Functional (PET/CT) compared to conventional (mammography [M], sonography [US], MRI) imaging: Defining novel assessment modalities for inflammatory breast cancer (IBC)

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 600-600
Author(s):  
W. T. Yang ◽  
H. T. Le-Petross ◽  
A. Gonzalez-Angulo ◽  
H. Macapinlac ◽  
H. Macapinlac ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Imaging Modality ◽  
Distant Metastases ◽  
Sudden Onset ◽  
Cancer Center ◽  
Architectural Distortion ◽  
Mri Imaging ◽  
Nodal Disease ◽  
Eligibility Criteria ◽  
Pet Ct

600 Background: IBC is an aggressive frequently lethal form of breast cancer that is defined by sudden onset breast erythema often without an associated clinical or radiological breast mass. Tissue diagnosis remains problematic due to inability to define an area for biopsy. The aim of this study was to compare conventional [M, US, MRI] vs. functional imaging [PET/CT] in detecting a primary breast parenchymal lesion (BPL) at initial presentation of IBC. Methods: Patients (pts) with a new clinical diagnosis of IBC evaluated at the M. D. Anderson Cancer Center between January 2003 to December 2006 who had M, US, MRI, or PET/CT were included in this study. The visibility of a BPL and skin abnormality on each imaging modality was compared. Regional (axillary, supraclavicular, internal mammary) nodal disease confirmed by pathology was assessed at US and PET/CT. The presence of metastatic disease at diagnosis with PET/CT was documented. Results: Sixty-seven pts met eligibility criteria. Median age was 51 years, (range, 25 to 78). Of these, 61 (91%) had M, 62 (93%) had US, 21 (31%) had MRI, and 13 (19%) had PET/CT. By M, no BPL (mass or calcifications) was observed in 16% (10/61), skin-only abnormality (SOA) in 14% (9/61), and a BPL in 84% (51/61). By US, no BPL (mass or architectural distortion) and SOA were noted in 6% (4/62), and a PBL in 94% (58/62). By MRI, 21/21 (100%) showed malignant enhancing BPL and skin thickening. By PET/CT, 100% (13/13) showed hypermetabolic BPL and skin thickening. Pathologically confirmed regional nodal disease was diagnosed in 96% (59/62) by US and in 69% (9/13) by PET/CT. Distant metastases in the bone and lung were diagnosed in 15% (2/13) by PET/CT, one of which was visible on bone scan. Conclusions: MRI and PET/CT showed a primary BPL in all cases of IBC while conventional imaging (M and US) failed to reveal a BPL amenable to biopsy in up to 16%. US can diagnose regional nodal disease to facilitate loco-regional therapeutic planning. PET/CT provides additional information on distant metastasis and should be considered in the initial staging of IBC. No significant financial relationships to disclose.

scholarly journals Rate of Distant Metastases on 18 F-FDG PET/CT at Initial Staging of Breast Cancer: Comparison of Women Younger and Older Than 40 Years

2016 ◽  
Vol 58 (2) ◽  
pp. 252-257 ◽  
Author(s):  
Vincent Lebon ◽  
Jean-Louis Alberini ◽  
Jean-Yves Pierga ◽  
Véronique Diéras ◽  
Nina Jehanno ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fdg Pet ◽  
Distant Metastases ◽  
Pet Ct ◽  
Fdg Pet Ct ◽  
Initial Staging

scholarly journals A Prospective Study Assessing the Post-Prostatectomy Detection Rate of a Presumed Local Failure at mpMR with Either 64CuCl2 or 64CuPSMA PET/CT

Cancers ◽  
2021 ◽  
Vol 13 (21) ◽  
pp. 5564
Author(s):  
Adriana Faiella ◽  
Rosa Sciuto ◽  
Diana Giannarelli ◽  
Marta Bottero ◽  
Alessia Farneti ◽  
...  
Keyword(s):  
Prospective Study ◽  
Detection Rate ◽  
Previous History ◽  
Distant Metastases ◽  
Salvage Radiotherapy ◽  
Local Failure ◽  
Eligibility Criteria ◽  
Positron Emission ◽  
Psma Pet ◽  
Pet Ct

