Clinical Features and Diagnostic Criteria of Depression in Down's Syndrome

1994 ◽  
Vol 165 (3) ◽  
pp. 399-403 ◽  
Author(s):  
Sally-Ann Cooper ◽  
Richard A. Collacott
Keyword(s):  
Diagnostic Criteria ◽  
Clinical Features ◽  
Depressive Episode ◽  
Major Depressive Episode ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Future Research ◽  
Major Depressive ◽  
Icd 10 ◽  
Depressive Episodes

BackgroundDepression occurs commonly in people with Down's syndrome, although there is little published about this association. This study explores the limitations of Diagnostic Criteria for Research, based on ICD-10 (DCR) and DSM–III–R depressive criteria.MethodCase note examination identified 42 adults with Down's syndrome who have sustained 56 depressive episodes. The clinical features are reported.ResultsAll episodes were diagnosed as depression. DSM–III–R criteria for major depressive episode were met by 50% of the episodes. DCR for depressive episode of at least mild severity were fulfilled by 68%.ConclusionsThese criteria were unduly restrictive for this group. Commonly occurring symptoms are not included in the criteria, while certain criteria items never occurred. Criteria should be modified to facilitate future research.

Age and marital status predictors of binge alcohol use among adults with major depressive episode

2020 ◽  
Author(s):  
Areen Omary
Keyword(s):  
At Risk ◽  
Alcohol Use ◽  
Marital Status ◽  
Depressive Episode ◽  
Major Depressive Episode ◽  
Age Groups ◽  
Future Research ◽  
Major Depressive ◽  
Never Married ◽  
At Risk Populations

Aims: This study aims to examine if age and marital status can predict the risk for binge alcohol use (BAU) among adults with a major depressive episode (MDE). Methods: Data from the Substance Abuse and Mental Health Services Administration’s (SAMHSA) 2018 National Survey for Drug Use and Health (NSDUH) were analyzed. The unweighted sample included 6,999 adults representing a weighted population size of 33,900,452.122 in the US. Results and Conclusions: The findings of this retrospective research confirmed that age and marital status significantly predicted BAU in the past month among adults with MDE. Adults with MDE at higher risk for BAU were adults under the age of 50, adults who were never married, and adults who were divorced/separated. Special attention must be paid to those in age groups under 50, never married, and have been separated/divorced who are particularly at-risk for future alcohol abuse. Future research should consider examining additional potential confounders for BAU among other at-risk populations.

Work stress as a risk factor for major depressive episode(s)

2004 ◽  
Vol 35 (6) ◽  
pp. 865-871 ◽  
Author(s):  
JIANLI WANG
Keyword(s):  
Multivariate Analysis ◽  
Risk Factor ◽  
Major Depression ◽  
Work Stress ◽  
Depressive Episode ◽  
Major Depressive Episode ◽  
Working Population ◽  
Major Depressive ◽  
Major Depressive Episodes ◽  
Depressive Episodes

Background. Major depression is a prevalent mental disorder in the general population, with a multi-factorial etiology. However, work stress as a risk factor for major depression has not been well studied.Method. Using a longitudinal study design, this analysis investigated the association between the levels of work stress and major depressive episode(s) in the Canadian working population, aged 18 to 64 years. Data from the longitudinal cohort of the Canadian National Population Health Survey (NPHS) were used (n=6663). The NPHS participants who did not have major depressive episodes (MDE) at baseline (1994–1995 NPHS) were classified into four groups by the quartile values of the baseline work stress scores. The proportion of MDE of each group was calculated using the 1996–1997 NPHS data.Results. The first three quartile groups had a similar risk of MDE. Those who had a work stress score above the 75th percentile had an elevated risk of MDE (7·1%). Using the 75th percentile as a cut-off, work stress was significantly associated with the risk of MDE in multivariate analysis (odds ratio=2·35, 95% confidence interval 1·54–3·77). Other factors associated with MDE in multivariate analysis included educational level, number of chronic medical illnesses and child and adulthood traumatic events. There was no evidence of effect modification between work stress and selected sociodemographic, clinical and psychosocial variables.Conclusions. Work stress is an independent risk factor for the development of MDE in the working population. Strategies to improve working environment are needed to keep workers mentally healthy and productive.

