The role of FDG-PET in low-grade non-Hodgkin lymphoma (NHL): Impact of histology

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 17534-17534
Author(s):  
M. Kassar ◽  
A. Go ◽  
H. Fung ◽  
P. Venugopal ◽  
A. Ali ◽  
...  
Keyword(s):  
Ct Scan ◽  
Fdg Pet ◽  
False Negative ◽  
Initial Evaluation ◽  
Low Grade ◽  
True Positive ◽  
True Negative ◽  
Non Hodgkin Lymphoma ◽  
Imaging Results ◽  
Fdg Pet Scan

17534 Background: FDG-PET scan was proved important diagnostic and prognostic tool in patients with aggressive (NHL). The objective of this study is to investigate the correlation between the histology subtype in low-grade NHL and the sensitivity of the FDG-PET. Methods: We included all patients who presented to our institution during the period from April 2001 till April 2004 and underwent staging evaluation by FDG-PET during the course of their disease. All patients had histologically confirmed low-grade NHL. Patients with history of active malignancy, other than NHL, within the last five years were excluded. Correlation was made with the CT-scan findings. Results: 53 patients were included. Age (range 30–82, median 54), 57% of them were male. 34 patients had follicular lymphoma (FL), 9 patients had marginal zone lymphoma (MZL), and 10 patients had small lymphocytic lymphoma (SLL). 24/34 patients with FL underwent FDG-PET during the initial evaluation of their disease, and 10/34 patients underwent FDG-PET as part of their restaging assessment. 33 patients had true positive FDG-PET findings when compared to CT-scan results. One patient had negative FDG-PET with CT-scan findings suggestive of pathologic lymphadenopathy (sensitivity 97%). The highest SUV was in the range of 3.5–15 (median = 7). 8/9 patients with MZL had true positive FDG-PET findings and one had false negative FDG-PET result (sensitivity 89%). The highest SUV was in the range of 2–6.30 (median 2.6). Among the ten patients with SLL, 5 had FDG-PET during the initial evaluation and 8 patients during re-staging workup. 13 FDG-PET results were available for analysis. 5 cases were false negative, 1 case was false positive, 5 cases were true positive, and 2 cases were true negative (sensitivity 50%). The highest SUV was in the range of 1.8–6.2 (median of 2.5). Conclusion: Histology in low-grade NHL has a major impact on the sensitivity of the FDG-PET imaging results. Whereas it is a highly sensitive diagnostic method in patients with FL, and to a lesser degree in patients with MZL, it has poor sensitivity in patients with SLL. No significant financial relationships to disclose.

FDG-PET in the Serial Assessment of Patients with Lymphoma in Complete Remission.

Blood ◽  
2007 ◽  
Vol 110 (11) ◽  
pp. 216-216 ◽  
Author(s):  
Pier Luigi Zinzani ◽  
Vittorio Stefoni ◽  
Valentina Ambrosini ◽  
Enrico Derenzini ◽  
Gerardo Musuraca ◽  
...  
Keyword(s):  
Complete Remission ◽  
Fdg Pet ◽  
False Negative ◽  
Great Majority ◽  
True Negative ◽  
Non Hodgkin Lymphoma ◽  
Pet Scans ◽  
Negative Scan

Abstract FDG-PET role in the assessment of lymphoma patients is well established but only few papers evaluated the usefulness of FDG-PET during follow up. Aim: to prospectively investigate the value of serial FDG-PET scans in the follow up of lymphoma patients in complete remission. All lymphoma patients who achieved a complete remission were prospectively enrolled in the study and scheduled for serial FDG-PET scans at 6, 12, 18 and 24 months; further scans were then carried out on annual basis (overall 421 pts, 160 pts with Hodgkin’s Disease (HD) and 261 pts with non-Hodgkin Lymphoma (NHL) were studied). All patients had a final assessment using other imaging procedures and/or biopsy and/or clinical evolution. FDG-PET findings were reported as positive, indeterminate or negative for relapse; after comparison with all available data, PET results were categorized as true positive (TP), true negative (TN), false positive (FP), indeterminate turned out to be relapse (I+) and indeterminate turned out to be complete remission (I-). Results: PET documented relapse in 42 cases at 6 mo (14 HD (8.8%) and 28 NHL (10.7%); in 31 cases at 12 mo (14 HD (9.5%) and 17 NHL (7.3%); in 27 cases at 18 mo (6 HD (4.5%) and 21 NHL (3.2%); in 9 cases at 24 mo (3 HD (2.4%) and 6 NHL (3.2%); and in 5 cases at > 36 mo (2 HD (2.8%) and 3 NHL (6.5%). Out of 125 scans reported as positive for relapse, 109 turned out to be TP (PPV of 87%); no false negative scan was recorded, and in the great majority of cases PET detected the presence of relapse before clinical evidence. Our results confirm that FDG-PET is a valid tool for lymphoma patients follow-up. The higher incidence of relapse occurred in both HD and NHL quite early after complete remission (at 6 and 12 months for HD and at 6, 12 and 18 months for NHD), thus confirming the usefulness of performing FDG-PET scans at these times in order to identify recurrence. The role of serial PET at later times (after 18 months for HD and 24 months for NHL) was found less relevant.

