Prevalence and risk factors of vitamin D insufficiency in cancer

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 9581-9581
Author(s):  
K. A. Hauser ◽  
M. Karafa ◽  
D. Seyidova-Khoshknabi ◽  
M. P. Davis ◽  
D. Walsh
Keyword(s):  
Vitamin D ◽  
African American ◽  
Laboratory Data ◽  
Cleveland Clinic ◽  
Vitamin D Insufficiency ◽  
Cancer Site ◽  
Stepwise Logistic Regression ◽  
Cancer Type ◽  
Chi Square ◽  
25 Hydroxy Vitamin D

9581 Background: Low vitamin D has been linked to increased cancer incidence and reduced prognosis. Little is known about prevalence and risks of insufficiency in cancer. Methods: Electronic medical records of all adult solid tumor patients treated at The Cleveland Clinic in 2006–2007 were reviewed. Data extracted: demographics (age, gender, race), cancer site (primary and metastatic, ICD-9 codes) and first 25 hydroxy vitamin D level [25OHD] during the study period. Laboratory data (calcium, hepatic and renal function), medications prescribed (anticonvulsants, antineoplastic, corticosteroids, vitamin D) and treatment procedures (chemotherapy and radiotherapy) in 2 months preceding vitamin D were recorded. Clinical factors were compared between those tested for 25OHD vs not, and those insufficient (25OH D ≤30ng/ml) vs not (25OH D >31ng/ml) by Chi square or T-tests. Stepwise logistic regression identified independent predictors of vitamin D insufficiency. Results: n=39,254. 19,030 (48%) were female, mean age 63 (± 14), 86% Caucasian. Most common cancers: breast (19%), prostate (18%), skin (13%). 2,100 (5%) had vitamin D tested. They were more likely female (66% vs 47%), and to have breast, hepatobiliary, skin or thyroid cancer, than those not tested (both p<0.001). 1446 (69%) were insufficient, and 200 (10%) were frankly deficient (25OHD ≤12ng/ml). Insufficiency was associated with male gender, race (African American), month of test (Feb-Apr, Oct), cancer type (hepatobiliary, genitourinary, pancreas, upper gastrointestinal), metastatic disease, low albumin, high bilirubin and AST, and lack of antineoplastic or vitamin D medication (all p<0.01). Multivariable predictors were cancer type, test month, African American race, low albumin, and lack of antineoplastic or vitamin D medication (all p<0.01). Conclusions: Vitamin D insufficiency is highly prevalent among cancer patients tested. This study is limited by selection bias but indicates need for prospective vitamin D evaluation in cancer. No significant financial relationships to disclose.

Short-Term Outcomes of Parathyroidectomy in Patients With or Without 25-Hydroxy Vitamin D Insufficiency

2007 ◽  
Vol 143 (1) ◽  
pp. 145-150 ◽  
Author(s):  
Todd D. Beyer ◽  
Emery L. Chen ◽  
Naris Nilubol ◽  
Richard A. Prinz ◽  
Carmen C. Solorzano
Keyword(s):  
Vitamin D ◽  
Vitamin D Insufficiency ◽  
Short Term ◽  
25 Hydroxy Vitamin D

scholarly journals Role of pregnancy and obesity on vitamin D status, transport, and metabolism in baboons

2019 ◽  
Vol 316 (1) ◽  
pp. E63-E72
Author(s):  
Eugenia Mata-Greenwood ◽  
Hillary F. Huber ◽  
Cun Li ◽  
Peter W. Nathanielsz
Keyword(s):  
Vitamin D ◽  
Maternal Obesity ◽  
Subcutaneous Fat ◽  
Placental Tissue ◽  
Vitamin D Insufficiency ◽  
Primate Species ◽  
Vitamin D Status ◽  
Vitamin D Levels ◽  
25 Hydroxy Vitamin D ◽  
Kidney Liver