Depression-related impairment: estimating concurrent and lingering effects

1993 ◽  
Vol 23 (2) ◽  
pp. 373-386 ◽  
Author(s):  
Dan L. Tweed
Keyword(s):  
Social Functioning ◽  
Linear Model ◽  
Clinical Features ◽  
Depressive Episode ◽  
Major Depressive Episode ◽  
Community Sample ◽  
Major Depressive ◽  
Large Community ◽  
Research Designs ◽  
Course Of Depression

SynopsisThis article examines the effects of depression in the sphere of social functioning. On the basis of previous research, it is hypothesized that a major depressive episode has both concurrent and lingering effects and that these effects are a function of the clinical features associated with the episode. This hypothesis is examined using a large community sample and a non-linear model containing both concurrent and lingering effect parameters. The results corroborate the hypothesized effects. Limitations of the current study are discussed and suggestions are offered regarding appropriate research designs. It is suggested that the most general limitation is theoretical. The existence of lingering effects is a phenomenon which presents a theoretical challenge that may prove strategic in understanding the nature and course of depression.

scholarly journals Major depressive episode among university students in Southern Brazil

2020 ◽  
Vol 54 ◽  
pp. 11 ◽  
Author(s):  
Betina Daniele Flesch ◽  
Gbènankpon Mathias Houvèssou ◽  
Tiago Neuenfeld Munhoz ◽  
Anaclaudia Gastal Fassa
Keyword(s):  
University Students ◽  
Depressive Episode ◽  
Major Depressive Episode ◽  
Negative Impact ◽  
Multivariable Analysis ◽  
Prevalence Ratio ◽  
Southern Brazil ◽  
Major Depressive ◽  
Major Depressive Episodes ◽  
Depressive Episodes

INTRODUCTION: Depression is the leading cause of disability around the world, and it has been increasingly affecting young people. This study evaluates the prevalence and factors associated with major depression in university students, with emphasis on the influence of the academic field, chosen study area and the environment they are inserted. METHODS: A census of students who entered the university in the first semester of 2017 was held at a university in Southern Brazil. The outcome of major depressive episode was evaluated using the Patient Health Questionnaire-9, considered when the individual had five or more depressive symptoms for at least one week. Its prevalence was estimated, and the associated factors were examined by the hierarchical multivariable analysis using the Poisson regression model. RESULTS: A total of 32% (95% confidence interval 29.9–34.2) of university students presented a major depressive episode, and the problem was more frequent among women (prevalence ratio [PR] = 1.59); people aged 21 to 23 years (PR = 1.24); those with a family history of depression (PR = 1.27); minorities’ sexual orientation (homosexuals, PR = 1.64, and bisexuals, PR = 1.69); who lived with friends or colleagues (PR = 1.36); students in the area of applied social and human sciences (PR = 1.28), and linguistics, language and literature, and art (PR = 1.25). The worst academic performance (PR = 2.61), alcohol abuse (PR = 1.25), and illicit drug use (PR = 1.30) were also positively associated with major depressive episode. CONCLUSION: In addition to individual, family, and behavioral aspects, already described as risk factors for major depressive episodes in the general population, academic aspects also influence the occurrence of depression among university students. Considering the high prevalence of major depressive episode and its negative impact on health, public and institutional policies are necessary to focus on students’ mental health promotion and care.

scholarly journals Underdiagnosis of Major Depressive Episodes in Hemodialysis Patients: The Need for Screening and Patient Education

2021 ◽  
Vol 10 (18) ◽  
pp. 4109
Author(s):  
Wojciech Orzechowski ◽  
Wiktor Buczek ◽  
Joanna Emma Szczerba ◽  
Ryszard Gellert ◽  
Andrzej Rydzewski ◽  
...  
Keyword(s):  
Depressive Episode ◽  
Major Depressive Episode ◽  
Coping Styles ◽  
Well Being ◽  
Major Depressive ◽  
Dialysis Vintage ◽  
Metacognitive Beliefs ◽  
Perception Of Self ◽  
Major Depressive Episodes ◽  
Depressive Episodes

This article aims to identify the reasons why patients with major depressive episode (MDE) do not seek treatment for their mental disorder. 89 out of 208 persons screened were diagnosed with major depressive episode using the Mini-International Neuropsychiatric Interview. 85 individuals with untreated depression filled out the following questionnaires: Beck Depression Inventory, List of Explanations of Well-Being (LEWB), Brief Measure to Assess Perception of Self-Influence on the Course of the Disease, Coping Inventory for Stressful Situations, Brief Method of Evaluating Coping with Disease, and Metacognitions Questionnaire. There were 43 women (50.6%) and 42 men (49.4%), aged 24 to 93 years (Mean (M) = 68.26 years; Standard Deviation (SD) = 14.19 years), with dialysis vintage ranging from 1 month to 33 years (M = 70.63 months; SD = 75.26 months). Among study patients, 70.6% declared that depression was the cause of their poor well-being, 75.3% attributed their depressive symptoms to kidney failure, and 49.4%, more specifically, to hemodialysis. A total of 64.7% of patients had a low perception of self-influence on the course of their kidney disease, and 58.5% presented a coping style focused on emotions. The most frequent dysfunctional metacognitive beliefs were negative beliefs about not controlling one’s own thoughts. This attitude was related to the low perception of self-influence on the course of the disease, maladaptive coping styles, and dysfunctional metacognitive beliefs.