scholarly journals Diagnostic and prognostic value of 99mTc-Tektrotyd scintigraphy and 18F-FDG PET/CT in a single-center cohort of neuroendocrine tumors

2021 ◽  
Author(s):  
Jelena Saponjski ◽  
Djuro Macut ◽  
Nebojša Petrovic ◽  
Sanja Ognjanovic ◽  
Bojana Popovic ◽  
...  
Keyword(s):  
False Positive ◽  
Fdg Pet ◽  
False Negative ◽  
Progression Free Survival ◽  
True Positive ◽  
True Negative ◽  
Free Survival ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

IntroductionThe aim was to assess the diagnostic value of 99mTc-Tektrotyd scintigraphy (TCT) and positron emission tomography/computed tomography using F-18 fluorodeoxyglucose (18F-FDG PET/CT) in the detection and follow-up of neuroendocrine tumors (NETs), and their predictive value for disease progression.Material and methodsIn this retrospective cohort, TCT and 18F-FDG PET/CT were performed in 90 patients (37 men, 53 women, mean age 52.7 ±15.1), with NET. Correlation of Ki67 and tumor grade versus Krenning score and SUVmax was assessed, Kaplan-Meier analysis was used for progression-free survival (PFS), and Cox regression analysis was performed to identify the association between progression-related factors and PFS.ResultsOut of 90, true positive TCT was detected in 56 (62.2%) patients, true negative in 19 (21.1%), false positive in 4 (4.4%), false negative in 11 (12.2%), while 18F-FDG PET/CT was true positive in 69 (76.7%) patients, true negative in 10 (11.1%), false positive in 5 (5.5%), false negative in 6 (6.7%). Mean 18F-FDG PET/CT SUVmax was 6.8 ±6.2. Diagnostic sensitivity of TCT was 83.6%, specificity 82.6%, accuracy 83.3% vs. 18F-FDG PET/CT sensitivity was 92.0%, specificity 66.7%, accuracy 87.8%. A significant correlation between Ki67 and SUVmax was found in positive 18F-FDG PET/CT findings, unlike the correlation between Ki67 and Krenning score. Median PFS was 25 months (95% CI: 18.2–31.8), in 18F-FDG PET/CT positive patients 23 months (95% CI: 16.3–29.7) and 18F-FDG PET/CT negative 26 months (p = 0.279). Progression-free survival predictors were SUVmax and Krenning score.ConclusionsIn our study, TCT and 18F-FDG PET/CT have high diagnostic accuracy in detection of NET. Higher Krenning score on TCT and SUVmax in positive 18F-FDG PET/CT findings are predictors of disease progression. 99mTc-Tektrotyd scintigraphy and 18F-FDG PET/CT can be useful complementary tools in management of patients with NETs and in predicting patients’ outcome.

scholarly journals Coupling Uncertainties with Accuracy Assessment in Object-based Slum Detections, Case Study: Jakarta, Indonesia

2017 ◽  
Author(s):  
Jati Pratomo ◽  
Monika Kuffer ◽  
Javier Martinez ◽  
Divyani Kohli
Keyword(s):  
Land Tenure ◽  
Classification Accuracy ◽  
Accuracy Assessment ◽  
False Negative ◽  
National Policy ◽  
True Positive ◽  
True Negative ◽  
Object Based ◽  
The Impact

Object-Based Image Analysis (OBIA) has been successfully used to map slums. In general, the occurrence of uncertainties in producing geographic data is inevitable. However, most studies concentrated solely on assessing the classification accuracy and neglecting the inherent uncertainties. Our research analyses the impact of uncertainties in measuring the accuracy of OBIA-based slum detection. We selected Jakarta as our case study area, because of a national policy of slum eradication, which is causing rapid changes in slum areas. Our research comprises of four parts: slum conceptualization, ruleset development, implementation, and accuracy and uncertainty measurements. Existential and extensional uncertainty arise when producing reference data. The comparison of a manual expert delineations of slums with OBIA slum classification results into four combinations: True Positive, False Positive, True Negative and False Negative. However, the higher the True Positive (which lead to a better accuracy), the lower the certainty of the results. This demonstrates the impact of extensional uncertainties. Our study also demonstrates the role of non-observable indicators (i.e., land tenure), to assist slum detection, particularly in areas where uncertainties exist. In conclusion, uncertainties are increasing when aiming to achieve a higher classification accuracy by matching manual delineation and OBIA classification.

