Caffeic acid rich Citrus macroptera peel powder supplementation prevented oxidative stress, fibrosis and hepatic damage in CCl4 treated rats

Oxidative stress causes biological changes responsible for carcinogenesis and aging in human cells. The retinal pigmented epithelium is continuously exposed to oxidative stress. Therefore reactive oxygen species (ROS) and products of lipid peroxidation accumulate in RPE. Neutralization of ROS occurs in retina by the action of antioxidant defence systems. In the present study, the protective effect of caffeic acid (3,4-dihydroxy cinnamic acid), a dietary phenolic compound, has been examined in normal and in oxidative stress conditions (500 µM peroxide oxygen) in cultures human epithelial pigment retinal cells (Nowak, M. et al.). The cell viability, the antioxidant enzymes activity (CAT, GPx, SOD) and the level of intracellular reactive oxygen species (ROS) were determined. Exposure to l00 µM caffeic acid for 24 h induced cellular changes indicating the protective effect of caffeic acid in RPE cells. Caffeic acid did not show any cytotoxic effect at concentrations lower than 200 μM in culture medium. Treatment of RPE cells with caffeic acid causes an increase of catalase, glutathione peroxidase and superoxide dismutase activity, especially in cells treated with hydrogen peroxide. Caffeic acid causes a decrease of ROS level in cells treated with hydrogen peroxide. This study proved that caffeic acid or food that contain high levels of this phenolic acid may have beneficial effects in prevention of retinal diseases associated with oxidative stress by improving antioxidant defence systems.

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Caffeic Acid Phenethyl Ester protects burn wounds against oxidative stress and improves wound healing

The FASEB Journal ◽

10.1096/fasebj.26.1_supplement.916.8 ◽

2012 ◽

Vol 26 (S1) ◽

Author(s):

Andrea Monte-Alto-Costa ◽

Jeanine Salles Santos

Keyword(s):

Oxidative Stress ◽

Wound Healing ◽

Caffeic Acid ◽

Caffeic Acid Phenethyl Ester ◽

Burn Wounds

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ANTIOXIDANT AND HEPATOPROTECTIVE EFFECT OF SWERTIA CHIRATA ON HYPOXIA-INDUCED OXIDATIVE STRESS IN WISTAR RATS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2019.v12i1.28502 ◽

2019 ◽

Vol 12 (1) ◽

pp. 76

Author(s):

Kritika Kaushal ◽

Harvinder Singh ◽

Anil Kant Thakur

Keyword(s):

Oxidative Stress ◽

Liver Function ◽

Wistar Rats ◽

Hepatic Damage ◽

Ros Generation ◽

Dependent Manner ◽

Traditional Use ◽

Hydroalcoholic Extract ◽

Swertia Chirata ◽

Liver Functions

Objective: Swertia chirata has been used in traditional and folklore medicine to treat several ailments such as hepatic disorders. However, the mechanistic and experimental justification to its traditional use is lacking. The present study was aimed to investigate the hepatoprotective potential of S. chirata during hypoxia (HYP)-induced hepatic damage in Wistar rats and to determine the underlying mechanism.Methods: Hydroalcoholic extract of S. chirata was prepared using Soxhlet extraction. Animals were divided into six groups (n=5). Animals in the HYP groups were subjected to HYP for 3 days (10% O2) to induce oxidative stress and hepatic damage. 50 and 100 mg/kg extract treatments were provided orally once daily for 7 days after which animals were sacrificed, and biochemical investigations for oxidative stress, liver function tests, and hepatic histopathology were performed.Results: HYP-induced marked oxidative stress as indicated by the significantly elevated mitochondrial ROS generation, lipid peroxidation, glutathione, and depleted catalase levels. Liver function test indicated hepatic damage as the levels of serum glutamic-oxaloacetic transaminase, serum glutamic pyruvic transaminase, and aspartate transaminase were significantly elevated in HYP animals. S. chirata treatment alleviated oxidative stress and improved liver functions in a dose-dependent manner. Liver histopathology confirmed the marked hepatic damage induced by HYP and revealed that S. chirata efficiently rescued liver from hypoxic damage.Conclusion: Hydroalcoholic extract of S. chirata is a potent hepatoprotective intervention which was associated with its potential to alleviate oxidative stress and improve liver functions. Moreover, it could find clinical application as a safer and alternative remedy for liver ailments.

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Caffeic acid phenethyl ester protects against oxidative stress and dampens inflammation via heme oxygenase 1

International Journal of Oral Science ◽

10.1038/s41368-018-0039-5 ◽

2019 ◽

Vol 11 (1) ◽

Cited By ~ 4

Author(s):

Alexandra Stähli ◽

Ceeneena Ubaidha Maheen ◽

Franz Josef Strauss ◽

Sigrun Eick ◽

Anton Sculean ◽

...