Background: We aimed assess the detection rate (DR) of positron emission tomography/computed tomography with two novel tracers in patients referred for salvage radiotherapy (sRT) with a presumed local recurrence at multiparametric magnetic resonance (mpMR) after radical prostatectomy (RP). Methods: The present prospective study was conducted at a single institution between August 2017 and June 2020. Eligibility criteria were undetectable PSA after RP; subsequent biochemical recurrence (two consecutive PSA rises to 0.2 ng/mL or greater); a presumed local failure at mpMR; no distant metastases at 18F-fluorocholine PET/CT (CH/PET); no previous history of androgen deprivation therapy. Patients were offered both 64CuCl2 PET/CT (CU/PET) and 64Cu-PSMA PET/CT (PSMA/PET) before sRT. After image co-registration, PET findings were compared to mpMR ones in terms of DR and independent predictors of DR investigated at logistic regression. Results: A total of 62 patients with 72 nodules at mpMR were accrued. Compared to mpMR (DR = 100%, 95%CI: 94.9–100%), DRs were 47.2% (95%CI: 36.1–58.6%) and 54.4% (95%CI: 42.7–65.7%) for CU/PET and PSMA/PET, respectively (p < 0.001 for both). Both experimental PET/CT performed particularly poorly at PSA levels consistent with early sRT. Conclusions: The two novel radiotracers are inferior to mpMR in restaging the prostatic fossa for sRT planning purposes, particularly in the context of early salvage radiotherapy.

Preoperative Staging of Large Primary Breast Cancer With [18F]Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Compared With Conventional Imaging Procedures

2008 ◽  
Vol 26 (29) ◽  
pp. 4746-4751 ◽  
Author(s):  
David Fuster ◽  
Joan Duch ◽  
Pilar Paredes ◽  
Martín Velasco ◽  
Montserrat Muñoz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Sensitivity And Specificity ◽  
Primary Breast Cancer ◽  
Distant Metastases ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Pet Ct ◽  
Large Primary

Purpose To evaluate the utility of positron emission tomography (PET) and [18F]fluorodeoxyglucose in the initial staging of large primary breast tumors. Patients and Methods This prospective study was approved by the ethics committee, and all patients gave their informed consent before enrollment. Sixty consecutive patients with large (> 3 cm) primary breast cancer diagnosed by clinical examination and breast magnetic resonance imaging (MRI) were entered onto the study. The mean age was 57 ± 13 years. Chest computed tomography (CT), liver ultrasonography, bone scan, and PET/CT were performed in all patients. All findings were histologically confirmed, and/or at least 1 year of follow-up was required. Correlation between parameters was calculated using Pearson's correlation coefficient. P < .05 was considered statistically significant. Results Primary tumor was identified by both PET/CT and MRI in all patients. Multifocal and/or multicentric tumors were found in 19 patients by MRI. Axillary lymph node metastases were found in 20 of 52 patients. Extra-axillary metastatic lymph nodes were also found in three patients. One patient showed an infiltrated lymph node in the contralateral axilla. The sensitivity and specificity for PET/CT to detect axillary lymph nodes metastases were 70% and 100%, respectively. PET/CT diagnosed all extra-axillary lymph nodes. The overall sensitivity and specificity of PET/CT in detecting distant metastases were 100% and 98%, respectively; whereas the sensitivity and specificity of conventional imaging were 60% and 83%, respectively. PET led to a change in the initial staging in 42% of patients. Conclusion PET/CT underestimates locoregional lymph node staging in large primary breast cancer patients. PET/CT is a valuable tool to discard unsuspected extra-axillary lymph nodes and distant metastases.