scholarly journals EVALUATING THE ROLE OF FDG PET-CT SCAN AS A SOLE IMAGING MODALITY IN THE MANAGEMENT OF MUO NECK

2020 ◽  
pp. 39-41
Author(s):  
Krishnappa Krishnappa ◽  
Krishna Prasad ◽  
Shruti Satish ◽  
Murali R Nadig
Keyword(s):  
Ct Scan ◽  
Predictive Value ◽  
Fdg Pet ◽  
Imaging Modality ◽  
False Negative ◽  
Unknown Primary ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Pet Ct Scan

Aim:to study the role of PET- CT SCAN as a single imaging modality in the diagnosis of MUO neck. methodology: retrospective study analysis of 51 cases of clinical unknown primary with cervical metastasis . RESULTS: FDG PET CT tracer uptake was detected in 24/51. true positive in 18 cases out of 24,false positive in 6 cases, false negative in 2 cases with sensitivity of 90%, specificity of 82%,positive predictive value of 75%,negative predictive value of 93% and accuracy of 84.91%. conclusion: FDG PET CT can be used as a sole imaging modality in the diagnosis of MUO neck.it is complimentary to endoscopy.

scholarly journals Comparison Study Between Local TSH IRMA Kit (CRRT) and Imported TSH IRMA Kit (Riakey, Korea)

2019 ◽  
Vol 4 (2) ◽  
pp. 77
Author(s):  
Gina Mondrida ◽  
Triningsih Triningsih ◽  
Kristina Dwi Purwanti ◽  
Sutari Sutari ◽  
Sri Setyowati ◽  
...  
Keyword(s):  
False Negative ◽  
Thyroid Stimulating Hormone ◽  
The Body ◽  
True Positive ◽  
Comparison Study ◽  
Complex Matrix ◽  
Normal Range ◽  
True Negative ◽  
Immunoassay Technique ◽  
Tsh Levels

<p><em>Thyroid Stimulating Hormone</em> (TSH) is one of hormones that our body need for growth of brains, bones and other tissues and regulate the metabolism in the body. Normal range of TSH for adult is from 0.3 to 5.5 µIU/ml, whereas for baby ranged from 3 to 18 µIU/ml. An Immunoradiometricassay (IRMA) is one of immunoassay technique using radionuclide as the tracer to detect low quantity of analyte. This technique is suitable for determine TSH levels in human blood serum which has complex matrix and various concentration. The Center for Radioisotope and Radiopharmaceutical Technology (CRRT)-BATAN has developed a reagent of TSH IRMA kit. The aim of this research is to compare between local TSH IRMA kit (CRRT-BATAN) and imported TSH IRMA kit (Riakey, Korea) toward 110 adult samples obtained from PTKMR - BATAN. The results showed 97 samples as true negative, 5 samples as true positive, 1 sample as false negative and 7 samples false positive. The comparison study gave diagnostic sensitivity as much as 83.33 %, diagnostic spesificity as much as 93.27 % and accuracy as much as 92.72 %.</p>

scholarly journals Discordance between fine-needle aspiration cytology and histopathology in patients with mucoepidermoid carcinoma of parotid gland

