Some Observations on Renal Function in Mental Disorder

1936 ◽  
Vol 82 (338) ◽  
pp. 242-253 ◽  
Author(s):  
B. H. Shaw
Keyword(s):  
Renal Function ◽  
Mental Disorder ◽  
Renal Dysfunction ◽  
Point Of View ◽  
Clear Cut ◽  
Clinical Type ◽  
Clinical Point ◽  
Selection Of

Renal dysfunction is so commonly present in cases of mental breakdown that it is of interest to know whether it is especially associated with any definite clinical type or types of mental disorder. In an endeavour to ascertain this, cases have been selected from recent admissions in which the form of disorder from a clinical point of view appeared to be sufficiently marked to warrant placing them in a definite category. Many cases present such a mixture of cycloid, schizoid, confusional or paranoid indications that in an investigation of this nature the selection of sufficiently clear-cut types from a clinical standpoint is not altogether an easy matter. To determine the degree of concentration and polyuria, Rosenberg's modification of the Volhard test has been adopted. It involves little discomfort to the patient and is as follows:—

scholarly journals Distinction between euthanasia and palliative sedation is clear-cut

2019 ◽  
Vol 46 (1) ◽  
pp. 55-56 ◽  
Author(s):  
Lars Johan Materstvedt
Keyword(s):  
Common Ground ◽  
Palliative Sedation ◽  
Point Of View ◽  
Opioid Use ◽  
Clear Cut ◽  
Clinical Point ◽  
Relief Of Suffering

This article is a response to Thomas David Riisfeldt’s paper entitled ‘Weakening the ethical distinction between euthanasia, palliative opioid use and palliative sedation’. It is shown that as far as euthanasia and palliative sedation are concerned, Riisfeldt has not established that a common ground, or a similarity, between the two is the relief of suffering. Quite the contrary, this is not characteristic of euthanasia, neither by definition nor from a clinical point of view. Hence, the argument hinges on a conceptually and empirically erroneous premise and is accordingly a non-starter.

Pharmacogenetic Testing in Nephrological Clinic

2016 ◽  
pp. 83-86
Author(s):  
D. Ivanov ◽  
A. Melnik
Keyword(s):  
Drug Response ◽  
Antihypertensive Drugs ◽  
Antihypertensive Agents ◽  
Point Of View ◽  
First Line ◽  
Pharmacogenetic Testing ◽  
Clinical Point ◽  
Slow Metabolizers ◽  
Selection Of

Selection of antihypertensive agents using pharmacogenetic tests and individual tolerance is essential in nephrology. Antihypertensive drugs are metabolized first line through various isoforms CYP (CYP2D6, CYP2C9, CYP2C19 and CYP3A4/5). These isoforms are the most significant for the patient in response to drug response. From a clinical point of view, it is important to establish the slow metabolizers (poor metabolism, PM), because it is they need to use other doses of antihypertensive drugs that different from the standard.

scholarly journals Features of anesthesia in pregnant women with subarachnoid hemorrhages

2013 ◽  
Vol 94 (1) ◽  
pp. 89-95
Author(s):  
A Z Bayalieva ◽  
R Y Shpaner ◽  
E I Bogdanova ◽  
I R Ganeeva
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Pregnant Women ◽  
Treatment Options ◽  
Systolic Pressure ◽  
Point Of View ◽  
Oxygen Intake ◽  
Review Of The Literature ◽  
Clinical Point ◽  
Subarachnoid Hemorrhages ◽  
Selection Of

The review of the literature on anesthesia in pregnant women with subarachnoid hemorrhage is presented. Physiological changes of pregnancy should by undoubtedly taken into consideration while performing anesthesia and surgery because of the comorbidities. Particularly, the oxygen intake is higher in pregnant. Adequate systolic pressure is also a very important parameter maintaining the intrauterine blood flow and fetus perfusion during the whole term of pregnancy. Medications used in pregnant women can also influence the fetus. From the clinical point of view, the selection of anesthetics and other medications allowed for use in pregnant women should be limited to medications that are proven to be safe. Pharmacological effects of the medications, used for anesthesia and treatment of pregnant women with subarachnoid hemorrhage are covered in the review, including their influence on fetus. Surgical treatment options for pregnant women at different pregnancy terms with different conditions requiring neurosurgery are surveyed. Post-surgical rehabilitation of pregnant women with subarachnoid hemorrhage is reviewed. In each particular clinical case an individual anesthesia plan should be created considering the pregnancy term and features of the disease.