Human studies show that obesity is associated with vitamin D insufficiency, which contributes to obesity-related disorders. Our aim was to elucidate the regulation of vitamin D during pregnancy and obesity in a nonhuman primate species. We studied lean and obese nonpregnant and pregnant baboons. Plasma 25-hydroxy vitamin D (25-OH-D) and 1α,25-(OH)2-D metabolites were analyzed using ELISA. Vitamin D-related gene expression was studied in maternal kidney, liver, subcutaneous fat, and placental tissue using real-time PCR and immunoblotting. Pregnancy was associated with an increase in plasma bioactive vitamin D levels compared with nonpregnant baboons in both lean and obese groups. Pregnant baboons had lower renal 24-hydroxylase CYP24A1 protein and chromatin-bound vitamin D receptor (VDR) than nonpregnant baboons. In contrast, pregnancy upregulated the expression of CYP24A1 and VDR in subcutaneous adipose tissue. Obesity decreased vitamin D status in pregnant baboons (162 ± 17 vs. 235 ± 28 nM for 25-OH-D, 671 ± 12 vs. 710 ± 10 pM for 1α,25-(OH)2-D; obese vs. lean pregnant baboons, P < 0.05). Lower vitamin D status correlated with decreased maternal renal expression of the vitamin D transporter cubulin and the 1α-hydroxylase CYP27B1. Maternal obesity also induced placental downregulation of the transporter megalin (LRP2), CYP27B1, the 25-hydroxylase CYP2J2, and VDR. We conclude that baboons represent a novel species to evaluate vitamin D regulation. Both pregnancy and obesity altered vitamin D status. Obesity-induced downregulation of vitamin D transport and bioactivation genes are novel mechanisms of obesity-induced vitamin D regulation.

scholarly journals Vitamin D Status Among Male Late Adolescents Living in Southern Switzerland: Role of Body Composition and Lifestyle

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2727 ◽  
Author(s):  
Andrea Rabufetti ◽  
Gregorio P. Milani ◽  
Sebastiano A. G. Lava ◽  
Valeria Edefonti ◽  
Mario G. Bianchetti ◽  
...  
Keyword(s):  
Physical Activity ◽  
Vitamin D ◽  
Body Fat ◽  
Vitamin D Insufficiency ◽  
Body Fat Percentage ◽  
Vitamin D Status ◽  
Late Adolescents ◽  
Recreational Physical Activity ◽  
Fat Percentage ◽  
25 Hydroxy Vitamin D

Background: Poor vitamin D status is a worldwide health problem. Yet, knowledge about vitamin D status among adolescents in Southern Europe is limited. This study investigated concentrations and modulating factors of vitamin D in a healthy population of male late adolescents living in Southern Switzerland. Methods: All apparently healthy subjects attending for the medical evaluation before the compulsory military service in Southern Switzerland during 2014-2016 were eligible. Dark-skin subjects, subjects on vitamin D supplementation or managed with diseases or drugs involved in vitamin D metabolism were excluded. Anthropometric measurements (body height, weight, fat percentage, mid-upper arm and waist circumference) and blood sampling for total 25-hydroxy-vitamin D, total cholesterol and ferritin concentrations testing, were collected. Participants filled in a structured questionnaire addressing their lifestyle. Characteristics of the subjects with adequate (≥50 nmol/L–≤250 nmol/L) and insufficient (<50 nmol/L) vitamin D values were compared by Kruskal-Wallis test or χ2 test. Odds ratios for 25-hydroxy-vitamin D insufficiency were calculated by univariate and AIC-selected multiple logistic regression models. Results: A total of 1045 subjects volunteered to participate in the study. Insufficient concentrations of vitamin D were detected in 184 (17%). The season of measurement was the most significant factor associated with vitamin D levels and approximately 40% of subjects presented insufficient vitamin D concentrations in winter. After model selection, body fat percentage, frequency and site of recreational physical activity, and the seasonality were significantly associated with the risk of vitamin D insufficiency. Conclusions: Among healthy male late adolescents in Southern Switzerland, about one every fourth subject presents a poor vitamin D status in non-summer seasons. Body fat percentage, frequent and outdoor recreational physical activity are modulating factors of vitamin D status in this population.

scholarly journals The Relationship between Obesity and Serum 1,25-Dihydroxy Vitamin D Concentrations in Healthy Adults