Depression in Primary Care 1: Elderly Patients' Disclosure of Depressive Symptoms to Their Doctors

2001 ◽  
Vol 13 (3) ◽  
pp. 359-365 ◽  
Author(s):  
Daniel W. O'Connor ◽  
Richard Rosewarne ◽  
Ann Bruce
Keyword(s):  
Depressive Symptoms ◽  
Depressive Episode ◽  
Older Patients ◽  
Medical Practitioner ◽  
Female Gender ◽  
Major Depressive ◽  
General Medical Practitioner ◽  
Icd 10 ◽  
Major Depressive Episodes ◽  
Depressive Episodes

Background: This article examines some of the factors responsible for older patients' decision to report current depressive symptoms to their general medical practitioner. A companion article considers factors contributing to general practitioners' (GPs') recognition of major depressive episode when it was present. Methods: A survey was conducted of a stratified sample of 1,021 patients aged 70+ years of 30 GPs in Melbourne, Australia, to gauge the prevalence of depressive symptoms, the frequency with which patients had informed GPs of their symptoms, and GPs' recognition of major depressive episodes. Patients and informants were questioned using the Canberra Interview for the Elderly, which generates rigorous ICD-10 research diagnoses. Results: Logistic regression analysis showed that symptom disclosure was associated in descending order of importance with higher depressive scores, previous contact with a psychiatrist, and female gender. Even so, 48% of persons with ICD-10 moderate or severe depressive episode had not reported any current complaints to their doctor at the time of interview. Conclusion: Older patients often do not report depressive symptoms to their medical practitioner. Men and patients lacking “psychological mindedness” may be at special risk.

scholarly journals Association between Depression and Renal Hyperfiltration in a General Chinese Population

2019 ◽  
Vol 44 (6) ◽  
pp. 1441-1452
Author(s):  
Miao Lin ◽  
Huibin Huang ◽  
Jin Yao ◽  
Jixing Liang ◽  
Liantao Li ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Depressive Episode ◽  
Major Depressive Episode ◽  
Structured Interview ◽  
Multivariable Logistic Regression Analysis ◽  
Major Depressive ◽  
Renal Hyperfiltration ◽  
A Minor ◽  
Major Depressive Episodes ◽  
Depressive Episodes

Background: Depression is prevalent in patients with all stages of CKD and is associated with adverse outcome. Abnormally elevated GFR, or hyperfiltration, may play a crucial role in the initiation and progression of CKD. However, the association between depression and hyperfiltration is not known. The aim of this study is to investigate the relationship between depression and hyperfiltration. Methods: This was an observational cross-sectional study. A total of 3,716 volunteers (1,303 males and 2,413 females) aged 40–75 years without CKD from a community in China were included for the study. Depressive symptoms and the presence of a minor or major depressive episode were assessed with the 9-item Patient Health Questionnaire (PHQ-9) and Diagnostic and Statistical Manual of Mental Disorders (4th edition)-based structured interview, respectively. Results: The mean age of the participants in the present study was 53.8 ± 9.0 years. 115 participants had clinically relevant depression, and 122 participants had a minor or major depressive episode. In a multivariable logistic regression analysis adjusted for potential confounders, the association between clinically relevant depression and renal hyperfiltration remained significant in men but not in women. As compared with men without depression (PHQ <5) or depressive episodes, those with clinically relevant depression (PHQ ≥10) had a significantly higher risk of renal hyperfiltration. The fully adjusted OR (95% CI) was 4.81 (1.62–14.30, p = 0.005), those with a major depressive episode had a higher risk of renal hyperfiltration (OR 7.45; 95% CI 2.04–27.21, p = 0.002). Conclusion: Depressive symptoms and major depressive episodes are associated with renal hyperfiltration in middle-aged and elderly Chinese men without CKD. Future studies are needed to verify and clarify the role of depression in the development of abnormally high eGFR and CKD.