scholarly journals PENDEKATAN SOSIAL DALAM PENELITIAN KESEHATAN REPRODUKSI

Populasi ◽  
2016 ◽  
Vol 6 (2) ◽  
Author(s):  
Rosalia Sciortino
Keyword(s):  
Family Planning Program ◽  
Reproductive Behaviour ◽  
Point Of View ◽  
Gender Relation ◽  
Planning Program ◽  
Cultural Research ◽  
Clinical Point ◽  
The Right ◽  
Goals And Objectives ◽  
Selection Of

Population problems, particularly fertility and family planning program, used to be approached from a clinical instead of socio-culture perspectives. A clinical point of view never involves through aspect of reproductive right thought; which includes the right of any individuals (men and women) and couples (husband-wife) in making decisions in terms of reproductive behaviour along their reproductive ages. In this regard, this paper states that reproductive healthproblems should be understood from a social perspective. This is because reproductive health problems is cause and influence social, political,and economic system as well as gender relation. Therefore, the selection of the appropriate social - cultural research methods/approaches is undoubtedly needed. Methodology should be developed appropriately to meet the research goals and objectives.

Tauchnitz for Translators. The Circulation of English-language Literature in Finland

2019 ◽  
Vol 16 (2-3) ◽  
pp. 161-179
Author(s):  
Outi Paloposki
Keyword(s):  
Foreign Language ◽  
English Language ◽  
Book History ◽  
Language Skills ◽  
Point Of View ◽  
Book Production ◽  
German Publisher ◽  
Language Literature ◽  
Selection Of

The article looks at book production and circulation from the point of view of translators, who, as purchasers and readers of foreign-language books, are an important mediating force in the selection of literature for translation. Taking the German publisher Tauchnitz's series ‘Collection of British Authors’ and its circulation in Finland in the nineteenth and early twentieth century as a case in point, the article argues that the increased availability of English-language books facilitated the acquiring and honing of translators' language skills and gradually diminished the need for indirect translating. Book history and translation studies meet here in an examination of the role of the Collection in Finnish translators' work.

COMBINATORIAL POLYNOMIALLY COMPUTABLE CHARACTERISTICS OF SUBSTITUTIONS AND THEIR PROPERTIES

2020 ◽  
Vol 7 (2) ◽  
pp. 34-41
Author(s):  
VLADIMIR NIKONOV ◽  
◽  
ANTON ZOBOV ◽  
Keyword(s):  
Mathematical Expectation ◽  
Point Of View ◽  
Small Range ◽  
Computational Point ◽  
Wide Range ◽  
Bijective Function ◽  
The Difference ◽  
Element Base ◽  
Selection Of

The construction and selection of a suitable bijective function, that is, substitution, is now becoming an important applied task, particularly for building block encryption systems. Many articles have suggested using different approaches to determining the quality of substitution, but most of them are highly computationally complex. The solution of this problem will significantly expand the range of methods for constructing and analyzing scheme in information protection systems. The purpose of research is to find easily measurable characteristics of substitutions, allowing to evaluate their quality, and also measures of the proximity of a particular substitutions to a random one, or its distance from it. For this purpose, several characteristics were proposed in this work: difference and polynomial, and their mathematical expectation was found, as well as variance for the difference characteristic. This allows us to make a conclusion about its quality by comparing the result of calculating the characteristic for a particular substitution with the calculated mathematical expectation. From a computational point of view, the thesises of the article are of exceptional interest due to the simplicity of the algorithm for quantifying the quality of bijective function substitutions. By its nature, the operation of calculating the difference characteristic carries out a simple summation of integer terms in a fixed and small range. Such an operation, both in the modern and in the prospective element base, is embedded in the logic of a wide range of functional elements, especially when implementing computational actions in the optical range, or on other carriers related to the field of nanotechnology.

