Zinn
Keyword(s):  
Nervous System ◽  
Tyrosine Kinase ◽  
Growth Cone ◽  
Growth Cones ◽  
Nervous System Development ◽  
The Body ◽  
Individual Growth ◽  
Kinase Inhibition ◽  
Tyrosine Kinase Inhibition ◽  
Herbimycin A

Tyrosine kinase signaling pathways are essential for process outgrowth and guidance during nervous system development. We have examined the roles of tyrosine kinase activity in programming growth cone guidance decisions in an intact nervous system in which neurons can be individually identified. We applied the tyrosine kinase inhibitors herbimycin A and genistein to whole 40% grasshopper embryos placed in medium, or injected the inhibitors into intact grasshopper eggs. Both inhibitors caused interneuronal axons that normally would grow along the longitudinal connectives to instead leave the central nervous system (CNS) within the segmental nerve root and grow out toward the body wall muscles. In addition, herbimycin A produced pathfinding errors in which many longitudinal axons crossed the CNS midline. To study how this drug affected guidance decisions made by individual growth cones, we dye-filled the pCC interneuron, which normally extends an axon anteriorly along the ipsilateral longitudinal connective. In the presence of herbimycin A, the pCC growth cone was redirected across the anterior commissure. These phenotypes suggest that tyrosine kinase inhibition blocks a signaling mechanism that repels the growth cones of longitudinal connective neurons and prevents them from crossing the midline.

scholarly journals TheC. elegansephrin EFN-4 functions non-cell autonomously with heparan sulfate proteoglycans to promote axon outgrowth and branching

2015 ◽  
Author(s):  
Alicia A Schwieterman ◽  
Alyse N Steves ◽  
Vivian Yee ◽  
Cory J Donelson ◽  
Aaron Pital ◽  
...  
Keyword(s):  
Nervous System ◽  
Neurite Outgrowth ◽  
Motor Neurons ◽  
System Development ◽  
Nervous System Development ◽  
The Body ◽  
Tissue Type ◽  
Eph Receptors ◽  
C Elegans ◽  
Core Proteins

The Eph receptors and their cognate ephrin ligands play key roles in many aspects of nervous system development. These interactions typically occur within an individual tissue type, serving either to guide axons to their terminal targets or to define boundaries between the rhombomeres of the hindbrain. We have identified a novel role for theCaenorhabditis elegansephrin EFN-4 in promoting primary neurite outgrowth in AIY interneurons and D-class motor neurons. Rescue experiments reveal that EFN-4 functions non-cell autonomously in the epidermis to promote primary neurite outgrowth. We also find that EFN-4 plays a role in promoting ectopic axon branching in aC. elegansmodel of X-linked Kallmann syndrome. In this context, EFN-4 functions non-cell autonomously in the body wall muscle, and in parallel with HS biosynthesis genes and HSPG core proteins, which function cell autonomously in the AIY neurons. This is the first report of an epidermal ephrin providing a developmental cue to the nervous system.

scholarly journals Influence of thyroid hormones on nervous system development – brief review

2016 ◽  
Vol 5 (1) ◽  
pp. 82
Author(s):  
Rafael Cisne ◽  
Rayssa Justo ◽  
Edimilson Migowski
Keyword(s):  
Nervous System ◽  
Thyroid Gland ◽  
System Development ◽  
Nervous System Development ◽  
Tissue Growth ◽  
The Body ◽  
Activity Level ◽  
O2 Uptake ◽  
Neonatal Life ◽  
Mental Slowness

<p>The thyroid gland secretes important hormones for the overall development of organism, which include some related to tissue growth, as well as hormones that stimulate the O2 uptake in the cells and help the regulation of lipid and carbohydrate metabolism. Therefore influence the body mass and activity level thereof, including the activities of nervous system. The thyroid gland is not essential for life, however their absence or hypofunction during fetal and neonatal life result in severe mental, physical and mental slowness, poor resistance to cold, as well as dwarfism. The hyperfunction of this gland leads to weight loss, nervousness, tachycardia, tremor and production of excess heat.</p>