2020 ◽  
Vol 102 (5) ◽  
pp. 340-342
Author(s):  
H Iftikhar ◽  
M Sohail Awan ◽  
M Usman ◽  
A Khoja ◽  
W Khan
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Mucoepidermoid Carcinoma ◽  
False Negative ◽  
Needle Aspiration ◽  
True Positive ◽  
Aspiration Cytology ◽  
True Negative ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Introduction Fine-needle aspiration cytology (FNAC) is an important diagnostic tool used preoperatively for the diagnosis of parotid lump. Mucoepidermoid carcinoma comprises 5–10% of all salivary gland tumours. It poses a diagnostic challenge on FNAC with high false negative rate. The objective of this study was to evaluate the discordance between cytology/FNAC and histopathology in patients with mucoepidermoid carcinoma. Material and methods A cross-sectional study was conducted from 1 January 2010 to 31 December 2014. Patients aged 18 years and above with FNAC or histopathology suggestive of mucoepidermoid carcinoma were identified. FNAC when compared with histology (gold standard) was classified into true positive (presence of mucoepidermoid carcinoma correctly diagnosed on FNAC), true negative (absence of mucoepidermoid carcinoma correctly diagnosed on FNAC), false positive (FNAC incorrectly diagnosed mucoepidermoid carcinoma), false negative (FNAC failed to diagnose mucoepidermoid carcinoma). Results A total of 16 patients fulfilled our eligibility criteria. Seven cytological samples were true positive (ie correctly diagnosed mucoepidermoid carcinoma by FNAC), eight cytological specimens were false negative (ie could not pick up mucoepidermoid carcinoma on FNAC). One case was false positive on cytology (ie diagnosed mucoepidermoid carcinoma on FNAC but was reported to be Warthin’s tumour on histopathology) and none were true negative. Conclusion FNAC is not reliable for diagnosis of mucoepidermoid carcinoma. More than 50% of our patients had discordant results between cytology and histology. We recommend a high index of suspicion for mucoepidermoid carcinoma given the poor yield of cytology.

Serum Levels of Carcinoembryonic Antigen, Gastrointestinal Cancer-Associated Antigen and Alphafetoprotein in Staging and Management of Patients with Advanced Carcinoma of the Stomach

1987 ◽  
Vol 2 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Janusz J. Szymendera ◽  
Andrzej W. Szawlowski ◽  
Marek P. Nowacki ◽  
Malgorzata Kowalska ◽  
Janina A. Kaminska ◽  
...  
Keyword(s):  
Carcinoembryonic Antigen ◽  
Gastrointestinal Cancer ◽  
False Negative ◽  
Serum Levels ◽  
True Positive ◽  
True Negative ◽  
Carcinoma Of The Stomach ◽  
Joint Application ◽  
Serum Cea

Serum levels of carcinoembryonic antigen (CEA), gastrointestinal cancer-associated antigen (GICA or CA 19-9), and alphafetoprotein (AFP) were concurrently determined in patients with carcinoma of the stomach: in 84 preoperatively, and in 67 serially postoperatively. Before surgery, serum CEA gave information about the tumor load analogous to serum GICA in 69% of the patients: true-positive in 25% and false-negative in 43%; less information in 18% and more in 14%. The sensitivity of the test tended to be better in the more advanced stages, and was higher for CEA with GICA than for CEA alone or GICA alone. During follow-up, serum CEA gave information about the presence or absence of active disease analogous to serum GIC A in 78% of the patients: true-positive in 30%, true-negative in 36% and false-negative in 12%; less information in 9% and more in 13%. Neither test gave any false-positive indications. Sensitivity of the test rose from 67% for CEA alone and 60% for GICA alone to 81% for CEA with GICA. Serum AFP was elevated only preoperatively in 2% of patients. We conclude that joint application of CEA and GICA tests gave only slightly better preoperative sensitivity than CEA alone or GICA alone but proved fairly sensitive for postoperative follow-up of the patients. AFP was of little value for either purpose.

scholarly journals CT-Scan Findings of Orbital Mass Among Pediatric Patients at a Tertiary Care Hospital in Bangladesh

2017 ◽  
Vol 8 (1) ◽  
pp. 17-23
Author(s):  
Meher Angez Rahman ◽  
Salauddin Al Azad ◽  
Nazrul Islam ◽  
Sadrul Amin ◽  
Md ziaul Haque ◽  
...  
Keyword(s):  
Ct Scan ◽  
Pediatric Patients ◽  
Tertiary Care ◽  
False Negative ◽  
Orbital Tumor ◽  
Care Hospital ◽  
True Negative ◽  
Cross Sectional ◽  
Orbital Mass ◽  
Imaging Department

Background: CT-Scan for the detection of orbital mass among pediatric patients is very important noninvasive radiological modality. The purpose of the study was to find out CT-Scan findings of orbital mass among pediatric patients in a tertiary care hospital.Methodology: This is a cross sectional study was carried out in Ophthalmology and Radiology and Imaging department of National Institute of Ophthalmology (NIO) from January 2012 to December 2013. All the patient below 18 years of age presented with suspected orbital mass at Ophthalmology and Radiology and Imaging department of NIO and performed CT- Scan of orbit for diagnosis of the disease and also done histopathology after operation was enrolled in this study.Results: In this study it was observed that a total of 29 cases identified as malignant evaluated by CT, among them 27 cases were true positive and 2 cases were false positive. Benign was found in 41 cases evaluated by CT scan, out of which 1 false negative and 40 cases were true negative. The sensitivity in diagnosis of orbital tumor by CT was 93.3%.Conclusion: The sensitivity in diagnosis of orbital tumor by CT was high and is a useful method in the differentiation between benign and malignant orbital mass.Anwer Khan Modern Medical College Journal Vol. 8, No. 1: Jan 2017, P 17-23

scholarly journals Fluoroscopy Guided Percutaneous Transpedicular Biopsy for Thoracic and Lumbar Vertebral Body Lesion: Technique and Safety in 23 Consecutive Cases