Presence of Irritability During Depressive Episodes in Bipolar Disorder

CNS Spectrums ◽  
2004 ◽  
Vol 9 (3) ◽  
pp. 227-231 ◽  
Author(s):  
Thilo Deckersbach ◽  
Roy H. Perlis ◽  
W. Gordon Frankle ◽  
Stephen M. Gray ◽  
Louisa Grandin ◽  
...  
Keyword(s):  
Depressive Episode ◽  
Major Depressive Episode ◽  
Massachusetts General Hospital ◽  
Bimodal Distribution ◽  
Significant Degree ◽  
Assessment Instrument ◽  
Major Depressive ◽  
Bipolar I Disorder ◽  
Dsm Iv ◽  
Depressive Episodes

ABSTRACTBackground:This study examined the prevalence of irritability in patients with bipolar I disorder during an episode of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) major depression who do not meet criteria for a mixed episode.Method:A chart review of 111 patients with bipolar I disorder treated at the Massachusetts General Hospital Bipolar Clinic between 1998 and 2000 identified 34 patients who met criteria for a DSM-IV major depressive episode in the absence of (1) mood elevation and/or (2) irritability associated with any additional above threshold DSM-IV symptoms of mania. Data gathered from the charts utilized prospective ratings made routinely at each clinic visit using the Clinical Monitoring Form (CMF), a structured assessment instrument which includes modified versions of the mood modules of the Structured Clinical Interview for DSM-IV. Data from these 34 patients were reviewed to determine the presence of irritability.Results:The frequency of abnormal irritability in these 34 patients followed a bimodal distribution: 26% of the patients showed abnormal irritability ≥75% of the time, compared with 68% of the patients with abnormal irritabihty ≤30% of the time. Of the high-irritability patients, psychomotor agitation was rated as definitely present to a significant degree in 44%. Talkativeness and distractibility were rated present but subthreshold in one patient each. All other symptoms of DSM-IV mania were absent.Conclusion:Approximately 25% of patients with bipolar I disorder who meet criteria for a DSM-IV major depressive episode also experienced substantial irritability in the absence of associated symptoms of mania. Our results suggest that abnormal irritability is not limited to mania or mixed states.

scholarly journals Blood microbiota and metabolomic signature of major depression before and after antidepressant treatment: a prospective case–control study

2021 ◽  
Vol 46 (3) ◽  
pp. E358-E368
Author(s):  
Dragos Ciocan ◽  
Anne-Marie Cassard ◽  
Laurent Becquemont ◽  
Céline Verstuyft ◽  
Cosmin Sebastian Voican ◽  
...  
Keyword(s):  
Depressive Episode ◽  
Major Depressive Episode ◽  
Antidepressant Treatment ◽  
Case Control ◽  
Healthy Controls ◽  
Major Depressive ◽  
Rdna Sequencing ◽  
Before And After ◽  
Major Depressive Episodes ◽  
Depressive Episodes

Background: The microbiota interacts with the brain through the gut–brain axis, and a distinct dysbiosis may lead to major depressive episodes. Bacteria can pass through the gut barrier and be found in the blood. Using a multiomic approach, we investigated whether a distinct blood microbiome and metabolome was associated with major depressive episodes, and how it was modulated by treatment. Methods: In this case–control multiomic study, we analyzed the blood microbiome composition, inferred bacterial functions and metabolomic profile of 56 patients experiencing a current major depressive episode and 56 matched healthy controls, before and after treatment, using 16S rDNA sequencing and liquid chromatography coupled to tandem mass spectrometry. Results: The baseline blood microbiome in patients with a major depressive episode was distinct from that of healthy controls (patients with a major depressive episode had a higher proportion of Janthinobacterium and lower levels of Neisseria) and changed after antidepressant treatment. Predicted microbiome functions confirmed by metabolomic profiling showed that patients who were experiencing a major depressive episode had alterations in the cyanoamino acid pathway at baseline. High baseline levels of Firmicutes and low proportions of Bosea and Tetrasphaera were associated with response to antidepressant treatment. Based on inferred baseline metagenomic profiles, bacterial pathways that were significantly associated with treatment response were related to xenobiotics, amino acids, and lipid and carbohydrate metabolism, including tryptophan and drug metabolism. Metabolomic analyses showed that plasma tryptophan levels are independently associated with response to antidepressant treatment. Limitations: Our study has some limitations, including a lack of information on blood microbiome origin and the lack of a validation cohort to confirm our results. Conclusion: Patients with depression have a distinct blood microbiome and metabolomic signature that changes after treatment. Dysbiosis could be a new therapeutic target and prognostic tool for the treatment of patients who are experiencing a major depressive episode.

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