The Role of Hippo Signaling Pathway in the Development of the Nervous System

2021 ◽  
pp. 1-8
Author(s):  
Xifan Li ◽  
Kaixuan Li ◽  
Yu Chen ◽  
Fang Fang
Keyword(s):  
Nervous System ◽  
Signaling Pathway ◽  
Hippo Pathway ◽  
Nervous System Development ◽  
Nerve Cells ◽  
The Body ◽  
Neurological Dysfunction ◽  
Hippo Signaling ◽  
Nervous System Diseases ◽  
Hippo Signaling Pathway

Hippo signaling pathway is a highly conserved and crucial signaling pathway that controls the size of tissues and organs by regulating the proliferation, differentiation, and apoptosis of cells. The nervous system is a complicated system that participates in information collection, integration, and procession. The balance of various aspects of the nervous system is vital for the normal regulation of physiological conditions of the body, like the population and distribution of nerve cells, nerve connections, and so on. Defects in these aspects may lead to cognitive, behavioral, and neurological dysfunction, resulting in various nervous system diseases. Recently, accumulating evidence proposes that Hippo pathway maintains numerous biological functions in the nervous system development, including modulating the proliferation and differentiation of nerve cells and promoting the development of synapse, corpus callosum, and cortex. In this review, we will summarize recent findings of Hippo pathway in the nervous system to improve our understanding on its function and to provide potential therapeutic strategies of nervous system diseases in the future.

scholarly journals Transcriptomic changes throughout post-hatch development in Gallus gallus pituitary

2017 ◽  
Vol 58 (1) ◽  
pp. 43-55 ◽  
Author(s):  
Elizabeth M Pritchett ◽  
Susan J Lamont ◽  
Carl J Schmidt
Keyword(s):  
Nervous System ◽  
Pituitary Gland ◽  
Nervous Tissue ◽  
System Development ◽  
Endocrine System ◽  
Tissue Expression ◽  
Nervous System Development ◽  
The Body ◽  
Tissue Development ◽  
Time Points

The pituitary gland is a neuroendocrine organ that works closely with the hypothalamus to affect multiple processes within the body including the stress response, metabolism, growth and immune function. Relative tissue expression (rEx) is a transcriptome analysis method that compares the genes expressed in a particular tissue to the genes expressed in all other tissues with available data. Using rEx, the aim of this study was to identify genes that are uniquely or more abundantly expressed in the pituitary when compared to all other collected chicken tissues. We applied rEx to define genes enriched in the chicken pituitaries at days 21, 22 and 42 post-hatch. rEx analysis identified 25 genes shared between all time points, 295 genes shared between days 21 and 22 and 407 genes unique to day 42. The 25 genes shared by all time points are involved in morphogenesis and general nervous tissue development. The 295 shared genes between days 21 and 22 are involved in neurogenesis and nervous system development and differentiation. The 407 unique day 42 genes are involved in pituitary development, endocrine system development and other hormonally related gene ontology terms. Overall, rEx analysis indicates a focus on nervous system/tissue development at days 21 and 22. By day 42, in addition to nervous tissue development, there is expression of genes involved in the endocrine system, possibly for maturation and preparation for reproduction. This study defines the transcriptome of the chicken pituitary gland and aids in understanding the expressed genes critical to its function and maturation.

scholarly journals The Monocarboxylate Transporter 8 Linked to Human Psychomotor Retardation Is Highly Expressed in Thyroid Hormone-Sensitive Neuron Populations

Endocrinology ◽  
2005 ◽  
Vol 146 (4) ◽  
pp. 1701-1706 ◽  
Author(s):  
Heike Heuer ◽  
Michael K. Maier ◽  
Sandra Iden ◽  
Jens Mittag ◽  
Edith C. H. Friesema ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Thyroid Hormone ◽  
System Development ◽  
Perinatal Period ◽  
Psychomotor Retardation ◽  
Nervous System Development ◽  
Monocarboxylate Transporter ◽  
Target Cells

