Computed Tomography in the Elderly: 1. the Normal Population

1980 ◽  
Vol 136 (3) ◽  
pp. 249-255 ◽  
Author(s):  
Robin J. Jacoby ◽  
Raymond Levy ◽  
John M. Dawson
Keyword(s):  
Psychiatric Patients ◽  
Normal Population ◽  
The Elderly ◽  
Reciprocal Relationship ◽  
Cortical Atrophy ◽  
Global Rating ◽  
Computed Tomographic ◽  
Methodological Problems ◽  
Ct Data ◽  
Healthy Community

SummaryComputed tomographic (CT) and brief psychometric findings on 50 psychiatrically and neurologically healthy community residents over 60 years old are presented. The need for normative CT data is emphasized, and the methodological problems in obtaining them are discussed. Measures of ventricular size were generally found to be greater than those reported by other workers, and variation with age was also found to be less marked than hitherto reported. A reciprocal relationship was found between a global rating of cortical atrophy and a test of memory and orientation. This communication forms the basis for comparison with groups of psychiatric patients to be presented in subsequent articles.

Computed Tomography in the Elderly 2. Senile Dementia: Diagnosis and Functional Impairment

1980 ◽  
Vol 136 (3) ◽  
pp. 256-269 ◽  
Author(s):  
Robin J. Jacoby ◽  
Raymond Levy
Keyword(s):  
Senile Dementia ◽  
Clinical Signs ◽  
Cerebral Atrophy ◽  
The Elderly ◽  
Cognitive Test ◽  
Cortical Atrophy ◽  
Elderly Subjects ◽  
Computed Tomographic ◽  
Dementia Patients ◽  
Ct Data

SummaryClinical, psychometric and computed tomographic (CT) data are presented on three groups of elderly subjects: 50 normals, 40 patients with senile dementia and 41 suffering from affective disorder. Demented subjects showed significantly more CT evidence of cerebral atrophy than non-demented subjects, but there was considerable overlap. Although patients with a history or clinical signs of cerebral infarction were specifically excluded, such infarcts were found more often in CT scans of the dementia subjects than in the others, particularly when the diastolic blood pressure was raised. When correlating cognitive impairment with CT changes, ventricular size emerged as more important in the dementia patients, in contrast to the controls, in whom cortical atrophy was related to lower scores on a cognitive test. Other interesting findings included an inverse relationship between cortical atrophy and paranoid delusions.

Computed Tomography in the Elderly 3. Affective Disorder

1980 ◽  
Vol 136 (3) ◽  
pp. 270-275 ◽  
Author(s):  
Robin J. Jacoby ◽  
Raymond Levy
Keyword(s):  
Computed Tomography ◽  
Elderly Patients ◽  
Affective Disorders ◽  
The Elderly ◽  
Consecutive Series ◽  
Healthy Controls ◽  
Ventricular Size ◽  
Radiological Criteria ◽  
Computed Tomographic ◽  
Ct Data

SummaryClinical and computed tomographic (CT) data on a consecutive series of 41 elderly patients with affective disorders are presented, and comparisons made with a group of 50 healthy controls. In both groups ventricular size increased with age, but only in the controls was there an age correlation with sulcal widening. Using clinical and radiological criteria, the prevalence of cerebrovascular disease in the patient group was 12 per cent. A sub-group of patients with enlarged ventricles emerged, whose first depression began later in life, and who at the time of this study were older and showed more ‘endogenous’ features than the remainder. It is suggested that this provides further evidence that organic cerebral factors may have aetiological significance in some depressions of old age.

Considerations for Post-processing Parameters in Mixed-Method 3D Analyses

2021 ◽  
Vol 9 (4) ◽  
pp. 325-337
Author(s):  
Robert Z. Selden ◽  
Lauren N. Butaric ◽  
Kersten Bergstrom ◽  
Dennis Van Gerven
Keyword(s):  
Three Dimensional ◽  
Processing Parameters ◽  
Surface Model ◽  
Digital Repositories ◽  
Computed Tomographic ◽  
Archaeological Data ◽  
3D Data ◽  
Morphometric Analyses ◽  
Smoothing Parameters ◽  
Ct Data

