scholarly journals Serum levels of leptin and adiponectin in patients with multiple sclerosis

2021 ◽  
Vol 57 (1) ◽  
Author(s):  
Rasha M. Fahmi ◽  
Amr E. Kamel ◽  
Dorreya A. Elsayed ◽  
Amal A. Zidan ◽  
Noha T. Sarhan
Keyword(s):  
Multiple Sclerosis ◽  
Potential Role ◽  
Case Control Study ◽  
Serum Levels ◽  
Serum Leptin ◽  
Disability Status ◽  
Egyptian Patients ◽  
Disability Severity ◽  
Control Study

Abstract Background The role of adipokines such as leptin and adiponectin in regulating the immunity has been documented, however data concerning their consequence on multiple sclerosis (MS) Egyptian patients are deficient. The aim of this study is to demonstrate the serum levels of leptin and adiponectin in MS patients and to assess their association with disease disability and severity. A case–control study including 60 subjects (30 MS patients and 30 age, sex and body mass index-matched healthy controls) was performed. Results Serum leptin level was significantly higher among MS patients than controls (P < 0.001) while adiponectin was not significantly elevated in MS patients (P = 0.24). There was a significant positive correlation between leptin levels with MS disability (Expanded Disability Status Scale) (r = 0.678; P < 0.001), severity (Multiple Sclerosis Severity Score) (r = 0.631; P < 0.001) and progression (progression index) (r = 0.461; P = 0.01). There was no statistically significant correlation between adiponectin with disease disability, severity or progression. Conclusions MS patients had significantly higher serum leptin levels and insignificant adiponectin levels compared to controls. Leptin has a potential role in multiple sclerosis disability and severity. However, adiponectin is not useful as a biomarker of MS disease, disability and severity.

Familial multiple sclerosis: does consanguinity have a role?

2010 ◽  
Vol 17 (4) ◽  
pp. 487-489 ◽  
Author(s):  
M Al Jumah ◽  
S Kojan ◽  
A Al Khathaami ◽  
I Al Abdulkaream ◽  
M Al Blawi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Potential Role ◽  
Case Control Study ◽  
Case Control ◽  
Parental Consanguinity ◽  
Affected Relative ◽  
History Of ◽  
Estimate Prevalence ◽  
Control Study

Parental consanguinity (PC) may be a risk factor for familial multiple sclerosis (FMS) throughout inbred communities. The objective of this report was to estimate prevalence of FMS and rate of PC among FMS versus non-FMS patients. All Saudi MS patients were identified from our registry. The history of PC was analyzed as a case-control study. In total 141 MS patients were identified. Of these, 30 (21%) reported having at least one affected relative, 37.6% reported PC and 16% presented first-degree PC. In addition, FMS patients were more likely than non-FMS patients to report PC. In conclusion, FMS is prevalent among Saudi MS patients. MS patients with a history of PC were more likely to have FMS, suggesting a potential role of consanguinity.

Multiple sclerosis and solar exposure before the age of 15 years: case—control study in Cuba, Martinique and Sicily

2010 ◽  
Vol 16 (8) ◽  
pp. 899-908 ◽  
Author(s):  
F. Dalmay ◽  
D. Bhalla ◽  
A. Nicoletti ◽  
JA Cabrera-Gomez ◽  
P. Cabre ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Case Control Study ◽  
Sun Exposure ◽  
Protective Role ◽  
Case Control ◽  
Solar Exposure ◽  
History Of ◽  
Water Sports ◽  
Control Study

Few studies report a protective role of childhood solar exposure to multiple sclerosis. Our objective was to confirm the protective role of childhood solar exposure in multiple sclerosis in Cuba, Martinique and Sicily. This was a matched case— control study, and cases met Poser criteria for clinically, laboratory (definite, probable) multiple sclerosis. Controls were resident population, without neurological disorder, living close to cases (within 100 km), matched for sex, age (±5 years), residence before age 15. We recruited 551 subjects during a 1-year period (193 cases, Cuba n = 95, Sicily n = 50, Martinique n = 48; 358 controls). Some (89%) met definite clinical multiple sclerosis criteria (relapsing remitting form (with and without sequel) (74%), secondary progressive (21%), primary progressive (5%)). Odds ratios in a uni-variate analysis were: family history of multiple sclerosis (5.1) and autoimmune disorder (4.0); wearing shirt (3.5), hat (2.7), pants (2.4); sun exposure causing sunburn (1.8); sun exposure duration (1 h more/day; weekends 0.91, weekdays 0.86); bare-chested (0.6); water sports (0.2). Independent factors in the multivariate analysis were family history of multiple sclerosis (4.8 (1.50—15.10)), wearing pants under sunlight (1.9 (1.10—3.20)), sun exposure duration (1 h more/ day, weekdays 0.90 (0.85—0.98), weekends 0.93 (0.87—0.99)), water sports (0.23 (0.13—0.40)). We conclude that outdoor leisure activities in addition to sun exposure reports are associated with a reduced multiple sclerosis risk, with evidence of dose response.