Early Renal Dysfunction in Obese Patients with Insulin Resistance

2019 ◽  
Vol 26 (3) ◽  
pp. 261-265
Author(s):  
Natalia Pertseva ◽  
Mariia Rokutova
Keyword(s):  
Insulin Resistance ◽  
Renal Function ◽  
Renal Dysfunction ◽  
Filtration Rate ◽  
Diagnostic Value ◽  
Glomerular Hyperfiltration ◽  
Model Assessment ◽  
Homa Index ◽  
Obese Patients ◽  
Homeostasis Model Assessment

Abstract Background and aims. Obese individuals have insulin resistance status assessed in the present study by the HOMA index (“Homeostasis model assessment”). This prospective study assessed renal disorders in the insulin resistance in obese patients. Material and Methods. The study included 73 young obese patients. The assessment included the HOMA index before meal and parameters of renal function (glomerular filtration rate, albuminuria, β2-microglobulinuria). Results. In young obese, insulin-resistance patients, glomerular hyperfiltration and β2-microglobulinuria are found in 77.0 and 93.4% of cases respectively. The albuminuria is noted in some cases, which reduces diagnostic value. Conclusions. In young obese patients with insulin resistance, glomerular hyperfiltration and β2-microglobulinuria are main diagnostic markers of renal dysfunction.

Der Sommer und Herbst 2003 aus phänologischer Sicht | Summer and autumn 2003 from a phenological point of view

2004 ◽  
Vol 155 (5) ◽  
pp. 142-145 ◽  
Author(s):  
Claudio Defila
Keyword(s):  
Time Series ◽  
New Record ◽  
Point Of View ◽  
Late Spring ◽  
Mean Deviation ◽  
Leaf Shedding ◽  
The Mean ◽  
Very High ◽  
Selection Of

The record-breaking heatwave of 2003 also had an impact on the vegetation in Switzerland. To examine its influences seven phenological late spring and summer phases were evaluated together with six phases in the autumn from a selection of stations. 30% of the 122 chosen phenological time series in late spring and summer phases set a new record (earliest arrival). The proportion of very early arrivals is very high and the mean deviation from the norm is between 10 and 20 days. The situation was less extreme in autumn, where 20% of the 103 time series chosen set a new record. The majority of the phenological arrivals were found in the class «normal» but the class«very early» is still well represented. The mean precocity lies between five and twenty days. As far as the leaf shedding of the beech is concerned, there was even a slight delay of around six days. The evaluation serves to show that the heatwave of 2003 strongly influenced the phenological events of summer and spring.

Design of Inhibitors for Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Enzyme of Leishmania mexicana

2020 ◽  
Vol 16 (6) ◽  
pp. 784-795
Author(s):  
Krisnna M.A. Alves ◽  
Fábio José Bonfim Cardoso ◽  
Kathia M. Honorio ◽  
Fábio A. de Molfetta
Keyword(s):  
Molecular Dynamics ◽  
Molecular Dynamics Simulations ◽  
Binding Site ◽  
Point Of View ◽  
New Drugs ◽  
Leishmania Mexicana ◽  
Receptor Complexes ◽  
Starting Point ◽  
Dynamics Simulations ◽  
Selection Of

Background:: Leishmaniosis is a neglected tropical disease and glyceraldehyde 3- phosphate dehydrogenase (GAPDH) is a key enzyme in the design of new drugs to fight this disease. Objective:: The present study aimed to evaluate potential inhibitors of GAPDH enzyme found in Leishmania mexicana (L. mexicana). Methods: A search for novel antileishmanial molecules was carried out based on similarities from the pharmacophoric point of view related to the binding site of the crystallographic enzyme using the ZINCPharmer server. The molecules selected in this screening were subjected to molecular docking and molecular dynamics simulations. Results:: Consensual analysis of the docking energy values was performed, resulting in the selection of ten compounds. These ligand-receptor complexes were visually inspected in order to analyze the main interactions and subjected to toxicophoric evaluation, culminating in the selection of three compounds, which were subsequently submitted to molecular dynamics simulations. The docking results showed that the selected compounds interacted with GAPDH from L. mexicana, especially by hydrogen bonds with Cys166, Arg249, His194, Thr167, and Thr226. From the results obtained from molecular dynamics, it was observed that one of the loop regions, corresponding to the residues 195-222, can be related to the fitting of the substrate at the binding site, assisting in the positioning and the molecular recognition via residues responsible for the catalytic activity. Conclusion:: he use of molecular modeling techniques enabled the identification of promising compounds as inhibitors of the GAPDH enzyme from L. mexicana, and the results obtained here can serve as a starting point to design new and more effective compounds than those currently available.

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