ABSTRACTThe production of three-dimensional (3D) digital meshes of surface and computed tomographic (CT) data has become widespread in morphometric analyses of anthropological and archaeological data. Given that processing methods are not standardized, this leaves questions regarding the comparability of processed and digitally curated 3D datasets. The goal of this study was to identify those processing parameters that result in the most consistent fit between CT-derived meshes and a 3D surface model of the same human mandible. Eight meshes, each using unique thresholding and smoothing parameters, were compared to assess whole-object deviations, deviations along curves, and deviations between specific anatomical features on the surface model when compared with the CT scans using a suite of comparison points. Based on calculated gap distances, the mesh that thresholded at “0” with an applied smoothing technique was found to deviate least from the surface model, although it is not the most biologically accurate. Results have implications for aggregated studies that employ multimodal 3D datasets, and caution is recommended for studies that enlist 3D data from websites and digital repositories, particularly if processing parameters are unknown or derived for studies with different research foci.

scholarly journals Cognitive reserve in elderly: neuropsychological aspects and the education role in the latest findings

2015 ◽  
Vol 94 (3) ◽  
pp. 136
Author(s):  
João Gabriel Magalhães Dias ◽  
Pablo Rodrigo Andrade da Silva ◽  
Tânia Corrêa de Toledo Ferraz Alvez
Keyword(s):  
Executive Function ◽  
Cognitive Decline ◽  
Cognitive Performance ◽  
Cognitive Abilities ◽  
Elderly Population ◽  
Cognitive Reserve ◽  
The Elderly ◽  
Cortical Atrophy ◽  
Print Exposure ◽  
Cognitive Markers

The elderly population is growing worldwide, and therefore cognitive decline and dementia is a major problem for healthcare system. However, many elders do not develop dementia or significant cognitive impairment even though present brain lesions, such as cortical atrophy and/or lesions, leading to the concept of Cognitive Reserve (CR). The main objective of this review is to establish the recent findings of CR in elderly cognition and explore some of the cognitive markers related to CR. In order to accomplish that we carried out a search for papers published either in English or Portuguese language in the last 5 years in the Medline database using as keywords cognitive reserve, elderly and aging/ageing. We filtered 14 studies that specifically approached the neuropsychological aspects (e.g, memory, attention, orientation, executive function) and reviewed them in detail. Based on these papers regarding old-aged individuals, education appears to have several implications on CR by strengthening cognitive abilities, however does not appear to impact on cognitive decline. Besides, we realized that cognitive performance is one of the form to measure CR, even though the methods cannot be standardized, which may be the cause of some varied conclusions. Regarding CR, education was the most prevalent measure, and CR seems to have a beneficial effect on executive function and episodic memory and it seems to act by both neural reserve and neural compensation. Print exposure appears as a potential variable positively related to cognitive performance and CR.

Small Intestinal Angiosarcoma Leading to Perforation and Acute Abdomen

2004 ◽  
Vol 128 (1) ◽  
pp. 95-98
Author(s):  
Katalin Kelemen ◽  
Qing Qing Yu ◽  
Lydia Howard
Keyword(s):  
Malignant Neoplasm ◽  
The Elderly ◽  
Severe Bleeding ◽  
Multiple Tumor ◽  
Distal Small Intestine ◽  
Computed Tomographic ◽  
Free Air ◽  
Undifferentiated Cells ◽  
History Of ◽  
Vascular Channels

Abstract A 76-year-old man presented to the emergency room with abdominal pain and fatigue. The patient had a history of gastrointestinal bleeding. An abdominal computed tomographic scan showed collections of free air in the abdomen with obstruction of the distal small intestine and multiple masses in the liver. Laparotomy revealed a widespread malignant neoplasm in the abdomen, with multiple tumor nodules in the ileal wall, mesentery, and liver. The ileal wall was perforated within the area of one of the tumors. Pathologic examination of the lesion showed a neoplasm composed of solid sheets of spindle and undifferentiated cells, forming interlacing delicate vascular channels with atypical endothelial cells. The tumor cells were positive for the endothelial marker CD31, whereas reactivity for a broad panel of epithelial and other endothelial markers was negative. This case demonstrates that although angiosarcomas of the gastrointestinal tract are rare, they should be considered in cases of intestinal perforation or severe bleeding, especially in the elderly. A broad panel of immunochemical markers might be necessary to establish the pathologic diagnosis.

scholarly journals The Natural Historian's Guide to the CT Galaxy: Step-by-Step Instructions for Preparing and Analyzing Computed Tomographic (CT) Data Using Cross-Platform, Open Access Software

2020 ◽  
Vol 2 (1) ◽  
Author(s):  
T J Buser ◽  
O F Boyd ◽  
Á Cortés ◽  
C M Donatelli ◽  
M A Kolmann ◽  
...  
Keyword(s):  
Open Access ◽  
3D Printing ◽  
3D Visualization ◽  
3D Models ◽  
Digital Data ◽  
Anatomical Structures ◽  
Computed Tomographic ◽  
Biomechanical Models ◽  
Cross Platform ◽  
Ct Data