Disparities in the treatment of brain metastases from breast cancer: Insights from the National Cancer Database.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. 2037-2037
Author(s):  
Zena Chahine ◽  
Muhammad Salman Faisal ◽  
Thejus Thayyil Jayakrishnan ◽  
Stephen Abel ◽  
Rodney E. Wegner
Keyword(s):  
Breast Cancer ◽  
Brain Metastases ◽  
Urban Areas ◽  
Cox Regression ◽  
Private Insurance ◽  
Cancer Center ◽  
National Cancer Database ◽  
Breast Cancer Patients ◽  
Eligibility Criteria ◽  
Brain Radiation

2037 Background: Breast cancer is the most common malignancy in women accounting for over 300,000 cases per year. Unfortunately, brain metastases are found in a sub-group of patients with breast cancer even at presentation. Management of brain metastases typically includes radiotherapy with conventional whole brain radiation therapy (WBRT) or more focused stereotactic radiosurgery (SRS). We queried the National Cancer Database (NCDB) to analyze the incidence of brain metastases at diagnosis in breast cancer patients, as well as trends in radiation use/technique. Methods: The NCDB was queried for patients who were diagnosed with breast cancer between 2004-2015 and had brain metastasis at presentation (N = 4,491). We excluded patients without brain radiation and inadequate follow up. Odds ratios were calculated to identify factors associated with treatment. Multivariable cox regression was used to determine predictors of survival. Results: Using the eligibility criteria above 1,505 patients were identified in the NCDB. The cohort had a median age of 58 years. A small portion were uninsured (7%) population uninsured and 81% of radiation treatments were delivered in metropolitan areas. Two hundred sixty-one (17.3%) patients received SRS while 1,244 (82.7%) received WBRT. Those patients with private insurance, higher income, metro location, and having care delivered at an academic center were more likely to receive SRS. Conversely, the likelihood of receiving WBRT was significantly higher in those with luminal type cancer, African Americans, the uninsured, and those located in urban areas or treated at a community cancer center. On Cox regression, predictors of worse survival were age > 60 with Hazard Ratio (HR) 1.3 (95% CI 1.17-1.49), a comorbidity score > 2 with HR 1.45 (95% CI 1.1-1.9), and extra cranial metastatic disease with HR 1.33 (95% CI 1.15-1.54). Conclusions: This analysis of the NCDB demonstrates socioeconomic and demographic disparities in the treatment of patients with brain metastases from breast cancer. There is a continued need to reduce these disparities and improve access to care for at-risk populations affected by this highly prevalent malignancy.

scholarly journals FDG‐PET/CT Compared with Conventional Imaging in the Detection of Distant Metastases of Primary Breast Cancer

2011 ◽  
Vol 16 (8) ◽  
pp. 1111-1119 ◽  
Author(s):  
Naoki Niikura ◽  
Colleen M. Costelloe ◽  
John E. Madewell ◽  
Naoki Hayashi ◽  
Tse‐Kuan Yu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fdg Pet ◽  
Primary Breast Cancer ◽  
Distant Metastases ◽  
Conventional Imaging ◽  
Pet Ct ◽  
Fdg Pet Ct

Staging PET–CT Scanning Provides Superior Detection of Lymph Nodes and Distant Metastases than Traditional Imaging in Locally Advanced Breast Cancer

2016 ◽  
Vol 40 (8) ◽  
pp. 2036-2042 ◽  
Author(s):  
Pankaj Kumar Garg ◽  
Suryanarayana V. S. Deo ◽  
Rakesh Kumar ◽  
Nootan Kumar Shukla ◽  
Sanjay Thulkar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Advanced Breast Cancer ◽  
Locally Advanced Breast Cancer ◽  
Locally Advanced ◽  
Ct Scanning ◽  
Distant Metastases ◽  
Advanced Breast ◽  
Pet Ct

Sudden onset fatigue (SOF) in patients with breast cancer: Characteristics and symptomatology

