Sniffing out cancer from real breath samples by means of nanomaterial-based electronic nose device

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e17552-e17552
Author(s):  
R. V. Abdah-Bortnyak ◽  
H. Haick ◽  
S. Billan ◽  
G. Peng ◽  
E. Trock ◽  
...  
Keyword(s):  
Cancer Detection ◽  
Electronic Nose ◽  
Au Nanoparticles ◽  
Similar Type ◽  
Healthy Controls ◽  
Mass Spectrometry Technique ◽  
Volatile Organic ◽  
Cancer Types ◽  
Spectrometry Technique ◽  
Electronic Nose Technology

e17552 Background: Several studies have shown that characteristic patterns of volatile organic compounds (VOCs) appear to be elevated in the alveolar breath of cancer patients, as compared to healthy controls. It has been shown, that VOCs’ composition acts as a fingerprint for the distinction of a certain cancer from other cancers, including the cases where various cancers have similar type of biomarkers. The goal of the current study is to establish a background to ultimately achieve a simple-to-use device that can detect such patterns of cancer when exhaling into it. Methods: Breath samples were collected from 40 healthy volunteers and 75 patients having known conditions in six main categories: (I) 40 healthy controls; (II) 30 patients with lung cancer; (III) 15 patients with breast cancer; (IV) 20 patients with colon cancer; (V) 5 patients with prostate cancer; and (VI) 5 patients with head and neck cancer. The breath of the volunteers was examined by means of gas chromatography linked with mass spectrometry technique (GC-MS) as well as by an electronic nose device that is based on molecularly modified Au nanoparticles to check the feasibility of the electronic nose in cancer detection via breath samples Results: GC-MS results showed that each category of cancer has a unique pattern (or mixture) of VOCs. In parallel to these findings, results indicate the ability of nanomaterial-based electronic nose devices to differentiate between “healthy” and “cancerous” breath, and, furthermore, between the breath of patients with different cancer types, with >92% sensitivity. Conclusions: The electronic nose technology has a high potential for assessing various types of cancer via simple exhalation procedure. The results provide a launching pad towards obtaining an inexpensive, compact tool that is amenable to widespread screening and that has a potential for direct and real-time monitoring (2–3 minutes only). No significant financial relationships to disclose.

scholarly journals Use of Electronic Noses for Diagnosis of Digestive and Respiratory Diseases through the Breath

Biosensors ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 35 ◽  
Author(s):  
Carlos Sánchez ◽  
J. Santos ◽  
Jesús Lozano
Keyword(s):  
Electronic Nose ◽  
Detrimental Effect ◽  
Point Of View ◽  
Diagnostic Methods ◽  
Electronic Noses ◽  
Medical Sector ◽  
Volatile Organic ◽  
Potential Applications ◽  
Electronic Nose Technology

The increased occurrence of chronic diseases related to lifestyle or environmental conditions may have a detrimental effect on long-term health if not diagnosed and controlled in time. For this reason, it is important to develop new noninvasive early diagnosis equipment that allows improvement of the current diagnostic methods. This, in turn, has led to an exponential development of technology applied to the medical sector, such as the electronic nose. In addition, the appearance of this type of technology has allowed the possibility of studying diseases from another point of view, such as through breath analysis. This paper presents a bibliographic review of past and recent studies, selecting those investigations in which a patient population was studied with electronic nose technology, in order to identify potential applications of this technology in the detection of respiratory and digestive diseases through the analysis of volatile organic compounds present in the breath.

THE PREVALENCE OF CANCER AND ITS RELATION TO DISEASE ACTIVITY IN PATIENTS WITH ACROMEGALY: TWO CENTERS EXPERIENCE

2020 ◽  
Author(s):  
Bekir Ucan ◽  
Muhammed Kizilgul ◽  
Alper Cagri Karci ◽  
Hakan Duger ◽  
Muhammed Erkam Sencar ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Cancer Risk ◽  
Animal Studies ◽  
Malignant Neoplasms ◽  
Insulin Like Growth Factor ◽  
Patients With Cancer ◽  
Mass Spectrometry Technique ◽  
Cancer Types ◽  
Spectrometry Technique

Background: Acromegaly is characterized by increased serum concentrations of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). Although animal studies demonstrated a relationship between these hormones and cancer risk, the results of human studies evaluating cancer prevalence in acromegaly are inconsistent. We aimed to investigate the prevalence of malignant neoplasms in patients with acromegaly. Material and Methods: Cancer risk was evaluated in a cohort of 280 patients (M/F 120/160, mean age 50.93 ±12.07 years) with acromegaly. Patients were categorized into two groups according to the presence of cancer or not. Standard incidence ratios (SIRs) were calculated as compared to the general population. Results: From 280 patients, cancer was diagnosed in 19 (6.8%) patients. 9 (47%) of them had thyroid cancer, which was the most common one in cancer types. SIRs of all cancers were 0.8 (95% CI 0.5–1.1) and 1.0 (95% CI 0.8–1.3) in men and women, respectively. Compared to patients without cancer, the current age was higher in patients with cancer (59 (49–65) to 51 (42–59), p:0.027). In contrast, the age at diagnosis was similar in both groups. Not only was time to diagnosis and disease duration similar in both groups but also basal and current GH and IGF-1 levels. The prevalence of active disease was also similar between groups (32% to 23%, p:0.394). Conclusions: Our findings were not consistent with the studies suggesting that acromegaly patients encounter an increased cancer risk. Furthermore, there was a similar basal and current GH and IGF-1 levels in both acromegalic patients with and without cancer. Abbreviations: GH = Growth hormone, IGF-1 = insulin-like growth factor 1, BMI = Body mass index, SIRs = Standard incidence ratios, ASR = age-standardized rate, LC-MS = liquid chromatography mass-spectrometry technique.

scholarly journals Assessing milk quality using the electronic nose

2007 ◽  
Author(s):  
◽  
Samantha Govender
Keyword(s):  
Sensory Evaluation ◽  
Electronic Nose ◽  
Traditional Approach ◽  
Milk Quality ◽  
Specific Chemical ◽  
Novel Technology ◽  
Volatile Organic ◽  
Microbiological Testing ◽  
Electronic Nose Technology ◽  
Milk And Dairy Products

There are many ways for milk and dairy products to develop flavour defects. Sensory evaluation, has been the traditional approach to characterize off flavours. The need for odour sensing devices becomes greater when volatile and semi-volatile organic compounds are present in the product in parts per billion or even in the parts per trillion concentration range that cause off flavours. Today, sophisticated, sensitive instrumental tests such as electronic nose technology coupled with gas chromatography are capable of detecting, identifying and quantifying the specific chemical agents responsible for off flavours. This study focused on the use of the electronic nose as a novel technology for the detection and monitoring of milk quality by testing the effects of heat treatment at 63˚C and shelf life. Microbiological testing, sensory evaluation and gas chromatographic analysis were carried out together with aroma profiling using the electronic nose to determine milk quality.

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