2004 ◽  
Vol 89 (3) ◽  
pp. 1196-1199 ◽  
Author(s):  
Shamik J. Parikh ◽  
Marni Edelman ◽  
Gabriel I. Uwaifo ◽  
Renee J. Freedman ◽  
Mariama Semega-Janneh ◽  
...  
Keyword(s):  
Vitamin D ◽  
African American ◽  
Body Fat ◽  
Fat Mass ◽  
Healthy Adults ◽  
Body Fat Mass ◽  
Intact Pth ◽  
Hormonal Mechanism ◽  
25 Hydroxy Vitamin D

Abstract Several previous reports of small cohorts have found significantly higher serum 1,25-dihydroxy vitamin D (1,25-vit D) in obese compared with nonobese whites. Based on these reports and on recent in vitro studies of adipocytes which suggest that administration of 1,25-vit D can stimulate lipogenesis and inhibit lipolysis, some investigators have proposed that high 1,25-vit D may play a role in promoting or maintaining adipocyte triglyceride stores in obese adults. To test the hypothesis that obesity is commonly associated with increased 1,25-vit D, we examined the relationships between calciotropic hormones and body adiposity in a large cohort of healthy adults. Serum intact PTH, 25-hydroxy vitamin D, and 1,25-vit D were measured in the postabsorptive state in 302 healthy adults who were Caucasian (n = 190; 71% female), African-American (n = 84; 89% female), and of other race/ethnicity (n = 28; 61% female). Results from the 154 obese subjects [body mass index (BMI) 37.3 ± 5.8 kg/m2; range, 30.1–58.2 kg/m2] were compared with those from 148 nonobese (BMI 25.6 ± 2.9 kg/m2; range, 18.0–29.9 kg/m2) age-, race-, and sex-matched participants. Body composition was measured by dual energy x-ray absorptiometry. Serum intact PTH was positively correlated with both BMI (r = 0.42; P &lt; 0.0001) and body fat mass (r = 0.37; P &lt; 0.0001). Serum 25-hydroxy vitamin D was negatively correlated with BMI (r = −0.4; P &lt; 0.0001) and body fat mass (r = −0.41; P &lt; 0.0001). Serum 1,25-vit D was also negatively correlated with BMI (r = −0.26; P &lt; 0.0001) and body fat mass (r = −0.25; P = 0.0001). Serum 1,25-vit D was significantly lower in obese than nonobese subjects (105.7 ± 41.1 vs. 124.8 ± 36.7 pmol/liter; P &lt; 0.0001) in both Caucasian and African-American adults. We conclude that, because 1,25-vit D concentrations fall with increasing adiposity, it appears unlikely that elevation in 1,25-vit D is an important hormonal mechanism causing or maintaining obesity in adults.

Vitamin D Insufficiency in Preadolescent African-American Children

2005 ◽  
Vol 44 (8) ◽  
pp. 683-692 ◽  
Author(s):  
Kumaravel Rajakumar ◽  
John D. Fernstrom ◽  
Janine E. Janosky ◽  
Susan L. Greenspan
Keyword(s):  
Vitamin D ◽  
African American ◽  
Vitamin D Insufficiency ◽  
African American Children ◽  
American Children

Sources of vitamin D for humans

2021 ◽  
Author(s):  
Evgen Benedik
Keyword(s):  
Vitamin D ◽  
Dietary Supplements ◽  
Current Knowledge ◽  
Vitamin D Insufficiency ◽  
Ultraviolet B ◽  
Dietary Vitamin ◽  
Fortified Foods ◽  
Fortified Food ◽  
25 Hydroxy Vitamin D ◽  
Different Sources