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e20637-e20637
Author(s):  
Z. A. Nahleh ◽  
H. Wu ◽  
E. Galvin ◽  
D. Leedy
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Health Care Professionals ◽  
Rating Scale ◽  
Rapid Onset ◽  
Sudden Onset ◽  
Cancer Center ◽  
Breast Cancer Patients ◽  
Cross Sectional ◽  
Cancer Related Fatigue

e20637 Background: Cancer-related fatigue is underrecognized and poorly managed. Unpredictability and rapid onset in fatigue is stressed by cancer patients but seldom addressed by health care professionals. Although sudden onset of cancer-related fatigue is anecdotally documented across qualitative studies, the symptom has never been systematically investigated. Our purpose is to describe the symptom and clinical characteristics of SOF in breast cancer patients receiving chemotherapy. Methods: This is a cross-sectional descriptive study enrolling female breast cancer outpatients undergoing chemotherapy in an urban cancer center. A brief questionnaire assessing the symptom characteristics of SOF was completed by subjects. Comprehensive metabolic panel and complete blood counts, were obtained. Descriptive statistics described the symptom characteristics of SOF. Mann-Whitney tests examined the differences between those who did and did not experience SOF. Results: Thirty patients have been enrolled. Median age 53 years (31 to 65; SD=7.7), 60% were Black. 80% (n=24) experienced SOF in the past 7 days with a median of 4 days a week and 2.5 episodes per day. SOF was most likely (75%) to occur in the afternoon while patients were engaging in activities. Levels of fatigue before, during, and after a specific episode of SOF were 5, 9, and 5, respectively, on 0–10 (highest) rating scale. Weakness, sweating, or pain sometimes accompanied SOF. When SOF occurred, individuals immediately needed to stop activities to rest until it went away. Those who experienced SOF had significantly lower levels of calcium (Median=8.9 vs. 9.4), albumin (Median=3.7 vs. 7.1), and hematocrit (Median=32.1 vs. 36) (p<0.05). Those who experienced SOF also had higher levels of GPT (Median=25.5 vs. 17), lower levels of total protein (Median=6.7 vs. 7.1), WBC (Median=4.9 vs. 8.9), RBC (Median=3.4 vs. 3.9), and hemoglobin (Median=10.7 vs. 11.4). Conclusions: Our ongoing study is one of the first to identify the characteristics of patients at high risk of SOF. SOF needs to be recognized and managed when patients undergo chemotherapy. Associated conditions should be identified and addressed. The ultimate goal is to minimize the distress and improve the quality of life of patients receiving chemotherapy. No significant financial relationships to disclose.

Outcome of mammography examination among asymptomatic women.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e13558-e13558
Author(s):  
Hadijat Oluseyi Kolade-Yunusa
Keyword(s):  
Breast Cancer ◽  
Early Detection ◽  
Early Stage ◽  
Imaging Modality ◽  
Positive Outcome ◽  
Radiology Department ◽  
Architectural Distortion ◽  
Cross Sectional ◽  
Mammographic Examination ◽  
Asymptomatic Women

e13558 Background: Early detection of breast cancer is important in reducing mortality, morbidity and high socio-economic burden associated with it. Mammography is currently the primary imaging modality used as a screening tool to detect early breast cancer in women experiencing no symptoms as they are most curable in the early stage. The aim of the study is to determine the mammographic outcome in asymptomatic women who presented for mammographic breast examination in Abuja,Nigeria. Methods: This descriptive cross-sectional study comprises of 113 asymptomatic women who presented for mammographic examination at the Radiology department of University of Abuja Teaching Hospital, Gwagwalada from March 2015 to December 2018. Two basic views (craniocaudal and mediolateral views) of the breast were obtained using EXR-650 machine.Additional views were obtained when necessary. Images of the breast were review by radiologist. Results: The mean age of study population was 40.72 ±10.45years with age range of 35 and 65 years. The mammographic outcome among asymptomatic women who had mammographic examination was negative in 69(61.1%) women and positive in 44(38.9%). The differences observed between the positive and negative mammographic outcome was statistically significant p = 0.01. The positive outcome noted in mammograms of women examined were: benign mass in 18(15.9%) women; 9(8.0%) had benign calcification; 7(6.2%) showed architectural distortion; 5(4.4%) was inconclusive; focal asymmetry in 3(2.6%); and suspicious mass in 2(1.8%). Conclusions: Mammogram is an important tool for screening and diagnoses of breast pathologies. In this study, screening of women reveals various benign and malignant breast changes which necessitate early interventions. Early detection of breast cancer save lives. [Table: see text]

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