Synopsis The decreasing cost of acquiring computed tomographic (CT) data has fueled a global effort to digitize the anatomy of museum specimens. This effort has produced a wealth of open access digital three-dimensional (3D) models of anatomy available to anyone with access to the Internet. The potential applications of these data are broad, ranging from 3D printing for purely educational purposes to the development of highly advanced biomechanical models of anatomical structures. However, while virtually anyone can access these digital data, relatively few have the training to easily derive a desirable product (e.g., a 3D visualization of an anatomical structure) from them. Here, we present a workflow based on free, open source, cross-platform software for processing CT data. We provide step-by-step instructions that start with acquiring CT data from a new reconstruction or an open access repository, and progress through visualizing, measuring, landmarking, and constructing digital 3D models of anatomical structures. We also include instructions for digital dissection, data reduction, and exporting data for use in downstream applications such as 3D printing. Finally, we provide Supplementary Videos and workflows that demonstrate how the workflow facilitates five specific applications: measuring functional traits associated with feeding, digitally isolating anatomical structures, isolating regions of interest using semi-automated segmentation, collecting data with simple visual tools, and reducing file size and converting file type of a 3D model.

Computer-Assisted Surgery Using 3D Printed Saw Guides for Acute Correction of Antebrachial Angular Limb Deformities in Dogs

2019 ◽  
Vol 32 (03) ◽  
pp. 241-249 ◽  
Author(s):  
Andrew Worth ◽  
Katherine Crosse ◽  
Andrew Kersley
Keyword(s):  
Computer Aided Design ◽  
Sagittal Plane ◽  
Three Dimensional ◽  
Frontal Plane ◽  
Computer Assisted Surgery ◽  
Computer Assisted ◽  
Computed Tomographic ◽  
Limb Deformities ◽  
Ct Data ◽  
Saw Blade

Objective The aim of this study was to report the use of custom saw guides produced using computed tomographic imaging (CT), computer simulation and three-dimensional (3D) printing to aid surgical correction of antebrachial deformities in six dogs. Materials and Methods Antebrachial limb deformities in four small, and two large, breed dogs (seven limbs) were surgically corrected by a radial closing wedge ostectomy and ulnar osteotomy. The location and orientation of the wedge ostectomy were determined using CT data, computer-assisted planning and production of a saw guide in plastic using a 3D printer. At surgery, the guide was clamped to the surface of the radius and used to direct the oscillating saw blade. The resultant ostectomy was closed and stabilized with a bone plate. Results Five limbs healed without complications. One limb was re-operated due to a poorly resolved rotational component of the deformity. One limb required additional stabilisation with external fixation due to screw loosening. The owners of five dogs completed a Canine Orthopedic Index survey at a follow-up period of 37 to 81 months. The median preoperative score was 3.5 and the median postoperative score was 1, representing an overall positive effect of surgery. Radiographically, 5/7 limbs were corrected in the frontal plane (2/7 were under-corrected). Similarly, 5/7 limbs were corrected in the sagittal plane, and 2/7 were over-corrected in the sagittal place. Conclusions Computer-aided design and rapid prototyping technologies can be used to create saw guides to simplify one-stage corrective osteotomies of the antebrachium using internal fixation in dogs. Despite the encouraging results, accurate correction of rotational deformity was problematic and this aspect requires further development.

Spontaneous spinal cerebrospinal fluid leaks as the cause of subdural hematomas in elderly patients on anticoagulation

2010 ◽  
Vol 112 (2) ◽  
pp. 295-299 ◽  
Author(s):  
Wouter I. Schievink ◽  
M. Marcel Maya ◽  
Brian K. Pikul ◽  
Charles Louy
Keyword(s):  
Elderly Patients ◽  
Intracranial Hypotension ◽  
Medical Center ◽  
Spontaneous Intracranial Hypotension ◽  
The Elderly ◽  
Cortical Atrophy ◽  
Csf Leak ◽  
Subdural Hematomas ◽  
Maximal Diameter ◽  
Subdural Bleeding