Keyword(s):

Oxidative Stress ◽

Caffeic Acid ◽

Heme Oxygenase ◽

Caffeic Acid Phenethyl Ester ◽

Heme Oxygenase 1

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Amoxycillin/clavulanic acid combinations (Augmentin® 375 and 625 tablets) induce - oxidative stress, and renal and hepatic damage in rats

African Journal of Pharmacy and Pharmacology ◽

10.5897/ajpp10.165 ◽

2012 ◽

Vol 6 (33) ◽

Author(s):

Olayinka E. Tunde

Keyword(s):

Oxidative Stress ◽

Clavulanic Acid ◽

Hepatic Damage

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Effect of dietary supplementation with Spirulina platensis on Atrazine-induced oxidative stress- mediated hepatic damage and inflammation in the common carp ( Cyprinus carpio L. )

Ecotoxicology and Environmental Safety ◽

10.1016/j.ecoenv.2017.11.018 ◽

2018 ◽

Vol 149 ◽

pp. 135-142 ◽

Cited By ~ 21

Author(s):

Hosam Toughan ◽

Samah R. Khalil ◽

Ashraf Ahmed El-Ghoneimy ◽

Ashraf Awad ◽

A.SH. Seddek

Keyword(s):

Oxidative Stress ◽

Common Carp ◽

Cyprinus Carpio ◽

Spirulina Platensis ◽

Dietary Supplementation ◽

Hepatic Damage ◽

Common Carp Cyprinus Carpio ◽

Carp Cyprinus Carpio ◽

The Common

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Caffeic acid phenethyl ester protects from oxidative stress and dampens inflammation via heme oxygenase 1

Clinical Oral Implants Research ◽

10.1111/clr.138_13358 ◽

2018 ◽

Vol 29 ◽

pp. 253-253

Author(s):

Alexandra Stähli ◽

Ceneena Ubaidha Maheen ◽

Franz Josef Strauss ◽

Sigrun Eick ◽

Anton Sculean ◽

...

Keyword(s):

Oxidative Stress ◽

Caffeic Acid ◽

Heme Oxygenase ◽

Caffeic Acid Phenethyl Ester ◽

Heme Oxygenase 1

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Identification of Six Phytochemical Compounds from Asparagus officinalis L. Root Cultivars from New Zealand and China Using UAE-SPE-UPLC-MS/MS: Effects of Extracts on H2O2-Induced Oxidative Stress

Nutrients ◽

10.3390/nu11010107 ◽

2019 ◽

Vol 11 (1) ◽

pp. 107 ◽

Cited By ~ 6

Author(s):

Hongxia Zhang ◽

John Birch ◽

Jinjin Pei ◽

Isam A. Mohamed Ahmed ◽

Haiyan Yang ◽

...

Keyword(s):

Oxidative Stress ◽

New Zealand ◽

Ferulic Acid ◽

Caffeic Acid ◽

Bioactive Compounds ◽

Limit Of Detection ◽

Solid Phase ◽

Asparagus Officinalis ◽

Commercial Application ◽

Relative Standard

A simple, rapid, specific, and sensitive method was developed for the simultaneous identification and quantification of six major bioactive compounds, namely, caffeic acid, quercetin, apigenin, ferulic acid, baicalein, and kaempferol, from Asparagus officinalis roots (ARs) native to New Zealand (green and purple cultivars) and China (yellow, green, purple, and white cultivars) using ultrasound-assisted, solid-phase extraction (UASE-SPE) coupled with ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The method was validated in terms of linearity, limit of detection (LOD), limit of quantification (LOQ), accuracy (expressed as recovery %), and precision (expressed as relative standard deviation (%RSD)). The retention times, ultraviolet visible (UV-vis) data, and mass spectral patterns of the detected peaks matched those of commercial standards, allowing characterization of the target compounds. The LODs and LOQs were 23 ng/mL and 70 ng/mL, 50 ng/mL and 150 ng/mL, 10 ng/mL and 30 ng/mL, 18 ng/mL and 54 ng/mL, 14.4 ng/mL and 43.6 ng/mL, and 7.5 ng/mL and 22.5 ng/mL for caffeic acid, quercetin, apigenin, ferulic acid, baicalein, and kaempferol, respectively, and the mean recovery rates were 85.8%, 73.0%, 90.2%, 80.6%, 76.7%, and 74.5% for the six compounds, respectively. The levels of the target compounds were significantly different (p < 0.05) among the six cultivars. The Chinese yellow AR had the highest levels of bioactive compounds: 6.0, 3.9, 0.4, 1.0, 0.86, and 0.8 mg/g for caffeic acid, quercetin, apigenin, ferulic acid, baicalein, and kaempferol, respectively. The AR extracts showed protective effects against oxidative stress in the HepG2 and L929 cell lines. The results indicate that AR extracts contain high flavonoid levels that provide protective functions against oxidative stress and support the potential commercial application of AR extracts.

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