Abstract Recent genetic analysis in several patients presenting a severe form of X-linked psychomotor retardation combined with abnormal thyroid hormone (TH) levels have revealed mutations or deletions in the gene of the monocarboxylate transporter 8 (MCT8). Because in vitro MCT8 functions as a TH transporter, the complex clinical picture of these patients indicated an important role for MCT8 in TH-dependent processes of brain development. To provide a clue to the cellular function of MCT8 in brain, we studied the expression of MCT8 mRNA in the murine central nervous system by in situ hybridization histochemistry. In addition to the choroid plexus structures, the highest transcript levels were found in neo- and allocortical regions (e.g. olfactory bulb, cerebral cortex, hippocampus, and amygdala), moderate signal intensities in striatum and cerebellum, and low levels in a few neuroendocrine nuclei. Colocalization studies revealed that MCT8 is predominantly expressed in neurons. Together with the spatiotemporal expression pattern of MCT8 during the perinatal period, these results strongly indicate that MCT8 plays an important role for proper central nervous system development by transporting TH into neurons as its main target cells.

THYROID HORMONES IN FETAL CENTRAL NERVOUS SYSTEM DEVELOPMENT

2003 ◽  
Vol 14 (3) ◽  
pp. 177-208 ◽  
Author(s):  
SHIAO CHAN ◽  
JOANNE ROVET
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Thyroid Hormone ◽  
Thyroid Hormones ◽  
Normal Development ◽  
Neonatal Period ◽  
System Development ◽  
Nervous System Development ◽  
Hormone Deficiency ◽  
Central Nervous System Development

Thyroid hormones are important for normal development of the human central nervous system (CNS). It is well established in children with congenital hypothyroidism that neonatal thyroid hormone deficiency significantly impairs subsequent neurodevelopment. In these children, the period of thyroid hormone insufficiency, which can begin in utero and extend until thyroid status is restored to normal in the neonatal period, determines the severity and type of defect manifested. While prompt and optimal thyroid hormone supplementation, following newborn screening is associated with far improved outcome and near normal development, subtle specific neurodevelopmental differences are still detectable compared to euthyroid controls. Because the particular impairments reflect the exact period of thyroid hormone insufficiency postnatally, as well as during gestation, this implies that brain development is not only thyroid hormone dependent in the neonatal period, but also prior to birth.

scholarly journals Neurodynamic compensatory mechanisms of visual impairment and biomechanical indicators of running in an elite athlete in the paralympic sprint

2019 ◽  
Keyword(s):  
Nervous System ◽  
Visual Impairment ◽  
Female Athlete ◽  
Elite Athlete ◽  
Nervous System Development ◽  
Individual Characteristics ◽  
The Body ◽  
Compensatory Mechanism ◽  
Compensatory Mechanisms ◽  
Visual Dysfunction

Introduction. The study of visual dysfunction compensatory mechanisms is of great importance both for the Paralympic athletes, as well as for people suffering from such dysfunctions, especially in cases when analyzer disorders occurred in adulthoodt, and natural adaptation mechanisms could not be included in the process of growth and development of the body. The aim: to identify potential compensatory mechanisms of visual impairment in an elite athlete in the Paralympic sprint based on an analysis of the biomechanical characteristics of running and neurodynamic indicators. Material and methods. A highly qualified athlete participated in the study, specializing in short-distance running and long jump among athletes with visual impairment (category T12). The individual characteristics of the psychophysiological state and the results in running for 60, 80,100, 120, 200 m were analyzed and the biomechanical characteristics of the run for 100 m were determined. In total, 36 series of measurements of each indicator were carried out for 5 months. Results. It is shown that the athlete being examined is an atypical sprinter from the point of view of the properties of the nervous system, development and maintenance of speed at a distance, some biomechanical characteristics of running. The subject athlete is a representative of a mobile and strong type of nervous system, which allows her to maintain a higher speed at a distance compared to other athletes for a longer time, which can be considered as a potential reserve. The role of the auditory analyzer at the time of the examination of the female athlete as a compensatory mechanism of visual dysfunction was not identified. The presence of a small irregularity in the change in the speed and acceleration of the movement of the ankle and knee joints, observed in some steps when lowering the limb after hip removal, was revealed. Conclusin. Revealed a high reliable relationship between the neurodynamic and biomechanical characteristics of the examined female athlete. Improving the biomechanics of running by focusing on the work of a kinestatic analyzer can give an increase in speed at a distance while maintaining it almost to the finish.

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