2017 ◽  
Vol 13 (3) ◽  
pp. 256-260
Author(s):  
D. Shrestha ◽  
R. Shrestha ◽  
D Dhoju
Keyword(s):  
Vertebral Body ◽  
False Negative ◽  
Invasive Technique ◽  
Safe Procedure ◽  
Microbiological Diagnosis ◽  
True Positive ◽  
True Negative ◽  
Lumbar Vertebral Body ◽  
Vertebral Biopsy ◽  
Fluoroscopy Guidance

Background Though some vertebral lesions have typical imaging findings, histological/ microbiological evidence are required for definitive diagnosis and management, specially for tumor and infective lesions so that wrong diagnosis and wrong treatment can be avoided. Conventionally, open biopsy methods are used. With availability of CT scan, MRI, percutaneous transpedicular vertebral biopsy has now become popular as a minimally invasive technique for biopsy of vertebral lesion.Objective To describes technique and to analyzes safety and feasibility of percutaneous transpedicular vertebral biopsy with fluoroscopy guidance for thoracic and lumbar vertebral body lesions.Method Twenty three patients who underwent percutaneous transpedicular vertebral biopsy under fluoroscopy guidance were retrospectively evaluated for demographic data, indication for biopsy, anatomical locations, histological/microbiological diagnosis, complications and final outcome of treatment. True positive, true negative, false positive and false negative cases were defined.Result There were 17 males and 6 female patients of mean age 47 (range 22-73 years). Biopsies were performed in 17 dorsal and six lumbar vertebral bodies. Adequate sample were obtained in all cases. Seventeen patients (12: tubercular pathology, 1: primary tumor, 3: metastasis, 1: osteoporotic fracture) had definitive histological/ microbiological diagnosis. Four patients had no granuloma and tumor. Two had histological features of chronic non specific inflammation. True positive cases were 17, true negative were four and false negative case were two. Overall accuracy was 92%. One patient developed small hematoma at biopsy site.Conclusion Fluoroscopy guided percutaneous transpedicular biopsy of is a safe procedure with high adequacy and accuracy and low complication rate for thoracic and lumbar vertebral body lesion.

Parotid Tumors: Fine-Needle Aspiration and/or Frozen Section

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P42-P43
Author(s):  
Peter Zbaren ◽  
Heinz Loosli ◽  
Edouard Stauffer
Keyword(s):  
Sensitivity And Specificity ◽  
Fine Needle Aspiration ◽  
False Positive ◽  
Frozen Section ◽  
False Negative ◽  
Needle Aspiration ◽  
True Positive ◽  
True Negative ◽  
Fine Needle ◽  
Parotid Neoplasms

Objective Assess the difficulties of preoperative and intraoperative tumor typing of parotid neoplasms. Know the advantages and pitfalls of fine-needle-aspiration cytology (FNAC) and frozen section (FS) analysis in primary parotid neoplasms. Methods In 113 parotid neoplasms (70 malignancies and 43 benign tumors) preoperative FNAC as well as intraoperative FS analysis were performed. FNAC and FS findings were analyzed and compared with the final histopathologic diagnosis. Results The FNAC smear was non-diagnostic in 6 tumors. In 2 FS specimens, it was not possible to determine the tumor dignity. FNAC findings and FS findings were both available in 105 neoplasMS The FNAC findings were true positive for malignancy in 54, true negative in 36, false positive in 4, and false negative in 11 tumors. The accuracy, sensitivity, and specificity were 86%, 83%, and 90% respectively. The FS findings were true positive in 60, true negative in 38, false positive in 2, and false negative in 5 tumors. The accuracy, sensitivity, and specificity were 93%, 92% and 95% respectively. The exact histologic tumor typing by FNAC was correct, false or not mentioned in 58%, 20% and 22% true positive or true negative evaluated tumors, and by FS in 83%, 5% and 12% true positive or true negative evaluated tumors. Conclusions The current analysis showed a superiority of FS compared with FNAC regarding the diagnosis of malignancy and especially of tumor typing. FNAC alone is not prone in many cases to determine the surgical management of primary parotid carcinomas.

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