Subdural hematoma is a relatively common complication of long-term anticoagulation, particularly in the elderly. The combination of anticoagulation and cerebral cortical atrophy is believed to be sufficient to explain the subdural bleeding. The authors report a series of elderly patients who were on a regimen of anticoagulation and developed chronic subdural hematomas (SDHs) due to a spontaneous spinal CSF leak. They reviewed the medical records and imaging studies of a consecutive group of patients with spontaneous intracranial hypotension who were evaluated at Cedars-Sinai Medical Center. Among 141 patients with spontaneous spinal CSF leaks and spontaneous intracranial hypotension, 3 (2%) were taking anticoagulants at the time of onset of symptoms. The mean age of the 3 patients (1 woman and 2 men) was 74 years (range 68–86 years). All 3 patients had chronic SDHs measuring between 12 and 23 mm in maximal diameter. The SDHs resolved after treatment of the underlying spontaneous spinal CSF leak, and there was no need for hematoma evacuation. Epidural blood patches were used in 2 patients, and percutaneous placement of a fibrin sealant was used in 1 patient. The presence of an underlying spontaneous spinal CSF leak should be considered in patients with chronic SDHs, even among the elderly taking anticoagulants.

scholarly journals Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer’s disease

2018 ◽  
Vol 115 (6) ◽  
pp. E1289-E1298 ◽  
Author(s):  
Rachel E. Bennett ◽  
Ashley B. Robbins ◽  
Miwei Hu ◽  
Xinrui Cao ◽  
Rebecca A. Betensky ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Blood Vessel ◽  
Cell Biology ◽  
The Elderly ◽  
Brain Regions ◽  
Cortical Atrophy ◽  
Vascular Abnormalities ◽  
Alzheimer Pathology

Mixed pathology, with both Alzheimer’s disease and vascular abnormalities, is the most common cause of clinical dementia in the elderly. While usually thought to be concurrent diseases, the fact that changes in cerebral blood flow are a prominent early and persistent alteration in Alzheimer’s disease raises the possibility that vascular alterations and Alzheimer pathology are more directly linked. Here, we report that aged tau-overexpressing mice develop changes to blood vessels including abnormal, spiraling morphologies; reduced blood vessel diameters; and increased overall blood vessel density in cortex. Blood flow in these vessels was altered, with periods of obstructed flow rarely observed in normal capillaries. These changes were accompanied by cortical atrophy as well as increased expression of angiogenesis-related genes such as Vegfa, Serpine1, and Plau in CD31-positive endothelial cells. Interestingly, mice overexpressing nonmutant forms of tau in the absence of frank neurodegeneration also demonstrated similar changes. Furthermore, many of the genes we observe in mice are also altered in human RNA datasets from Alzheimer patients, particularly in brain regions classically associated with tau pathology such as the temporal lobe and limbic system regions. Together these data indicate that tau pathological changes in neurons can impact brain endothelial cell biology, altering the integrity of the brain’s microvasculature.

scholarly journals Substance Use Disorders in Elderly Admissions to an Academic Psychiatric Inpatient Service over a 10-Year Period

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Dennis Dombrowski ◽  
Nelly Norrell ◽  
Suzanne Holroyd
Keyword(s):  
Substance Use ◽  
Substance Use Disorders ◽  
Psychiatric Patients ◽  
Psychiatric Inpatient ◽  
Psychiatric Inpatients ◽  
The Elderly ◽  
Inpatient Service ◽  
Chi Square ◽  
Lengths Of Stay ◽  
Psychiatric Admissions

Objective. There is a paucity of research on substance use disorders (SUDs) in the elderly psychiatric population. This study examines SUDs in a geriatric psychiatry inpatient service over a 10-year period.Methods. Data from 1788 elderly psychiatric inpatients from a ten-year period was collected. Variables collected included psychiatric diagnoses, SUD, number of psychiatric admissions, and length of stay. Those with and without a SUD were compared using Chi-Square or Student’st-test as appropriate using SPSS.Results. 11.7% (N=210) of patients had a SUD, and the most common substance was alcohol at 73.3% (N=154) or 8.6% of all admissions. Other SUDs were sedative-hypnotics (11%), opiate (2.9%), cannabis (1%), tobacco (1.4%), and unspecified SUD (38.6%). SUD patients were significantly younger, divorced, male, and less frequently readmitted and had shorter lengths of stay. The most common comorbid diagnoses were major depression (26.1%), bipolar disorder (10.5%), and dementia (17.1%).Conclusions. Over 10% of psychogeriatric admissions were associated with a SUD, with alcohol being the most common. Considering the difficulties in diagnosing SUD in this population and the retrospective study design, the true prevalence in elderly psychiatric inpatients is likely higher. This study adds to sparse literature on SUD in elderly psychiatric patients.

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