Weight Management and Physical Activity for Breast Cancer Prevention and Control

2019 ◽  
pp. e22-e33 ◽  
Author(s):  
Jennifer A. Ligibel ◽  
Karen Basen-Engquist ◽  
Jennifer W. Bea
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cancer Prevention ◽  
Weight Management ◽  
Lifestyle Changes ◽  
Lifestyle Interventions ◽  
Secondary Breast Cancer ◽  
The Impact

Observational evidence has consistently linked excess adiposity and inactivity to increased breast cancer risk and to poor outcomes in individuals diagnosed with early-stage, potentially curable breast cancer. There is less information from clinical trials testing the effect of weight management or physical activity interventions on breast cancer risk or outcomes, but a number of ongoing trials will test the impact of weight loss and other lifestyle changes after cancer diagnosis on the risk of breast cancer recurrence. Lifestyle changes have additional benefits beyond their potential to decrease primary or secondary breast cancer risk, including improvements in metabolic parameters, reduction in the risk of comorbidities such as diabetes and heart disease, improvement of physical functioning, and mitigation of side effects of cancer therapy. Despite these myriad benefits, implementation of lifestyle interventions in at-risk and survivor populations has been limited to date. This article reviews the evidence linking lifestyle factors to breast cancer risk and outcomes, discusses completed and ongoing randomized trials testing the impact of lifestyle change in primary and secondary breast cancer prevention, and reviews efforts to implement and disseminate lifestyle interventions in at-risk and breast cancer survivor populations.

scholarly journals Modifiable Lifestyle Factors: Opportunities for (Hereditary) Breast Cancer Prevention - a Narrative Review

Breast Care ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. 108-113 ◽  
Author(s):  
Jacqueline Lammert ◽  
Sabine Grill ◽  
Marion Kiechle
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cancer Prevention ◽  
Healthy Lifestyle ◽  
Absolute Risk ◽  
Lifestyle Factors ◽  
Breast Cancer Prevention ◽  
The Impact

Increasing rates of obesity, lack of physical activity, sedentary behavior, and frequent alcohol consumption are major lifestyle-related risk factors for breast cancer. In fact, it has been estimated that about one-third of breast cancer cases are attributable to factors women can change. Most research has focused on examining the impact of one single exposure on breast cancer risk while adjusting for other risk modifiers. Capitalizing on big data, major efforts have been made to evaluate the combined impact of well-established lifestyle factors on overall breast cancer risk. At the individual level, data indicate that even simple behavior modifications could have a considerable impact on breast cancer prevention. Moreover, there is emerging new evidence that adopting a healthy lifestyle may be particularly relevant for women with hereditary susceptibility to breast cancer. On the absolute risk scale, studies suggest that the presence of certain risk factors, such as excessive body weight, had a substantially higher impact on breast cancer risk if women had a hereditary predisposition to cancer. The existing body of knowledge gives the medical professionals guidance as to which factors to focus on when counseling patients. However, well-designed randomized controlled trials utilizing objective methods are crucial to providing concrete recommendations.

scholarly journals The impact of alcohol consumption and physical activity on breast cancer: The role of breast cancer risk

2020 ◽  
Vol 147 (4) ◽  
pp. 931-939 ◽  
Author(s):  
Linda Rainey ◽  
Mikael Eriksson ◽  
Thang Trinh ◽  
Kamila Czene ◽  
Mireille J.M. Broeders ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Physical Activity ◽  
Alcohol Consumption ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
The Impact

Abstract PD11-01: Adherence to the new WCRF cancer prevention recommendations associates with a decreased breast cancer risk

2021 ◽  
Author(s):  
Mélanie Deschasaux ◽  
Laurent Bourhis ◽  
Laurent Zelek ◽  
Eloi Chazelas ◽  
Charlotte Debras ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cancer Prevention

scholarly journals The impact of having a sister diagnosed with breast cancer on cancer-related distress and breast cancer risk perception

Cancer ◽  
2013 ◽  
Vol 119 (9) ◽  
pp. 1722-1728 ◽  
Author(s):  
Kelly A. Metcalfe ◽  
May-Lynn Quan ◽  
Andrea Eisen ◽  
Tulin Cil ◽  
Ping Sun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Perception ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cancer Risk Perception ◽  
The Impact

scholarly journals From the Table to the Tumor: The Role of Mediterranean and Western Dietary Patterns in Shifting Microbial-Mediated Signaling to Impact Breast Cancer Risk

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2565 ◽  
Author(s):  
Tiffany M. Newman ◽  
Mara Z. Vitolins ◽  
Katherine L. Cook
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Mediterranean Diet ◽  
Dietary Patterns ◽  
Gut Microbiome ◽  
Western Diet ◽  
Diet Pattern ◽  
The Mediterranean ◽  
The Impact

Diet is a modifiable component of lifestyle that could influence breast cancer development. The Mediterranean dietary pattern is considered one of the healthiest of all dietary patterns. Adherence to the Mediterranean diet protects against diabetes, cardiovascular disease, and cancer. Reported consumption of a Mediterranean diet pattern was associated with lower breast cancer risk for women with all subtypes of breast cancer, and a Western diet pattern was associated with greater risk. In this review, we contrast the available epidemiological breast cancer data, comparing the impact of consuming a Mediterranean diet to the Western diet. Furthermore, we will review the preclinical data highlighting the anticancer molecular mechanism of Mediterranean diet consumption in both cancer prevention and therapeutic outcomes. Diet composition is a major constituent shaping the gut microbiome. Distinct patterns of gut microbiota composition are associated with the habitual consumption of animal fats, high-fiber diets, and vegetable-based diets. We will review the impact of Mediterranean diet on the gut microbiome and inflammation. Outside of the gut, we recently demonstrated that Mediterranean diet consumption led to distinct microbiota shifts in the mammary gland tissue, suggesting possible anticancer effects by diet on breast-specific microbiome. Taken together, these data support the anti-breast-cancer impact of Mediterranean diet consumption.

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