Abstract. Both vitamin D insufficiency and deficiency are now well-documented worldwide in relation to human health, and this has raised interest in vitamin D research. The aim of this article is therefore to review the literature on sources of vitamin D. It can be endogenously synthesised under ultraviolet B radiation in the skin, or ingested through dietary supplements and dietary sources, which include food of animal and plant origin, as well as fortified foods. Vitamin D is mainly found in two forms, D3 (cholecalciferol) and D2 (ergocalciferol). In addition to the D3 and D2 forms of vitamin D, 25-hydroxy vitamin D also contributes significantly to dietary vitamin D intake. It is found in many animal-derived products. Fortified food can contain D3 or D2 forms or vitamin D metabolite 25-hydroxy vitamin D. Not many foods are a rich source (> 4 μg/100 g) of vitamin D (D represents D3 and/or D2), e.g., many but not all fish (5–25 μg/100 g), mushrooms (21.1–58.7 μg/100 g), Reindeer lichen (87 μg/100 g) and fish liver oils (250 μg/100 g). Other dietary sources are cheese, beef liver and eggs (1.3–2.9 μg/100 g), dark chocolate (4 μg/100 g), as well as fortified foods (milk, yoghurt, fat spreads, orange juice, breakfast grains, plant-based beverages). Since an adequate intake of vitamin D (15 μg/day set by the European Food Safety Authority) is hard to achieve through diet alone, dietary supplements of vitamin D are usually recommended. This review summarizes current knowledge about different sources of vitamin D for humans.

Vitamin D insufficiency is associated with lower hip bone density in African American men

2007 ◽  
Vol 10 (2) ◽  
pp. S210-S211
Author(s):  
N. Akhter ◽  
B. Sinnott ◽  
D. Rao ◽  
S. Kukreja ◽  
E. Barengolts
Keyword(s):  
Vitamin D ◽  
African American ◽  
Bone Density ◽  
African American Men ◽  
Vitamin D Insufficiency

scholarly journals Interaction Between Vitamin D and Interleukin 6 on Slow Gait Speed: 6-Year Follow-up Data of Older Adults From InCHIANTI

2019 ◽  
Vol 75 (6) ◽  
pp. 1161-1166
Author(s):  
Jatupol Kositsawat ◽  
Chia-Ling Kuo ◽  
Lisa C Barry ◽  
David Melzer ◽  
Stefania Bandinelli ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Interleukin 6 ◽  
Gait Speed ◽  
Estimating Equation ◽  
Population Based ◽  
Vitamin D Insufficiency ◽  
Reactive Protein ◽  
25 Hydroxy Vitamin D ◽  
Independent Effects

Abstract Background Whereas the independent effects of biomarkers, including 25-hydroxy vitamin D (25(OH)D), insulin-like growth factor 1, C-reactive protein, and interleukin 6 (IL-6), on gait speed in older adults have been evaluated, their joint effects on gait speed are not well understood. Methods Study subjects aged at least 65 at baseline (N = 970) were enrolled in the population-based Invecchiare in Chianti (InCHIANTI) study from 1998 to 2000 and were followed up at 3 and 6 years. All above biomarkers and gait speed data were measured at each of the three time points. Using a generalized estimating equation approach, we determined if slow gait speed (&lt;0.8 m/s) was associated with the biomarkers. Further investigation was conducted for interactions between high IL-6 (≥.87 pg/mL) and other biomarkers focusing on low 25(OH)D (&lt;20 ng/mL). Results After controlling for other biomarkers and potential confounders, IL-6 emerged as the only biomarker independently associated with gait speed. The association between high IL-6 and slow gait speed was enhanced by low 25(OH)D, with significant interaction between high IL-6 and low 25(OH)D (p = .038). The odds ratio of slow gait speed for low 25(OH)D and high IL-6 was 1.63 (95% confidence interval [CI]: 1.15, 2.32) compared with the reference groups with both biomarker levels at the other ends. Conclusion The association of low vitamin D with slow gait speed statistically interacts with high IL-6. Coexisting vitamin D insufficiency and inflammation may provide a better biomarker for identifying those at risk of developing impairments in gait speed than either factor alone.

Effects of vitamin D insufficiency on bone mineral density in African American men

2008 ◽  
Vol 20 (5) ◽  
pp. 745-750 ◽  
Author(s):  
N. Akhter ◽  
B. Sinnott ◽  
K. Mahmood ◽  
S. Rao ◽  
S. Kukreja ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
African American ◽  
Bone Mineral ◽  
African American Men ◽  
Vitamin D Insufficiency ◽  
Mineral Density
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