Predisposing role of vitamin D receptor (VDR) polymorphisms in the development of multiple sclerosis: A case-control study

2016 ◽  
Vol 367 ◽  
pp. 148-151 ◽  
Author(s):  
Rasoul Abdollahzadeh ◽  
Mahsa Sobhani Fard ◽  
Farideh Rahmani ◽  
Kaveh Moloudi ◽  
Behrooz Sadeghi kalani ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Case Control Study ◽  
Case Control ◽  
Control Study ◽  
Vdr Polymorphisms

scholarly journals The Role of Toxoplasma gondii Infection Among Multiple Sclerosis Patient Compared to Ordinary People in South of Iran: A Case-Control Study

2020 ◽  
Vol 17 (3) ◽  
Author(s):  
Mahsa Rahnama ◽  
Qasem Asgari ◽  
Peiman Petramfar ◽  
Davod Tasa ◽  
Vahid Hemati ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Toxoplasma Gondii ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Ordinary People ◽  
Serum Samples ◽  
Significant Difference ◽  
Control Study

Background: Toxoplasmosis is a common parasitic disease, which leads to serious disease symptoms in immunocompromised hosts and infants. Recent epidemiologic surveys showed that microbial agents may be associated with some cases of multiple sclerosis (MS). Objectives: This case-control study aimed to examine the role of Toxoplasma gondii in MS by evaluating sero-frequency of anti-T. gondii IgG (ATXAb) antibody between patients with MS and ordinary people in Shiraz Province, south of Iran during 2016 - 2018. Methods: Serum samples obtained from MS patients (n = 130), and a group of age and gender-matched controls (n = 130) with the same socioeconomic status with the patients’ group were collected to evaluate the prevalence of T. gondii IgG antibodies (ATXAb). Moreover, the presence of the ATXAb antibody of the patients and controls was determined by the ELISA test. SPSS 20 software was used to perform the statistical analysis (SPSS, inc., Chicago, USA). Results: Out of 130 (35.4%) cases with MS and 130 (13.8%) controls, 46 and 18 subjects were seropositive for ATXAb, respectively. Based on the chi-square test, a significant difference was observed in terms of the positivity rates of ATXAb between the MS patient group and the control group (P = 0.001). The mean ± standard deviation ATXAb levels in controls and MS patients were found to be 61 ± 34 and 114 ± 47 IU/mL, respectively. Also, there were statistically significant differences between the levels of these two groups (P = 0.001). Conclusions: Given the relationship between toxoplasmosis and MS, it is possible that the prevalence of MS decreases by increasing hygiene and preventing toxoplasmosis.

Serum CTRP3 Level is Associated with Osteoporosis in Postmenopausal Women

2018 ◽  
Vol 126 (09) ◽  
pp. 559-563 ◽  
Author(s):  
Zhong-Hua Xu ◽  
Xing Zhang ◽  
Hua Xie ◽  
Jin He ◽  
Wen-Chao Zhang ◽  
...  
Keyword(s):  
Postmenopausal Women ◽  
Case Control Study ◽  
Serum Levels ◽  
Case Control ◽  
Dual Energy ◽  
Complex Interaction ◽  
Mineral Density ◽  
X Ray ◽  
Control Study

Abstract Background As a novel adipokine, CTRP3 involves in various functions of energy metabolism. Recent advance reveals a complex interaction between bone and adipose tissue via the secretion of adipokines. Aims A hospital-based case-control study was conducted to investigate the role of serum CTRP3 in osteoporosis among postmenopausal women. Methods Serum levels of CTRP3 and osteocalcin were measured. Bone mineral density (BMD) was obtained on femoral neck and lumbar spines by dual energy X-ray absorptiometry. Results Serum CTRP3 level was lower in subjects with osteoporosis (76.7±22.1 ng/ml) than it in controls (89.4±22.5 ng/ml) (P<0.001). Meanwhile, the frequency of osteoporosis presented a significant decrease (66.4%, 53.9% and 35.9%, P<0.001), in the tertiles of serum CTRP3. Furthermore, serum CTRP3 witnessed an association with a lower risk of osteoporosis (adjusted odds ratio=0.973, 95% confidence interval [0.963–0.983], P<0.001). Lastly, serum CTRP3 level was positively correlated with femoral BMD (r=0.403, P<0.001), lumbar BMD (r=0.368, P<0.001), and HDL-C (r=0.118, P=0.022), among all participants after adjustment. Meanwhile, CTRP3 presented negative correlations with HOMA-IR (r=−0.136, P=0.008) and insulin (r=−0.192, P <0.001). Conclusions It shows that a decreased serum level of CTRP3 was independently associated with osteoporosis.

scholarly journals Potential Role of Vegetarianism on Nutritional and Cardiovascular Status in Taiwanese Dialysis Patients: A Case-Control Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0156297 ◽  
Author(s):  
Shih-Hsiang Ou ◽  
Mei-Yin Chen ◽  
Chien-Wei Huang ◽  
Nai-Ching Chen ◽  
Chien-Hsing Wu ◽  
...  
Keyword(s):  
Potential Role ◽  
Case Control Study ◽  
Case Control ◽  
Dialysis Patients ◽  
Control Study

scholarly journals Migraine and frequent tension-type headache are not associated with multiple sclerosis in a Norwegian case-control study

2016 ◽  
Vol 2 ◽  
pp. 205521731668297 ◽  
Author(s):  
MW Gustavsen ◽  
EG Celius ◽  
BS Winsvold ◽  
SM Moen ◽  
GO Nygaard ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Case Control Study ◽  
Case Control ◽  
Tension Type Headache ◽  
Expanded Disability Status Scale ◽  
Disability Status ◽  
Type Headache ◽  
One Year ◽  
The One ◽  
Control Study

Background Inconsistent results have been obtained with regard to headache comorbidity in multiple sclerosis (MS). Objective Investigate the one-year prevalence of migraine and tension-type headache (TTH) in Norwegian MS patients and relate this to clinical parameters. Methods A questionnaire concerning headache was administered to 756 MS patients and 1090 controls and used to determine the one-year prevalence of migraine and frequent TTH. Results No significant differences were seen between patients and controls or between patients with different disease course. Less migraine was observed in patients with Expanded Disability Status Scale score (EDSS) ≥4.0. Conclusions This case-control study does not support an association between migraine or TTH and MS.

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